1,280 results match your criteria: "Eccrine Carcinoma"
Hidradenocarcinoma of the Chest With Axillary Lymph Node Metastasis: Report of 2 Cases and Systematic Literature Review of a Breast Cancer Mimicker.
Am J Dermatopathol
December 2024
Surgical Pathology and Cytopathology Unit, University Hospital of Padova, Padova, Italy.
Hidradenocarcinoma (HAC) is a rare malignant neoplasm originating from eccrine sweat glands, often presenting diagnostic challenges because of its resemblance to other malignancies, particularly breast cancer when occurring in the chest region. This report describes 2 cases of HAC with axillary lymph node metastasis, both initially misinterpreted clinically. The first case involved a 63-year-old woman with a sternal mass, near the right breast, initially suspected to be a sebaceous cyst.
View Article and Find Full Text PDFSquamoid Eccrine Ductal Carcinoma: An Unusual Diagnosis in a Pregnant Patient.
Cureus
October 2024
Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, USA.
Squamoid eccrine ductal carcinoma (SEDC) is an unusually rare neoplasm of the skin with a relatively high risk for local recurrence and a potential for metastasis. While typical presentations occur in older, male patients, this case report describes the diagnosis made in a pregnant patient in her third trimester. The clinical presentation, pathology, and treatment course of SEDC are outlined in this article.
View Article and Find Full Text PDFDiagnosis and Management of Malignant Epithelial Nail Unit Tumors.
Diagnostics (Basel)
October 2024
Dermatology Department, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Article Synopsis
- Malignant tumors of the nail unit, like squamous cell carcinoma and basal cell carcinoma, can be hard to diagnose because they often look like benign issues, making early detection important.
- * This review examines various types of malignancies affecting the nail unit, discussing their clinical features, pathology, and surgical management challenges.
- * Proper evaluation and treatment strategies are critical for improving patient outcomes and preserving nail function during surgery.*
Familiar cylindromatosis in a Colombian family caused by a mutation in CYLD.
Ecancermedicalscience
September 2024
Department of Human Genetics, Fundación Valle del Lili, Cali 760026, Colombia.
Article Synopsis
- The CYLD cutaneous syndrome leads to multiple skin tumors like cylindromas and spiradenomas, primarily affecting the face and head, with more frequent occurrence in women.
- A Colombian family spanning three generations showcased early onset of this syndrome, confirmed by genetic analysis identifying a specific variant in the CYLD gene.
- Understanding the genetic and environmental factors behind the syndrome is vital for developing better treatments and enhancing patient care.
A Recurrent Case of Papillary Eccrine Adenoma.
Cureus
July 2024
Dermatopathology, Prime West Consortium, Newport Beach, USA.
Article Synopsis
Primary cutaneous adnexal adenocarcinoma not otherwise specified versus metastatic breast carcinoma: A case report and review of the literature.
JAAD Case Rep
September 2024
Department of Pathology, Stamford Hospital, Stamford, Connecticut.
Squamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Mod Pathol
November 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Article Synopsis
- Squamoid eccrine ductal carcinoma is a rare tumor with characteristics that fall between squamous cell carcinoma (SCC) and certain sweat gland carcinomas, leading to debates on its classification.
- The study examined 15 cases of this carcinoma, revealing that most cases had UV signature mutations and TP53 mutations as the most common genetic alterations.
- Transcriptome analysis indicated that this carcinoma expresses 364 genes more and 525 genes less compared to SCC and sweat gland tumors, reinforcing the idea that it has an intermediate phenotype between these cancer types.
Pedunculated eccrine poromas on non-acral sites.
BMJ Case Rep
August 2024
Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Article Synopsis
- A woman in her 50s with breast cancer had some strange red growths on her neck and chest, but didn’t feel any pain from them.
- Doctors looked at the growths and thought they could be several different things, but after testing, they found out these growths were a rare type called eccrine poroma (EP).
- The woman had the growths removed using a special heat method, and a year later there was no sign of them coming back, showing how important it is to recognize EP when looking at similar-looking skin issues.
Squamoid eccrine ductal carcinoma: series of five cases of a rare tumor.
An Bras Dermatol
August 2024
Department of Dermatology, Faculty of Medicine, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.
A Rare Case of Eccrine Carcinoma Demonstrating Intracranial Invasion in a Patient With Advanced Hepatocellular Carcinoma.
Cureus
July 2024
Vascular and Interventional Radiology, University of Texas Medical Branch at Galveston, Galveston, USA.
Article Synopsis
Squamoid eccrine ductal carcinoma: clinical, histological and immunohistochemical features.
Dermatol Online J
April 2024
Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Squamoid eccrine ductal carcinoma (SEDC) is a cutaneous adnexal malignancy that is histologically challenging to distinguish from squamous cell carcinoma. We report three cases of this rare entity and review the present literature regarding clinical, histological, and immunohistochemical features. Patients presented with a single nodule or plaque lesion on their back and temple.
View Article and Find Full Text PDFGene expression profiling in porocarcinoma indicates heterogeneous tumor development and substantiates poromas as precursor lesions.
J Dtsch Dermatol Ges
August 2024
Institute of Human Genetics, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Article Synopsis
- Malignant sweat gland tumors, particularly eccrine porocarcinoma (EP), are rare, with about 18% of benign eccrine poroma (EPO) cases progressing to EP, highlighting a need for more understanding of EP biology and mutations involved in this transformation.
- Transcriptome profiling of 23 EP and normal skin samples showed significant gene expression diversity and downregulation in EP, including specific genes that indicated a stepwise transition from normal skin to EPO to EP.
- The study suggests that EP has a complex molecular nature linked to tumor development, with potential involvement of the p53 and EGFR pathways, and calls for further research with larger sample sizes to validate these findings.
Porocarcinoma: Clinical and Histological Features, Immunohistochemistry and Outcomes: A Systematic Review.
Int J Mol Sci
May 2024
Department of Dermatology, University Hospitals Leuven, 3000 Leuven, Belgium.
Article Synopsis
- Porocarcinoma (PC) is a rare skin tumor primarily affecting older adults, originating from sweat glands and associated with a high risk of metastasis.
- Differentiating PC from squamous cell carcinoma can be challenging, but markers like NUT expression and YAP1 fusions aid in diagnosis.
- Treatment typically involves wide local excision, with Mohs surgery as a potential alternative; systemic therapies like pembrolizumab show promise, but guidelines for lymph node biopsy and radiotherapy are lacking.
Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Hum Pathol
August 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, 32224, USA. Electronic address:
Article Synopsis
- - Sweat gland neoplasms are complex and rare skin tumors, making them a tricky area for doctors who study skin diseases (dermatopathology) and recent research has revealed different biological markers for several types of these tumors.
- - A study evaluated various sweat gland tumors in patients, using techniques like immunohistochemistry and RNA sequencing to help identify specific tumor types based on their unique features.
- - Findings showed that specific tests, such as p63 IHC, BRAF V600E IHC, and MAML2 FISH, can effectively assist in accurately diagnosing sweat gland tumors, offering valuable tools for pathologists when the usual assessment is unclear.
Thumb-Sparing Surgery for Digital Papillary Adenocarcinoma: A Case Report.
Cureus
April 2024
Orthopedic Surgery, Rothman Orthopaedics Florida at AdventHealth, Orlando, USA.
Digital papillary adenocarcinoma (DPA) is a rare eccrine sweat gland tumor that often appears as a solitary, non-painful, gradually enlarging mass. Clinically, DPA presents considerable challenges due to its high likelihood of recurrence and its tendency to spread to the lymph nodes and lungs. This case report focuses on the surgical treatment of a unique case of DPA located on the dorsal thumb in a 46-year-old male.
View Article and Find Full Text PDFMohs surgery for squamoid eccrine ductal carcinoma.
J Cutan Aesthet Surg
January 2024
Central Clinical School, University of Sydney, The Skin Hospital, Darlinghurst, New South Wales, Australia.
Squamous eccrine ductal carcinoma is a rare cutaneous malignancy. It has the potential to locally recur and may occasionally metastasize. It presents a diagnostic challenge given its rare nature and overlapping histopathological features with other cutaneous carcinomas.
View Article and Find Full Text PDFUlcerated nodules with zosteriform distribution on the upper extremity.
Int J Dermatol
December 2024
Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, China.
Article Synopsis
Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
Histopathology
October 2024
CARADERM Network.
Article Synopsis
- Porocarcinoma is a malignant sweat gland tumor that can develop from benign poromas, and recent studies have identified specific genetic fusions like PAK1/2/3 in some cases.
- In a study of 12 porocarcinoma patients, most were older males with tumors located on various parts of the body, and some patients developed distant metastases.
- The research indicates that PAK1/2/3 fusions might drive cancer development in porocarcinomas that do not have YAP1 rearrangements, highlighting a potential target for treatment.
Primary Cutaneous Apocrine Carcinoma of the Thigh: A Rare Case Report.
Cureus
April 2024
Department of Radiation Oncology, Centre Hospitalier Universitaire Mohammed VI, Oujda, MAR.
Adnexal carcinomas are rare cutaneous malignancies arising from the eccrine and apocrine sweat glands, follicles and sebaceous glands. They occur mainly in elderly people. We report the case of a patient treated for locally advanced apocrine adnexal carcinoma of the thigh, with a review of the literature.
View Article and Find Full Text PDFArticle Synopsis
- A 23-year-old South Asian man developed a darkly pigmented papule on his scalp, which grew within a pre-existing warty plaque present since birth.
- The papule showed characteristics indicative of basal cell carcinoma (BCC) when examined and biopsied, confirming it developed from a sebaceous naevus.
- Sebaceous naevi are benign skin lesions that can develop into malignancies like BCC in a small percentage of cases, especially in adults.
Eccrine porocarcinoma in the tempus of an elderly woman: A case report.
World J Clin Cases
March 2024
Department of Dermatology, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China.
Background: Eccrine porocarcinoma (EPC) is a rare skin tumor that mainly affects the elderly population. Tumors often present with slow growth and a good prognosis. EPCs are usually distinguished from other skin tumors using histopathology and immunohistochemistry.
View Article and Find Full Text PDFCase Report: A challenging diagnosis of an apocrine sweat gland carcinoma.
Front Surg
March 2024
Department of Surgery, College of Human Medicine, Michigan State University, Lansing, MI, United States.
Article Synopsis
Primary Mucinous Eccrine Carcinoma in Nasomaxillary Region: a Rare Case Report and Management Insights.
Indian J Otolaryngol Head Neck Surg
April 2024
Department of Pathology, Hitkarini Dental College and Hospital, Jabalpur, India.
Primary Mucinous eccrine carcinoma (MEC) is a rare malignant neoplasm of skin believed to arise from eccrine sweat gland commonly with periocular involvement. Here we report a case of 60-year male with a recurrence of unilateral nasomaxillary mass and epiphora. Imaging suggested nasolacrimal duct as probable site of origin.
View Article and Find Full Text PDFEpidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features.
Virchows Arch
March 2024
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Article Synopsis
- Most tumors result from genetic changes, but some are linked to viral infections like HPV, which can lead to specific skin conditions.
- Epidermodysplasia verruciformis (EDV) is a rare HPV infection characterized by unique histological features and specific HPV subtypes.
- The study discusses a particular type of EDV-related tumor found in two patients, highlighting consistent features and suggesting it could be a unique, reproducible form of skin tumor.