10 results match your criteria: "Eberhard Karl University Tuebingen[Affiliation]"
Treated Cases of Retinopathy of Prematurity in Germany: 10-Year Data from the Retina.net Retinopathy of Prematurity Registry.
Ophthalmol Retina
June 2024
Department of Ophthalmology, University Medicine Greifswald, Greifswald, Germany. Electronic address:
Purpose: To analyze changes in demographic parameters and retreatment patterns over a 10-year period in a clinical routine setting of infants with retinopathy of prematurity (ROP) requiring treatment documented in the German Retina.net ROP registry.
Design: Multicenter, noninterventional, observational registry study recruiting patients treated for ROP.
Microvascular tissue transfer after the resection of soft tissue sarcomas.
J Plast Reconstr Aesthet Surg
May 2021
Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Background: Microvascular tissue transfer enables the oncological resection of soft tissue sarcomas of the extremities and the trunk by covering the resulting tissue defects that are often extensive. This study was performed to investigate the long-term survival and functional outcome of patients treated with free flaps after sarcoma resection.
Methods: A total of 78 sarcoma patients received microvascular tissue transfer in our institution between March 2003 and January 2013.
ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD).
Br J Ophthalmol
November 2020
Department of Ophthalmology, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Germany.
Article Synopsis
- The ORCA module of the OCEAN study assessed how well clinicians in Germany interpreted SD-OCT images for neovascular age-related macular degeneration (nAMD) and made treatment decisions over a 24-month period.
- 2286 SD-OCT scans from 205 eyes were independently reviewed for indications of choroidal neovascularization (CNV) activity, revealing a 74.9% agreement rate between clinicians and reading centers (RCs).
- Despite detecting CNV activity in a substantial number of scans, clinicians initiated treatment in only 35.5% of those cases, leading to concerns about visual acuity decline due to potential undertreatment and the need for better decision-making in therapy based on SD-OCT
Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca Entry in Megakaryocytes.
Sci Rep
February 2020
Department of Vegetative and Clinical Physiology, Eberhard Karl University Tuebingen, Tuebingen, Germany.
Article Synopsis
- Impairment in renal phosphate elimination in chronic kidney disease leads to increased phosphate levels, activating NFAT5 and SGK1, which enhance the function of ORAI1 and promote store-operated calcium entry (SOCE).
- The study investigated the effects of the phosphate-donor ß-glycerophosphate on NFAT5 and ORAI gene expressions in human megakaryocytic cells and found that it significantly increased their levels along with SOCE.
- Platelets from patients with kidney impairments showed higher transcript and protein levels of NFAT5 and ORAI1 compared to healthy individuals, indicating a strong relationship between phosphate dysregulation and cellular signaling pathways.
Retrospective single center analysis of outcome, risk factors and therapy in steroid refractory graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Bone Marrow Transplant
November 2019
Department of Hematology and Oncology, Medical Center University Hospital Tuebingen, Tuebingen, Germany.
Acute and chronic graft-vs.-host disease (aGvHD and cGvHD) are major complications after allogeneic hematopoietic cell transplantation (HCT) leading to substantial morbidity and mortality. This retrospective single-center study analyzes incidence, therapy, and outcome of GvHD in n = 721 patients ≥18 years having received allogeneic HCT 2004-2013 with a special focus on steroid refractory GvHD.
View Article and Find Full Text PDFPre-Analytical Parameters Affecting Vascular Endothelial Growth Factor Measurement in Plasma: Identifying Confounders.
PLoS One
July 2016
Eye Center, University of Freiburg, Freiburg, Germany.
Background: Vascular endothelial growth factor-A (VEGF-A) is intensively investigated in various medical fields. However, comparing VEGF-A measurements is difficult because sample acquisition and pre-analytic procedures differ between studies. We therefore investigated which variables act as confounders of VEGF-A measurements.
View Article and Find Full Text PDFRe: Boyer et al.: Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema (Ophthalmology 2014;121:1904-14).
Ophthalmology
March 2015
Center for Ophthalmology, Eberhard-Karl University Tuebingen, Eye Center, Albert-Ludwigs-University Freiburg, Tuebingen and Freiburg, Germany.
Refining the treatment parameters of diabetic retinopathy: new prospects and limitations on the horizon.
J Diabetes Complications
November 2014
Institute of Ophthalmology, St Franziskus Hospital, Muenster, Germany.
Anti-Vascular endothelial growth factor therapy impairs endothelial function of retinal microcirculation in colon cancer patients - an observational study.
Exp Transl Stroke Med
May 2013
Autonomic and neuroendocrinological laboratory, Center of Clinical Neuroscience, University Hospital Carl Gustav Carus, Dresden, Fetscherstr 74, Germany.
Background: To assess acute effects of bevacizumab (anti-VEGF therapy) on cerebral microvessels and systemic cardiovascular regulation.
Design And Subjects: 20 consecutive patients with colorectal cancer (median age: 60.4 years, range 45.
Evaluation of verteporfin pharmakokinetics--redefining the need of photosensitizers in ophthalmology.
Expert Opin Drug Metab Toxicol
August 2012
Eberhard Karl University Tuebingen-Center for Ophthalmology, Schleichstr. 12, Tuebingen 72076, Germany.
Introduction: The benzoporphyrine derivative verteporfin has lost its importance to the treatment of the most frequent neovascular eye diseases. Nevertheless, it is still mandatory to define the remaining applications, role, and potential of verteporfin in ocular photodynamic therapy (PDT), including the dosages of administration, effectiveness, and safety profile.
Areas Covered: Although verteporfin PDT has forfeited the first-line status and value of treating subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration or pathologic myopia, the treatment remains the standard of care for choroidal haemangioma and polypoidal choroidal vasculopathy.