Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review.

The link between medication-related osteonecrosis of the jaw (MRONJ) and bone modulating drugs, such as bisphosphonates and denosumab, is well established, and the number of reported cases is increasing. The development of novel medications used in the treatment of cancer, as well as autoimmune and bone conditions, has led to more cases of MRONJ being reported. However, in addition to this group of medications, increasing numbers of new agents in cancer therapy, such as antiangiogenic agents, have also been implicated in the development of MRONJ.

Perceptions of outcomes of orthodontic treatment in adolescent patients: a qualitative study.

Background: The outcomes of orthodontic treatment are frequently classified as aesthetic, functional, and psychosocial. However, there is limited research looking at outcomes of treatment in a qualitative manner from the patients' perspective. It is crucial to have a better understanding of these outcomes to allow management of expectations and enhance satisfaction with treatment.

Parents' perceptions of outcomes of orthodontic treatment in adolescent patients: a qualitative study.

Background And Objectives: Recent years have seen increased research investigating treatment outcomes from a patient perspective. However, parental perceptions are also important, as parents provide useful feedback. There is general acceptance that patients, and their parents, seek treatment for reasons including improvements in aesthetics, function, and quality of life.

Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience.

Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.

Methods: This was an international, multicenter, placebo-controlled, randomized withdrawal study that included a 7-day run-in period, a 21-day open-label phase, and a 28-day double-blind phase in which patients (planned n = 30) were randomized to vixotrigine or placebo.

Qualitative study to identify issues affecting quality of life in adults with craniofacial anomalies.

Our objective was to identify key issues that affect the quality of life (QoL) of adult patients with craniofacial anomalies. This was a qualitative prospective study using in-depth, semi-structured interviews. Ten patients who fulfilled the inclusion criteria were recruited during their attendance at the Adult Craniofacial Clinic at the Eastman Dental Hospital, University College London Hospitals NHS Foundation Trust.

Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery.

Objectives: To describe changes in growth factor mediators in the gingival crevicular fluid (GCF) of patients with aggressive periodontitis (AgP) undergoing regenerative (GTR) and access flap (AF) surgery.

Materials And Methods: This was a 12-month, single-blind, split-mouth RCT involving 18 AgP patients with a bilateral intrabony defect which was treated with GTR or AF. GCF was collected prior to surgery and at subsequent follow-up visits from 3 days to 12 months post-operatively, and the levels of angiopoietin-1 (Ang-1), vascular-endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), bone morphogenetic protein-2 (BMP-2), osteoprotegerin (OPG), tissue inhibitor of metalloproteinase 1 (TIMP-1), keratinocyte growth factor (KGF) and platelet-derived growth factor-AB (PDGF-AB) were measured.

Group 3 ITI Consensus Report: Patient-reported outcome measures associated with implant dentistry.

Objectives: The aim of Working Group 3 was to focus on three topics that were assessed using patient-reported outcome measures (PROMs). These topics included the following: (a) the aesthetics of tooth and implant-supported fixed dental prostheses focusing on partially edentulous patients, (b) a comparison of fixed and removable implant-retained prostheses for edentulous populations, and (c) immediate versus early/conventional loading of immediately placed implants in partially edentate patients. PROMs include ratings of satisfaction and oral health-related quality of life (QHRQoL), as well as other indicators, that is, pain, general health-related quality of life (e.

Biomechanical aspects: Summary and consensus statements of group 4. The 5 EAO Consensus Conference 2018.

Objectives: The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentulous patients, on biological and technical complications of tilted in comparison with straight implants, and on the effects of osseointegrated implants functioning in a residual dentition.

Material And Methods: The group discussed, evaluated, corrected where deemed appropriate, and made recommendations to the authors regarding the following five reviews submitted: (a) Is there an effect of crown-to-implant ratio on implant treatment outcomes?; (b) Implant-supported cantilevered fixed dental rehabilitations in fully edentulous patients; (c) and in partially edentulous patients; (d) Biological and technical complications of tilted implants in comparison with straight implants supporting fixed dental prostheses; (e) What are the adverse effects of osseointegrated implants functioning among natural teeth of a residual dentition? Based on the five manuscripts and the discussion among the group as well as the plenum members, the major findings were summarized, consensus statements were formulated, clinical recommendations were proposed, and areas of future research were identified.

Guidelines for development of Implant Dentistry in the next 10 years regarding innovation, education, certification, and associations.

Background: During the third Summer Camp of European Association of Osseointegration (EAO), 40 junior representatives from various European societies and associations were brought together to discuss and explore the following topics in Implant Dentistry in the next 10 years: (I) certification, (II) societies and associations, (III) continuing education, and (IV) innovations.

Aims: The aims of all working groups were to identify and outline the present situation in the area of the selected topic and to propose improvements and innovations to be implemented in the following 10 years.

Materials And Methods: Four different groups were assigned randomly to one of the four working units.

Methods of space maintenance for premature loss of a primary molar: a review.

Aim: This critical appraisal attempts to answer the question: What is the best method of space maintenance (SM) following premature loss of a primary molar in children under 12 years old?

Methods: A search to identify studies relevant to the PICO was conducted. Single case reports and studies prior to 1986 were excluded. The principles of GRADE were followed to appraise the evidence.

Space maintainers in the primary and mixed dentition - a clinical guide.

This paper describes different types of space maintainers and the clinical situations where they may be useful, for example, when primary teeth have been lost prematurely. It serves as a clinical guide for practitioners on the best types of space maintainers to use and on the clinical uses of space maintainers in preventing undesirable tooth movements and resulting loss of arch length.

Straight to the point: considering sharp safety in dentistry.

All members of the clinical dental team face a daily risk of a personal sharp injury. A wide range of sharp instruments are used, some of which are specifically designed to easily pierce the skin and mucosa. The instruments are placed, moved, passed between colleagues, used for treatment, replaced and cleaned, all in relatively confined areas.

Injectable local anaesthetic agents for dental anaesthesia.

Background: Pain during dental treatment, which is a common fear of patients, can be controlled successfully by local anaesthetic. Several different local anaesthetic formulations and techniques are available to dentists.

Objectives: Our primary objectives were to compare the success of anaesthesia, the speed of onset and duration of anaesthesia, and systemic and local adverse effects amongst different local anaesthetic formulations for dental anaesthesia.

Bilateral root resorption of maxillary first permanent molars by unerupted second molars associated with orthodontic distalisation.

Root resorption is a common but undesirable side-effect of orthodontic treatment. It is a well-recognised phenomenon largely associated with impacted or unerupted teeth and in most cases, is mild and does not affect longevity of the affected teeth. This case report of a medically fit and healthy Caucasian boy who was undergoing orthodontic treatment at the Eastman Dental Hospital, UCLH (EDH) for management of his severe hypodontia, presents an unusual incident of bilateral resorption of his maxillary first permanent molars by the unerupted second molars.

A comparative study to investigate the effect of orthodontic treatment on the uniqueness of the human anterior dentition.

Aim: The human dentition contains many features which can be used to identify an individual from the dentition or from bite marks created and bite mark evidence may be used to link a suspect to a crime. The aim of this research was to investigate the effect of orthodontic treatment on the uniqueness of the human anterior dentition by comparison of the number of dental shape matches between pre- and post-treatment dental casts for a group of patients who have undergone orthodontic treatment (dental braces) to improve the alignment of their teeth.

Method: This comparative study utilised pre- and post-orthodontic treatment dental casts from 36 patients.

Images as catalysts for meaning-making in medical pain encounters: a multidisciplinary analysis.

The challenge for those treating or witnessing pain is to find a way of crossing the chasm of meaning between them and the person living with pain. This paper proposes that images can strengthen agency in the person with pain, particularly but not only in the clinical setting, and can create a shared space within which to negotiate meaning. It draws on multidisciplinary analyses of unique material resulting from two fine art/medical collaborations in London, UK, in which the invisible experience of pain was made visible in the form of co-created photographic images, which were then made available to other patients as a resource to use in specialist consultations.

Measuring the impact of trigeminal neuralgia pain: the Penn Facial Pain Scale-Revised.

Background And Objective: The Penn Facial Pain Scale (Penn-FPS) was originally developed as a supplemental module to the Brief Pain Inventory Pain Interference Index (BPI-PII) in order to fully assess the impact of trigeminal neuralgia (TN) pain on patients' health-related quality of life (HRQoL). The current objective is to create and establish the content validity of a new stand-alone version of the measure, the Penn-FPS-Revised (Penn-FPS-R).

Methods: Twenty participants (15 USA and 5 UK) with confirmed TN engaged in concept elicitation and cognitive debriefing interviews.

Factors influencing satisfaction with the process of orthodontic treatment in adult patients.

Introduction: Despite the increases in adults undergoing orthodontic treatment in both the public and private sectors, satisfaction with the treatment process has not been widely explored. In this study, we investigated factors influencing satisfaction with the process of orthodontic treatment in adult patients.

Methods: This was a prospective cross-sectional qualitative study.