4 results match your criteria: "Eastern Piedmont University Novara[Affiliation]"
Practical recommendations for managing severe chronic rhinosinusitis with nasal polyps in the era of biologics.
Acta Otorhinolaryngol Ital
October 2023
Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.
Objective: We conducted a national survey to understand how rhinology practice has changed with the advent of biologics and how this affected patients with uncontrolled, severe chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to analyse the results of the survey and infer practical recommendations for clinical practice.
Methods: A group of ear, nose, and throat specialists (ENTs) experienced in the management of CRSwNP developed a 74-question survey.
Case-fatality rate of major bleeding events in patients on dual antiplatelet therapy after percutaneous coronary intervention: A systematic review and meta-analysis.
Res Pract Thromb Haemost
October 2022
Department of Medicine Ottawa Hospital Research Institute, University of Ottawa Ottawa Ontario Canada.
Article Synopsis
- - The study aims to assess the case-fatality rate (CFR) of major bleeding in patients on dual antiplatelet therapy (DAPT) after undergoing percutaneous coronary intervention (PCI) and to analyze how this rate varies based on the duration of DAPT.
- - From a search of 2777 potential studies, 16 studies were included, revealing 823 major bleeding events with 91 being fatal among nearly 49,000 patients on DAPT, resulting in an overall CFR of 10.8%.
- - The findings indicate that while fatal bleeding is often not reported in DAPT studies, the CFR is significant, particularly higher within the first 12 months, suggesting that shorter DAPT durations may
Time Course of Ischemic and Bleeding Burden in Elderly Patients With Acute Coronary Syndromes Randomized to Low-Dose Prasugrel or Clopidogrel.
J Am Heart Assoc
January 2019
14 Department of Cardiology Multimedica IRCSS Milan Italy.
Article Synopsis
- Elderly patients (aged >74) with acute coronary syndrome experience high rates of ischemic and bleeding complications over time, prompting a study to evaluate these rates with different medications.
- The study analyzed average daily ischemic rates (ADIRs) and average daily bleeding rates (ADBRs) over one year for patients undergoing percutaneous coronary intervention, comparing the effects of low-dose prasugrel and clopidogrel.
- Results indicated that ischemic events were consistently higher than bleeding events, with low-dose prasugrel showing better outcomes by reducing ischemic incidents in the subacute and late phases compared to clopidogrel, while bleeding was less with clopidogrel in the late phase.
Randomized evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with the COMBO dual therapy stent: rationale and design of the REDUCE trial.
Am Heart J
August 2016
Department of Cardiology, AOU Maggiore della Carità, Eastern Piedmont University Novara, Italy.
Background: The optimal duration of dual antiplatelet therapy (DAPT) in acute coronary syndrome (ACS) patients treated with drug eluting stents (DES) is still under debate. Recent meta-analyses on ≤6months versus 12months DAPT suggest that bleeding rates can be reduced, without a higher rate of thrombotic complications. In particular, the COMBO dual therapy stent, being associated with early re-endothelialization, may allow for a reduction of the duration of DAPT without increasing the thrombotic risk, while reducing the risk of bleeding complications.
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