Development of non-governmental organisation-academic partnership to tackle rabies in Africa and Asia.

Rabies kills approximately 60,000 people each year, mainly in sub-Saharan Africa and Asia, of which 40% of victims are less than 15 years old. Once clinical signs develop, the disease is almost invariably fatal. Globally, rabies has been estimated to cause 3∙7 million disability-adjusted life years and $8∙6B in economic losses annually.

Tricarbocyanine -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells .

Herein tricarbocyanine -triazoles are first described as a rationally-designed near-infrared (NIR) structure overcoming the brightness and photostability limitations of tricarbocyanines for long-term imaging. The straightforward synthetic approach and the wide availability of alkynes makes this strategy a versatile methodology for the preparation of highly stable -substituted tricarbocyanines. Furthermore, we validated as a non-transferable marker to monitor the fate of therapeutic T cells non-invasively , showing enhanced performance over conventional NIR fluorophores ( , IR800CW and indocyanine green) as well as compatibility with human cells for translational studies.

The prevalence of brucellosis and bovine tuberculosis in ruminants in Sidi Kacem Province, Morocco.

Bovine tuberculosis (BTB) and brucellosis are major endemic zoonoses in ruminants in Morocco that impact on both animal and human health. This study presents an assessment of the epidemiological and socioeconomic burden of bacterial zoonoses in Sidi Kacem Province in Northern Morocco from a cross-sectional survey of 125 cattle and/or small ruminant-owning households. In total, 1082 sheep and goats were examined from 81 households.

Horses with solar foot penetration, deep digital flexor tendon injury, and absence of concurrent synovial sepsis can have a positive outcome.

Solar foot penetration is one of the causes of deep digital flexor tendon injuries in horses, however, limited information is available on the prognosis for return to soundness in the absence of synovial sepsis. Objectives of this retrospective observational study were to describe low-field magnetic resonance imaging (MRI) findings and long-term outcome for a group of horses with this combination of clinical problems. Horses were included if low-field standing MRI of the foot was performed following puncture wounds, injury of the deep digital flexor tendon was diagnosed, and sepsis was confirmed to be absent in all adjacent synovial structures (distal interphalangeal joint, navicular bursa, and digital flexor tendon sheath).

Population genetics of benzimidazole-resistant Haemonchus contortus and Haemonchus placei from buffalo and cattle: implications for the emergence and spread of resistance mutations.

The population genetics of nematode parasites are poorly understood with practical reference to the selection and spread of anthelmintic resistance mutations. Haemonchus species are important to study the nematode population genetics due to their clinical importance in ruminant livestock, and the availability of genomic resources. In the present study, it has been examined that Haemonchus contortus and Haemonchus placei populations from three buffalo and nine cattle hosts.

The potential of small ruminant farming as a means of poverty alleviation in rural southern India.

Small ruminant production has the potential to address the global challenge of greatly increased food production in impoverished rural areas in a manner that is socioeconomically sustainable and carbon efficient. Twenty-six small ruminant landless farmers in three villages in the Kanchipuram District of the state of Tamil Nadu were surveyed with regard to their sheep farming practice and production indices, with the preliminary aim of evaluating the potential of small ruminant farming in alleviating poverty in parts of rural in southern India. The small ruminant farmers reared mostly indigenous Madras Red sheep as a means of generating primary or supplementary income.

Delivery and evaluation of participatory education for animal keepers led by veterinarians and para-veterinarians around the Kanha Tiger Reserve, Madhya Pradesh, India.

Aim: We aim to investigate local perceptions of animal health challenges; current animal health knowledge; and methods to provide effective, relevant education to animal keepers in the Kanha Tiger Reserve area.

Materials And Methods: A farmer education programme was undertaken in the Kanha Tiger Reserve area. Local animal health priorities were investigated through participatory village meetings (n = 38), individual animal keeper questionnaires (n = 100) and a written survey of local paravets (n = 16).

One million dog vaccinations recorded on mHealth innovation used to direct teams in numerous rabies control campaigns.

Background: Canine transmitted rabies kills an estimated 59,000 people annually, despite proven methods for elimination through mass dog vaccination. Challenges in directing and monitoring numerous remote vaccination teams across large geographic areas remain a significant barrier to the up-scaling of focal vaccination programmes to sub-national and national level. Smartphone technology (mHealth) is increasingly being used to enhance the coordination and efficiency of public health initiatives in developing countries, however examples of successful scaling beyond pilot implementation are rare.

Evaluation of factors associated with retained surgical sponges in veterinary patients: a survey of veterinary practitioners.

Objectives: To evaluate factors that could be associated with retained surgical sponges in veterinary patients.

Materials And Methods: A survey was distributed to 322 veterinarians attending a national veterinary conference in the UK. The survey included questions about the staff, scheduling, type of surgical procedure, surgical sponges, methods to track surgical sponges and details of clinical cases with retained surgical sponges.

Behaviour-Based Husbandry-A Holistic Approach to the Management of Abnormal Repetitive Behaviors.

The field of zoo animal welfare science has developed significantly over recent years. However despite this progress in terms of scientific research, globally, zoo animals still face many welfare challenges. Recently, animal welfare frameworks such as the five domains or five needs have been developed and suggested to improve the welfare of zoo animals, but without practical guidance, such tools may remain abstract from the daily experience of zoo animals.

Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock.

Monepantel resistance was diagnosed during routine monitoring of the effectiveness of a farm's roundworm control strategy. Weaned lambs had become ill thrifty and developed diarrhoea, despite the routine use of monepantel. This clinical presentation was caused by trichostrongylosis.

A review of factors affecting analgesic selection in large animals undergoing translational research.

The widespread physiological effects of pain in experimental animals are likely to reduce the validity of data except when pain itself is studied. Appropriately prescribed analgesics will limit pain and improve the welfare of animals undergoing noxious experimental procedures. However, their injudicious use may also introduce variability in data and limit study reproducibility.

First genetic evidence for the presence of the rumen fluke Paramphistomum epiclitum in Pakistan.

More than 70 species of the Superfamily Paramphistomoidea, have been identified in ruminants in different parts of the world. Most are pathogenic, causing amphistomosis. Adult flukes within this family have a predilection for the forestomach (rumen) or bile duct of the liver, where they may cause epithelial damage.

Fanconi Syndrome in Irish Wolfhound Siblings.

Three juvenile male Irish wolfhound littermates presented with marked polyuria and polydipsia. The four female siblings were apparently unaffected. Diagnostic testing revealed glucosuria with normoglycemia, generalized aminoaciduria, hypokalemia and metabolic acidosis consistent with Fanconi syndrome.

A rabies lesson improves rabies knowledge amongst primary school children in Zomba, Malawi.

Rabies is an important neglected disease, which kills around 59,000 people a year. Over a third of these deaths are in children less than 15 years of age. Almost all human rabies deaths in Africa and Asia are due to bites from infected dogs.

Investigation of short-term surgical complications in a low-resource, high-volume dog sterilisation clinic in India.

Background: Surgical sterilisation is currently the method of choice for controlling free-roaming dog populations. However, there are significant logistical challenges to neutering large numbers of dogs in low-resource clinics. The aim of this study was to investigate the incidence of short-term surgical complications in a low-resource sterilisation clinic which did not routinely administer post-operative antibiotics.

Vitamin D Receptor Expression in Dogs.

Background: There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog.

Rhesus macaque personality, dominance, behavior, and health.

Previous studies of nonhuman primates have found relationships between health and individual differences in personality, behavior, and social status. However, despite knowing these factors are intercorrelated, many studies focus only on a single measure, for example, rank. Consequently, it is difficult to determine the degree to which these individual differences are independently associated with health.

Use of computed tomography imaging during long-term follow-up of nine feline tuberculosis cases.

Case series summary Feline tuberculosis is an increasingly recognised potential zoonosis of cats. Treatment is challenging and prognosis can vary greatly between cases. Pulmonary infection requires extended courses of antibiotics, but methodologies for sensitively monitoring response to treatment are currently lacking.

Barriers of attendance to dog rabies static point vaccination clinics in Blantyre, Malawi.

Rabies is a devastating yet preventable disease that causes around 59,000 human deaths annually. Almost all human rabies cases are caused by bites from rabies-infected dogs. A large proportion of these cases occur in Sub Saharan Africa (SSA).

Tricuspid valve dysplasia: A retrospective study of clinical features and outcome in dogs in the UK.

The objective of this study was to determine the demographic, clinical and survival characteristics and to identify risk factors for mortality due to tricuspid valve dysplasia in UK dogs. Records of client-owned dogs diagnosed with tricuspid valve dysplasia at a referral centre were retrospectively reviewed. Only dogs diagnosed with tricuspid valve dysplasia based on the presence of a right-sided heart murmur identified prior to one year of age, and confirmed with Doppler echocardiography, were included.

Evaluation of ex vivo restoration of carious equine maxillary cheek teeth infundibulae following debridement with dental drills and Hedstrom files.

An ex-vivo study was performed on vertically mounted equine maxillary cheek teeth that had caries of 30 infundibulae, using high and low speed contra-angle dental drills and Hedstrom files to debride infundibular food debris and carious dental tissues. This technique effectively debrided 27/30 infundibulae with a mean depth of 19mm (range 9.4-34.