5,801 results match your criteria: "East London NHS Foundation Trust & Queen Mary University of London[Affiliation]"

Article Synopsis
  • The study evaluated the safety and efficacy of glyceryl trinitrate (GTN) for patients experiencing transient ischaemic attack (TIA) during stroke trials, as part of the RIGHT-2 trial.
  • Conducted as a multicenter, randomized, sham-controlled trial, the research involved administering GTN to patients with suspected ultra-acute stroke and assessing outcomes at 90 days using the modified Rankin Scale (mRS).
  • Results showed that while GTN effectively lowered blood pressure, it did not improve functional outcomes or mortality rates compared to the sham treatment, indicating no benefit for TIA patients.
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Background: Maternity outcomes for women from certain ethnic groups are notably poor, partly owing to their not receiving treatment from services.

Aims: To explore barriers to access among Black and south Asian women with perinatal mental health problems who did not access perinatal mental health services and suggestions for improvements, and to map findings on to the perinatal care pathway.

Method: Semi-structured interviews were conducted in 2020 and 2021 in the UK.

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Ménière's Disease (MD) is a disease that may be difficult to diagnose and manage. Our UK survey showed variability in the practice of UK Otolaryngology consultants. We hence surveyed Otolaryngology consultants internationally, to assess their confidence levels in diagnosing MD, their use of the AAO-HNS guidelines and current diagnostic and treatment modalities.

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Unlabelled: Early identification of emotional and behavioural difficulties in very young children is crucial for intervention and prevention. The Strengths and Difficulties Questionnaire (SDQ) is a widely used measure of child and adolescent mental health that is brief, cost-effective, and easy to administer. The aims of this study were to establish the validity and reliability of the preschool SDQ in UK 1-2-year-olds.

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Background: Preservation of residual kidney function (RKF) in dialysis patients has been associated with improved survival. RKF in the BISTRO trial was relatively well preserved and here we describe its association with survival during the trial and extended follow-up.

Methods: RKF, measured as the average urea and creatinine clearance (GFR) or 24-hour urine volume was assessed at baseline, one, two and three months and three-monthly up to 2 years in incident haemodialysis patients.

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Article Synopsis
  • Several guidelines endorse TLC-NOSF dressings for chronic wounds, but they are often seen as second-line treatments, risking patient care and increasing costs.
  • A systematic review analyzed existing studies from various databases, focusing on wound healing rates, quality of life, and costs when TLC-NOSF dressings were used as initial therapy.
  • The review included 17 studies published between 2017 and 2024, comparing TLC-NOSF as both first-line and second-line treatments, revealing important insights into their effectiveness and implications for patient outcomes.
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Objective: The first COVID-19 pandemic wave was a period of reduced surgical activity and redistribution of resources to only those with late stage or critical presentations. This Vascular and Endovascular Research Network COVID-19 Vascular Service (COVER) study aimed to describe the six-month outcomes of patients who underwent open surgery and or endovascular interventions for major vascular conditions during this period.

Methods: In this international, multicentre, prospective, observational study, centres recruited consecutive patients undergoing vascular procedures over a 12-week period.

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Background: In the absence of direct evidence supporting how to use nasal endoscopy findings to judge chronic rhinosinusitis (CRS) disease control, experts' practice patterns could provide guidance.

Methodology: Participants consisted of a diverse group of twenty-nine rhinologists. Participants were presented with every possible combination of bilateral nasal endoscopy findings represented by the modified Lund-Kennedy (MLK; range: 0-12) endoscopic scoring system and Nasal Polyp Score (NPS; range: 0-8).

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Article Synopsis
  • - The study examined the differences in causes of undiagnosed pleural effusions between outpatient and inpatient settings, involving 1,080 adult patients from four UK hospitals.
  • - Results showed that malignant effusions were more frequent in outpatients (48.3%) while infections were more common in inpatients (36.2%), indicating significant differences based on patient status.
  • - The findings suggest that diagnostic approaches should be tailored based on whether patients are admitted to the hospital or seen as outpatients.
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  • - The study evaluated the Arabic version of the EQ-5D tool for measuring health-related quality of life in atrial fibrillation patients in Syria, addressing a gap in existing data.
  • - Involving 432 participants, the research demonstrated strong reliability and validity of the EQ-5D through various testing methods, confirming its effectiveness for this patient group.
  • - The successful validation of the EQ-5D in this context encourages its broader use across Arabic-speaking regions, potentially enhancing healthcare decision-making and patient care strategies.
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  • Recovery Colleges (RCs) are special communities that help people recover from mental health issues through learning, but their success in different cultures is not well studied.
  • Researchers looked at 169 RCs from various countries to see how cultural differences affect how well they operate.
  • They found that RCs work best in cultures that are more individualistic and indulgent, but it's important to consider other cultures to make these programs better for everyone around the world.
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  • Researchers are studying the selection criteria for medical training in the UK to see if they help or hurt certain ethnic and socioeconomic groups.
  • The study will use documents and surveys to gather information from medical students about how they're chosen for the Specialised Foundation Programme.
  • Understanding any unfairness in selection is important because it can affect the future of medical professionals and healthcare diversity.
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Background: This study examined the power of theory-derived models to account for the development of PTSD, Complex PTSD (CPTSD), depression, and anxiety in children and adolescents who had experienced a single-event trauma.

Methods: Children ( = 234, aged 8-17 years) recruited from local Emergency Departments were assessed at two and nine weeks post-trauma. Data obtained from self-report questionnaires completed by the child, telephone interviews with parents, and hospital data were used to develop four predictive models of risk factors for PTSD, CPTSD, depression, and Generalized Anxiety Disorder (GAD).

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  • An error grid is a tool that helps compare glucose levels measured by devices to see if they are correct and to identify any risks.
  • Experts created a new error grid called the DTS Error Grid that works for both blood glucose monitors (BGMs) and continuous glucose monitors (CGMs), organizing accuracy into five risk zones.
  • The results showed that the DTS Error Grid provides a clearer picture of how accurate these devices are and includes a separate matrix to evaluate how well CGMs track glucose trends over time.
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  • There are not enough treatments for children with moderate to severe intellectual disabilities who have specific phobias.
  • The study aims to create a special intervention for these kids and find out how well it works, along with checking in with their parents and doctors.
  • They will also explore ways to make the intervention easy to access and understand for everyone involved.
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Article Synopsis
  • * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
  • * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
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Practice Patterns and Challenges in Managing Inherited Retinal Diseases Across Asia-Pacific: A Survey from the APIED Network.

Asia Pac J Ophthalmol (Phila)

October 2024

Centre for Innovation & Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Ophthalmology, National University Hospital, National University Health System, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Article Synopsis
  • The paper looks at how inherited retinal diseases (IRD) are diagnosed and treated in the Asia-Pacific region.
  • They surveyed 36 centers about their practices, including how they collect patient information and provide help for low vision.
  • The results showed there are important gaps, like many centers not having a database for patients, not enough genetic counselors, and a need for better support for low-vision rehabilitation.
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Background: Sleep disturbances are common and distressing for people with dementia and their families. Non-pharmacological interventions should be first-line management, avoiding harmful pharmacological side-effects, but there is none with known effectiveness. We aimed to establish whether DREAMS START, a multicomponent intervention, reduced sleep disturbance in people with dementia living at home compared with usual care.

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Background: People with severe mental illness (SMI) have worse physical health than the general population. There is evidence that support from volunteers can help the mental health of people with SMI, but little evidence regarding the support they can give for physical health.

Aims: To evaluate the feasibility of an intervention where volunteer 'Health Champions' support people with SMI in managing their physical health.

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  • A recent cross-sectional study conducted by dermatologists from Denmark, the UK, and Switzerland in May 2022 assessed the prevalence of skin diseases among adults in Tasiilaq, East Greenland, revealing significant health concerns.* -
  • Out of 295 participants (about 22.5% of the adult population), 69% exhibited visible signs of skin disease, with common conditions being hand eczema, lichen simplex, and scabies being the most prevalent.* -
  • The findings highlight a high prevalence of skin diseases and emphasize the need for improved access to dermatological care in the region, as many cases were severe and differed from typical presentations.*
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Prenatal sequencing tests are being introduced into clinical practice in many developed countries. In part due to its greater ability to detect genetic variation, offering prenatal sequencing can present ethical challenges. Here we review ethical issues arising following the implementation of prenatal sequencing in the English National Health Service (NHS).

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The European Society of Intensive Care Medicine (ESICM) has developed evidence-based recommendations and expert opinions about end-of-life (EoL) and palliative care for critically ill adults to optimize patient-centered care, improving outcomes of relatives, and supporting intensive care unit (ICU) staff in delivering compassionate and effective EoL and palliative care. An international multi-disciplinary panel of clinical experts, a methodologist, and representatives of patients and families examined key domains, including variability across countries, decision-making, palliative-care integration, communication, family-centered care, and conflict management. Eight evidence-based recommendations (6 of low level of evidence and 2 of high level of evidence) and 19 expert opinions were presented.

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