Generating Beta Zeolite Nanosheets of Intergrown Polymorph B and C Using Polycationic Structure-Directing Agent.

Zeolitic nanosheets possess great potential in catalysis due to their enhanced transport property and accessibility toward bulky molecules compared to conventional micron- meter scale crystals. However, the generation of Beta zeolite nanosheets, which are crucial for industrial catalysis, is still challenging for its intergrowth nature. In this work, aluminosilicate Beta nanosheets of ca.

Detection of the Novel HLA-A*02:01:01:257 Allele by Pacific Biosciences HiFi Sequencing in a Chinese Individual.

HLA-A*02:01:01:257 differs from HLA-A*02:01:01:01 by a single nucleotide substitution in intron 7.

Metal-Assisted Synthesis of Diverse Porphyrinoids by Cyclization of an N-Confused Thia-Pentapyrrane.

Oxidation of thia-pentapyrrane S-P4 with terminal β-linked pyrrole and thiophene units in the presence of various metal ions has been found to afford distinct porphyrinoids. Specifically, N-confused thiasapphyrin (1), Cu(III) norrole (2), neo-confused phlorin (3), and p-benzinorrole (4) were obtained, when S-P4 was oxidized with p-chloranil in acetonitrile in the presence of Ni2+, Cu2+, Cd2+, and Co2+, respectively. The structures of 1-4 have been clearly elucidated by NMR spectroscopy, HRMS, and X-ray crystal diffraction (for 2-4).

An interracial Mendelian analysis revealed a link between lipid-lowering drugs and renal failure.

Lipid-lowering drugs have been used in clinics widely. It is unclear whether the drugs have an effect on renal failure. We chose high-density lipoprotein cholesterol (ieu-b-109), low-density lipoprotein cholesterol (ieu-a-300), triglyceride (ieu-b-111), and total cholesterol (ebi-a-GCST90038690) as exposures.

The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.

Overexpression of uridine-cytidine kinase 2 (UCK2), a key enzyme in the pyrimidine salvage pathway, is implicated in human cancer development, while its regulation under nutrient stress remains to be investigated. Here, we show that under glucose limitation, AMPK phosphorylates glycinamide ribonucleotide formyltransferase (GART) at Ser440, and this modification facilitates its interaction with UCK2. Through its binding to UCK2, GART generates tetrahydrofolate (THF) and thus inhibits the activity of integrin-linked kinase associated phosphatase (ILKAP) for removing AKT1-mediated UCK2-Ser254 phosphorylation under glucose limitation, in which dephosphorylation of UCK2-Ser254 tends to cause Trim21-mediated UCK2 polyubiquitination and degradation.

Impacts of irrigation expansion on moist-heat stress based on IRRMIP results.

Irrigation rapidly expanded during the 20 century, affecting climate via water, energy, and biogeochemical changes. Previous assessments of these effects predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP).

Temperature seasonality regulates organic carbon burial in lake.

Organic carbon burial (OCB) in lakes, a critical component of the global carbon cycle, surpasses that in oceans, yet its response to global warming and associated feedbacks remains poorly understood. Using a well-dated biomarker sequence from the southern Tibetan Plateau and a comprehensive analysis of Holocene total organic carbon variations in lakes across the region, here we demonstrate that lake OCB significantly declined throughout the Holocene, closely linked to changes in temperature seasonality. Process-based land surface model simulations clarified the key impact of temperature seasonality on OCB in lakes: increased seasonality in the early Holocene saw warmer summers enhancing ecosystem productivity and organic matter deposition, while cooler winters improved organic matter preservation.

Predicting land use and land cover changes for sustainable land management using CA-Markov modelling and GIS techniques.

This study addresses the significant issue of rapid land use and land cover (LULC) changes in Lahore District, which is critical for supporting ecological management and sustainable land-use planning. Understanding these changes is crucial for mitigating adverse environmental impacts and promoting sustainable development. The main goal is to evaluate historical LULC changes from 1994 to 2024 and forecast future trends for 2034 and 2044 utilizing the CA-Markov hybrid model combined with GIS methodologies.

Total population for a resource-limited single consumer model.

In the past several decades, much attention has been focused on the effects of dispersal on total populations of species. In Zhang (EL 20:1118-1128, 2017), a rigorous biological experiment was performed to confirm the mathematical conclusion: Dispersal tends to enhance populations under a suitable hypothesis. In addition, mathematical models keeping track of resource dynamics in population growth were also proposed in Zhang (EL 20:1118-1128, 2017) to understand this remarkable phenomenon.

Investigation into the PSD characteristics of internally unstable soils susceptible to suffosion.

Internal instability of embankment soils under seepage can occur in two distinct ways: suffusion and suffosion. Suffusion involves the removal of fine particles from the matrix without causing significant disturbance to the soil skeleton, while suffosion is characterized by the movement of fine particles accompanied by skeleton collapse or deformation. In terms of dam safety, suffosion poses a greater threat than suffusion.

Quasi-vertically asymmetric channels of graphene oxide membrane for ultrafast ion sieving.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes, demonstrating potential for highly efficient water desalination and purification, gas and ion separation, and organic solvent waste treatment. Here, we report the construction of vertical channels in graphene oxide (GO) membrane based on a substrate template with asymmetric pores. The membranes achieved water permeance of 2647 L m h bar while still maintaining an ultrahigh rejection rate of 99.

MarR family regulator LcbR2 activates lincomycin biosynthesis in multiple ways.

Lincomycin, produced by the actinomycete Streptomyces lincolnensis, is highly effective against Gram-positive bacteria and protozoans, making it widely used in clinical settings. This study identified LcbR2, a MarR family transcriptional regulator, as an activator of lincomycin biosynthesis. Knocking out the lcbR2 gene reduced lincomycin production by 63.

An electrochemical aptasensor based on bimetallic carbon nanocomposites AuPt@rGO for ultrasensitive detection of adenosine on portable potentiostat.

Adenosine plays a crucial role in the cardiovascular and nervous systems of living organisms. Excessive adenosine can lead to arrhythmias or heart failure, making the accurate detection of adenosine highly valuable. Given the widespread use of sensors for detecting small molecules, we propose a sensitive electrochemical aptasensor for adenosine detection in this study.

Antibiotic resistance genes (ARGs) in microorganisms and their indications for the nitrogen/sulfur cycle in the East China Sea sediments.

Antibiotic resistance genes (ARGs) are emerging environmental pollutants, posing an escalating threat to public health and environmental security worldwide. However, the relationship between ARGs and microbial communities in the environment, as well as their ecological effects on the microbe-mediated materials cycle remain unclear. In this study, we investigated the spatial distribution pattern, influence mechanism, relationship with microorganisms, and their effects on the elemental cycling of ARGs in East China Sea sediments.

The Association Between Egg and Egg-Derived Cholesterol Consumption, and Their Change Trajectories, with Obesity Among Chinese Adults: Results from the China Health and Nutrition Survey.

As a widely consumed, nutritious, and affordable food, eggs and their derivatives' impacts on obesity remain inconclusive. In this study, we aimed to determine the association between egg and egg-derived cholesterol consumption, and their change trajectories, with obesity among Chinese adults. : Longitudinal data collected by the China Health and Nutrition Survey from 1997 to 2015 were analyzed.

Research on Sensitivity Improvement Methods for RTD Fluxgates Based on Feedback-Driven Stochastic Resonance with PSO.

With the wide application of Residence Time Difference (RTD) fluxgate sensors in Unmanned Aerial Vehicle (UAV) aeromagnetic measurements, the requirements for their measurement accuracy are increasing. The core characteristics of the RTD fluxgate sensor limit its sensitivity; the high-permeability soft magnetic core is especially easily interfered with by the input noise. In this paper, based on the study of the excitation signal and input noise characteristics, the stochastic resonance is proposed to be realized by adding feedback by taking advantage of the high hysteresis loop rectangular ratio, low coercivity and bistability characteristics of the soft magnetic material core.

Research on RTD Fluxgate Induction Signal Denoising Method Based on Particle Swarm Optimization Wavelet Neural Network.

Aeromagnetic surveying technology detects minute variations in Earth's magnetic field and is essential for geological studies, environmental monitoring, and resource exploration. Compared to conventional methods, residence time difference (RTD) fluxgate sensors deployed on unmanned aerial vehicles (UAVs) offer increased flexibility in complex terrains. However, measurement accuracy and reliability are adversely affected by environmental and sensor noise, including Barkhausen noise.

Dual-Mechanism Study of Metal-Free g-CN Catalysts for Advanced Oxidation Under Non-Photocatalytic Conditions.

Metal-free materials have been proved to be promising replacements of traditional metal-based catalysts for advanced oxidation reactions. Carbon nitride was found to be able to activate HO and generate hydroxyl radicals (•OH). Nevertheless, the performance of carbon nitride is highly dependent on an external light source.

Enhanced Electrochemical Performance of Dual-Ion Batteries with T-NbO/Nitrogen-Doped Three-Dimensional Porous Carbon Composites.

Niobium pentoxide (T-NbO) is a promising anode material for dual-ion batteries due to its high lithium capacity and fast ion storage and release mechanism. However, T-NbO suffers from the disadvantages of poor electrical conductivity and fast cycling capacity decay. Herein, a nitrogen-doped three-dimensional porous carbon (RMF) was prepared for loading niobium pentoxide to construct a composite system with excellent electrochemical performance.

Research on the Composition and Casting Technology of Bronze Arrowheads Unearthed from the Ruins of the Imperial City of the Minyue Kingdom.

The ruins of the Imperial City of the Minyue Kingdom were an important site of the Minyue Kingdom during the Han Dynasty. Characteristic bronze arrowheads unearthed from the East Gate, with their exquisite craftsmanship, provide important physical evidence for studying ancient bronze casting technology and the military activities of that time. However, there is still a lack of systematic research on the alloy composition, casting process, and chemical stability of these arrowheads in long-term burial environments.

Phylogenetic and Comparative Genomics Study of Based on Mitochondrial Genomes.

Camel bot fly () larvae cause myiasis in domesticated and wild camels, resulting in significant economic losses to the camel industry and posing a serious global public health concern. To date, only one mitochondrial genome (mitogenome) of isolated from the Alxa Bactrian camel has been reported. Herein, was isolated from the Junggar Bactrian camel to assemble a complete circular mitogenome with a length of 16,552 bp encoding 13 protein-coding genes, 22 tRNA genes, and two rRNA genes.

Subacute PM2.5 Exposure Induces Hepatic Insulin Resistance Through Inflammation and Oxidative Stress.

Epidemiological studies prove that type II diabetes, characterized by insulin resistance (IR), may be caused by fine particulate matter 2.5 (PM2.5).

Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages.

Tuberculosis (TB) remains the major cause of mortality and morbidity, causing approximately 1.3 million deaths annually. As a highly successful pathogen, () has evolved numerous strategies to evade host immune responses, making it essential to understand the interactions between and host cells.

Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes.

Background: The increasing prevalence of drug-resistant tuberculosis (TB) underscores the urgent need for novel antimicrobial agents.

Methods: This study integrates cultivation optimization, nuclear magnetic resonance (NMR) fingerprinting, and principal component analysis (PCA) to explore microbial secondary metabolites as potential anti-TB agents.

Results: Using the combined approach, 11 bioactive compounds were isolated and identified, all exhibiting anti- BCG activity.

Antimicrobial Resistance Genes in Clinical Strains from Livestock and Poultry in Shandong Province, China During 2015-2020.

Antimicrobial resistant (AMR) () isolated from animals may lead to antibiotic treatment failure and economic losses to farmers. The co-existence of antimicrobial resistant genes (ARGs) in the same isolate presents a major challenge for the prevention and control of infection in multidrug-resistant (MDR) Gram-negative organisms. There have been a lot of studies on the antibiotic resistance of in livestock and poultry, but few of them have focused on clinical pathogens.