Genetic Theory behind the Molar Incisor Hypomineralisation.

Much effort has been spent in the identification of an environmental factor that explains the occurrence of molar incisor hypomineralisation (MIH). The best explanation, however, is accepting that MIH has a complex or multifactorial mode of inheritance. This chapter provides an analysis of how multifactorial inheritance operates in determining MIH, an explanation that accommodates the variation seen in the phenotype and the frequency of the problem around the world.

Immunophenotypic and Gene Expression Analyses of the Inflammatory Microenvironment in High-Grade Oral Epithelial Dysplasia and Oral Lichen Planus.

Background: Oral lichen planus (OLP) and oral epithelial dysplasia (OED) present diagnostic challenges due to clinical and histologic overlap. This study explores the immune microenvironment in OED, hypothesizing that immune signatures could aid in diagnostic differentiation and predict malignant transformation.

Methods: Tissue samples from OED and OLP cases were analyzed using immunofluorescence/immunohistochemistry (IF/IHC) for CD4, CD8, CD163/STAT1, and PD-1/PDL-1 expression.

The use of teledentistry in clinical oral and maxillofacial pathology practice: an institutional experience.

Background: Although there has been a slight increase in dental professionals since 2011, 98 of North Carolina's 100 counties are designated as Dental Health Professional Shortage Areas by the Heath Resources and Service Administration. This shortage significantly increases disparities and access to primary and specialized oral health care. Also, dental professionals in these remote locations may feel the access and referrals to oral and maxillofacial pathologists cumbersome.

Extracolonic manifestations of Gardner syndrome: A case report.

Gardner syndrome has head and neck manifestations that may be recognized during dental visits. Features such as multiple gnathic osteomas, impacted supernumerary teeth, and multiple foci of idiopathic osteosclerosis can be easily identified on dental radiographs, prompting the clinician to refer the patient for further investigation. A dental examination and routine radiographs play a vital role in revealing the extracolonic presentation of Gardner syndrome, which facilitates timely screening and detection of colorectal cancer and other malignancies associated with this condition.

Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2.

Parathyroid hormone 2 (Pth2) is a vertebrate-specific neuropeptide for which thalamic expression is upregulated by social contact with conspecifics. However, social interactions fail to stimulate pth2 expression in isolated zebrafish in which lateral line hair cells have been chemically ablated. These results suggest that modulation of pth2 by social context is acutely dependent on mechanosensory information from the lateral line.

Comparison of CBCT Prescriptions among Different Campuses of East Carolina University School of Dental Medicine.

Objectives: East Carolina University School of Dental Medicine (ECU SoDM) has established a unique education model that delivers the dental curriculum through student rotations at community service learning centers (CSLCs) in underserved areas across North Carolina in their senior year. The objective of the study is to analyze the patient composition and CBCT prescription patterns at the main campus (Ross Hall) and eight CSLCs, to determine if students have comparable training at various sites.

Methods: CBCTs taken at ECU SoDM in 2017-2021 were evaluated.

Malignant Lymphoproliferative Disorders of the Oral and Maxillofacial Region: Report of Two Institutions.

Background: Report of the incidence of malignant hematologic neoplasms in the oral cavity according to the experience of the two oral and maxillofacial pathology institutions in North Carolina, USA.

Methods: A 10-year retrospective review was carried out in the records of patients at ECU SoDM and UNC Adams SoD. Age, sex, location of the lesion, clinical impression, initial diagnosis, and the expression immunohistochemical and molecular markers were recorded for each subject.

Development and characterization of experimental ZnO cement containing niobophosphate bioactive glass as filling temporary material.

Aims: The aim of this study was to develop and characterize a temporary restorative material based on a zinc oxide matrix containing niobophosphate bioactive glass (NbG) for the caries-affected dentin treatment.

Material And Methods: NbG was added to a ZnO matrix in different concentrations (wt%). EDS-SEM, ATR-FTIR and XRD analyses were performed to characterize the cement.

Clinical Instructions for Using Silver Diamine Fluoride (SDF) in Dental Caries Management.

Unlabelled: Manufacturer instructions for 38% silver diamine fluoride (SDF) are limited to current FDA clearance for tooth desensitization. There is a need for instructions to provide best-practice recommendations for off-label use of SDF for caries prevention and arrest.

Methods: The authors considered existing clinical approaches to the use of 38% SDF at pH 10 for the prevention and arrest of active dental caries, in light of the best current evidence.

Collaborating and teaching a synchronous, multi-university, virtual course: Health policy and access to dental care.

Purpose: In response to COVID-19, dental educators have been tasked with maintaining the quality of education while reducing cost, increasing efficiency, and leveraging technology.

Methods: This collaborative, multisite virtual health policy course used the Staged Self-Directed Learning Model (SSDL) to lead a diverse group of students studying health policy. Twelve Core sessions were offered with three additional sessions in August or December for a total of 15 total synchronous Zoom sessions that covered policy issues on supply, demand, and need for dental care.

Should dental schools adopt teledentistry in their curricula? Two viewpoints.

Introduction: Teledentistry is a cutting edge technology that could be used to improve access to care to underserved populations and those in remote areas.

Objectives: To discuss the advantages and disadvantages of adopting teledentistry into the predoctoral dental curriculum.

Methods: Two teams of dentists reviewed the pros and cons of introducing teledentistry into the predoctoral dental curriculum.

The ability of a nanobioglass-doped self-etching adhesive to re-mineralize and bond to artificially demineralized dentin.

Objective: To a self-etch adhesive doped with nano-bioglass and evaluate its ability to bond and re-mineralize artificially demineralized dentin.

Methods: Experimental Si, Ca, Na and PO based nanobioglass particles were synthesized, doped into experimental self-etch adhesives, and divided into 3 groups: Clearfi SE2 (CSE2), experimental (EXC), and experimental doped with 10% of nanobioglass (ExNB). The adhesives were applied onto the caries-affected dentin (chemically simulated), and evaluated after 24 h and 28 days of immersion in simulated body fluid.

Risk Indicators of Urgent and Extensive Dental Treatment Needs in U.S. Air Force Recruits.

Introduction: Dental Readiness Classifications (DRCs) enable the Military Health System to prioritize dental care in garrison, minimizing dental emergencies and mission degradation during deployments. Over half (52.4%) of 2008 military recruits presented with high-priority urgent needs classified as DRC3 upon initial dental examination and 18.

Effect of crystalline phase assemblage on reliability of 3Y-TZP.

Statement Of Problem: Strengthening mechanisms of zirconia ceramics stabilized with 3 mol% yttria (3Y-TZP) are complex and dictated by the crystalline phase assemblage. Although their clinical performance for dental restorations has been excellent, there is evidence that framework fractures do occur and have been underreported. Meanwhile, the relationship between phase assemblage and reliability of 3Y-TZP is not properly understood.

Oral Mucositis Due to High-Dose Chemotherapy and/or Head and Neck Radiation Therapy.

Oral mucositis is a common side-effect associated with conventional cancer therapy and has also recently been reported in association with newly emerging cancer therapies. It is characterized as an inflammation of the oral mucous membranes accompanied by many complex mucosal and submucosal changes. Ulcerative oral mucositis can cause significant oral pain, impair nutritional intake, lead to local or systemic infection, and cause significant economic cost.

Influence of Community-Based Dental Education on Practice Choice: Preliminary Data from East Carolina University.

Maldistribution of the dental workforce contributes to poor access to oral health care. Community-based dental education (CBDE) may help to address this problem by using experiential learning to encourage new dentists to practice in underserved areas. The East Carolina University School of Dental Medicine (East Carolina University SoDM) employs a multifaceted strategy, including CBDE, to increase the number of dentists practicing in underserved areas of North Carolina.

Use of the Dental Electronic Health Record for Research: Assessing Demographic and Oral Health Characteristics Data for Clinic Patients.

Dental schools in the United States increasingly emphasize community-based practice targeting underserved populations. However, the impact on target populations remains largely undocumented. East Carolina University School of Dental Medicine (ECU SoDM) developed an integrated electronic health record database that aggregates patient data from all clinics in the ECU SoDM system and enables longitudinal assessment of the impact of clinical care on oral health outcomes.

Analyzing Dental Students' Clinic Production Using Time-Based Relative Value Units: Ten-Year Cross-Cohort Mapping.

The analysis of dental students' clinical production/participation has been used to assess whether a prospective graduate is capable of unsupervised and independent practice (that is, competent to perform that practice). This method and others have inherent biases that may not accurately reflect whether the student has mastered the associated concepts and techniques required for dentistry. The aim of this study was to assess an informatics system that assigned curriculum meta-tags with time-based relative educational value units (ReVUs) to each clinical procedure performed by Medical University of South Carolina (MUSC) students.

Methacrylate Resin Adhesion in Root Canals Conditioned with Phosphoric Acid and Ethylenediaminetetraacetic Acid.

Objective: The purpose of this study was to determine the ability of a methacrylate resin dentin bonding agent to adhere to the dentin surfaces of prepared and conditioned root canals with either 32% phosphoric acid (PA) or 17% ethylenediaminetetraacetic acid (EDTA).

Methods: Prior to the application of the methacrylate resin, the root canals of 54 intact, caries-free, single- rooted, de-crowned, extracted human maxillary incisor and canine teeth were endodontically prepared and conditioned with either 32% PA or 17% EDTA or with distilled water as the unconditioned control. The resin-treated roots were cross-sectioned at three levels and scanning electron microscope (SEM) imaged for circumferential views of the root canals at 60-90× magnification and site-specific views at 250× magnification, and then randomly coded for independent and blind evaluation by four calibrated examiners.

Odontogenic Cysts and Neoplasms.

This article reviews a myriad of common and uncommon odontogenic cysts and tumors. The clinical presentation, gross and microscopic features, differential diagnosis, prognosis, and diagnostic pitfalls are addressed for inflammatory cysts (periapical cyst, mandibular infected buccal cyst/paradental cyst), developmental cysts (dentigerous, lateral periodontal, glandular odontogenic, orthokeratinized odontogenic cyst), benign tumors (keratocystic odontogenic tumor, ameloblastoma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroma and fibroodontoma, odontoma, squamous odontogenic tumor, calcifying cystic odontogenic tumor, primordial odontogenic tumor, central odontogenic fibroma, and odontogenic myxomas), and malignant tumors (clear cell odontogenic carcinoma, ameloblastic carcinoma, ameloblastic fibrosarcoma).