Exploring the nexus of urban form, transport, environment and health in large-scale urban studies: A state-of-the-art scoping review.

Background: As the world becomes increasingly urbanised, there is recognition that public and planetary health relies upon a ubiquitous transition to sustainable cities. Disentanglement of the complex pathways of urban design, environmental exposures, and health, and the magnitude of these associations, remains a challenge. A state-of-the-art account of large-scale urban health studies is required to shape future research priorities and equity- and evidence-informed policies.

Global WaterPack - The development of global surface water over the past 20 years at daily temporal resolution.

Open surface water across the globe is essential for many life forms and is an important source for human settlements, agriculture, and industry. The presence and variation in time and space is influenced by different natural conditions (e.g.

IceLines - A new data set of Antarctic ice shelf front positions.

The frontal position of an ice shelf is an important parameter for ice dynamic modelling, the computation of mass fluxes, mapping glacier area change, calculating iceberg production rates and the estimation of ice discharge to the ocean. Until now, continuous and up-to-date information on Antarctic calving front locations is scarce due to the time-consuming manual delineation of fronts and the previously limited amount of suitable earth observation data. Here, we present IceLines, a novel data set on Antarctic ice shelf front positions to assess calving front change at an unprecedented temporal and spatial resolution.

Seasonal and Diurnal Variation of Land Surface Temperature Distribution and Its Relation to Land Use/Land Cover Patterns.

The surface urban heat island (SUHI) affects the quality of urban life. Because varying urban structures have varying impacts on SUHI, it is crucial to understand the impact of land use/land cover characteristics for improving the quality of life in cities and urban health. Satellite-based data on land surface temperatures (LST) and derived land use/cover pattern (LUCP) indicators provide an efficient opportunity to derive the required data at a large scale.

A Closer Look at Non-random Patterns Within Chemistry Space for a Smaller, Earlier Amino Acid Alphabet.

Recent findings, in vitro and in silico, are strengthening the idea of a simpler, earlier stage of genetically encoded proteins which used amino acids produced by prebiotic chemistry. These findings motivate a re-examination of prior work which has identified unusual properties of the set of twenty amino acids found within the full genetic code, while leaving it unclear whether similar patterns also characterize the subset of prebiotically plausible amino acids. We have suggested previously that this ambiguity may result from the low number of amino acids recognized by the definition of prebiotic plausibility used for the analysis.

Priority list of biodiversity metrics to observe from space.

Monitoring global biodiversity from space through remotely sensing geospatial patterns has high potential to add to our knowledge acquired by field observation. Although a framework of essential biodiversity variables (EBVs) is emerging for monitoring biodiversity, its poor alignment with remote sensing products hinders interpolation between field observations. This study compiles a comprehensive, prioritized list of remote sensing biodiversity products that can further improve the monitoring of geospatial biodiversity patterns, enhancing the EBV framework and its applicability.

Open questions in understanding life's origins.

The chemical space of prebiotic chemistry is extremely large, while extant biochemistry uses only a few thousand interconnected molecules. Here we discuss how the connection between these two regimes can be investigated, and explore major outstanding questions in the origin of life.

[Satellite data for recording health-relevant environmental conditions: examples and interdisciplinary potential].

Environmental conditions influence human health and interact with other factors such as DNA, lifestyle, or the social environment. Earth observations from space provide data on the most diverse manifestations of these environmental conditions and make it possible to quantify them spatially. Using two examples - the availability of open and recreational space and the spatial distribution of air pollution - this article presents the potential of Earth observations for health studies.

Optimized Performance Parameters for Nighttime Multispectral Satellite Imagery to Analyze Lightings in Urban Areas.

Contrary to its daytime counterpart, nighttime visible and near infrared (VIS/NIR) satellite imagery is limited in both spectral and spatial resolution. Nevertheless, the relevance of such systems is unquestioned with applications to, e.g.

Radar vision in the mapping of forest biodiversity from space.

Recent progress in remote sensing provides much-needed, large-scale spatio-temporal information on habitat structures important for biodiversity conservation. Here we examine the potential of a newly launched satellite-borne radar system (Sentinel-1) to map the biodiversity of twelve taxa across five temperate forest regions in central Europe. We show that the sensitivity of radar to habitat structure is similar to that of airborne laser scanning (ALS), the current gold standard in the measurement of forest structure.

One Among Millions: The Chemical Space of Nucleic Acid-Like Molecules.

Biology encodes hereditary information in DNA and RNA, which are finely tuned to their biological functions and modes of biological production. The central role of nucleic acids in biological information flow makes them key targets of pharmaceutical research. Indeed, other nucleic acid-like polymers can play similar roles to natural nucleic acids both and ; yet despite remarkable advances over the last few decades, much remains unknown regarding which structures are compatible with molecular information storage.

Adaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subsets.

Life uses a common set of 20 coded amino acids (CAAs) to construct proteins. This set was likely canonicalized during early evolution; before this, smaller amino acid sets were gradually expanded as new synthetic, proofreading and coding mechanisms became biologically available. Many possible subsets of the modern CAAs or other presently uncoded amino acids could have comprised the earlier sets.

Computational exploration of the chemical structure space of possible reverse tricarboxylic acid cycle constituents.

The reverse tricarboxylic acid (rTCA) cycle has been explored from various standpoints as an idealized primordial metabolic cycle. Its simplicity and apparent ubiquity in diverse organisms across the tree of life have been used to argue for its antiquity and its optimality. In 2000 it was proposed that chemoinformatics approaches support some of these views.

Exploring astrobiology using molecular structure generation.

The origin of life is typically understood as a transition from inanimate or disorganized matter to self-organized, 'animate' matter. This transition probably took place largely in the context of organic compounds, and most approaches, to date, have focused on using the organic chemical composition of modern organisms as the main guide for understanding this process. However, it has gradually come to be appreciated that biochemistry, as we know it, occupies a minute volume of the possible organic 'chemical space'.

Mapping Mediterranean seagrasses with Sentinel-2 imagery.

Mediterranean seagrasses have been hailed for their numerous ecosystem services, yet they are undergoing a decline in their coverage. The major complication with resolving this tendency is the sparsity of data on their overall distribution. This study addresses the suitability of the recently launched Sentinel-2 satellite for mapping the distribution of Mediterranean seagrass meadows.

227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?

Ribonucleic acid (RNA) is one of the two nucleic acids used by extant biochemistry and plays a central role as the intermediary carrier of genetic information in transcription and translation. If RNA was involved in the origin of life, it should have a facile prebiotic synthesis. A wide variety of such syntheses have been explored.

Extraordinarily adaptive properties of the genetically encoded amino acids.

Using novel advances in computational chemistry, we demonstrate that the set of 20 genetically encoded amino acids, used nearly universally to construct all coded terrestrial proteins, has been highly influenced by natural selection. We defined an adaptive set of amino acids as one whose members thoroughly cover relevant physico-chemical properties, or "chemistry space." Using this metric, we compared the encoded amino acid alphabet to random sets of amino acids.

Beyond terrestrial biology: charting the chemical universe of α-amino acid structures.

α-Amino acids are fundamental to biochemistry as the monomeric building blocks with which cells construct proteins according to genetic instructions. However, the 20 amino acids of the standard genetic code represent a tiny fraction of the number of α-amino acid chemical structures that could plausibly play such a role, both from the perspective of natural processes by which life emerged and evolved, and from the perspective of human-engineered genetically coded proteins. Until now, efforts to describe the structures comprising this broader set, or even estimate their number, have been hampered by the complex combinatorial properties of organic molecules.

Small Molecule Identification with MOLGEN and Mass Spectrometry.

This paper details the MOLGEN entries for the 2012 CASMI contest for small molecule identification to demonstrate structure elucidation using structure generation approaches. Different MOLGEN programs were used for different categories, including MOLGEN-MS/MS for Category 1, MOLGEN 3.5 and 5.