Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection.

Cisplatin-induced ototoxicity is attributed to the aberrant accumulation of reactive oxygen species (ROS) within the inner ear. Antioxidants represented by α-lipoic acid (ALA) have been demonstrated to scavenge ROS in the cochlea, while effective delivery of these agents in vivo remains a major challenge. Here, a novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable is presented ALA delivery and deafness prevention.

Estimating Earphone Level and Dose Using Real-Ear Measures and Ecological Momentary Assessment.

Purpose: Prior work estimating sound exposure dose from earphone use has typically measured earphone use time with retrospective questionnaires or device-based tracking, both of which have limitations. This research note presents an exploratory analysis of sound exposure dose from earphone use among college-aged adults using real-ear measures to estimate exposure level and ecological momentary assessment (EMA) to estimate use time.

Method: Earphone levels were measured at the ear drum of 53 college students using their own devices, earphones, and preferred music and speech stimuli at their normal listening volume.

NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations.

Current models for the study of neuroendocrine tumours (NETs) are severely limited. While (e.g.

BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis.

Otitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. Boswellic acid (BA), a natural triterpene compound extracted from frankincense resin, has been proven to possess significant anti-inflammatory and immunomodulatory effects.

Ocular Injuries and Intimate Partner Violence: A Review of the Literature.

Purpose Of Review: Intimate partner violence (IPV) is a leading cause of death and disability across the world. We sought to investigate the prevalence and clinical presentation of ocular injuries in IPV.

Recent Findings: Literature review revealed 16 published studies that evaluated ocular injuries in IPV, of which the study types included 9 retrospective studies, 2 prospective, 1 review, 1 invited commentary, 2 case reports, and 1 population-based cross-sectional survey.

REPRINTED FROM THE 2023 HYPERBARIC INDICATIONS MANUAL 15 Edition: Sudden Sensorineural Hearing Loss.

Sudden sensorineural hearing loss (SSNHL) presents as the abrupt onset of hearing loss. Approximately 88% of SSNHL has no identifiable etiology and is termed idiopathic sudden sensorineural hearing loss (ISSHL). Hearing specialists have investigated ISSHL since the 1970s.

Optimizing the hyperbaric chamber pressurization profile during standard hyperbaric oxygen therapy.

Middle ear barotrauma (MEBT) is the most common complication in providing hyperbaric oxygen therapy (HBO). This study explored the impact of altering the shape of the time-pressure curve with the aim of reducing the occurrence of MEBT and optimizing the HBO experience during the pressurization process. Four distinct mathematically derived protocols-Constant Pressure Difference (CPD), Constant Volume Difference (CVD), Constant Ratio (CR), and Inverted Constant Ratio (ICR)-were investigated using computer simulations on a simple ear model.

Piloting of a Decision Aid for Recurrent Tonsillitis.

Objective: Currently, there is no adult-specific decision aid (DA) to support decision-making regarding recurrent tonsillitis. This study intends to address this gap by piloting a prototype DA.

Design: Randomised clinical trial.

Attentional Inhibition Ability Predicts Neural Representation During Challenging Auditory Streaming.

Focusing on a single source within a complex auditory scene is challenging. M/EEG-based auditory attention detection (AAD) allows to detect which stream an individual is attending to within a set of multiple concurrent streams. The high interindividual variability in the auditory attention detection performance often is attributed to physiological factors and signal-to-noise ratio of neural data.

Real-world safety of maribavir: a retrospective study based on signal detection in the FDA adverse event reporting system.

Background: Maribavir is a novel antiviral agent targeting cytomegalovirus through inhibition of the UL97 protein kinase, exhibiting a distinct mechanism of action. However, limited data are available on its safety profile post-marketing.

Aim: This study aimed to evaluate the adverse events (AEs) associated with maribavir using the Food and Drug Administration's Adverse Event Reporting System (FAERS), providing insights to inform clinical practice.

Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin.

Utilizing single-cell transcriptome sequencing (scRNA-seq) technology, this study explores the viability of employing mesenchymal stem cells (MSCs) as a therapeutic approach for age-related hearing loss (ARHL). The research demonstrates MSCs' ability to differentiate into inner ear cell subpopulations, particularly hair cells, delivering Apelin via extracellular vesicles (EVs) to promote M2 macrophage polarization. In vitro experiments show reduced inflammation and preservation of hair cell health.

Nasal septum deviation after rapid maxillary expansion in the early mixed dentition.

Objectives: To evaluate nasal septum changes after rapid maxillary expansion (RME) during the mixed dentition and to verify the association between quantitative and qualitative assessments of nasal septum deviation (NSD) by ear, nose, and throat (ENT) specialists.

Materials And Methods: The sample comprised 24 patients (11 male, 13 female) with a mean age of 7.62 ± 0.

Speech Perception in Noise After Cochlear Implantation for Single-Sided Deafness: A Randomized Clinical Trial.

Importance: There is a lack of high level of evidence studies comparing the effect of different treatment options for single-sided deafness (SSD).

Objective: To determine the effect of a cochlear implant (CI), bone conduction device (BCD), contralateral routing of signals hearing aid (CROS), and no treatment on speech perception in noise outcomes in patients with SSD.

Design, Setting, And Participants: In this single-center randomized clinical trial, adult patients with SSD were randomized into 3 groups: CI; a trial period with first a BCD on a headband and then a CROS; or a trial period with first a CROS and then a BCD on a headband.

Punctate Inner Choroidopathy (PIC)-like Reaction in Stage 3 Extensive Macular Atrophy with Pseudodrusen-like Appearance (EMAP).

Purpose: To describe a rare complication in a patient with extensive macular atrophy with pseudodrusen-like appearance (EMAP), suggesting immune dysregulation in advanced stages of the disease.

Methods: Case Report. Multimodal imaging -including true-color fundus photography, blue autofluorescence, high-resolution optical coherence tomography (Hi-Res OCT), swept-source OCT angiography, and dye-based angiography- was used to evaluate retinal alterations.

Small Cell Neuroendocrine Carcinoma of the Nasopharynx.

Background: Nasopharyngeal malignant tumors were relatively rare head and neck tumors with a low global incidence. There were various pathologic types of nasopharyngeal malignant tumors, and small cell neuroendocrine carcinoma (SCNEC) was a highly malignant subtype with rapid growth and early metastasis. SCNEC was rare in the nasopharynx, and its clinical presentation and treatment strategy were different from other types of nasopharyngeal malignancies, posing a challenge to clinicians.

Normative CLEFT-Q Data From the General Dutch Population.

Patient-Reported Outcome Measures (PROMs), such as the CLEFT-Q, have become essential for outcomes in patients with CL/P. Normative values of the CLEFT-Q for non-CL/P peers have not yet been established. This study aims to establish normative values for the CLEFT-Q in the general Dutch population.

Anthropometric Study of Auricular Development in Human Fetal Cadavers.

The aim of the study is to comprehensively examine the composition and localization of the auricle in formalin-fixed human fetuses during the second and third trimesters of the antenatal period. Ninety-seven auricles were evaluated (33 females and 31 males in the second, and 22 females and 11 males in the third trimester). Nine morphometric dimensions were directly measured from auricles.

Mitochondria-Targeted Antioxidant (MitoQ) and Nontargeted Antioxidant (Idebenone) Mitigate Mitochondrial Dysfunction in Corneal Endothelial Cells.

Purpose: To investigate the effectiveness of mitochondrial-targeted antioxidant mitoquinone (MitoQ) and nontargeted antioxidant idebenone (Idb) in alleviating mitochondrial dysfunction in corneal endothelial cells (CEnCs).

Methods: In vitro experiments were conducted using immortalized normal human corneal endothelial cells (HCEnC-21T; SVN1-67F) and Fuchs endothelial corneal dystrophy (FECD) cells (SVF5-54F; SVF3-76M). Cells were pretreated with MitoQ or Idb and then exposed to menadione (MN) with simultaneous antioxidant treatment.

Fishhook Injuries and Antibiotic Prescribing Patterns: A Retrospective Analysis.

Introduction: Fishhook injuries are a common occurrence among anglers. There are no guidelines for prophylactic antibiotic use after fishhook removal. This study analyzed the management of embedded fishhooks, prophylactic antibiotic use, and complication rate at a Michigan county emergency department to observe whether antibiotic use changes patient outcome.

Analysis and long-term outcomes of spontaneous cerebrospinal otorrhea repair via the middle cranial fossa approach.

Background: The incidence of spontaneous CSF otorrhea is increasing and knowledge about treatment management is growing.

Objectives: To analyse the cases operated the middle cranial fossa approach (MCFA) for spontaneous CSF otorrhea in our clinic and to evaluate the long-term surgical results in the light of the literature.

Methods: Demographic data, presenting complaints, complications, hearing outcomes, recurrence rates and long-term success of patients operated with MCFA between 2012 and 2022 in our tertiary care centre were evaluated.

Familial Oculoauriculovertebral Spectrum: A Genomic Investigation of Autosomal Dominant Inheritance.

Objective: Oculoauriculovertebral spectrum (OAVS) encompasses abnormalities on derivatives from the first and second pharyngeal arches including macrostomia, hemifacial microsomia, micrognathia, preauricular tags, ocular, and vertebral anomalies. We present genetic findings on a 3-generation family affected with macrostomia, preauricular tags and ptosis following an autosomal dominant pattern.

Design: We generated whole-genome sequencing data for the proband, affected father, and unaffected paternal grandmother followed by Sanger sequencing on 23 family members for the top candidate gene mutations.

Squamous Cell Carcinomas of the Sinonasal Region and Temporal Bone Diagnosed After Recurrences: A Report of Two Patients.

squamous cell carcinoma is a recently recognized entity characterized by a non-viral-related non-keratinizing squamous cell carcinoma with chromosomal rearrangement between on 6p22.3 and on Xq28. This neoplasm is associated with an aggressive clinical behavior, particularly regarding local recurrences and distant metastases even with its deceptively bland histomorphology.