339 results match your criteria: "Eales Disease"

Eales' disease with secondary coats'-like reaction: a case report.

BMC Ophthalmol

September 2024

Department of Ophthalmology, Faculty of Medicine, 1UM Eye Research Centre (UMERC), Universiti Malaya, Kuala Lumpur, Malaysia.

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A Review of Eales' Disease and .

Biology (Basel)

June 2024

Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Eales' Disease is an idiopathic peripheral retinal vasculopathy first described by British ophthalmologist Henry Eales in 1880. Most prevalent in healthy young males, Eales' Disease often presents with symptoms of sudden blurry or decreased vision and floaters. Although no clear, standardized stage of the disease exists, it progresses through three overlapping phases-peripheral periphlebitis, ischemic capillary ischemia, and retinal neovascularization.

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Trends in application of fundus fluorescein angiography in fundus diseases during a recent ten-year period.

Photodiagnosis Photodyn Ther

April 2024

National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address:

Article Synopsis
  • The study aimed to analyze trends in the use of fundus fluorescein angiography (FFA) for diagnosing fundus diseases over a decade from 2012 to 2021.
  • A total of 37,038 FFA examinations were performed, with central serous chorioretinopathy, diabetic retinopathy, and retinal vein occlusion consistently being the top three diagnosed conditions.
  • The findings suggest that while the number of FFA examinations varied year-to-year, the technique remains essential for understanding and diagnosing various fundus diseases, possibly due to improvements in non-invasive examination technologies.
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Article Synopsis
  • * A case study of a 36-year-old man diagnosed with Eales disease illustrates its symptoms, including sudden flashes of light and vision loss, alongside complications like retinal artery and vein occlusions, ultimately confirmed through specific retinal findings.
  • * Treatment with systemic corticosteroids led to improvement in the patient's vision, highlighting the importance of early diagnosis and management to prevent further vision loss in Eales disease patients.
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This review provides an overview of retinal vascular disorders that are less frequent in Germany and Europe compared to diabetic retinopathy and retinal venous or arterial occlusive disorders. The knowledge of these disorders is important for the differential diagnosis of retinal vascular disorders as well as potentially associated systemic disorders. In the current part one epidemiology, pathophysiology, clinical presentation, and therapy are discussed for hypertensive retinochoroidopathy, ocular ischemic syndrome, retinal alterations in sickle cell disease, Eales disease, radiation retinopathy, peripheral exudative hemorrhagic chorioretinopathy, and retinal disorders associated with pregnancy.

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Article Synopsis
  • A case study was reported on a 26-year-old male diagnosed with bilateral Eales' disease, resulting in total blindness in the left eye and legal blindness in the right within a short time frame.
  • Various examinations and imaging techniques, including CT, MRI, and genetic testing, were performed to assess the severity and underlying causes of the condition.
  • Despite undergoing intensive treatment, including laser therapy, anti-VEGF injections, and systemic immunosuppressants, the patient's vision deteriorated, culminating in aggressive neovascular glaucoma and further loss of sight.
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Clinical Features, Long-Term Outcomes, and Prognostic Factors of Eales' Disease in Korean Patients.

Ocul Immunol Inflamm

July 2024

Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Purpose: We studied Korean patients with Eales' disease to document clinical features, long-term outcomes, and explore its association with TB, given South Korea's high TB burden.

Methods: We retrospectively reviewed medical records of Eales' disease patients for clinical characteristics, long-term outcomes, and its association with TB.

Results: Among 106 eyes, the average age of diagnosis was 39.

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Cocaine Abuse as an Immunological Trigger in a Case Diagnosed with Eales Disease.

Medicina (Kaunas)

January 2023

Department of Sense Organs, Sapienza University of Rome, Head and Neck Department, Policlinico Umberto I University Hospital, Viale del Policlinico 155, 00161 Rome, Italy.

Article Synopsis
  • - Eales disease is a condition that affects the retina, causing issues like occlusive vasculitis and potential vision-threatening complications, often seen in patients like a 40-year-old man with a cocaine abuse history who developed blurred vision and retinal problems.
  • - The patient exhibited symptoms like vitreous hemorrhages and retinal neovascularization, and tests revealed a factor V Leiden mutation along with a negative serologic panel, leading to a diagnosis of Eales disease.
  • - Treatment involved tapering dexamethasone and peripheral laser photocoagulation, resulting in improvement, and highlights the need for eye doctors to consider drug abuse and coagulation issues when diagnosing similar retinal disorders.
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Purpose: To evaluate clinical features and manifestations of Eales disease and the efficacy of different interventions.

Methods: The databases PubMed, EMBASE, and Ovid from inception until February 2021 were searched. Pooled analyses included 1) presenting features, 2) symptoms and signs, and 3) postoperative vision outcomes and complications.

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Quantile-Dependent Expressivity of Serum Interleukin-6 Concentrations as a Possible Explanation of Gene-Disease Interactions, Gene-Environment Interactions, and Pharmacogenetic Effects.

Inflammation

June 2022

Lawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, 1 Cyclotron Road, Berkeley, CA, 94720, USA.

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Eales' disease: epidemiology, diagnostic and therapeutic concepts.

Int J Retina Vitreous

January 2022

Instituto Privado de Oftalmología, La Paz, Bolivia.

Background: To describe the epidemiological traits, clinical characteristics, diagnostic procedures, therapeutic interventions and evolution in a large series of patients with diagnosis of Eales' disease.

Methods: A clinical retrospective review of patients with Eales' disease, evaluated and treated between April 2009 and April 2018, with a 1-year minimum follow-up. Thirty patients (59 eyes), were included.

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Eales' disease is an idiopathic vasculitis that affects the peripheral retina. It is characterized by recurrent vitreous hemorrhage as a complication of retinal neovascularization. It is more prevalent in India and affects young males.

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Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales' disease.

J Ophthalmic Inflamm Infect

September 2021

Uvea Department, Medical Research Foundation, Sankara Nethralaya, 18 College Road, Tamilnadu, 600006, Chennai, India.

Article Synopsis
  • * A case study was conducted on a 29-year-old male with Eales' disease affecting both eyes and continuous inflammation, leading to the removal of one eye for examination.
  • * Research indicates that Eales' disease may be driven by T cells and could be triggered by DNA from mycobacterial tuberculosis, but additional studies are necessary to verify these findings.
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Eales' disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales' disease.

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Reply to Comments on Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series".

Ocul Immunol Inflamm

December 2022

Larsen & Toubro Ocular Pathology Department, Medical Research Foundation, SankaraNethralaya, Chennai, India.

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Objectives: To investigate visual and anatomical outcomes of vitreoretinal surgeries in patients with Eales' disease.

Materials And Methods: In this retrospective study, 22 eyes of 21 patients with vitreous hemorrhage (VH) or tractional retinal detachment (TRD) secondary to Eales' disease who underwent vitreoretinal surgery between January 1997 and December 2015 and had at least 1 year of follow-up were included.

Results: The mean best corrected visual acuity (BCVA) was significantly higher at final visit (0.

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We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal neovascularization following retinal photocoagulation, periocular triamcinolone, and intravitreal ranibizumab injection.

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Papillophlebitis as an initial presentation of Eales' disease.

Oman J Ophthalmol

November 2020

Department of Uvea, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India.

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