Autistic and schizotypal traits exhibit similarities in their impact on mentalization and adult attachment impairments: a cross-sectional study.

Background: Deficits in mentalizing and attachment occur in the autism and schizophrenia spectrum, and their extended traits in the general population. Parental attachment and the broader social environment highly influence the development of mentalizing. Given the similarities in the symptomatology and neurodevelopmental correlates of autism spectrum disorder (ASD) and schizophrenia (SCH), it is crucial to identify their overlaps and differences to support screening, differential diagnosis, and intervention.

Assessing obsessive-compulsive symptoms in a subclinical and clinical sample: the development of the Hungarian version of the OCI-R.

Objectives: The prevalence of clinical obsessive-compulsive disorder (OCD) is around 1-2% in the population. Questionnaires, such as the OCI-R, are a useful tool in the diagnositc process. The purpose of this study was to develop the Hungarian version of the OCI-R, examine its validity and reliability, and its ability to differentiate between clinical and subclinical OCD.

Event as the central construal of psychological time in humans.

Time is a fundamental dimension of our perception and mental construction of reality. It enables resolving changes in our environment without a direct sensory representation of elapsed time. Therefore, the concept of time is inferential by nature, but the units of subjective time that provide meaningful segmentation of the influx of sensory input remain to be determined.

The genome sequence of the Hungarian meadow viper, (Méhely, 1893).

We present a genome assembly from an individual female (the Hungarian meadow viper; Chordata; Lepidosauria; Squamata; Viperidae). The genome sequence is 1,625.0 megabases in span.

The W2024 database of the water isotopologue .

The rovibrational spectrum of the water molecule is the crown jewel of high-resolution molecular spectroscopy. While its significance in numerous scientific and engineering applications and the challenges behind its interpretation have been well known, the extensive experimental analysis performed for this molecule, from the microwave to the ultraviolet, is admirable. To determine empirical energy levels for , this study utilizes an improved version of the MARVEL (Measured Active Rotational-Vibrational Energy Levels) scheme, which now takes into account multiplet constraints and first-principles energy-level splittings.

An Unprecedented Tridentate-Bridging Coordination Mode of Permanganate Ions: The Synthesis of an Anionic Coordination Polymer-[Co(NH)][(K(κ-Cl)(μ-(κ-O,O',O″-MnO))]-Containing Potassium Central Ion and Chlorido and Permanganato Ligands.

A unique compound (compound ) with structural features including an unprecedented tridentate-bridging coordination mode of permanganate ions and an eight-coordinated (rhombohedral) κ-chlorido and tridentate permanganato ligand in a potassium complex containing coordination polymer (Co(NH)][(K(κ-Cl)(μ-(κ-O,O',O″-MnO))) with isolated regular octahedral hexamminecobalt(III) cation was synthesized with a yield of >90%. The structure was found to be stabilized by mono and bifurcated N-H∙∙∙Cl and N-H∙∙∙O (bridging and non-bridging) hydrogen bonds. Detailed spectroscopic (IR, far-IR, and Raman) studies and correlation analysis were performed to assign all vibrational modes.

Putative Role of Adenosine A1 Receptors in Exogenous Ketone Supplements-Evoked Anti-Epileptic Effect.

Approximately 30% of patients with epilepsy are drug-refractory. There is an urgent need to elucidate the exact pathophysiology of different types of epilepsies and the mechanisms of action of both antiseizure medication and metabolic therapies to treat patients more effectively and safely. For example, it has been demonstrated that exogenous ketone supplement (EKS)-generated therapeutic ketosis, as a metabolic therapy, may decrease epileptic activity in both animal models and humans, but its exact mechanism of action is unknown.

The Effectiveness of Individualized Oral Hygiene Education in Preventing Dental Diseases: A Clinical Study.

: Without mechanical cleaning, gingivitis can develop within three weeks. The first clinical sign is bleeding on positive probing. The accumulation of dental biofilm triggers an inflammatory gingival response.

Flower Visitation through the Lens: Exploring the Foraging Behaviour of with a Computer Vision-Based Application.

To understand the processes behind pollinator declines and for the conservation of pollination services, we need to understand fundamental drivers influencing pollinator behaviour. Here, we aimed to elucidate how wild bumblebees interact with three plant species and investigated their foraging behaviour with varying flower densities. We video-recorded in 60 × 60 cm quadrats of , , and in urban areas of Terceira (Azores, Portugal).

Annealing Behavior of a Mg-Y-Zn-Al Alloy Processed by Rapidly Solidified Ribbon Consolidation.

Mg-Y-Zn-Al alloys processed by the rapidly solidified ribbon consolidation (RSRC) technique are candidate materials for structural applications due to their improved mechanical performance. Their outstanding mechanical strength is attributed to solute-enriched stacking faults (SESFs), which can form cluster-arranged layers (CALs) and cluster-arranged nanoplates (CANaPs) or complete the long-period stacking ordered (LPSO) phase. The thermal stability of these solute arrangements strongly influences mechanical performance at elevated temperatures.

Dog Domestication Strongly Relied on Translation Regulation According to Differential Gene Expression Analysis.

Domestication of dogs from their shared ancestors with wolves occurred more than 15,000 years ago and affected many characteristics of the species. We analyzed the blood RNA sequence data of 12 dogs and 11 wolves from Europe and Asia to shed more light on the domestication history of dogs. We implemented a differential gene expression analysis, a weighted gene correlation network analysis, gene ontology and genetic pathway analyses.

Gender and trait rumination moderates the link between trait impulsivity and gambling problems severity in young adults.

Aims: Trait impulsivity and trait rumination appear to uniquely contribute to problem gambling. However, only a limited number of studies have investigated their relationship with each other, and no study has tested whether their interplay could explain problem gambling. In this study, we aimed to examine these associations, especially focusing on the putative moderator role of gender.

Insulin receptor substrate 1 is a novel member of EGFR signaling in pancreatic cells.

Pancreatic ductal adenocarcinoma is an extremely incurable cancer type characterized by cells with highly proliferative capacity and resistance against the current therapeutic options. Our study reveals that IRS1 acts as a bridging molecule between EGFR and IGFR/InsR signalization providing a potential mechanism for the interplay between signaling pathways and bypassing EGFR-targeted or IGFR/InsR-targeted therapies. The analysis of IRS1 phosphorylation status in four pancreatic cell lines identified the impact of EGFR signaling on IRS1 activation in comparison with InsR/IGFR signaling.

Data losses and synchronization according to delay in PLC-based industrial automation systems.

PLC (Programmable Logic Controllers) based data collection is integral to industrial automation and data acquisition processes. The pipeline - between the device and the database - is a complex system with many components and often causes some time delay, due to the synchronization and the applied hardware and software components. This delay can also lead to data loss on the database site.

The curve of control: Nonmonotonic effects of task difficulty on cognitive control.

The U-shaped curve has long been recognized as a fundamental concept in psychological science, particularly in theories about motivational accounts and cognitive control. In this study ( = 330), we empirically tested the prediction of a nonmonotonic, curvilinear relationship between task difficulty and control adaptation. Drawing from motivational intensity theory and the expected value of control framework, we hypothesized that control intensity would increase with task difficulty until a maximum tolerable level, after which it would decrease.

The High-Affinity Chymotrypsin Inhibitor Eglin C Poorly Inhibits Human Chymotrypsin-Like Protease: Gln192 and Lys218 Are Key Determinants.

Eglin C, a small protein from the medicinal leech, has been long considered a general high-affinity inhibitor of chymotrypsins and elastases. Here, we demonstrate that eglin C inhibits human chymotrypsin-like protease (CTRL) weaker by several orders of magnitude than other chymotrypsins. In order to identify the underlying structural aspects of this unique deviation, we performed comparative molecular dynamics simulations on experimental and AlphaFold model structures of bovine CTRA and human CTRL.

Precipitation and temperature timings underlying bioclimatic variables rearrange under climate change globally.

Modeling how climate change may affect the potential distribution of species and communities typically utilizes bioclimatic variables. Distribution predictions rely on the values of the bioclimatic variable (e.g.