Vestibular hydrops in patients with semicircular canal malformation.

Objective: To investigate the vestibular endolymphatic hydrops in patients with semicircular canal malformation.

Methods: We searched 7864 patients who underwent MR Imaging after contrast injection and found 21 patients with semicircular canal malformations. Another 9 non-malformed patients with unilateral hearing loss were randomly included.

Development and Characteristics of Hearing Loss With the Progression of Endolymphatic Hydrops.

Objectives: This study aims to explore how patients' hearing loss developed with the progression of endolymphatic hydrops and the characteristics of hearing loss at different stages.

Materials And Methods: We collected 73 patients with definite or possible unilateral Meniere's disease or sudden hearing loss who underwent magnetic resonance imaging after intravenous contrast agent injection. There were 25 cases of isolated cochlear hydrops, 24 cases of isolated vestibular hydrops, and 24 cases of cochlear and vestibular hydrops.

Do the Nonlinear Dynamic Acoustic Measurements, Nonlinear Energy Difference Ratio and Spectrum Convergence Ratio, Correlate with Perceptual Evaluation of Esophageal Voice Speakers?

Background: The acoustic assessment of phonation after total laryngectomy is challenged by signal aperiodicity which makes frequency-based acoustic measures less reliable. This is important for patients who use esophageal voice since voice samples mostly include type III (highly aperiodic) and 4 (chaotic) signals. As such, using non-linear measures, which are better suited for aperiodic phonation, may be useful to investigate the relationship between acoustic signal characteristics and perception of esophageal voice quality.

[Development of Gun-type Tube-Guide Device of Laser Fiber].

With the development of laryngeal microsurgery, the requirements for the flexibility and convenience of surgical instruments are increasing. The research on related instruments has important value for the clinical application of laryngeal microsurgery. We have redesigned a gun-type tube-guide device of laser fiber by comparing the shortcomings of existing laser fiber introducers.

Gradual healing of macular retinoschisis after photodynamic therapy for choroidal neovascularization in pathological myopia eyes.

Three patients with pathological myopia(PM) due to both active macular choroidal neovascularization (CNV) and macular retinoschisis (MRS) in the same eye were treated by photodynamic therapy for CNV. The patients were evaluated before and after photodynamic therapy (PDT) treatment by best corrected visual acuity (BCVA), color fundus photography, optical coherent tomography (OCT), and fundus fluorescein angiography (FFA) when necessary. The patients were followed for 120, 94, 34 months.

Dynamically Monitoring Vocal Fatigue and Recovery Using Aerodynamic, Acoustic, and Subjective Self-Rating Measurements.

Objectives: This study aimed to quantify the effects of vocal loading and vocal rest using aerodynamic, acoustic, and self-rating measurements.

Methods: Ten participants were recruited to perform vocal loading tasks lasting 60 minutes, followed by 30 minutes of vocal rest. Objective parameters (phonation threshold pressure, fundamental frequency, jitter, shimmer, and noise-to-harmonics ratio) and subjective parameters (current speaking effort level and laryngeal discomfort) were taken at different time intervals: before vocal loading (baseline), after 15 minutes (L15), 30 minutes (L30), 45 minutes (L45), and 60 minutes (L60) of vocal loading, as well as after 5 minutes (R5), 10 minutes (R10), 20 minutes (R20), and 30 minutes (R30) of vocal rest.

Mutation spectrum of the bestrophin-1 gene in a large Chinese cohort with bestrophinopathy.

Background: Bestrophin-1 () gene is associated with a wide range of ocular phenotypes, collectively termed as bestrophinopathy. The aim of the current study was to identify the mutation spectrum of in a large cohort of Chinese patients with bestrophinopathy.

Methods: Patients clinically suspected of bestrophinopathy were screened using multigene panel testing.

Effects of a simulated system of straw phonation on the complete phonatory range of excised canine larynges.

Purpose: This study investigated the effects of straw phonation therapy on the aerodynamic and acoustic parameters of the vocal folds at different levels of elongation and subglottal pressure.

Methods: 20 excised canine larynges were used in both experimental (straw phonation therapy simulation) and control conditions. Aerodynamic parameters, including phonation threshold pressure (PTP), phonation instability pressure (PIP), phonation pressure range (PPR), phonation threshold flow (PTF), phonation instability flow (PIF), phonation flow range (PFR), were obtained at different levels of vocal fold elongation (0%, 10%, 20%).

Lingering Effects of Straw Phonation Exercises on Aerodynamic, Electroglottographic, and Acoustic Parameters.

Objective: This study aimed to investigate the duration of straw phonation effects using aerodynamic, electroglottographic, and acoustic metrics.

Methods: Twenty-four participants were recruited to perform both a 5-minute and a 10-minute straw phonation exercise. Upon completion of the exercises, phonation threshold pressure (PTP), mean airflow, contact quotient, fundamental frequency, jitter, shimmer, and noise-to-harmonics ratio were measured over a 20-minute time frame.

Erratum to "Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee".

[This corrects the article DOI: 10.1155/2018/6513049.].

[Clinical analysis of tympanoplasty combined with ventilation tube insertion in otitis media].

The aim of this study is to explore the feasibility and clinical effect of tympanoplasty combined with ventilation tube insertion in otitis media. Retrospective analysis of 35 patients with eustachian tube obstruction or tympanic adhesions for tympanoplasty combined with ventil ation tube insertion in otitis media in EENT Hospital of Fudan University from April 2008 to December 2010. Preoperative routine hearing tests and temporal bone CT examination.

[Analysis of curative effect on chronic suppurative otitis media by tympanoplasty with or without mastoidectomy].

Analysis of perforation rate and hearing improvement rate of patients with chronic suppurative otitis media after operation, to observe the effect of tympanoplasty with or without mastoidectomy.Retrospective analysis the clinical data of EENT Hospital of Fudan University from January 2011 to December 2016, 167 cases (ears) by tympanoplasty. According to the surgical approach were divided into simple tympanoplasty in 108 cases (group A), tympanoplasty with mastoidectomy in 59 cases(group B)(CWU in 23 cases, IBM in 11 cases, CWD in 25 cases).

[Differences in myringoplasty between endoscopic and microscope].

The intraoperative and postoperative clinical indexes of myringoplasty performed by endoscope or by microscope were collected retrospectively, the differences between the two different surgical methods were analysized. Retrospective analysis of the clinical data of 70 cases (70 ears) udergoing myringoplasty in the department of Otolaryngology-Head and Neck Surgery, at the Second People's Hospital of Kashi from June 2014 to August 2015. According to the surgical approach cases were divided into two groups, 30 cases in group A by endoscopic myringoplasty and 40 cases in group B by microscope myringoplasty.

[Different states of otitis media were retrospectively analyzed of myringoplasty].

Through analysis of the tympanic membrane perforation rate and hearing improvement rate with chronic suppurative otitis media (CSOM) by myringoplasty,to observe the effect of different preoperative conditions such as middle ear lesion,eustachian tube (ET) function and infection status on the postoperative curative effect.Retrospective analysis of EENT Hospital of Fudan University from January 2012 to November 2016 during the 203 cases (203 ears) with clinical data of myringoplasty: according to intraoperative exploration of the presence of purulent secretions in the tympanic cavity,divided into infection active group and infection quiescence group; according to the preoperative results of the function of ET with acoustic impedance test divided into dysfunction or good group; according to the preoperative temporal bone HRCT suggested that the middle ear (mastoid cells,tympanic antrum and tympanic cavity) with or without soft tissue density,divided into the group with no focal lesion and the group with focal lesion. Review endoscopy and pure tone audiometry after 3 to 6 months.

Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee.

Objective: To evaluate the therapeutic effectiveness and safety of mesotherapy by comparing it with the classic systematic therapy in patients with osteoarthritis (OA).

Methods: Sixty patients were included and classified into two groups based on the existence of contraindications for nonsteroidal anti-inflammatory drugs (NSAIDs). These patients were treated with oral NSAIDs (Group A) or mesotherapy (Group B).

Comparing the Exposure-Response Relationships of Physiological and Traditional Vocal Warm-ups on Aerodynamic and Acoustic Parameters in Untrained Singers.

Objectives: The aim of this study was to quantify the effects of traditional and physiological warm-up exercises and to determine the optimal duration of these methods using acoustic and aerodynamic metrics.

Methods: Twenty-six subjects were recruited to participate in both straw phonation exercises (physiological vocal warm-up) and traditional singing exercises (traditional vocal warm-up) for 20 minutes each, 24 hours apart. Phonation threshold pressure (PTP), fundamental frequency, jitter, shimmer, and noise-to-harmonics ratio were measured before the intervention (m0), as well as after 5 minutes (m5), 10 minutes (m10), 15 minutes (m15), and 20 minutes (m20) of intervention.

The Finite Element Simulation of the Upper Airway of Patients with Moderate and Severe Obstructive Sleep Apnea Hypopnea Syndrome.

Objectives: To investigate the snoring modes of patients with Obstructive Sleep Apnea Hypopnea Syndrome and to discover the main sources of snoring in soft tissue vibrations.

Methods: A three-dimensional finite element model was developed with SolidEdge to simulate the human upper airway. The inherent modal simulation was conducted to obtain the frequencies and the corresponding shapes of the soft tissue vibrations.

A Review of the Physiological Effects and Mechanisms of Singing.

Daily experience suggests that singing can energize us and even provide a physical workout. A growing amount of evidence has been presented to support anecdotal claims of the benefits of singing on health and well-being. Singing has been shown to be related to numerous physiological changes.

A Gelated Colloidal Crystal Attached Lens for Noninvasive Continuous Monitoring of Tear Glucose.

Patients of diabetes mellitus urgently need noninvasive and continuous glucose monitoring in daily point-of-care. As the tear glucose concentration has a positive correlation with that in blood, the hydrogel colloidal crystal integrated into contact lens possesses promising potential for noninvasive monitoring of glucose in tears. This paper presents a new glucose-responsive sensor, which consists a crystalline colloidal array (CCA) embedded in hydrogel matrix, attached onto a rigid gas permeable (RGP) contact lens.

Development of an Innovative 3D Printed Rigid Bronchoscopy Training Model.

Objectives: The objective of this study was to create a 3D printed airway model simulating the size and mechanical properties of various age groups for foreign body removal training.

Methods: Three-dimensional printing technology was used to print the anatomically correct airway from rubber-like translucent material, simulating the mechanical properties of human airway tissue. The model's effectiveness in trainee education was evaluated by otolaryngology residents with varying levels of experience.

R102W mutation in the RS1 gene responsible for retinoschisis and recurrent glaucoma.

Aim: To identify the mutations in RS1 gene associated with typical phenotype of X-linked juvenile retinoschisis (XLRS) and a rare condition of concomitant glaucoma.

Methods: Complete ophthalmic examinations were performed in the proband. The coding regions of the RS1 gene that encode retinoschisin were amplified by polymerase chain reaction and directly sequenced.

Expression of hypoxia inducible factor-1α and vascular endothelia growth factor in vocal polyps.

Objectives/hypothesis: Long-term vocal overuse or sudden vocal-fold microvascular disruption may lead to the formation of a hypoxic zone of injury and the subsequent release of a cascade of cytokines in the vocal fold. To test this hypothesis, we investigated the expression and the role of hypoxia inducible factor-1α (HIF-1α) and vascular endothelia growth factor (VEGF) in the formation of vocal polyps.

Methods: Expression patterns of HIF-1α and VEGF in surgical specimens of vocal polyps from 36 patients were analyzed using the immunohistochemistry and Western blot method.

Interaction of copolymer-1-activated T cells and microglia in retinal ganglion cell protection.

Background: The interaction of copolymer-1-activated T cells and microglia on retinal ganglion cells survival in vitro was explored.

Methods: Copolymer-1-specific T cells were made by repeated copolymer-1 stimulation of T cells, microglia were isolated from the retinas of newborn rats, and then, they were co-cultured (the experimental group) for 48 h. Retinal ganglion cells were collected from the retinas of adult rats, purified, and then, the supernatants from different groups were added.

Study of the head and neck position in microlaryngoscopy using magnetic resonance imaging.

Several studies have critically analyzed the ideal position for laryngeal exposure during microlaryngoscopy; however, these studies have lacked the ability to evaluate the head and neck position while maintaining a direct view into the airway. Therefore, a newly established two-curve methodology was used to investigate the influence of head and neck position during microlaryngoscopy in MRI images. Fourteen normal adult volunteers were used in this magnetic resonance imaging study.

Analysis of pressure applied during microlaryngoscopy.

Direct laryngoscopy is the most predominantly used technique in laryngology, with the fulcrum-based laryngoscope serving as the most popular instrument. The purpose of this study was to accurately calculate and measure the pressure acting on the laryngopharynx and the tongue base during microlaryngoscopy. The relationship between postoperative throat pain and the time and pressure applied during microlaryngoscopy were also investigated.