4,667 results match your criteria: "EEG in Dementia and Encephalopathy"
Exp Neurol
January 2025
Department of Neurology, Affiliated Jinling Hospital, Medical School, Nanjing University, Nanjing, Jiangsu 210000, China; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210000, China. Electronic address:
Vascular cognitive impairment and dementia (VCID) is mainly caused by chronic cerebral hypoperfusion and subsequent white matter lesions. Noninvasive transcranial magnetic stimulation has been utilized in treating various neurological disorders. However, the function of theta-burst transcranial magnetic stimulation on VCID remains to be defined.
View Article and Find Full Text PDFClin Neurophysiol
December 2024
Dipartimento di Neuroscienze, Università degli Studi di Padova, Italy; Padova Neuroscience Center, Università degli Studi di Padova, Italy. Electronic address:
Objective: Complex visual hallucinations (VH) are a core feature of dementia with Lewy bodies (DLB), though they may not occur in all patients. Power spectral density (PSD) analysis of resting-state EEG (rs-EEG) shows associations between some frequency bands (e.g.
View Article and Find Full Text PDFEpilepsia Open
December 2024
Department of Neurology, John Radcliffe Hospital, Oxford, UK.
Objective: To assess whether the antiseizure medication levetiracetam may improve cognition in individuals with Alzheimer's disease who have not previously experienced a seizure.
Methods: We performed a randomized, double-blind, placebo-controlled crossover pilot study in individuals with mild-to-moderate Alzheimer's disease. Electroencephalography was performed at baseline and those with active epileptiform discharges were excluded.
Cereb Cortex
October 2024
Center for Mind and Brain, University of California, 267 Cousteau Place, Davis, CA 95618, United States.
Impaired episodic memory is the primary feature of early Alzheimer's disease (AD), but not all memories are equally affected. Patients with AD and amnestic Mild Cognitive Impairment (aMCI) remember pictures better than words, to a greater extent than healthy elderly. We investigated neural mechanisms for visual object recognition in 30 patients (14 AD, 16 aMCI) and 36 cognitively unimpaired healthy (19 in the "preclinical" stage of AD).
View Article and Find Full Text PDFSci Rep
October 2024
Department of Neurology, MassGeneral Institute of Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta (Aβ) accumulations. Alzheimer's patients experience sleep disturbances at early stages of the disease. APPswe/PS1dE9 (APP) mice exhibit sleep disruptions, including reductions in non-rapid eye movement (NREM) sleep, that contribute to their disease progression.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
October 2024
Dr. Ming Tao, M.D. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Binwen Road 548, Hangzhou, 310053, Zhejiang, China, Email: Dr. María Trinidad Herrero, M.D., Ph.D. Clinical and Experimental Neuroscience (NiCE), Biomedical Research Institute of Murcia (IMIB), Institute for Aging Research (IUIE), School of Medicine, University of Murcia, Murcia, 30120, Spain, Email:
Background: Alzheimer's disease (AD) is a neurodegenerative disorder featured by progressive cognitive decline, which manifests in severe impairment of memory, attention, emotional processing and daily activities, leading to significant disability and social burden. Investigation on Mild Cognitive Impairment (MCI), the prodromal and transitional stage between normal aging and AD, serves as a key in diagnosing and slowing down the progression of AD. Numerous effects have been made up to date, however, the attentional mechanisms under different external emotion stimuli in MCI and AD are still unexplored in deep.
View Article and Find Full Text PDFPsychophysiology
December 2024
Department of Psychology, Marquette University, Milwaukee, Wisconsin, USA.
The P300 event-related potential (ERP) is widely investigated in cognitive neuroscience, including related to aging, with smaller amplitudes and delayed latency consistently reported in Alzheimer's disease (AD). Given that AD-related neurological changes begin years before symptom onset, ERPs in asymptomatic elders with AD risk may characterize early changes. ERPs are seldom studied in this population.
View Article and Find Full Text PDFClin Neurophysiol
November 2024
Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy; Department of Neuroscience and Rehabilitation, University of Ferrara, and Center for Translational Neurophysiology of Speech and Communication (CTNSC), Italian Institute of Technology (IIT), Ferrara, Italy. Electronic address:
Background: The neural activity of the Default Mode Network (DMN) is disrupted in patients with In Alzheimer's disease (AD).
Objectives: We used a novel multimodal approach to track neural signal propagation within the DMN in AD patients.
Methods: Twenty mild to moderate AD patients were recruited.
Neurology
November 2024
From the Department of Neurology (A.D.L., S.H., K.R.P., A.V., K.A.J.), Massachusetts General Hospital, Boston; Harvard Medical School (A.D.L., A.V., S.B., R.A. Sarkis, H.L.J., K.A.J., R.A. Sperling), Boston; Department of Radiology (E.G.T., D.V.M., H.L.J., K.A.J.), Massachusetts General Hospital, Boston; Department of Neurology (E.J.S.), Milford Regional Medical Center; Department of Neurology (S.B.), Beth Israel Deaconess Medical Center, Boston; and Department of Neurology (R.A.Sarkis, R.A.Sperling), Brigham and Women's Hospital, Boston, MA.
Background And Objectives: Alzheimer disease (AD) is associated with a 2 to 3-fold increased risk of developing late-onset focal epilepsy, yet it remains unclear how development of focal epilepsy in AD is related to AD pathology. The objective of this study was to examine spatial relationships between the epileptogenic zone and tau deposition, amyloid deposition, and brain atrophy in individuals with AD who developed late-onset, otherwise unexplained focal epilepsy. We hypothesized that if network hyperexcitability is mechanistically linked to AD pathology, then there would be increased tau and amyloid deposition within the epileptogenic hemisphere.
View Article and Find Full Text PDFNeuroimage Clin
November 2024
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom. Electronic address:
The consequences of frontotemporal lobar degeneration include changes in prefrontal cortical neurophysiology, with abnormalities of neural dynamics reported in the beta frequency range (14-30 Hz) that correlate with functional severity. We examined beta dynamics in two clinical syndromes associated with frontotemporal lobar degeneration: the behavioral variant of frontotemporal dementia (bvFTD) and progressive supranuclear palsy (PSP). Whilst these two syndromes are partially convergent in cognitive effects, they differ in disease mechanisms such as molecular pathologies and prefrontal atrophy.
View Article and Find Full Text PDFJ Neurol Sci
November 2024
Inserm, Neuro-Diderot, U1141 and Université Paris-Cité, F-75019 Paris, France; Translational Neurovascular Centre and Centre de reference CERVCO, FHU NeuroVasc, Paris, France. Electronic address:
fMRI-based studies on neurodegenerative diseases rarely report single-subject information, which is useful for assessing potential biomarkers. In a previous fMRI study, CADASIL patients showed, at the group level, a significant reduction of the long-lasting visually stimulated hyperaemic response. Here, we used data interpolation and computed a hemodynamic response function from the 20-s visual response to achieve a 40-s response prediction at the individual level.
View Article and Find Full Text PDFEur J Neurol
January 2025
Aldo Ravelli Research Centre, Department of Health Science, University of Milan, Milan, Italy.
Background And Purpose: Boxing is associated with a high risk of head injuries and increases the likelihood of chronic traumatic encephalopathy. This study explores the effects of sub-concussive impacts on boxers by applying both linear and nonlinear analysis methods to electroencephalogram (EEG) data.
Methods: Twenty-one boxers were selected (mean ± SD, age 28.
Sleep
September 2024
Center for Neurodegenerative Diseases and the Aging Brain, University of Bari Aldo Moro at Pia Fondazione "Card. G. Panico", Tricase, Italy.
Study Objectives: Sleep disorders have been recognized as an integral component of the clinical syndrome in several neurodegenerative diseases, including Alzheimer's Disease (AD). However, limited data exists for rarer types of neurodegenerative diseases, such as behavioral variant Frontotemporal Dementia (bvFTD). This study aims to analyze EEG power spectra and sleep stage transitions in bvFTD patients, hypothesizing that bvFTD may show distinctive sleep stage transitions compared to patients with Alzheimer's Disease (AD).
View Article and Find Full Text PDFAlzheimers Res Ther
September 2024
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Int J Geriatr Psychiatry
September 2024
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Background: Predicting which individuals may convert to dementia from mild cognitive impairment (MCI) remains difficult in clinical practice. Electroencephalography (EEG) is a widely available investigation but there is limited research exploring EEG connectivity differences in patients with MCI who convert to dementia.
Methods: Participants with a diagnosis of MCI due to Alzheimer's disease (MCI-AD) or Lewy body disease (MCI-LB) underwent resting state EEG recording.
J Acquir Immune Defic Syndr
October 2024
Department of Medical Sciences, Unit of Infectious Diseases, University of Turin, Turin, Italy.
Parkinsonism Relat Disord
November 2024
Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA.
Neuromodulation
September 2024
Department of Psychiatry and Behavioral Sciences, Neuro-X Lab, Medical University of South Carolina, Charleston, SC, USA.
Objectives: Low-intensity focused ultrasound (LIFU) is gaining increased interest as a potential therapeutic modality for a range of neuropsychiatric diseases. Current neuromodulation modalities often require a choice between high spatial fidelity or invasiveness. LIFU is unique in this regard because it provides high spatial acuity of both superficial and deep neural structures while remaining noninvasive.
View Article and Find Full Text PDFHum Brain Mapp
September 2024
Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK.
The characterisation of resting-state networks (RSNs) using neuroimaging techniques has significantly contributed to our understanding of the organisation of brain activity. Prior work has demonstrated the electrophysiological basis of RSNs and their dynamic nature, revealing transient activations of brain networks with millisecond timescales. While previous research has confirmed the comparability of RSNs identified by electroencephalography (EEG) to those identified by magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI), most studies have utilised static analysis techniques, ignoring the dynamic nature of brain activity.
View Article and Find Full Text PDFMed Devices (Auckl)
August 2024
Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, People's Republic of China.
Background: Electroencephalography (EEG) has been rapidly developed and is widely used in both clinical and scientific fields. Original studies on non-invasive EEG in the elderly have been of great importance owing to the global aging trend. The present study aimed to provide a bibliometric overview on current status and trends in this research field.
View Article and Find Full Text PDFAlzheimers Dement
October 2024
Cognito Therapeutics, Cambridge, Massachusetts, USA.
Many coronavirus disease 2019 (COVID-19) positive individuals exhibit abnormal electroencephalographic (EEG) activity reflecting "brain fog" and mild cognitive impairments even months after the acute phase of infection. Resting-state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID-19 and to Alzheimer's disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities.
View Article and Find Full Text PDFEpilepsy Res
October 2024
Basic Research Center in Dementia and Central Nervous System Demyelinating Diseases, Instituto Nacional de Ciencias Neurológicas, Lima-Perú.
Introduction: Seizures and epilepsy are well-documented in association with autoimmune encephalitis. Despite this, a notable gap exists in understanding the persistence of seizures beyond the acute phase, particularly within the context of low- and low-middle-income settings.
Objective: To evaluate the frequency, clinical characteristics, diagnosis, and potential factors associated with the occurrence and persistence of seizures in autoimmune encephalitis patients.
Nat Med
December 2024
Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Transl Psychiatry
August 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Department of Child and Adolescent Psychiatry, 13353, Berlin, Germany.
Magnetoencephalography (MEG) allows the non-invasive measurement of brain activity at millisecond precision combined with localization of the underlying generators. So far, MEG-systems consisted of superconducting quantum interference devices (SQUIDS), which suffer from several limitations. Recent technological advances, however, have enabled the development of novel MEG-systems based on optically pumped magnetometers (OPMs), offering several advantages over conventional SQUID-MEG systems.
View Article and Find Full Text PDFCommun Biol
August 2024
Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA.
Alterations in functional connectivity (FC) have been observed in individuals with Alzheimer's disease (AD) with elevated amyloid (Aβ) and tau. However, it is not yet known whether directed FC is already influenced by Aβ and tau load in cognitively healthy (CH) individuals. A 21-channel electroencephalogram (EEG) was used from 46 CHs classified based on cerebrospinal fluid (CSF) Aβ tau ratio: pathological (CH-PAT) or normal (CH-NAT).
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