4,667 results match your criteria: "EEG in Dementia and Encephalopathy"
Clin Neurophysiol
December 2024
School of Psychological and Cognitive Sciences, Peking University, Beijing, China. Electronic address:
Objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.
Methods: Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics.
BMC Neurol
December 2024
Laboratory for Epilepsy Research, KU Leuven, Belgium.
Background: Neuronal hyperexcitability has been proposed to play a key role in Alzheimer's disease (AD). Understanding the relation between this enhanced excitability and AD pathology could provide a window for therapeutic interventions. However epileptiform activity is often subclinical, hidden on scalp EEG and very challenging to assess with current diagnostic modalities.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
December 2024
Siberian State Medical University, Tomsk, Russia.
Creutzfeldt-Jakob disease (CJD) is a classic representative of the group of prion diseases and is characterized by progressive degeneration of the structures of the nervous system with a variety of neurological symptoms, steady progression and inevitable death. The disease is based on a change in the tertiary structure of the protein, which leads to disruption of the normal functioning of cells. Despite the fact that the etiology and pathogenesis of CJD are now well studied, intravital diagnosis of this serious disease remains difficult due to the peculiarities of the pathological process (unusually long incubation period, variety of clinical symptoms), the lack of pathognomonic markers that make it possible to make a diagnosis with a high degree of confidence, and also insufficient awareness of medical workers.
View Article and Find Full Text PDFRadiol Case Rep
February 2025
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Creutzfeldt-Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder that is caused by prion proteins. Patients often present with rapidly progressive dementia, ataxia, myoclonus, memory impairment, visual problems, and changes in personality. In this case report, we aimed to address the course of a 62 year old female who presented with progressive decline in cognitive function and died within 6 months of presentation.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy.
This study investigates the effectiveness of amplitude transformation in enhancing the performance and robustness of Multiscale Fuzzy Entropy for Alzheimer's disease detection using electroencephalography signals. Multiscale Fuzzy Entropy is a complexity measure particularly sensitive to intra- and inter-subject variations in signal amplitude, as well as the selection of key parameters such as embedding dimension () and similarity criterion (), which often result in inconsistent outcomes when applied to multivariate data, such as electroencephalography signals. To address these challenges and to generalize the possibility of adopting Multiscale Fuzzy Entropy as a diagnostic tool for Alzheimer's disease, this research explores amplitude transformation preprocessing on electroencephalography signals in Multiscale Fuzzy Entropy calculation across varying parameters.
View Article and Find Full Text PDFJ Neurol
December 2024
Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, U 1127, CNRS, UMR 7225, AP-HP, CENIR, Centre MEG-EEG, Hôpital de La Pitié-Salpêtrière, 47 Boulevard de L'Hôpital, 75013, Paris, France.
Episodic memory (EM) alterations are a hallmark of Alzheimer's disease (AD). We assessed EM longitudinally in cognitively normal elders at-risk for AD (with subjective memory complaints), as a function of amyloid-β (Aβ) burden, neurodegeneration (N), and progression to prodromal AD. We stratified 264 INSIGHT-preAD study subjects in controls (Aβ-/N-), stable/N- or N + (Aβ +), and progressors/N- or N + (Aβ +) groups (progressors were included only until AD-diagnosis).
View Article and Find Full Text PDFJ Neurol
December 2024
The UK National CJD Research and Surveillance Unit, Centre for Clinical Brain Sciences, Chancellor's Building, University of Edinburgh, Edinburgh, EH16 4TG, UK.
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive and fatal prion disease with significant public health implications. Survival is heterogenous, posing challenges for prognostication and care planning. We developed a survival model using diagnostic data from comprehensive UK sCJD surveillance.
View Article and Find Full Text PDFPLoS One
December 2024
School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Resting-state electroencephalogram (EEG) microstate analysis resolves EEG signals into topographical maps representing discrete, sequential network activations. These maps can be used to identify patterns in EEGs that may be indicative of underlying neurological conditions. One such pattern is observed in EEGs of patients with Alzheimer's disease (AD), where a global microstate disorganization is evident.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Pl., Building 324, 2800, Kgs. Lyngby, Denmark.
Neuroimage
December 2024
School of Biomedical Sciences and Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address:
The escalating global trend of aging has intensified the focus on health concerns prevalent among the elderly. Notably, Dementia related diseases, including Alzheimer's disease (AD) and frontotemporal dementia (FTD), significantly impair the quality of life for both affected seniors and their caregivers. However, the underlying neural mechanisms of these diseases remain incompletely understood, especially in terms of neural oscillations.
View Article and Find Full Text PDFComput Methods Programs Biomed
February 2025
National Heart Centre Singapore, Singapore, Duke-NUS Medical School, Singapore.
BMC Neurol
November 2024
Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Background: Diffusion-weighted magnetic resonance imaging (DWI) is essential for diagnosing Creutzfeldt-Jakob disease (CJD). Thalamic lesions are rarely detected by DWI in sporadic CJD (sCJD) cases with methionine homozygosity at polymorphic codon 129 (129MM) of the prion protein (PrP) gene. Here, we describe an unusual sCJD case, characterized by prolonged isolated thalamic diffusion hyperintensities and atypical brain pathology, in combination with the 129MM genotype.
View Article and Find Full Text PDFJ Prev Alzheimers Dis
November 2024
Anthony O. Caggiano, MD, PhD, Cognition Therapeutics, Inc., 2500 Westchester Avenue, Purchase, NY 10577,
Background: CT1812 is a first-in-class, sigma-2 receptor ligand, that prevents and displaces binding of amyloid beta (Aβ) oligomers. Normalization of quantitative electroencephalography (qEEG) markers suggests that CT1812 protects synapses from Aβ oligomer toxicity.
Objectives: Evaluate CT1812 impact on synaptic function using qEEG measurements.
Am J Transl Res
October 2024
Inflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (UNICAMP) Campinas, São Paulo, Brazil.
Sleep Med
December 2024
Department of Neurology, University Hospital Zurich (USZ), Switzerland; Neuroscience Center Zurich (ZNZ), Switzerland; Center of Competence Sleep and Health, University of Zurich (UZH), Switzerland. Electronic address:
Cell Rep
November 2024
Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark; Center for Translational Neuromedicine, University of Rochester Medical School, Elmwood Avenue 601, Rochester, NY 14642, USA. Electronic address:
Biomedica
November 2024
Departmento de Radiología, Hospital Central de la Policía, Bogotá, D. C., Colombia.
Creutzfeldt-Jakob disease is a rare neurodegenerative disease caused by prions. We present the case of a woman in the seventh decade of life with rapidly progressive dementia and myoclonus. Her brain magnetic resonance imaging revealed lesions in the basal nuclei, and the electroencephalogram showed periodic bilateral epileptiform discharges.
View Article and Find Full Text PDFJ Alzheimers Dis
November 2024
Linus Health, Inc., Boston, MA, USA.
Background: Distinguishing between mild cognitive impairment (MCI) and early dementia requires both neuropsychological and functional assessment that often relies on caregivers' insights. Contacting a patient's caregiver can be time-consuming in a physician's already-filled workday.
Objective: To assess the utility of a brief, machine learning (ML)-enabled digital cognitive assessment, the Digital Clock and Recall (DCR), for detecting functional dependence.
Age Ageing
November 2024
Thompson Institute, University of the Sunshine Coast, 12 Innovation Pkwy, Birtinya QLD 4575, Australia.
Background: The rising prevalence of dementia necessitates identifying early neurobiological markers of dementia risk. Reduced cerebral white matter volume and flattening of the slope of the electrophysiological 1/f spectral power distribution provide neurobiological markers of brain ageing alongside cognitive decline. However, their association with modifiable dementia risk remains to be understood.
View Article and Find Full Text PDFAlzheimers Res Ther
November 2024
Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, Rome, 00185, RM, Italy.
Alzheimer disease (AD) remains a significant global health concern. The progression from preclinical stages to overt dementia has become a crucial point of interest for researchers. This paper reviews the potential of neurophysiological biomarkers in predicting AD progression, based on a systematic literature search following PRISMA guidelines, including 55 studies.
View Article and Find Full Text PDFBMJ Case Rep
November 2024
Neurology, Northampton General Hospital NHS Trust, Northampton, Northamptonshire, UK.
Sci Rep
October 2024
Department of Electrical Engineering, Shiraz University of Technology, Shiraz, Iran.
The Internet of Medical Things (IoMT) is poised to play a pivotal role in future medical support systems, enabling pervasive health monitoring in smart cities. Alzheimer's disease (AD) afflicts millions globally, and this paper explores the potential of electroencephalogram (EEG) data in addressing this challenge. We propose the Convolutional Learning Attention-Bidirectional Time-Aware Long-Short-Term Memory (CL-ATBiLSTM) model, a deep learning approach designed to classify different AD phases through EEG data analysis.
View Article and Find Full Text PDFNeural Netw
January 2025
DICEAM, University Mediterranea of Reggio Calabria, 89122, Reggio Calabria, Italy.
Electroencephalography (EEG) is widely used as a non-invasive technique for the diagnosis of several brain disorders, including Alzheimer's disease and epilepsy. Until recently, diseases have been identified over EEG readings by human experts, which may not only be specific and difficult to find, but are also subject to human error. Despite the recent emergence of machine learning methods for the interpretation of EEGs, most approaches are not capable of capturing the underlying arbitrary non-Euclidean relations between signals in the different regions of the human brain.
View Article and Find Full Text PDFSensors (Basel)
October 2024
Department of Information Engineering, Università Politecnica delle Marche, Via Brecce Bianche 12, I-60131 Ancona, Italy.
Alzheimers Res Ther
October 2024
Centre for Brain Research, Indian Institute of Science, CV Raman Avenue, Bangalore, 560 012, India.
Background: Biomarkers of Alzheimer's disease (AD) and mild cognitive impairment (MCI, or prodromal AD) are highly significant for early diagnosis, clinical trials and treatment outcome evaluations. Electroencephalography (EEG), being noninvasive and easily accessible, has recently been the center of focus. However, a comprehensive understanding of EEG in dementia is still needed.
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