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[Allele Frequency and Distribution of Single Nucleotide Polymorphisms in Promoter Region of Gene Encoding the Kidd Blood Group Antigens].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2020
Shenzhen Blood Center, Shenzhen 518035, Guangdong Province, China,Shenzhen Research Institute of Population and Family Planning, Shenzhen 518040, Guangdong Province, China, E-mail:
Objective: To study the single nucleotide polymorphisms (SNPs) in promoter region of the Jk gene and its allele frequency as well as distribution characteristics in the Chinese Han nationality population.
Methods: 127 blood samples containing 8 Jk(a-b-) and 119 samples (as control) taken randomly from voluntary blood donors of Chinese Han nationality persons in Shenzhen Blood Center were collected. The Kidd phenotypes were identified by using the serologic test and urea hemolysis test; the Jk promoter, exon 1-11 region and respective flanking area were amplified and sequenced, then the sequence information was analyzed.