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Distinct associations of complement C3a and its precursor C3 with atherosclerosis and cardiovascular disease. The CODAM study.
Thromb Haemost
June 2014
Elisabeth Hertle, MSc, PhD candidate, Department of Internal Medicine and CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, The Netherlands, Tel.: +31 43 388 2462, Fax: +31 43 387 5006, E-mail:
Complement C3 is a novel risk factor for cardiovascular disease (CVD), but the underlying mechanism is currently unknown. We determined the associations of the anaphylatoxin C3a, the activation product of C3, and of C3 itself with estimates of atherosclerosis and CVD. We studied associations of C3a and C3 with carotid intima-media thickness (cIMT), ankle-arm blood pressure index (AAIx) and CVD in cross-sectional analyses among 545 participants of the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study (62% men, 59.
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