779 results match your criteria: "Dystonia Tardive"
Complete relief of tardive truncal dystonia with a low dose of levodopa/carbidopa: A case report.
J Mov Disord
December 2024
Center for Drug Discovery and Development Sciences, Research Organization of Science and Technology, Ritsumeikan University, Kyoto 603-8577, Japan.
Successful Electroconvulsive Therapy for Tardive Dyskinesia and Tardive Dystonia Refractory to Valbenazine Treatment: A Case Report and Narrative Literature Review.
Clin Psychopharmacol Neurosci
November 2024
Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
Article Synopsis
- Tardive dyskinesia and dystonia are persistent movement disorders caused by antipsychotic medications blocking dopamine receptors.
- Treatments like valbenazine and botulinum toxin have shown some effectiveness, but their overall success is still not completely proven.
- A case study is presented of a woman with bipolar disorder and treatment-resistant symptoms who improved after undergoing electroconvulsive therapy, along with a review of existing literature on its safety and efficacy for these conditions.
Antipsychotics and chronic dystonia at a Botulinum Toxin clinic.
S Afr J Psychiatr
September 2024
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Article Synopsis
- The study focuses on adults with chronic dystonia, especially those whose condition is linked to antipsychotic medication use, highlighting the clinical challenges involved.
- It analyzes 119 patients from a Botulinum Toxin Clinic in Cape Town, revealing that individuals with antipsychotic-induced dystonia are generally younger, more likely to be female, and require more intensive Botulinum toxin treatment.
- The findings indicate a notable link between the type of dystonia and additional mental health issues, suggesting the need for improved patient management strategies in this population.
Management of tardive dyskinesia and tardive dystonia with clozapine: A retrospective study.
Asian J Psychiatr
December 2024
Post Graduate Institute of Medical Education & Research, Chandigarh, India.
Article Synopsis
- The study looked at how effective clozapine is for treating tardive syndromes, which are problems that can happen after taking certain medications for a long time.
- Most of the patients in the study had issues like muscle spasms or uncontrolled movements when they started using clozapine.
- After treatment, many patients saw a big improvement, with some having their symptoms completely go away!
Chronic Cocaine Use and Parkinson's Disease: An Interpretative Model.
Int J Environ Res Public Health
August 2024
VP Dole Research Group, G. De Lisio Institute of Behavioural Sciences, Via di Pratale 3, 56121 Pisa, Italy.
Article Synopsis
- Cocaine use has become a significant public health issue, with roughly 24.6 million users globally and 1 million diagnosed with cocaine use disorder, according to the 2023 World Drug Report.
- While short-term effects of cocaine are well-documented, there is a lack of comprehensive data on its medium and long-term impacts, which suggest increased risks for cardiovascular issues and neurodegenerative diseases.
- The paper proposes that chronic cocaine use leads to neurobiological changes affecting neurotransmitter systems, particularly dopaminergic pathways, which may increase vulnerability to neurodegenerative disorders and highlights the need for further research to inform therapeutic interventions.
Pisa Syndrome Secondary to Drugs: A Scope Review.
Geriatrics (Basel)
July 2024
Neurology Department, Cooper University Hospital, Camden, NJ 08103, USA.
Article Synopsis
- Pisa syndrome, also known as pleurothotonus, is a neurological condition causing a noticeable lateral curvature of the spine when standing, often linked to certain medications.
- A systematic review identified 109 articles detailing 191 cases of drug-induced Pisa syndrome, showing a prevalence ranging from 0.037 to 9.3%, primarily affecting females around the age of 59.70 years.
- The review suggested new diagnostic criteria for Pisa syndrome and indicated that various mechanisms might contribute to balance control and the development of the condition.
Levodopa-responsive dystonia, parkinsonism, and treatment-resistant schizoaffective disorder in Williams syndrome.
Neurol Sci
July 2024
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Williams syndrome (WS) is a rare genetic disorder linked to chromosome 7, characterized by developmental delays and various neuropsychiatric issues, including movement disorders and psychiatric conditions.
- The study presents two adult cases of WS with severe treatment-resistant schizoaffective disorder and associated movement issues, such as parkinsonism and dystonia, observed after clozapine treatment.
- The findings suggest that low-dose levodopa may effectively alleviate movement symptoms without worsening psychotic or mood symptoms, indicating new potential treatment avenues for individuals with WS.
Gastroparesis treatment options metoclopramide and prucalopride: analysis of the FDA Adverse Event Reporting System (FAERS) database.
Expert Rev Gastroenterol Hepatol
July 2024
Center for Advanced Therapeutic Endoscopy (CATE), Porter Adventist Hospital/PEAK Gastroenterology, Denver, CO, USA.
Article Synopsis
- The study investigates adverse drug reactions (ADRs) for metoclopramide and prucalopride, both used for gastrointestinal issues, using the FDA's Adverse Event Reporting System (FAERS) data from January 2013 to December 2023.
- Key ADRs for metoclopramide include tardive dyskinesia (36.2%), dystonia (15.7%), and serious heart risks like Torsade de pointes, while prucalopride commonly causes headaches (13.9%), diarrhea (13.4%), and abdominal pain (11.6%).
- The findings suggest that both drugs carry significant risks for serious side effects, with metoclop
An experience of using Clozapine in elderly patients with mental disorders.
Asian J Psychiatr
August 2024
Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
Article Synopsis
- There is limited research on the use of clozapine in elderly patients (aged 60 and above) with mental disorders in India, prompting this study to evaluate their clinical and sociodemographic profiles.
- Out of 1,058 patients registered, only 42 were elderly, with most having treatment-resistant psychosis or tardive dyskinesia, benefiting from clozapine treatment for an average of 3.55 years.
- While three-fourths of patients experienced side effects—most commonly constipation—most showed significant improvement, suggesting clozapine can be safely administered to elderly patients when necessary.
Anterior capsulotomy combined with subthalamic nucleus deep brain stimulation for tardive dystonia.
J Psychiatr Res
August 2024
Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Article Synopsis
- Deep brain stimulation (DBS) can help manage severe tardive dystonia (TD) symptoms, even in patients with major psychiatric disorders, who typically don't qualify for DBS.
- A study of six TD patients who underwent bilateral anterior capsulotomy with STN-DBS showed significant improvements in dystonia, disability, depression, anxiety, and overall quality of life over 1-3 years post-treatment.
- The research indicated a high percentage of symptom reduction and no serious side effects, suggesting this combination therapy is both effective and safe for severe TD patients.
An Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders.
CNS Drugs
April 2024
Neurocrine Biosciences, Inc, San Diego, CA, USA.
Article Synopsis
- * Anticholinergic medications can effectively treat conditions like drug-induced parkinsonism and dystonia but are not suitable for tardive dyskinesia, akathisia, or neuroleptic malignant syndrome.
- * Caution is advised when prescribing anticholinergics due to their potential serious side effects, especially in older patients; they should be used at the lowest effective dose and tapered off gradually.
Illustration of the Dramatic and Dynamic Efficacy of Chronic GPi-DBS Therapy in a Patient with Tardive Dyskinesia/Dystonia.
Ann Indian Acad Neurol
December 2023
Department of Neurology Clinic, Etlik City Hospital, Ankara, Turkey.
Bridging the gap between statistical significance and clinical relevance: A systematic review of minimum clinically important difference (MCID) thresholds of scales reported in movement disorders research.
Heliyon
March 2024
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- The study focuses on Minimum Clinically Important Difference (MCID), which is the smallest change in a measure that has real clinical significance, helping with treatment assessment and outcome measure development.
- The systematic review analyzed 2763 reports, ultimately including 32 studies, with most being of good quality, and highlighted the Unified Parkinson's Disease Rating Scale (UPDRS) as the most frequently evaluated.
- The review provides a comprehensive list of MCID thresholds for various scales used in movement disorders, emphasizing the importance of standardized MCID measures for future research.
Brexpiprazole-related tardive dystonia in a young patient with schizophrenia: A case report.
Psychiatry Clin Neurosci
May 2024
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Polypharmacy-Associated Tardive Dystonia Responding to Clozapine Optimization.
Am J Ther
July 2024
Internal Medicine, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.
Retraction Note: Pallidal deep brain stimulation for tardive dystonia: meta-analysis of clinical outcomes.
Neurol Sci
March 2024
Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, USA.
The Extrapyramidal Symptom Rating Scale and Its Abbreviated Version: A Critical Review of Clinimetric Properties.
Psychother Psychosom
January 2024
Larry Alphs Consulting, Princeton, New Jersey, USA.
Article Synopsis
- The Extrapyramidal Symptom Rating Scale - Abbreviated (ESRS-A) is a streamlined tool for assessing drug-induced movement disorders, focusing on conditions like parkinsonism and tardive dyskinesia.
- Research shows that both the ESRS and ESRS-A have high inter-rater reliability and good concurrent validity when compared to other established scales, meaning different raters get consistent results.
- These tools are important for clinical research and practice, helping to identify and measure the severity of movement disorders caused by medications, especially antipsychotics.
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant.
Daru
June 2024
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Article Synopsis
- Typical antipsychotics can cause various movement disorders known as extrapyramidal side effects, including rabbit syndrome, which involves rhythmic mouth movements.
- This report focuses on a rare case of rabbit syndrome in an elderly patient who developed atypical symptoms, including horizontal jaw movements and tongue involvement, after starting treatment with haloperidol and escitalopram.
- The patient's condition improved after stopping the antipsychotic medication, with the tongue movements thought to be mainly caused by escitalopram.
Overview of Movement Disorders Secondary to Drugs.
Clin Pract
August 2023
Medicine Department, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.
Article Synopsis
- Drug-induced movement disorders are common, often overlooked, and can be complicated by other health issues, making diagnosis difficult.
- Multiple factors like genetics, environment, and age contribute to these disorders' development and severity.
- Current classification systems such as DSM and ICD are used to categorize these disorders, with significant attention needed on conditions like myoclonus and tardive syndromes linked to medications like antiseizure drugs and antipsychotics.*
The Outcome of Antipsychotics-induced Tardive Syndromes: A Ten-year Follow-up Study.
Clin Psychopharmacol Neurosci
August 2023
Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Article Synopsis
- Tardive syndrome (TS), caused by long-term use of dopamine receptor-blocking agents like antipsychotics, affects movement and has few follow-up studies on its outcomes.* -
- In a study of 123 patients in Taiwan, about 42.4% experienced TS, with tardive dyskinesia being the most common type, and the overall remission rate after 10 years was found to be 74.3% with factors like vitamin B6 influencing recovery.* -
- The research emphasizes that early detection and treatment, including monitoring for TS symptoms and using antioxidants, can lead to better outcomes for patients on antipsychotics.*
Non-Psychosis Symptoms of Clozapine Withdrawal: a Systematic Review.
East Asian Arch Psychiatry
June 2023
Department of Medicine, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Article Synopsis
- Clozapine is an effective antipsychotic used for schizophrenia that can cause various withdrawal symptoms, particularly when discontinued.* -
- A review analyzing five studies found that about 20% of patients reported non-psychosis symptoms after stopping clozapine, including cholinergic rebound and extrapyramidal symptoms.* -
- Clinicians need to recognize these withdrawal symptoms for timely treatment, and more research is needed to understand their prevalence and best management strategies.*
Clinical Evolution of Tardive Cervical Dystonia from Antecollis to Retrocollis.
Cureus
May 2023
Neurology Department, Hospital de Braga, Braga, PRT.
Article Synopsis
- A 61-year-old woman with Alzheimer's experienced severe neck flexion and akathisia after being treated with olanzapine, leading to difficulties with feeding.
- After stopping olanzapine, her condition improved with other medications, but she still faced overlapping issues, highlighting the risks of dystonia, especially in patients with degenerative diseases and the need for careful medication management.
Intra thecal baclofen pump as an ad hoc measure for a case of severe tardive dystonia refractory to multiple lesioning.
Ann Med Surg (Lond)
May 2023
Department of Neurosurgery, Annapurna Neurological Institute and Allied Sciences, Maitighar, Kathmandu, Nepal.
Article Synopsis
- * A case involving a 31-year-old woman with progressive tardive dystonia showcased the use of globus pallidus interna lesioning, but after initial success, her symptoms returned, leading to a switch to baclofen therapy, which proved effective after the insertion of a baclofen pump.
- * Tardive dystonia is linked to increased sensitivity of dopamine receptors due to antipsychotics, and while oral medications are common treatment options, deep brain stimulation may be recommended for certain patients.