The synergistic gelation of novel Bletilla striata polysaccharide with hyaluronic acid: Characterization, rheology.

Bletilla striata polysaccharide (BSP) has attracted considerable interest due to its diverse biological activities. In this research, a novel low-molecular-weight water-soluble polysaccharide (BSP-182) was isolated and purified from Bletilla striata tubers, and its structure was characterized. The findings indicated that BSP-182 is predominantly composed of β-1,4-linked glucose (Glc) and β-1,4-linked mannose (Man) in a molar ratio of approximately 7.

Correction: Severe Scoliosis As the Clue for an Early Onset Myopathy, Areflexia, Respiratory Distress, and Dysphagia (EMARDD) Diagnosis During Childhood: A Case Report.

[This corrects the article DOI: 10.7759/cureus.74966.

Efficacy and safety of a novel multisegmented fully covered self-expanding metal stent for malignant esophageal obstruction: a prospective pilot study with historical control.

Background And Aims: Self-expanding metal stents (SEMSs) are effective for symptom palliation in patients with esophageal obstruction. However, their placement can lead to adverse events such as stent migration and restenosis. A novel fully covered SEMS (FCSEMS) with antimigration properties has been developed to address these issues.

Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling.

Eosinophilic esophagitis (EoE) is a chronic allergic disorder characterized by eosinophilia and epithelial thickening, resulting in dysphagia. While emerging evidence implicates increased frequencies of group 2 innate lymphoid cells (ILC2s) and increased interleukin (IL)-33 expression in EoE pathogenesis, the precise mechanisms remain unclear. In this study, we investigated the role of ILC2s in EoE pathogenesis.

How Would You Manage This Patient With Gastroesophageal Reflux Symptoms? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Gastroesophageal reflux disease (GERD) is a common medical condition presenting with heartburn, regurgitation, cough, hoarseness, and/or wheezing. Patients with classic GERD symptoms often do not require diagnostic studies before empirical treatment is initiated. However, if atypical features are present, including alarm symptoms for malignancy, or if symptoms do not respond to conventional treatment, upper endoscopy may be necessary.

Patient centered outcomes of transoral robotic surgery for obstructive sleep apnea: a retrospective analysis.

Purpose: Obstructive Sleep Apnea (OSA) is usually caused by collapse of the base of tongue (BOT) and impacts patients' overall health. Despite current conventional therapies, some patients do not achieve satisfactory results. Reduction of BOT using Trans Oral Robotic Surgery (TORS) emerges as a promising treatment.

Validation of the Japanese version of the Esophageal Hypervigilance and Anxiety Scale for esophageal symptoms.

Background: The Esophageal Hypervigilance and Anxiety Scale (EHAS) is an English questionnaire created in the USA to assess these factors in all patients with esophageal diseases. The aim of this study was to develop and validate the Japanese version of EHAS and investigate the relationship between EHAS scores and symptoms in untreated disorders of esophagogastric junction (EGJ) outflow.

Methods: This prospective study recruited patients who underwent high-resolution manometry (HRM) at six tertiary centers in Japan.

A Posterior Cranial Fossa Lesion Mimicking Myasthenia Gravis.

Unlabelled: A 41-year-old male with prior diagnosis of seronegative myasthenia gravis presented with complaints of bilateral ptosis, dysphagia, nasal voice and nasal regurgitation. Despite treatment with pyridostigmine, there was lack of significant improvement in the symptoms. Further investigations, including antibody assays and nerve conduction studies did not support the diagnosis.

An Unusual Case of Esophageal Perforation Following C5-C7 Anterior Cervical Corpectomy and Fusion Managed Surgically With Esophageal Repair and Long-Segment Cervical Fusion.

Anterior cervical corpectomy and fusion (ACCF) is frequently the surgical management for myelopathy, radiculopathy, and cervical spine trauma. Although esophageal perforation is an uncommon complication, it remains a serious concern. This report details the case of a 50-year-old female who underwent a C6 corpectomy with C5-C7 ACCF due to degenerative pathology and subsequently developed an esophageal perforation that required revision surgery and surgical repair of the perforated esophagus.

From Dizziness to Dysphagia: A Complex Presentation of Lateral Medullary Syndrome.

Lateral medullary syndrome (LMS), also known as Wallenberg syndrome, is a rare neurological condition most commonly resulting from occlusion of the posterior inferior cerebellar artery (PICA). This syndrome is characterized by a constellation of symptoms including vertigo, ataxia, sensory deficits, and cranial nerve abnormalities, which arise due to infarction of the lateral medulla. We report the case of a 74-year-old female patient with a history of hypertension who presented to the emergency department with acute onset of vertigo and an unsteady gait.

The rare coexistence of gastric and esophagus squamous cell carcinoma: a case report.

Squamous cell carcinoma (SCC) of the stomach is a rare entity with fewer than 100 cases of primary SCC reported in the literature, while esophageal SCC is prevalent and more common. However, a synchronous squamous cell carcinoma found in the esophagus and stomach remains very uncommon. We present the case of a 64-year-old with a history of dysphagia who had an endoscopy that showed an impassable stenosis of the middle esophagus, with histopathology in favor of an esophagus squamous cell carcinoma.

An unexpected cause of intractable dysphagia after 20 years following cervical spine instrumentation using bone cement alone: a case report.

Introduction And Importance: Postoperative dysphagia following anterior cervical discectomy fusion (ACDF) for cervical disc herniation is still poorly understood. Dysphagia after anterior spinal cervical approach is mild and transient. Here, the authors present a rare case suffering with severe progressive dysphagia for over 1 year after 20 years of ACDF due to expulsed bone cement abutting the esophagus which was successfully removed after reoperation.

Protein-losing enteropathy as the first presentation of systemic lupus erythematosus the first case reported in Palestine with systemic review.

Introduction: Systemic lupus erythematosus is a chronic inflammatory disease affecting women, causing gastrointestinal issues like acute pancreatitis, esophagitis, and protein-losing enteropathy. Protein loss is uncommon, but a case study shows protein-losing enteropathy as a first sign.

Importance: Protein-losing enteropathy (PLE) is a rare gastrointestinal manifestation of SLE, often seen years before diagnosis.

Carotid endarterectomy in the setting of persistent hypoglossal artery.

Persistent hypoglossal artery (PHA) is a rare, anatomical variant in which the posterior cerebral circulation is primarily supplied by a branch of the carotid artery, rather than the vertebral arteries. This case report discusses carotid endarterectomy performed on a man, 67 years of age, with high-grade, asymptomatic carotid artery stenosis and ipsilateral PHA. Preoperative computed tomography angiography identified the PHA arising from the internal carotid artery, compensating for atretic bilateral vertebral arteries and providing primary perfusion to anterior spinal artery.

Pediatric gastrostomy tube referral patterns and postoperative use: A single-center experience.

Objectives: Practice variability exists regarding the timing of gastrostomy tube (GT) placement in patients unable to maintain adequate oral nutrition. We sought to assess patient factors predictive of longer surgical GT use to inform patient selection.

Methods: We conducted a single-center, retrospective cohort study including children ≤18 years who underwent surgical GT placement from June 1, 2018 to June 1, 2021 at a children's hospital.

Exploring multidisciplinary team members' experiences of supporting eating and drinking with acknowledged risk in healthcare and aged care settings.

Purpose: Dysphagia is a swallowing condition which has significant health and quality of life implications. Speech-language pathologists provide assessment and support shared decision making to optimise swallowing safety. Many people elect to eat and drink with acknowledged risk.

Acute suppurative thyroiditis caused by Gemella Morbillorum: a case report.

Background: Acute suppurative thyroiditis (AST) is a rare form of thyroid inflammation prevalently of bacterial origin, that usually affects subjects with risk factors such as immunodeficiency, sepsis, and neck fistulas. The most prevalent pathogens associated with AST are gram-positive aerobic bacteria, followed by gram-negatives, while infections by anaerobic germs are exceptionally rare. Gemella morbillorum is a facultative anaerobic gram-positive bacterium that commonly populates the upper respiratory tract.

An update on pharyngeal assessment by the modified barium swallow.

The modified barium swallow study (MBSS) is a diagnostic examination that visualizes the functional anatomy and physiology of the oral pharyngeal swallowing mechanism in real time. The MBSS, a videofluoroscopic imaging method, is indicated for patients with known or suspected oropharyngeal dysphagia and ideally involves the combined expertise of a radiologist and speech pathologist. The MBSS provides critical diagnostic insights that help in identifying and assessing the type and severity of physiological swallowing impairments, evaluating the safety of oral intake, testing the effectiveness of evidence-based interventions, and developing treatment plans.

[A Case of Esophageal Perforation Caused by Metallic Stent Placement after Long-Term Chemotherapy for Advanced Gastric Cancer].

A 72-year-old man had been undergoing chemotherapy for advanced gastric cancer for over 4 years. He presented with dysphagia, and esophagogastroduodenoscopy(EGD)revealed esophageal stricture due to tumor growth. Subsequently, he underwent placement of a partially covered esophageal stent(HANAROSTENT® Esophagus, M.