4,184 results match your criteria: "Dysfunctional Uterine Bleeding"
Analysis of Sulfate Compounds From Sanguisorbae Radix and Its Major Metabolites in Rats by UPLC-MS/MS and Molecular Docking.
Rapid Commun Mass Spectrom
February 2025
State Key Laboratory of Chinese Medicine Modernization, Tasly Pharmaceutical Group Co. Ltd., Tianjin, China.
Rationale: Sanguisorbae Radix that mainly contains tannins and phenolic compounds has been widely used as a traditional Chinese medicine for treating hemafecia, hemorrhoids metrorrhagia and metrostaxis in clinics. However, there is no report about the sulfate phenolic compounds in Sanguisorbae Radix.
Methods: Extraction of Sanguisorbae Radix was separated and purified by polyamide resin and octadecyl silane-bonded silica, which were analyzed by HPLC-IT-TOF/MS.
Case Report of Placenta Accreta Spectrum and Arteriovenous Malformations with Successful Preservation of Fertility After Birth.
Diagnostics (Basel)
November 2024
Department of Microbiology, County Clinical Emergency Hospital, University of Medicine and Pharmacy, 200642 Craiova, Romania.
Article Synopsis
- Uterine arteriovenous malformations (UAVMs) are a rare cause of heavy bleeding after childbirth, often linked to placenta accreta spectrum (PAS).
- A case study highlighted a woman with PAS who experienced significant bleeding post-delivery and required several treatments, including uterine artery embolization, which proved effective.
- The study suggests that UAVMs may arise from residual PAS tissue and emphasizes the importance of preserving fertility while managing severe bleeding, avoiding more drastic measures like hysterectomy.
Article Synopsis
- - Postpartum venous thromboembolism (VTE) is a serious complication that can occur after childbirth, driven by factors like increased blood clotting, reduced mobility, and injury to blood vessels, leading to high risks for new mothers.
- - A case study details a 37-year-old woman with a history of recurrent clots and pregnancy issues that ultimately resulted in severe chronic venous obstruction despite various treatments, necessitating advanced procedures like stent implantation.
- - The patient's medical journey involved multiple challenges, including spontaneous abortions, a pulmonary embolism linked to contraceptive use, and serious complications during and after her last pregnancy, highlighting the importance of careful monitoring and effective prevention strategies for postpartum VTE.
Histopathological pattern in endometrial biopsies in reproductive age group and Post-menopausal women.
J Pak Med Assoc
November 2024
Department of Pathology, Dow International Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Article Synopsis
- The study aimed to identify and analyze different morphological patterns in endometrial biopsies and their diagnoses across various age groups.
- Conducted in Karachi over a year, it used data from pre-existing medical records, splitting patients into two age groups: reproductive age (≤45 years) and postmenopausal age (≥46 years).
- Results showed that endometrial polyps were the most common finding in both age groups, with malignant changes occurring more frequently in the postmenopausal group.
Recognizing Endometrial Cancer Risks in Perimenopausal and Postmenopausal Experiences: Insights From Community Qualitative Interviews and Workshop.
J Obstet Gynaecol Can
December 2024
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC. Electronic address:
Article Synopsis
- The study aimed to evaluate how perimenopausal and postmenopausal women in British Columbia perceive reproductive aging and their concerns about endometrial cancer (EC).
- Interviews with 31 women revealed a simplistic understanding of midlife changes, a tendency to "tough it out," and low awareness of EC risk factors, with confusion between cervical cancer and EC.
- Participants expressed the need for better education on EC and recommendations for raising awareness about it during discussions on perimenopause and menopause.
Uterine carcinosarcomas: A case series of 9 cases from a low-income country.
Medicine (Baltimore)
October 2024
Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger.
Article Synopsis
[From perimenopausal metrorrhagia to life-threatening haematological emergency].
Gynecol Obstet Fertil Senol
October 2024
Pôle de gynécologie-obstétrique, hôpitaux universitaires de Strasbourg, site du CMCO, 19, rue Louis-Pasteur, 67300 Schiltigheim, France.
Integrated metabolomics and network pharmacology reveal the procoagulant mechanisms of Cirsium setosum extracts.
J Chromatogr B Analyt Technol Biomed Life Sci
October 2024
Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
As a medicinal plant, Cirsium setosum has excellent procoagulant effects and has long been used as a cure for hemoptysis, epistaxis, uremia and metrorrhagia caused by blood heat. However, the key medicinal part of C. setosum, as well as the biologically active substances that play a major role, are not known.
View Article and Find Full Text PDFArticle Synopsis
- - This study, conducted from April 2021 to October 2022, focused on the potential impact of COVID-19 vaccines on menstrual cycles in women who received three doses of the vaccine.
- - Out of 308 participants, 22 women (7.1%) reported abnormal menstrual changes after vaccination, with metrorrhagia being the most common issue observed in nearly half of these cases.
- - A significant percentage (59%) of those who reported disturbances experienced persistent symptoms, and some participants also contracted COVID-19 after showing menstrual disorders, suggesting that the virus might contribute to these changes alongside vaccination effects.
Musculoskeletal Pain and Right Leg Paresthesia Revealed as Large Ovarian Mucinous Cystadenoma: A Case Report.
Am J Case Rep
September 2024
Obstetrics and Gynecology Clinic, K.M.P THERAPIS Paphos Medical Center, Paphos, Cyprus.
Article Synopsis
- * Small ovarian cystadenomas are often asymptomatic but can cause discomfort and other symptoms as they grow, including abdominal pain and urinary issues.
- * A case study of a 31-year-old woman highlights how a large mucinous cystadenoma in the sacrococcygeal area can be mistaken for musculoskeletal issues, underscoring the need for early diagnosis to ensure proper treatment and symptom relief.
Lipoleiomyosarcoma with pleomorphic liposarcoma of the uterus: Computed tomography findings with pathological correlation. A case report and review of literature.
Radiol Case Rep
November 2024
Radiology Department, Buon Consiglio Fatebenefratelli Hospital, Naples 80123, Italy.
Article Synopsis
- Uterine lipoleiomyosarcomas (L-LMS) and liposarcomas (LPS) are very rare malignant tumors occurring in the uterus, particularly affecting postmenopausal women, with common symptoms being metrorrhagia and abdominal pain.
- The case discussed involves a patient with L-LMS and pleomorphic LPS, with contrast-enhanced computed tomography (CECT) playing a critical role in diagnosis by distinguishing between the tumor components.
- The essay aims to highlight the importance of CECT imaging in diagnosing these rare tumors and includes a review of existing literature on liposarcomas in the uterine corpus.
Treatments of unscheduled vaginal bleeding due to progestin-only contraception.
Cochrane Database Syst Rev
September 2024
Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Article Synopsis
- The protocol outlines a Cochrane Review aimed at assessing treatment options for unscheduled vaginal bleeding in premenopausal women.
- The review will focus on evaluating the effectiveness, safety, and side effects of progestin-only pills as a treatment method.
- The overall goal is to provide reliable evidence on the use of these treatments for women experiencing this health issue.
Embolization of the hypogastric artery after surgical ligation: A case series of two patients.
Int J Surg Case Rep
October 2024
Tunis Faculty of Medicine El Manar University, Gynecology and Obstetrics Department C at the Tunis Maternity and Neonatology Center, Tunisia.
Article Synopsis
- The increasing rates of obstetric complications, like post-partum hemorrhage from placenta accreta spectrum, necessitate new treatment methods, highlighting the effectiveness of internal iliac artery embolization for managing obstetric bleeding.
- Two case studies demonstrate successful outcomes: a 38-year-old patient experienced persistent bleeding after a subtotal hysterectomy and was saved by arterial embolization, while a 35-year-old patient with placenta accreta after a hysterectomy also benefited from the procedure.
- The discussion emphasizes the importance of interventional radiology in treating postpartum hemorrhage and suggests that consulting a specialized radiologist can be crucial for improving patient outcomes post-surgery.
Challenges in Diagnosing Metastatic Uterine PEComa: Insights from Two Case Studies.
Am J Case Rep
August 2024
Department of Anatomopathology, Epicura Hospital, Hornu, Belgium.
Article Synopsis
- Perivascular epithelioid cell tumor (PEComa) is generally a benign tumor, but this report details two cases of advanced malignant PEComa in women aged 74 and 50, leading to complex surgical management.* -
- The first patient presented with a large, painful abdominal mass and difficult pathological diagnosis, while the second patient showed typical immunohistochemical patterns and received targeted therapy, resulting in no recurrence after 8 months.* -
- The study highlights the variability in clinical features of metastatic PEComa and the challenges in diagnosis, noting that there are currently no definitive diagnostic markers for these tumors.*
Unusual radiologic imaging in juvenile granulosa cell tumor with precocious puberty: A unilocular cyst.
Radiol Case Rep
October 2024
Department of Radiology, Faculty of Medicine - Universitas Airlangga, Surabaya, Indonesia.
Article Synopsis
Complementary Chinese Herbal Medicine Treatment is Associated with a Reduction of Surgical Rate in Patients with Dysfunctional Uterine Bleeding: A Propensity-Score Matched Cohort Study.
Int J Womens Health
August 2024
Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 404, Taiwan.
Article Synopsis
[TruClear™ treatment of caesarean scar pregnancy interrupted after methotrexate injection].
Rev Med Liege
July 2024
Service de Gynécologie-Obstétrique, CHU Liège, Belgique.
Background: Cesarean scar pregnancy is a complicated and potentially life-threatening type of ectopic pregnancy. There is no gold standard for its management. The aim is to demonstrate the efficacy and safety of treatment by hysteroscopic tissue removal system after systemic methotrexate injection.
View Article and Find Full Text PDFHigh prevalence of dysfunctional uterine bleeding in candidates for metabolic/bariatric surgery: increased endometrial cancer risk?
Surg Obes Relat Dis
November 2024
Metamor Institute, Pennington Biomedical Research Center at Louisiana State University, Baton Rouge, Louisiana; Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, New Orleans, Louisiana; Our Lady of the Lake Regional Medical Center, Franciscan Missionaries of Our Lady Healthcare System, Baton Rouge, Louisiana. Electronic address:
Article Synopsis
- Endometrial cancer (EC) is closely linked to obesity, particularly affecting young women, and identifying it early can improve treatment options, especially for those with severe obesity undergoing metabolic/bariatric surgery.
- A screening program using a modified questionnaire, called Modified SAMANTA, was implemented to identify women with abnormal or postmenopausal uterine bleeding (APUB) before their surgery to check for possible underlying endometrial issues.
- Over a study period from March 2021 to May 2023, nearly half of the 1371 women screened were found to have APUB, with higher prevalence linked to factors like increased BMI and certain racial demographics, highlighting the need for careful monitoring in these patients.*
Use of morcellation in laparoscopic myomectomy. Medical malpractice and medicolegal considerations.
Clin Ter
August 2024
Legal Medicine Section, Biomorf Department, Messina University, Messina, Italy.
Article Synopsis
- The Sicilian Regional Health System has implemented direct management procedures for medical malpractice claims, emphasizing sentinel event monitoring to enhance patient safety and reduce insurance costs.
- A 28-year-old woman underwent laparoscopic surgery for uterine fibroids, but later discovered she had leiomyosarcoma after complications, ultimately leading to her death six months post-diagnosis.
- The case raises concerns about informed consent, the use of the risky morcellation technique, and potential misdiagnosis, suggesting possible medical malpractice by the healthcare providers involved.
Vaginal assisted NOTES hysterectomy in The Netherlands; A prospective cohort study.
Eur J Obstet Gynecol Reprod Biol X
September 2024
Department of Obstetrics & Gynecology, Zuyderland Medical Centre Heerlen, Henri Dunantstraat 5, 6419 PC Heerlen, Limburg, the Netherlands.
Article Synopsis
- This study evaluates the first vaginal assisted Natural Orifice Transluminal Endoscopic Surgery (NOTES) hysterectomies (VANH) in the Netherlands, showcasing its advantages over traditional surgical methods.
- Conducted from August 2019 to April 2023, the study involved 200 patients with benign conditions and recorded key surgical metrics, including average procedure time, blood loss, and complication rates.
- The results indicate that VANH is a safe and feasible option for hysterectomies, but highlights the need for skilled surgeons and thorough patient selection, along with the call for further randomized clinical trials to validate findings.
Article Synopsis
- Jinkui Wenjing Tang (JKWJT) is a Traditional Chinese Medicine used for gynecological issues, particularly for anovulatory dysfunctional uterine bleeding (ADUB), and its mechanisms and active ingredients need further investigation.
- The study utilized various databases and techniques, including TCMSP, GeneCards, and molecular docking, to identify JKWJT's chemical composition and its potential targets in relation to ADUB.
- Findings revealed key targets (like ESR1 and OXTR) and pathways (such as estrogen signaling and HIF-1 signaling) involved in JKWJT's action, with significant reductions in OXTR expression observed in ADUB patients after treatment.
Menstrual Cycle Characteristics in Women With and Without Thyroid Disease.
Cureus
June 2024
Endocrinology and Metabolism, Celal Bayar University, Manisa, TUR.
Article Synopsis
- * A total of 485 women with diagnosed thyroid dysfunction and 108 healthy controls were studied, focusing on various menstrual issues like hypermenorrhea and amenorrhea.
- * Results showed that hypermenorrhea was notably more common in those with overt hypothyroidism compared to controls, while hyperthyroid patients didn't show significant differences in menstrual disorders compared to healthy individuals.
Joint deficiency of coagulation factors VII and IX: a case report.
Blood Coagul Fibrinolysis
September 2024
Fundación Cardiovascular de Colombia, Piedecuesta, Santander, Colombia.
Article Synopsis
- A 23-year-old female with a history of bleeding issues presents with hematuria and metrorrhagia, and is found to have low hemoglobin (5.2 g/dl) and abnormal coagulation tests.
- Diagnosis includes uterine myoma, and she starts treatment with progesterone, antibiotics, and blood components while being monitored for factor levels.
- Despite initial improvement with recombinant factor VII, she faces complications requiring surgical intervention, with no similar cases found in literature to guide her treatment.
The Role of Endometrial Sampling before Hysterectomy in Premenopausal Women with Abnormal Uterine Bleeding.
J Clin Med
June 2024
Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul 34098, Türkiye.
Article Synopsis
- An endometrial sampling is recommended for women over 40 or 45 with abnormal bleeding to assess the risk of endometrial cancer while avoiding unnecessary biopsies in premenopausal women.* -
- A study analyzed 339 premenopausal women who had endometrial sampling before hysterectomy due to abnormal bleeding, revealing that most biopsies showed benign results, with low concordance between biopsy and hysterectomy findings.* -
- The results indicated that factors like body mass index and smoking status significantly affected the outcomes, with a low Kappa value showing poor agreement between biopsy and final pathologies.*
Effect of norethisterone dose and duration in the management of abnormal uterine bleeding: a narrative review and case report.
Drugs Context
July 2024
Mankind Pharma Ltd, New Delhi, India.
Article Synopsis
- * Treatment options for AUB vary from lifestyle changes and hormonal therapies to more invasive interventions, with hormonal therapy being the preferred initial option despite potential side effects.
- * Norethisterone, a synthetic progestogen, shows promise for managing AUB using controlled-release formulations, and a case study demonstrates positive outcomes and high patient satisfaction with its use.