8 results match your criteria: "Durham V.A. Medical Center[Affiliation]"
Scand J Urol
August 2019
f Department of Urology , University of Illinois at Chicago, Chicago , I.L., U.S.A.
Introduction: To evaluate whether the presence of prostate atrophy (P.A.) in negative prostate biopsy is associated with prostate cancer (P.
View Article and Find Full Text PDFJ Pers Assess
April 2006
Pacific Graduate School of Psychology, Durham V.A. Medical Center, 5639 Old Chapel Hill Road, Durham, NC 27707, USA.
In this study, we examined the capacity of MMPI-2 (Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 2001) validity indexes to identify malingered depression associated with a workplace injury. We compared 27 graduate students simulating depression with archival records of 33 inpatients diagnosed with major depressive disorder. We employed a mixed-group validation design to generate true positive rates (TPR) and false positive rates (FPR) for the various MMPI-2 validity scales [F, FB, F(p), FBS, F - K, Ds2] while we accounted for base rates of malingering in each sample.
View Article and Find Full Text PDFNeuropeptides
February 2003
Department of Cell Biology, Box 3709, Duke University Medical Center, Durham V.A. Medical Center, Durham, NC 27710, USA.
Neurokinin A (NKA) has previously been shown to be a full agonist of the neurokinin-1 receptor (NK-1R) but is only able to cause partial homologous desensitization of the receptor compared to substance P (SP). NKA and SP share the same amino acid sequence at their C-terminal active site domains but differ in structure at their N-terminal domains. These observations have led to the proposal that the N-terminal domains of tachykinin peptides affect the desensitization but not the agonist activities of the peptides.
View Article and Find Full Text PDFPeptides
September 2001
Department of Cell Biology, Box 3709, Duke University Medical Center and Durham V. A. Medical Center, Durham, North Carolina 27710, USA.
The mechanism by which Clostridium difficile toxin A causes substance P (SP) release and subsequent inflammation in the rat ileum is unknown. Pretreatment with the vanilloid receptor subtype 1 (VR1) antagonist, capsazepine, before toxin A administration significantly inhibited toxin A-induced SP release and intestinal inflammation. Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A.
View Article and Find Full Text PDFLab Anim Sci
February 1999
Durham V.A. Medical Center, North Carolina, USA.
One of the earliest pathologic changes of diabetes mellitus is increased nonenzymatic glycosylation (i.e., glycation) of proteins, which results in abnormal aggregation of collagen fibrils and production of superoxide radicals.
View Article and Find Full Text PDFJ Invest Dermatol
December 1993
Department of Medicine, Durham V.A. Medical Center, North Carolina.
Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized in part by the presence of circulating and tissue-bound IgG antibodies directed against the epidermal basement membrane zone. IgG from over 95% of patients with BP have been shown to immunoprecipitate a 230-kD epidermal protein, BPAg1, which has been cloned and sequenced. Although sera from almost all patients with BP react with the 230-kD BP antigen the specific epitope(s) of BPAg1 that IgG binds is not known.
View Article and Find Full Text PDFJ Comp Neurol
August 1990
Neurology Research Laboratory Durham V.A. Medical Center, North Carolina 27705.
We studied the immunocytochemical distribution of catecholaminergic fibers in the hippocampal formation from two cynomolgus monkeys by using phenylethanolamine-N-methyltransferase, dopamine-beta-hydroxylase, and tyrosine-hydroxylase antibodies. There were no phenylethanolamine-N-methyltransferase immunoreactive fibers suggesting the lack of epinephrine containing fibers. In order to compare the distributions of tyrosine-hydroxylase and dopamine-beta-hydroxylase immunoreactive fibers, we counted fibers in four hippocampal regions, the dentate gyrus, CA3, CA1, and the subiculum at three different rostrocaudal levels.
View Article and Find Full Text PDFNeurosci Lett
May 1990
Neurology Research Laboratory, Durham V.A. Medical Center, NC 27705.
We used a sensitive silver degeneration staining method to study the effects of insertion of microdialysis probes in rat dorsal hippocampus and neocortex. Nine animals were sacrificed 24 h, 3 days or 7 days after implantation of dialysis tubing. Although mild neuronal cell death and small petechial hemorrhages were seen in close proximity to the implantation site, the striking finding was the presence of degenerating axons both adjacent to the implantation site and in remote sites such as the corpus callosum and contralateral hippocampus.
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