Are restricted and repetitive behaviours in two- and six-year-olds associated with emotional and behavioural difficulties?

Background: Restricted and repetitive patterns of behaviour (RRBs) serve an adaptive role in development. Elevated levels of RRBs beyond the early years, however, are associated with poorer outcome in language, cognition, and wellbeing, and are seen across a range of neurodevelopmental conditions. This study aimed to characterize the association of distinct RRB subtypes at two and six years of age, with internalising and externalising difficulties in a community sample of children.

Detection rates and diel activity patterns of four understudied felids from Borneo.

Carnivore guilds are charismatic and have vital and irreplaceable roles in their native ecosystems, yet many of these species are threatened and remain understudied. Borneo is a biodiversity hotspot that hosts a rich diversity of endemic wildlife but is threatened by deforestation and habitat loss. Using cameras placed by the Smithsonian Institution in Sabah, Borneo, we assessed the detection rates and diel activity patterns of the native felid species.

What is disability history the history ?

This article has two connected aims. First, to contour the boundaries of modern disability history through outlining its development and second, to provide a new methodological agenda for disability history. The design model of disability has outlined an important new programme to integrate the social and medical models of disability by foregrounding materials.

Temporal activity and detection rates of chilla () in Tierra del Fuego, Argentina.

Designing mitigation strategies for invasive species requires a clear understanding of their ecology and behaviour. Chilla (or grey fox; ) were introduced to Isla Grande de Tierra del Fuego (Tierra del Fuego Island) in 1951 to control European rabbit () populations. Although this management strategy was unsuccessful, the chilla spread across the island and are now considered invasive.

Model-free portfolio theory: A rough path approach.

Based on a rough path foundation, we develop a model-free approach to stochastic portfolio theory (SPT). Our approach allows to handle significantly more general portfolios compared to previous model-free approaches based on Föllmer integration. Without the assumption of any underlying probabilistic model, we prove a pathwise formula for the relative wealth process, which reduces in the special case of functionally generated portfolios to a pathwise version of the so-called master formula of classical SPT.

Health-Damaging Climate Events Highlight the Need for Interdisciplinary, Engaged Research.

In 2023 human populations experienced multiple record-breaking climate events, with widespread impacts on human health and well-being. These events include extreme heat domes, drought, severe storms, flooding, and wildfires. Due to inherent lags in the climate system, we can expect such extremes to continue for multiple decades after reaching net zero carbon emissions.

Why cuckoos remove host eggs: Biting eggs facilitates faster parasitic egg-laying.

Brood parasitism by cuckoos relies on manipulating hosts to raise their offspring and has evolved stunning adaptations to aid in their deception. The fact that cuckoos usually but not always, remove one or two host eggs while laying their eggs has been a longstanding focus of intensive research. However, the benefit of this behavior remains elusive.

Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid.

The phenomenon of molecular crystal polymorphism is of central importance for all those industries that rely on crystallisation for the manufacturing of their products. Computational methods for the evaluation of thermodynamic properties of polymorphs have become incredibly accurate and prediction of crystal structures is becoming routine. The computational study and prediction of the kinetics of crystallisation impacting polymorphism, however, have received considerably less attention despite their crucial role in directing crystallisation outcomes.

First record of the introduced ladybird beetle, Linnaeus (1758), on South Georgia (sub-Antarctic).

Biological invasions represent a growing threat to islands and their biodiversity across the world. The isolated sub-Antarctic island of South Georgia in the South Atlantic Ocean is a highly protected area that relies on effective biosecurity including prevention, surveillance and eradication to limit the risk of biological invasions. Based on an opportunistic field discovery, we provide the first report of an introduced ladybird beetle on South Georgia.

Development of a mammalian neurosensory full-thickness skin equivalent and its application to screen sensitizing stimuli.

Human skin equivalents (HSEs) are an increasingly popular research tool due to limitations associated with animal testing for dermatological research. They recapitulate many aspects of skin structure and function, however, many only contain two basic cell types to model dermal and epidermal compartments, which limits their application. We describe advances in the field skin tissue modeling to produce a construct containing sensory-like neurons that is responsive to known noxious stimuli.

Investigation into the effect of skin tone modulators and exogenous stress on skin pigmentation utilizing a novel bioengineered skin equivalent.

Human skin equivalents (HSEs) are a popular technology due to limitations in animal testing, particularly as they recapitulate aspects of structure and function of human skin. Many HSEs contain two basic cell types to model dermal and epidermal compartments, however this limits their application, particularly when investigating the effect of exogenous stressors on skin health. We describe the development of a novel platform technology that accurately replicates skin pigmentation in vitro.

Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections.

The Saimaa ringed seal () is endemic to Lake Saimaa in Finland. The subspecies is thought to have originated when parts of the ringed seal population of the Baltic region were trapped in lakes emerging due to postglacial bedrock rebound around 9000 years ago. During the 20th century, the population experienced a drastic human-induced bottleneck.

Bubble rise in molten glasses and silicate melts during heating and cooling cycles.

The Hadamard-Rybczynski equation describes the steady-state buoyant rise velocity of an unconfined spherical bubble in a viscous liquid. This solution has been experimentally validated for the case where the liquid viscosity is held constant. Here, we extend this result for non-isothermal conditions, by developing a solution for bubble position in which we account for the time-dependent liquid viscosity, liquid and gas densities, and bubble radius.

The influence of ambient cure chemistry and stoichiometry on epoxy coating surfaces.

The surface properties of epoxy resin coatings influence their function as substrates for subsequent coats. Variation in ambient cure conditions (temperature and relative humidity, RH), stoichiometry (ratio of epoxy: amine) and delay time between epoxy component mixing and film casting ("induction time") significantly altered the surface properties of ambient cured epoxy resin coatings (Dow Epoxy Novolac D.E.

The Permeability of Porous Volcanic Rock Through the Brittle-Ductile Transition.

The permeability of volcanic rock controls the distribution of pore fluids and pore fluid pressure within a volcanic edifice, and is therefore considered to influence eruptive style and volcano deformation. We measured the porosity and permeability of a porous volcanic rock during deformation in the brittle and ductile regimes. In the brittle regime, permeability decreases by a factor of 2-6 up to the peak stress due the closure of narrow pore throats but, following shear fracture formation, remains approximately constant as strain is accommodated by sliding on the fracture.

Disruptions, adjustments and hopes: The impact of the COVID-19 pandemic on child well-being in five Majority World Countries.

Drawing on integrated data from focus groups and diary entries, we explored the impact of the COVID-19 pandemic on child well-being for children from five Majority World Countries. We focus on the disruptions the pandemic caused, the adjustments made in response to these, and children's vision of a post-pandemic world. Underlying children's experiences of loss, boredom and concerns about educational progress, was an awareness of systemic inequalities that disadvantaged them or others in their community.

Inference for epidemic models with time-varying infection rates: Tracking the dynamics of oak processionary moth in the UK.

Invasive pests pose a great threat to forest, woodland, and urban tree ecosystems. The oak processionary moth (OPM) is a destructive pest of oak trees, first reported in the UK in 2006. Despite great efforts to contain the outbreak within the original infested area of South-East England, OPM continues to spread.

Plant growth promotion by the interaction of a novel synthetic small molecule with GA-DELLA function.

Synthesized small molecules are useful as tools to investigate hormonal signaling involved in plant growth and development. They are also important as agrochemicals to promote beneficial properties of crops in the field. We describe here the synthesis and mode of action of a novel growth-promoting chemical, A1.

Paramagnetic solid-state NMR assignment and novel chemical conversion of the aldehyde group to dihydrogen ester and hemiacetal moieties in copper(ii)- and cobalt(ii)-pyridinecarboxaldehyde complexes.

The complex chemical functionalization of aldehyde moieties in Cu(ii)- and Co(ii)-pyridinecarboxaldehyde complexes was studied. X-ray studies demonstrated that the aldehyde group (RHO) of the four pyridine molecules is converted to dihydrogen ester (R(OCH)(OH)) and hemiacetal (RH(OH)(OCH)) moieties in both 4-pyridinecarboxaldehyde copper and cobalt complexes. In contrast, the aldehyde group is retained when the 3-pyridinecarboxaldehyde ligand is complexed with cobalt.

Abundance and accessibility of forage for reindeer in forests of Northern Sweden: Impacts of landscape and winter climate regime.

The survival of reindeer during winter, their period of greatest food stress, depends largely on the abundance and accessibility of forage in their pastures. In Northern Sweden, realized availability of forage is notably affected by snow conditions and the impacts of forestry. While these factors have been examined in isolation, their combined effect has, to the best of our knowledge to date, not been researched.

A content analysis of the aims, strategies, and effects of food and nonalcoholic drink advertising based on advertising industry case studies.

Background: Placing limitations on advertising of food and nonalcoholic drinks to children is an effective strategy in addressing childhood obesity. The industry maintains that further restrictions are unnecessary.

Aims: To ascertain whether the advertising campaigns were successful according to the industry evaluations and more specifically the effects of marketing on children.