Robust near-infrared modeling for pharmaceutical powder streams: External variable augmented iterative optimization technology (EVA-IOT).

The adoption of pure component models, such as iterative optimization technology (IOT) algorithms, is gaining significant interest in the pharmaceutical industry, primarily because of their calibration-free/minimal calibration requirements for process analytical technology applications. The IOT methods have recently demonstrated great potential for monitoring the quality of continuous powder mixtures by Near-infrared (NIR) spectroscopy. However, the dynamic conditions of continuous manufacturing processes may limit the effectiveness of such approaches.

Enhancing Sensory Experiences for Infants Born Preterm: A Quality Improvement Project.

Objective: To enhance neonatal sensory experiences in infants born preterm: a quality improvement project.

Design: This was a time-interruption quality improvement project. The time-interruption lasted 4 weeks with an 8-week data collection period before and after.

Volumetric bioprinting of the osteoid niche.

Volumetric bioprinting has revolutionized the field of biofabrication by enabling the creation of cubic centimeter-scale living constructs at faster printing times (in the order of seconds). However, a key challenge remains: developing a wider variety of available osteogenic bioinks that allow osteogenic maturation of the encapsulated cells within the construct. Herein, the bioink exploiting a step-growth mechanism (norbornene-norbornene functionalized gelatin in combination with thiolated gelatin-GelNBNBSH) outperformed the bioink exploiting a chain-growth mechanism (gelatin methacryloyl-GelMA), as the necessary photo-initiator concentration was three times lower combined with a more than 50% reduction in required light exposure dose resulting in an improved positive and negative resolution.

Effect of Older Age on Postoperative Urinary Retention After Prolapse Surgery.

Importance: Postoperative urinary retention (POUR) is common after reconstructive pelvic surgery. Little is known about the relationship between older age (≥70 years) and POUR after pelvic organ prolapse surgery.

Objectives: We aimed to investigate the relationship between age ≥70 years and POUR.

Effect of Sex and Age on Knee Strength in Young Athletes: A Systematic Review and Meta-analysis.

The purpose was to summarize the studies examining knee strength in young athletes and provide valuable insights into the magnitude of changes in knee flexion and extension strength during the transition from pre-puberty to puberty among male and female athletes. The literature search was conducted through Cochrane Library, Embase, PubMed, Web of Science. Cohen's effect size (ES) and 95% confidence intervals (CIs) were computed using a random effects model.

Integrating Sensor Technologies with Conversational AI: Enhancing Context-Sensitive Interaction Through Real-Time Data Fusion.

This article examines how sensor technologies (such as environmental sensors, biometric sensors, and IoT devices) intersect with conversational AI models like ChatGPT 4.0. In particular, this article explores how data from different sensors in real time can improve AI models' comprehension of surroundings, user contexts, and physical conditions.

Ultrasensitive Characterization of Native Bacterial Biofilms via Dynamic Nuclear Polarization-Enhanced Solid-State NMR.

Bacterial biofilms are major contributors to persistent infections and antimicrobial resistance, posing significant challenges to treatment. However, obtaining high-resolution structural information on native bacterial biofilms has remained elusive due to the methodological limitations associated with analyzing complex biological samples. Solid-state NMR (ssNMR) has shown promise in this regard, but its conventional application is hindered by sensitivity constraints for unlabeled samples.

Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation.

Skin inflammation represents a hallmark of many skin conditions, from psoriasis to eczema. Here, we present a novel microemulsion formulation for delivering a low dose of potent immunosuppressant, tacrolimus, to the skin for local inflammation control. The efficacy of topically delivered tacrolimus in controlling skin inflammation can be enhanced by packaging it into microemulsions.

Evaluation of Potential Developmental Precursors to Executive Function in Young Children with Motor Delays: Exploratory Study.

This study aimed to explore whether early developmental abilities are related to future executive function (EF) in children with motor delays. Fourteen children with motor delays ( = 10.76, = 2.

Prolonged or perpetual growth of replacement teeth in the rock hyrax.

Tusks are ever-growing teeth present in mammals of the clade Paenungulata. Unlike the perpetually growing incisors of rodents, tusks are not used in mastication, and in at least some paenungulatans, the tusk is composed of dentin alone in adults. Few studies have provided tissue-level information on tusks of adult paenungulatans with embedding techniques that identify epithelial and other soft tissues.

- a large-scale dataset of 3D medical shapes for computer vision.

Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

Development of a capstone exam as pre-advanced pharmacy practice experiences domains assessment.

Introduction: Accreditation Council for Pharmacy Education's (ACPE) standards require pharmacy schools to assess Advanced Pharmacy Practice Experience (APPE) readiness. This paper describes the development and implementation of a Capstone Exam for assessing APPE-readiness and exploration of potential correlations between student performance on the Exam and performance measures within the didactic curriculum.

Methods: Faculty developed a Capstone examination aligned to the Pre-APPE Domains in Appendix A of the ACPE standards consisting of five stations assessing skills, which include: interviewing, counseling, prescription checking, professional communication, and inpatient order verification.

A Modified Delphi Process to Achieve Consensus on Social/Administrative Science Topics in Pharmacy Curricula.

Objective: This study aimed to identify a consensus among pharmacy educators regarding relevant social and administrative science (SAS) topic areas and their priorities within pharmacy curricula.

Methods: A modified Delphi process was conducted with members of selected American Association of Colleges of Pharmacy affinity groups as the expert panel. A total of 83 potential topic areas across 12 domains were gathered via an informal literature review.

Parents' perspectives and behaviors regarding their child's access to alcohol: Variation by race/ethnicity, socioeconomic status, and neighborhood.

Background: Setting rules about alcohol use and minimizing its availability in the home are known effective parent-level strategies for reducing underage drinking risk. However, parents' restrictions and their perceptions of their child's alcohol access have rarely been considered in combination (e.g.

Real life data of ONC201 (dordaviprone) in pediatric and adult H3K27-altered recurrent diffuse midline glioma: Results of an international academia-driven compassionate use program.

Introduction: H3K27-altered diffuse midline gliomas (DMG) have limited therapeutic options and a very poor prognosis. Encouraging responses were observed in early clinical trials with ONC201. As ONC201 was unavailable in Europe, a compassionate use program supported by the French Authorities was launched for patients at progression after standard of care radiotherapy.

Understanding resource use and dietary niche partitioning in a high-altitude predator guild using seasonal sampling and DNA metabarcoding.

Understanding of predator feeding ecology, interactions among co-occurring predator species, and seasonal changes is critical for conservation management given the important role that predators play in shaping their ecosystems, but is lacking for most regions of the world. Dietary studies have demonstrated varying conclusions in the role that resource partitioning plays in the maintenance of predator communities due to complex inter-related factors that may shape prey use. We used DNA metabarcoding on 581 scat samples to determine the dietary composition, similarity, diversity, and niche overlap of eight predator species (Tibetan wolf (Canis lupus), snow leopard (Panthera uncia), Tibetan brown bear (Ursus arctos pruinosus), Eurasian lynx (Lynx lynx), Tibetan fox (Vulpes ferrilata), red fox (V.

University students' knowledge, perceptions, and sources of information on routinely recommended vaccines.

To evaluate university students' perceptions of the importance of routine vaccines, knowledge of vaccines, most trusted sources of vaccine information, and interest in learning more about vaccines. 2,223 students attending four universities across Pennsylvania. A 32-question electronic survey was administered to university students between March and May 2023.

Expanded range of Nasutitermes callimorphus Mathews, 1977 (Isoptera: Termitidae: Nasutitermitinae), comparison with N. corniger (Motschulsky, 1855) and N. ephratae (Holmgren, 1910), and synonymy of N. dasyopsis Thorne, 1989 into N. nigriceps (Haldeman, 1854).

The imago of N. callimorphus is described for the first time. Nasutitermes callimorphus occurs from Mexico to Paraguay.

Creation of Gas-Phase Organo-Uranium Species by Removal of "yl" Oxo Ligands From UO Carboxylate Precursor Ions.

Rationale: These experiments were conducted to measure the diversity of organo-U (IV) and U (III) ions created using multiple-stage tandem MS and collision-induced dissociation of halogen-substituted UO-phenide complexes [UO(CHFX)], X = Cl, Br, or I.

Methods: Samples of UO(OC-CHFX) were prepared by digesting UO with appropriate halogen-substituted carboxylic acids in deionized water. Solutions for ESI were created by diluting the digested sample in 50:50 HO/CHOH.