14 results match your criteria: "Dupuytren Limoges University Hospital[Affiliation]"
PIPAC Pharmacologic and Clinical Data.
J Surg Oncol
September 2024
Department of General Surgery C and Surgical Oncology, Sheba Medical Center, Ramat Gan, Israel, Tel-Aviv University, Tel-Aviv, Israel.
Article Synopsis
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new method for delivering chemotherapy directly into the abdominal cavity to enhance treatment effectiveness for peritoneal cancers.
- It has shown promising results for patients with various types of peritoneal malignancies, offering a better alternative than just palliative care.
- Ongoing clinical trials are expected to provide further insights into the real advantages of PIPAC in cancer treatment.
Comparison of arterial wall integration of different flow diverters in rabbits: The CICAFLOW study.
J Neuroradiol
May 2024
University Hospital of Limoges, Neuroradiology Department, 2 avenue Martin Luther-King, Dupuytren, Limoges 87042, France; University of Limoges, XLIM UMR CNRS, Limoges 7252, France.
Article Synopsis
- The study compares the endothelial coverage of new coated and uncoated flow diverters (FDs) in rabbits, focusing on the effects of different antiplatelet therapies.
- Three types of FDs were implanted in rabbits, and their integration into the arterial wall was assessed after four weeks using various imaging and histopathological techniques.
- Results show that the integration of coated and uncoated FDs is similar, while the antiplatelet regimen influenced the rates of coverage, with no therapy showing the highest rate of neointimal formation.
Developing a core set of patient-reported outcomes and patient-reported experience measures for peritoneal surface malignancies (COMETE).
Br J Surg
August 2023
Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
First Case of Abdominal and Tunica Vaginalis Multicystic Benign Mesothelioma: Management and Review of Literature.
Indian J Surg Oncol
June 2023
Digestive Surgery Department, Dupuytren Limoges University Hospital, Limoges, France.
Multicystic benign mesothelioma is a rare tumor that affects the serosa. Most cases present with peritoneal lesions exclusively. Some identified risk factors are chronic abdominal inflammation, woman of childbearing age, and asbestos exposure.
View Article and Find Full Text PDFA prediction model to refine the timing of an early second-look laparoscopic exploration in patients with colon cancer at high risk of early peritoneal metastasis recurrence.
J Surg Oncol
September 2023
Department of Digestive, Hepatobiliary and Liver Transplantation Surgery, Hôpital de la Pitié Salpêtrière, Assistance Publique-Hôpitaux de Paris and Sorbonne Université, Paris, France.
Background: In patients at high risk of peritoneal metastasis (PM) recurrence following surgical treatment of colon cancer (CC), second-look laparoscopic exploration (SLLE) is mandatory; however, the best timing is unknown. We created a tool to refine the timing of early SLLE in patients at high risk of PM recurrence.
Methods: This international cohort study included patients who underwent CC surgery between 2009 and 2020.
ASO Author Reflections: Preoperative Biliary Drainage Before Pancreatic Surgery.
Ann Surg Oncol
August 2023
Digestive Surgery Department, Dupuytren Limoges University Hospital, Limoges, France.
Pancreatoduodenectomy Following Preoperative Biliary Drainage Using Endoscopic Ultrasound-Guided Choledochoduodenostomy Versus a Transpapillary Stent: A Multicenter Comparative Cohort Study of the ACHBT-FRENCH-SFED Intergroup.
Ann Surg Oncol
August 2023
Digestive Surgery Department, Dupuytren Limoges University Hospital, Limoges, France.
Background: It is unclear whether preoperative biliary drainage (PBD) by endoscopic retrograde cholangiopancreatography (ERCP) is equivalent to electrocautery-enhanced lumen-apposing metal stent (ECE-LAMS) before pancreatoduodenectomy (PD).
Methods: Patients who underwent PBD for distal malignant biliary obstruction (DMBO) followed by PD were retrospectively included in nine expert centers between 2015 and 2022. ERCP or endoscopic ultrasound-guided choledochoduodenostomy with ECE-LAMS were performed.
Effect of 5-Fluoro-Uracile + Oxaliplatin chemotherapy on the histological response of PEritoneal and hePatIc corectal metasTases in a mOuse model: PEPITO experimental study.
Eur J Surg Oncol
March 2023
Digestive Surgery Department, Dupuytren Limoges University Hospital, France; University Limoges, CNRS, XLIM, UMR 7252, F-87000, Limoges, France. Electronic address:
Background: The histological responses (HRs) after systemic chemotherapy should be used to determine the optimal management of patients with peritoneal and liver metastasis from colorectal cancer (cPM, cLM), in curative intent. We aimed to compare HRs of cPM and cLM in metastatic mice model after chemotherapy.
Methods: Colon carcinoma CT26-luc cells were transplanted into syngeneic BALB/c mice by intraperitoneal (leading to cPM), intrasplenic (leading to cLM), or intraperitoneal + intrasplenic (leading to cPM cLM) injections and follow up using bioluminescence during 21 days.
Selection Criteria for Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Treatment in Patients with Peritoneal Metastases.
Cancers (Basel)
May 2022
Department of Visceral Surgery, Faculty of Biology and Medicine UNIL, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland.
Article Synopsis
- The study investigates predictors that influence the completion of PIPAC treatment, which consists of three procedures, and its correlation with improved survival rates.
- It analyzes data from 183 patients undergoing PIPAC across three expert centers, revealing that 52% completed the full treatment protocol, with disease progression and bowel obstruction as main reasons for discontinuation.
- Key findings indicate that patients with less ascites and no history of bowel obstruction are more likely to complete treatment, and combining PIPAC with systemic chemotherapy enhances survival rates significantly.
ASO Author Reflections: Is There Still a Role for Intraperitoneal Oxaliplatin for Colorectal Peritoneal Metastases?
Ann Surg Oncol
August 2022
Department of Surgical Oncology, Cancer Institute of Montpellier, University of Montpellier, Montpellier, France.
Feasibility and Safety of Oxaliplatin-Based Pressurized Intraperitoneal Aerosol Chemotherapy With or Without Intraoperative Intravenous 5-Fluorouracil and Leucovorin for Colorectal Peritoneal Metastases: A Multicenter Comparative Cohort Study.
Ann Surg Oncol
August 2022
Department of General Surgery and Surgical Oncology, Lyon Sud University Hospital, Pierre Benite, France.
Background: This retrospective multicenter cohort study compared the feasibility and safety of oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (PIPAC-Ox) with or without intraoperative intravenous 5-fluorouracil (5-FU) and leucovorin (L).
Methods: Our study included consecutive patients with histologically proven unresectable and isolated colorectal peritoneal metastases (cPM) treated with PIPAC-Ox in seven tertiary referral centers between January 2015 and April 2020. Toxicity events and oncological outcomes (histological response, progression-free survival, and overall survival) were compared between patients who received intraoperative intravenous 5-FU/L (PIPAC-Ox + 5-FU/L group) and patients who did not (PIPAC-Ox group).
Assessment of workplace environmental contamination and occupational exposure to cisplatin and doxorubicin aerosols during electrostatic pressurized intraperitoneal aerosol chemotherapy.
Eur J Surg Oncol
November 2021
Pharmacy Department, Dupuytren Limoges University Hospital, France.
Background: Electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (ePIPAC) is a novel approach for intraperitoneal drug delivery. As ePIPAC using cisplatin and doxorubicin is performed in an operating room, the challenge is to safely deliver the chemotherapeutic aerosol intraperitoneally while preventing exposure to healthcare workers. The objective of this study was to describe cisplatin and doxorubicin workplace environmental contamination and healthcare worker exposure during ePIPAC.
View Article and Find Full Text PDFPressurized Intraperitoneal Aerosol Chemotherapy Enhanced by Electrostatic Precipitation (ePIPAC) for Patients with Peritoneal Metastases.
Ann Surg Oncol
July 2021
Surgical Oncology Department, Montpellier Cancer Institute (ICM), University of Montpellier, Montpellier, France.
Background: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new mode of intraperitoneal chemotherapy administration that can potentially be improved by the addition of electrostatic precipitation (ePIPAC). This study aimed to describe the procedural details of ePIPAC and to analyze its safety for patients with nonresectable peritoneal metastasis as well as their tolerance and response to this treatment.
Methods: This retrospective cohort study included consecutive patients treated with ePIPAC in three centers from April 2019 to April 2020.
ASO Author Reflections: Developing Next-Generation Intraperitoneal Chemotherapy.
Ann Surg Oncol
July 2021
Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.