956 results match your criteria: "Dunarea de Jos University[Affiliation]"

Head trauma (HT) in pediatric patients is the number one cause of mortality and morbidity in children. Although computer tomography (CT) imaging provides ample information in assessing acute traumatic brain injuries (TBIs), there are instances when magnetic resonance imaging (MRI) is needed. Due to its high sensitivity in diagnosing small bleeds, MRI offers a well-documented evaluation of primary acute TBIs.

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Nature relatedness, flow experience, and environmental behaviors in nature-based leisure activities.

Front Psychol

June 2024

Department of Individual Sports and Physical Therapy, Faculty of Physical Education and Sport, Dunarea de Jos University of Galati, Galati, Romania.

Introduction: Through nature-based leisure activities, spending time in nature offers opportunities to reduce stress, relax the mind, and enhance feelings of well-being. Being aware of the benefits provided by these activities increases the nature relatedness, and during the time spent in nature, it enables experiencing positive and satisfying moments by entering into a state of flow. The concepts of nature-relatedness and flow experience represent psychological experiences and characteristics that play an important role in enhancing psychological well-being and life quality.

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Background: Premature birth remains a public health problem worldwide, involving a broader context and a multidisciplinary team aimed at combating this phenomenon as much as possible. The consumption of addictive substances by women who are pregnant can occur in different social contexts and at different stages of their lives, which modulate its extent. Obstetricians and anesthetists should consider the anesthetic maternal risks that may arise due to these addictive behaviors.

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Article Synopsis
  • Alzheimer's disease and diabetes impact global health, with specific enzymes targeted for treatment: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) for AD, and α-amylase, α-glucosidase for diabetes.
  • A study isolated various compounds from a medicinal plant, identifying several derivatives of ellagic acid that showed moderate to strong inhibition of AChE and BChE, with 3,3'-di-O-methyl ellagic acid being the most potent.
  • In addition, some compounds effectively inhibited α-amylase and α-glucosidase, outperforming acarbose, indicating their potential as therapeutic agents for diabetes management.
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  • * Researchers used a response surface methodology with various extraction parameters (temperature, time, and solvent ratio) to determine the best conditions for extracting total carotenoids and assessing antioxidant activity.
  • * Optimal extraction settings were found to be a temperature of 80 °C, a solvent volume of 10 mL, and an extraction time of 100 minutes, yielding significant concentrations of carotenoids and antioxidant activity.
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Head trauma in paediatric patients is a worldwide and constant issue. It is the number one cause for childhood mortality and morbidity. Children of all ages are susceptible to sustaining head trauma and the anatomical characteristics of the region put them in a high-risk category for developing severe traumatic brain injuries.

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Atopic dermatitis (AD) is a frequent inflammatory condition that usually begins during early childhood, but it increasingly starts to debut, even in the elderly. Based on immunoglobulin E (IgE) levels and clinical features, two subsets of this disease have been recognized: intrinsic and extrinsic. When speaking about AD, most specialists think about filaggrin (FLG) mutations resulting in epidermal barrier defects, which is the case in most atopic patients, but some have a normal barrier, as seen by imaging, and still have specific clinical lesions along with metal allergies.

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Turmeric () has been extensively studied for its diverse pharmacological properties, including its potential role as an anticancer agent, antioxidant, and radioprotector. This review provides an overview of the chemical composition of turmeric, focusing on its main bioactive compounds, such as curcuminoids and volatile oils. Curcumin, the most abundant curcuminoid in turmeric, has been widely investigated for its various biological activities, including anti-inflammatory, antioxidant, and anticancer effects.

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Introduction:  Motion analysis, the study of movement patterns to evaluate performance, plays a crucial role in surgical training. It provides objective data that can be used to assess and improve trainee's precision, efficiency, and overall surgical technique. The primary aim of this study is to employ accelerometer-based sensors placed on the wrist to analyze hand motions during endoscopic sinus surgery training using the sheep's head.

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: Intra-abdominal cystic formations represent heterogeneous pathologies with varied localization and clinical manifestation. The first challenge of a giant intra-abdominal cystic lesion is identifying the organ of origin. The clinical presentation of intra-abdominal cystic lesions varies from acute manifestations to non-specific symptoms or accidental discovery.

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  • * Both groups showed similar demographics, primarily affecting men around 51 years old, with common symptoms like cough and weight loss; however, TB+COV+ patients experienced additional symptoms like fever and myalgia.
  • * While TB+COV+ patients had more severe lung lesions on radiological exams, the overall impact of COVID-19 on tuberculosis severity was mild, with low mortality rates and no major differences in biological parameters between the two groups.
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A promising strategy for combating bacterial infections involves the development of agents that disarm the virulence factors of pathogenic bacteria, thereby reducing their pathogenicity without inducing direct lethality. Sortase A, a crucial enzyme responsible for anchoring virulence factors to the cell surface of several pathogenic bacteria, has emerged as a possible target for antivirulence strategies. A series of hippocastanum species (, , , and ) were used to prepare ethanol- and water-based extracts for assessing their effect on sortase A.

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In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology.

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Primary Hyperhidrosis in Children-A Retrospective Study and a Short Review.

Life (Basel)

May 2024

Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica-CIM-CID), Dunărea de Jos University, 800201 Galati, Romania.

Primary hyperhidrosis (PH) is a relatively common chronic disorder, characterized by significant and uncontrollable sweating. The predominant areas of occurrence are hands, feet, head and armpits, and it affects both men and women equally, with a false impression of increased prevalence in women. This study aims to determine the incidence of cases of hyperhidrosis, the gender of the patients and the environment of origin and to identify the most affected age groups and the distribution of hyperhidrosis, as well as creating a curve of cases within the time interval studied and their comparison with those in the specialized literature.

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: The newly emergent COVID-19 pandemic involved primarily the respiratory system and had also major cardiovascular system (CVS) implications, revealed by acute myocardial infarction (AMI), arrhythmias, myocardial injury, and thromboembolism. CVS involvement is done through main mechanisms-direct and indirect heart muscle injury, with high mortality rates, worse short-term outcomes, and severe complications. AMI is the echo of myocardial injury (revealed by increases in CK, CK-MB, and troponin serum markers-which are taken into consideration as possible COVID-19 risk stratification markers).

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  • * Conducted in three Romanian hospitals over several years, the retrospective study identified 11 AFE patients, with the majority experiencing AFE either during labor or soon after childbirth.
  • * The study found that AFE is associated with significant maternal mortality (36.3%) and challenges in neonatal outcomes, highlighting the need for a multidisciplinary care approach and advanced life support techniques during management.
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New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone.

Int J Mol Sci

May 2024

Department of Analytical Chemistry, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.

The modified release of active substances such as chlorzoxazone from matrix tablets, based on KollidonSR and chitosan, depends both on the drug solubility in the dissolution medium and on the matrix composition. The aim of this study is to obtain some new oral matrix tablet formulations, based on KollidonSR and chitosan, in order to optimize the low-dose oral bioavailability of chlorzoxazone, a non-steroidal anti-inflammatory drug of class II Biopharmaceutical Classification System. Nine types of chlorzoxazone matrix tablets were obtained using the direct compression method by varying the components ratio as 1:1, 1:2, and 1:3 chlorzoxazone/excipients, 20-40 w/w % KollidonSR, 3-7 w/w % chitosan while the auxiliary substances: Aerosil 1 w/w %, magnesium stearate 0.

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Valorisation of food by-products, like spent brewer's yeast and fruit pomaces, represents an important strategy for contributing to sustainable food production. The aims of this study were to obtain Maillard conjugates based on spent yeast protein hydrolysate (SYH) with dextran (D) or maltodextrin (MD) by means of ultrasound treatment and to use them for developing encapsulation systems for the anthocyanins from aronia pomace. The ultrasound-assisted Maillard conjugation promoted the increase of antioxidant activity by about 50% compared to conventional heating and SYH, and was not dependent on the polysaccharide type.

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The Impact of Aerobic Dance Intervention on Postural Balance in Children: A Randomized Controlled Trial.

Children (Basel)

May 2024

Research Laboratory Education, Motricité, Sport et Santé (EM2S) LR19JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3029, Tunisia.

This study aimed to investigate the impact of an 8-week aerobic dance intervention on postural balance in children. Forty-one children, aged 9 to 11, were randomly assigned to either an aerobic dance group (ADG) or a control group (CG) from a primary school. Postural balance was assessed using center of pressure (CoP) excursions before and after the 8-week intervention period.

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This study investigated the efficacy of an Adapted Kata Training Program (AKTP) in enhancing balance for a 10-year-old child with Autism Spectrum Disorder (ASD), employing a mixed-model approach for data collection. Over 12 weeks, the AKTP demonstrated significant improvements in the child's balance abilities, with an 11% increase in static balance, 8% in proprioceptive, 12% in horizontal, and 14% in vertical balance performance. These improvements persisted in a follow-up assessment after four weeks.

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According to current predictions, one-fifth of all Americans will develop skin cancer during their lifetime. Cutaneous squamous cell carcinoma (cSCC) most commonly occurs in the head and neck region, which is the area of the body with the highest level of sun exposure. High-risk head and neck cSCC (HNcSCC) is a broad category with numerous high-risk factors that are associated with unfavorable results.

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Caffeine (CAF) has been shown to be an effective ergogenic aid in enhancing sports performance, including vertical jump (VJ), sprint, balance, agility, and freestyle swimming performance (FSP). However, whether acute CAF supplementation improves FSP in moderately trained female swimmers has not been well documented. Therefore, this study aimed to investigate the effects of CAF intake on vertical jump, balance, auditory reaction time (ART), and swimming performance in female swimmers.

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Hemp ( L.) has experienced a significant resurgence in popularity, and global interest in diversifying its use in various industries, including the food industry, is growing. Therefore, due to their exceptional nutritional value, hemp seeds have recently gained increasing interest as a valuable ingredient for obtaining high-quality foods and dietary supplements.

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(L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated stem bark (Berberidis cortex) by extraction with 50% ethanol.

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Ideas about Artificial intelligence appeared about half a century ago, but only now is it becoming an essential element of everyday life. The data provided are becoming a bigger pool and we need artificial intelligence that will help us with its superhuman powers. Its interaction with medicine is improving more and more, with medicine being a domain that continues to be perfected.

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