7 results match your criteria: "Dum Dum Motijheel College[Affiliation]"
Morroniside interaction with poly (ADP-ribose) polymerase accentuates metabolic mitigation of alloxan-induced genotoxicity and hyperglycaemia: a molecular docking based and experimental therapeutic insight.
J Biomol Struct Dyn
October 2024
Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, Nadia, India.
The present study tends to evaluate the possible potential of bio-active Morroniside (MOR), against alloxan (ALX)-induced genotoxicity and hyperglycaemia. prediction revealed the interaction of MOR with Poly (ADP-ribose) polymerase (PARP) protein which corroborated well with experimental L6 cell line and mice models. Data revealed the efficacy of MOR in the selective activation of PARP protein and modulating other stress proteins NF-κB, and TNF-α to initiate protective potential against ALX-induced genotoxicity and hyperglycaemia.
View Article and Find Full Text PDFComparison the effects of 5-Aza-2'-deoxycytidine and zebularine on the in vitro development, blastocyst quality, methylation pattern and conception rate on handmade cloned buffalo embryos.
Reprod Domest Anim
January 2023
Embryo Biotechnology Laboratory, Animal Biotechnology Centre, National Dairy Research Institute, Karnal, India.
In this study we treated the handmade cloned (HMC) buffalo embryos with the DNA methylation inhibitors; 5-aza-2'-deoxycytidine (AzadC) or Zebularine individually after post-fusion and during in vitro culture till eighth day. The blastocysts production rate significantly improved (p < .01) after treating embryos independently with 5 nM AzadC and 5 nM zebularine compared with 2 and 10 nM AzadC or zebularine groups, respectively.
View Article and Find Full Text PDFDevelopment of homologous hemizona assay as a potential predictor of fertility in buffalo bulls: A preliminary approach.
Reprod Domest Anim
November 2022
Embryo Biotechnology Laboratory, Animal Biotechnology Centre, National Dairy Research Institute, Karnal, India.
Although, myriads of tests are routinely used, no single test can accurately predict fertilization potential of semen. The hemizona assay (HZA) has advantages in two ways: (a) it determines multitude traits of sperm and (b) it is a controlled sperm function test. In the present study, we developed homologous HZA in buffaloes to predict bull fertility.
View Article and Find Full Text PDFPhyto-chlorophyllin Prevents Food Additive Induced Genotoxicity and Mitochondrial Dysfunction via Cytochrome c Mediated Pathway in Mice Model.
Comb Chem High Throughput Screen
December 2021
Dum Dum Motijheel College, 1, Motijheel Avenue, Kolkata 700074, India.
Objectives: The issue of food-additive-toxicity causing several health hazards needs to be therapeutically managed with an immediate effect. Alloxan, a food additive, is used for whitening and shining flour. It is capable of inducing genotoxicity, diabetes, and associated mitochondrial dysfunction.
View Article and Find Full Text PDFEfficacy of nanoencapsulated pelargonidin in ameliorating pesticide toxicity in fish and L6 cells: Modulation of oxidative stress and signalling cascade.
Sci Total Environ
June 2019
School of Life Science, Jawaharlal Nehru University, New Delhi 110067, India.
Article Synopsis
- The study investigates a solution for removing pesticide toxins from edible fish, particularly focusing on the effects of cypermethrin on the fish model Oreochromis mossambica and L6 muscle cells.
- Researchers tested biodegradable poly-lactide-co-glycolide nanoparticles loaded with a phytochemical (NPG) to assess its protective capabilities against the toxicity caused by the pesticide.
- Results indicated that NPG significantly improved cell viability, reduced DNA damage, and modulated oxidative stress in both fish muscle cells and L6 cells, highlighting its potential as an effective treatment for pesticide toxicity in fish.
Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction.
Environ Toxicol Pharmacol
September 2016
Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, India. Electronic address:
Article Synopsis
- Chlorophyllin (CHL) is a compound derived from chlorophyll used as a food dye with potential anti-cancer effects; researchers tested a version loaded in PLGA (NCHL) for better drug delivery to cancer cells.
- NCHL showed significant drug uptake and anti-cancer activity against A549 lung cancer cells, indicated by various cellular markers and changes in DNA structure.
- In animal studies, NCHL effectively crossed the blood-brain barrier and aided in recovery from tissue damage, suggesting promising applications for cancer therapy at lower doses.
Psorinum 6 × triggers apoptosis signals in human lung cancer cells.
J Integr Med
March 2016
Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani-741235, India.
Article Synopsis
- The study aimed to investigate the effects of homeopathic Psorinum 6× on cancer cell lines, particularly focusing on cell viability and apoptosis.
- Psorinum treatment showed significant anticancer effects specifically in A549 cells, leading to cell cycle arrest, increased reactive oxygen species (ROS), and DNA damage.
- The results suggest that Psorinum induces apoptosis in A549 cells through the regulation of key signal proteins like p53 and caspase-3, indicating a potential mechanism for its anticancer activity.