12,769 results match your criteria: "Duke-NUS Medical School; hu.jiancheng@nccs.com.sg.[Affiliation]"
Pilot implementation study of a web-based men's health screening app in primary care during COVID-19: a mixed-methods approach.
BMC Health Serv Res
October 2024
Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- The COVID-19 pandemic disrupted traditional healthcare and led to the development of eHealth solutions like ScreenMen, a web-based app for men's health screening in a primary care environment.
- A mixed-method study design was used to measure patient engagement and healthcare provider acceptance of ScreenMen, employing both quantitative (Google Analytics, questionnaires) and qualitative (interviews) data collection methods.
- Results showed a 55.3% participation rate from healthcare providers, with 75 app accesses recording a 20% completion rate; effective strategies included using QR codes for visibility and having champions to support the implementation.
Effectiveness of Horticultural Therapy in Older Adults without Dementia: A Systematic Review and Meta-Analysis.
J Am Med Dir Assoc
December 2024
Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; National University Health System, Singapore, Singapore. Electronic address:
Objectives: Horticultural therapy (HT) has garnered growing interest because of its psychological and physical benefits. Previous reviews have demonstrated its therapeutic effects in older adults with cognitive impairment or mental illnesses. However, its impact on older adults without dementia has not been synthesized.
View Article and Find Full Text PDFEvaluating progress and accountability for achieving COP26 Health Programme international ambitions for sustainable, low-carbon, resilient health-care systems.
Lancet Planet Health
October 2024
Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Article Synopsis
- The COP26 Health Programme, launched at the 2021 UN Climate Change Conference, aims to create low-carbon and resilient health systems, with 83 countries committed to the initiative as of May 2024.
- The analysis highlights significant issues in current monitoring practices, showing that many countries focus on process indicators that don't truly measure progress towards sustainable health-care systems.
- There is a critical need for better, adaptable indicators that can effectively track health-care outcomes and contribute to climate strategies, ensuring that the COP26 Health Programme achieves its goals without misleading claims.
Synergistic combination of perphenazine and temozolomide suppresses patient-derived glioblastoma tumorspheres.
Neuro Oncol
October 2024
Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Glioblastoma (GBM), a primary malignant brain tumor, has a poor prognosis, even with standard treatments such as radiotherapy and chemotherapy. In this study, we explored the anticancer effects of the synergistic combination of perphenazine (PER), a dopamine receptor D2/3 (DRD2/3) antagonist, and temozolomide (TMZ), a standard treatment for GBM, in patient-derived human GBM tumorspheres (TSs).
Methods: The biological effects of the combination of PER and TMZ in GBM TSs were assessed by measuring cell viability, ATP, stemness, invasiveness, and apoptosis.
Employment, work hours, and wages in adults with myelin oligodendrocyte glycoprotein antibody disease: An international cohort study.
Mult Scler
November 2024
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Article Synopsis
- - The study aimed to analyze how myelin oligodendrocyte glycoprotein-associated antibody disease (MOGAD) affects employment among adults internationally by measuring job loss, hours worked, and wages.
- - Researchers gathered data from 117 adults diagnosed with MOGAD across 13 countries, finding a decline in employment from 63.2% before diagnosis to 48.7% after, and a drop in average work hours from 31.6 to 19.5 hours per week.
- - Results showed that living in a high-income country was linked to better employment outcomes post-MOGAD, while factors like depressed mood and pain were associated with increased unemployment and reduced work hours.
Reply to: Correspondence on Editorial regarding "Genetically modified, redirected T cells target hepatitis B surface antigen-positive hepatocytes and hepatocellular carcinoma lesions in a clinical setting".
Clin Mol Hepatol
October 2024
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
A systematic scoping review on group non-written reflections in medical education.
BMC Med Educ
October 2024
Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, Level 11, Singapore, 119228, Singapore.
Article Synopsis
- Medical education focuses on developing Professional Identity Formation (PIF) in students, emphasizing reflective practice amid challenges like resource constraints.
- Group non-written reflections (GNWR) involve facilitator-led discussions to foster shared reflection, potentially improving PIF in medical training.
- A systematic scoping review identified 98 relevant studies, highlighting four key areas: the value of GNWR, its structure, models of reflective practice, and elements of communities that aid socialization.
Nirmatrelvir/ritonavir treatment and risk for post-acute sequelae of COVID-19 in older Singaporeans: author's response.
Clin Microbiol Infect
January 2025
National Centre for Infectious Diseases, Singapore, Singapore; Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Ministry of Health, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Beading plot: a novel graphics for ranking interventions in network evidence.
BMC Med Res Methodol
October 2024
Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan.
Background: Network meta-analysis is developed to compare all available treatments; therefore it enriches evidence for clinical decision-making, offering insights into treatment effectiveness and safety when faced with multiple options. However, the complexity and numerous treatment comparisons in network meta-analysis can challenge healthcare providers and patients. The purpose of this study aimed to introduce a graphic design to present complex rankings of multiple interventions comprehensively.
View Article and Find Full Text PDFBiomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera.
Commun Eng
October 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore, Singapore.
Retina-derived growth signals relayed from the choroid to the sclera cause remodeling of the extracellular scleral matrix, resulting in myopic ocular elongation. However, to the best of our knowledge, no studies have assessed changes in choroidal stromal biomechanical properties during myopia progression. Here we utilized 7 µm-resolution scanning acoustic microscopy (SAM) to assess biomechanical properties (bulk modulus (K) and mass density (rho)) of choroidal stroma from guinea pig eyes with form-deprivation (FD) induced myopia.
View Article and Find Full Text PDFThe burden of chronic kidney disease in Asia region: a review of the evidence, current challenges, and future directions.
Kidney Res Clin Pract
September 2024
Division of Nephrology, Department of Medicine, Queen Mary Hospital, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Article Synopsis
- Chronic kidney disease (CKD) is a serious health issue in Asia, affected by things like diabetes, high blood pressure, and obesity, but not enough research has been done on it.
- Many countries in Asia struggle with limited resources and don't have good records to track how many people have CKD or how well treatments are working.
- It's really important for healthcare workers and governments to work together to find CKD early and come up with better ways to treat it so that people live healthier lives and avoid serious problems like kidney failure.
Interleukin 11 therapy causes acute left ventricular dysfunction.
Cardiovasc Res
December 2024
MRC-Laboratory of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.
Article Synopsis
- Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
- The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
- Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
Enhancing palliative care for advanced cancer patients: evaluating implementation and impact of a virtual nurse-led symptom monitoring and telehealth initiative.
BMC Palliat Care
October 2024
Division of Supportive and Palliative Care, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore, S169610, Singapore.
Article Synopsis
- A novel nurse-led telehealth program was implemented for advanced cancer patients during the COVID-19 pandemic to monitor symptoms and provide palliative care support.
- The study evaluated various aspects of the program including reach, effectiveness, adoption, implementation, maintenance, and acceptability over a period from June 2020 to October 2021.
- Results showed a high satisfaction rate among participants, a significant decrease in symptom severity and emergency visits, and a successful adoption rate with 70% of oncologists referring patients to the program.
Key role for inflammation-related signaling in the pathogenesis of myopia based on evidence from proteomics analysis.
Sci Rep
October 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, 20 College Rd, Singapore, 169856, Singapore.
Article Synopsis
- The causes of myopia (nearsightedness) are not fully understood, but new research is using animal and human datasets to explore implicated proteins and signaling pathways related to this condition.
- Proteins from human blood and eye fluids, as well as from animal models, were analyzed using the QIAGEN Ingenuity Pathway Analysis software to identify important biological pathways affected in myopia.
- Key findings showed that immune responses and inflammation, particularly involving specific proteins and signaling pathways, play a significant role in the development of myopia, potentially leading to better-targeted treatment options.
Detection of soft tissue emphysema in emergency head and neck imaging.
Singapore Med J
October 2024
Department of Radiology, Sengkang General Hospital, Singapore.
Effect of childhood atropine treatment on adult choroidal thickness using sequential deep learning-enabled segmentation.
Asia Pac J Ophthalmol (Phila)
October 2024
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. Electronic address:
Article Synopsis
- The study aimed to measure choroidal thickness in adults who underwent childhood atropine treatment for myopia using a deep learning segmentation method.
- It found that 77.7% of the participants received atropine, which was linked to a choroid thickness increase of 20-40 μm in specific regions of the eye, after accounting for age and sex.
- The research also indicated a relationship between greater central choroidal thickness and a lower incidence of tessellated fundus, implying childhood atropine exposure may have lasting effects on eye structure.
Effectiveness of a Digital Health Intervention Leveraging Reinforcement Learning: Results From the Diabetes and Mental Health Adaptive Notification Tracking and Evaluation (DIAMANTE) Randomized Clinical Trial.
J Med Internet Res
October 2024
Center for Healthcare Policy and Research, UC Davis Health, Sacramento, CA, United States.
Article Synopsis
- Scientists used a study called DIAMANTE to see if personalized text messages could help people with diabetes and depression walk more.
- They had three groups: one got normal messages, one got random messages, and the last group got special messages chosen by a computer.
- The people who got the personalized messages walked an average of 3.6 more steps every day, showing that the method was really helpful!
Diagnostic Accuracy of Skin Prick Test, Food-Specific IgE and Component Testing for IgE-Mediated Peanut, Egg, Milk and Wheat Allergy.
Clin Exp Allergy
October 2024
Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore.
Knowledge, attitudes, and practices of paediatric medical officers and registrars on the developmental origins of health and disease in a tertiary women's and children's hospital.
BMC Med Educ
October 2024
Endocrinology Service, KK Women's and Children's Hospital, Singapore, Singapore.
Article Synopsis
- Pediatricians in training need to understand the Developmental Origins of Health and Disease (DOHaD) to address the increasing issues of non-communicable diseases.
- A survey conducted among 95 doctors revealed that only 23.2% were aware of DOHaD, with most believing their peers lacked knowledge on the topic.
- Despite their limited knowledge, nearly all physicians expressed a desire to learn more about DOHaD and recognized the importance of guiding patients on healthy practices for better long-term health outcomes.
Digital versus speculum-based balloon catheter insertion for labor induction: a systematic review and meta-analysis.
Am J Obstet Gynecol MFM
December 2024
Department of Obstetrics and Gynaecology, Monash University, Faculty of Medicine, Nursing and Health Sciences, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria 3168 Australia (Seo, Davies-Tuck, Warty, Smith, and Palmer); Monash Women's, Monash Health, 246 Clayton Rd, Clayton, Victoria Australia (Palmer).
Article Synopsis
- The study examines the effectiveness, safety, and acceptability of two methods for cervical preparation prior to labor induction: digital insertion vs. speculum-based insertion of catheter balloons.
- It utilized various medical databases to find randomized controlled trials that met specific criteria, focusing on viable singleton pregnancies and excluding studies that didn't involve cervical balloons.
- The results indicated that while digital insertion was generally less painful and had comparable maternal satisfaction, overall outcomes showed no significant difference between the two methods, despite some concerns over study biases.
Evaluating the role of technology in disseminating education to patients with chronic kidney disease.
Ann Acad Med Singap
September 2024
Department of Renal Medicine, Sengkang General Hospital, Singapore.
Assessing the accuracy and consistency of generative pretrained transformers in assigning Eastern Cooperative Oncology Group performance status.
Ann Acad Med Singap
September 2024
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
2023 guidelines on the management of psoriasis by the Dermatological Society of Singapore.
Ann Acad Med Singap
September 2024
Dr SN Wong Skin, Hair, Nails & Laser Specialist Clinic, Singapore.
Article Synopsis
- Psoriasis is a chronic inflammatory skin disease that requires varied management approaches, which the study aimed to standardize through new guidelines tailored for dermatology practice in Singapore.
- A specialized workgroup conducted a comprehensive literature review on psoriasis treatments from 2013 to 2023, refining clinical questions to create practical guidelines covering assessment and management strategies for different severity levels of psoriasis.
- The resulting guidelines suggest various therapies, including both systemic and topical treatments, while addressing specific concerns for special populations and providing recommendations for managing related conditions like psoriatic arthritis.
Investigating urinary characteristics and optimal urine white blood cell threshold in paediatric urinary tract infection: A prospective observational study.
Ann Acad Med Singap
September 2024
Department of Emergency Medicine, KK Women's and Children's Hospital, Singapore.
Introduction: While the definitive diagnosis of urinary tract infection (UTI) requires a positive urine culture, the likelihood of UTI can be determined by urinalysis that includes white blood cell (WBC) count. We aimed to determine the optimal urine WBC threshold in urinalysis to predict UTIs in children presenting at the emergency department (ED).
Method: We performed a prospective observational study in the ED at KK Women's and Children's Hospital for children below 18 years old who underwent both urine microscopy and urine cultures, between 10 January and 7 November 2022.