34 results match your criteria: "Duke University Medical Center and Durham Veterans Affairs Medical Center[Affiliation]"
J Cardiopulm Rehabil Prev
March 2023
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut (Dr Hu); Departments of Biostatistics (Dr Huang) and Medicine (Drs Mayberry, Kripalani, Roumie, and Bachmann), Vanderbilt University Medical Center, Nashville, Tennessee; Departments of Population Health Sciences and Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina (Dr Bosworth); Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri (Dr Freedland); Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee (Drs Mayberry, Kripalani, Wallston, Roumie and Bachmann); and Medicine Service, Veterans Affairs Tennessee Valley Healthcare System-Nashville Campus, Nashville, Tennessee (Drs Roumie and Bachmann).
Purpose: Cardiac rehabilitation (CR), a program of supervised exercise and cardiovascular risk management, is widely underutilized. Psychological factors such as perceived health competence, or belief in one's ability to achieve health-related goals, may play a role in CR initiation. The aim of this study was to evaluate the association of perceived health competence with CR initiation among patients hospitalized for acute coronary syndrome (ACS) after adjusting for demographic, clinical, and psychosocial characteristics.
View Article and Find Full Text PDFJ Stroke Cerebrovasc Dis
September 2020
NYC Health+Hospitals/Jacobi, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:
Background And Purpose: Acute vertigo (sense of motion) can be the sole manifestation of a posterior circulation stroke, and often gets missed in the emergency department (ED). The studies for evaluation of central vertigo have focused on physical exam findings, which require expertise and may not be suitable for rapid triage by a nurse in ED or by paramedics.
Methods: This cross sectional study included retrospective chart review of patients 18 years of age and older who presented to the Adult ED with acute dizziness or vertigo during the calendar year 2017.
Ann Intern Med
July 2019
Durham Veterans Affairs Medical Center and Duke University School of Medicine, Durham, North Carolina (D.V.B., K.M.G., J.M.G., J.W.W.).
Background: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain.
Purpose: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwelling persons.
Data Sources: English-language searches of MEDLINE, Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL in April 2018; the MEDLINE search was updated in March 2019.
Arthritis Care Res (Hoboken)
June 2019
Duke University Medical Center, Durham, North Carolina.
Am J Crit Care
May 2018
Karthik Raghunathan is an associate professor, Department of Anesthesiology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina. Mandeep Singh is an assistant professor, Department of Anesthesiology, University of Southern California, Los Angeles, California. Brian H. Nathanson is chief executive officer, OptiStatim, LLC, Longmeadow, Massachusetts. Elliott Bennett-Guerrero is a professor, Department of Anesthesiology, Stony Brook University Medical Center, Stony Brook, New York. Peter K. Lindenauer is director, Institute for Healthcare Delivery and Population Science, and professor of medicine, University of Massachusetts-Baystate; professor of quantitative health sciences, University of Massachusetts Medical School, Worcester; and an adjunct professor, Tufts University School of Medicine, and Tufts Clinical and Translational Science Institute, Boston, Massachusetts.
Background: Early red blood cell transfusions are a common treatment for adults hospitalized for sepsis without shock. However, their utility and association with mortality and costs have not been well studied.
Objectives: To examine early transfusion rates for patients with sepsis treated outside intensive care units, and to find a correlation between transfusion rates and survival rates and costs.
J Am Soc Nephrol
January 2018
Department of Medicine, University of Virginia, Charlottesville, Virginia;
Intronic variants of the gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle cell disease-associated nephropathy. However, the causal functional variants of have remained elusive. Rare missense mutations in cause macrothrombocytopenia and are occasionally associated with development of nephropathy.
View Article and Find Full Text PDFPurpose: We evaluated the relative risk of biochemical recurrence, metastasis and death from prostate cancer contributed by biopsy Gleason pattern 5 among men at high risk with Gleason 8-10 disease in the SEARCH (Shared Equal Access Regional Cancer Hospital) cohort.
Materials And Methods: Men with biopsy Gleason sum 8-10 prostate cancer treated with radical prostatectomy were evaluated. The cohort was divided into men with Gleason 4 + 4 vs those with any pattern 5 (ie Gleason 3 + 5, 5 + 3, 4 + 5, 5 + 4 or 5 + 5).
CPT Pharmacometrics Syst Pharmacol
November 2015
Achieving hypertension (HTN) control and mitigating the adverse health effects associated with HTN continues to be a global challenge. Some individuals respond poorly to current HTN therapies, and mechanisms for response variation remain poorly understood. We used a nontargeted metabolomics approach (gas chromatography time-of-flight/mass spectrometry gas chromatography time-of-flight/mass spectrometry) measuring 489 metabolites to characterize metabolite signatures associated with treatment response to anti-HTN drugs, atenolol (ATEN), and hydrochlorothiazide (HCTZ), in white and black participants with uncomplicated HTN enrolled in the Pharmacogenomic Evaluation of Antihypertensive Responses study.
View Article and Find Full Text PDFTransfusion
July 2013
Department of Pathology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Am J Physiol Renal Physiol
November 2011
Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
Activation of type 1 angiotensin II (AT(1)) receptors in the kidney promotes blood pressure elevation and target organ damage, but whether renal AT(1) receptors influence the level of hypertension by stimulating sodium retention or by raising systemic vascular resistance has not been established. In the current studies, we used a kidney cross-transplantation strategy to determine whether increased sodium reabsorption by AT(1) receptors in the kidney mediates the chronic hypertensive response to angiotensin II. We found this to be true.
View Article and Find Full Text PDFAnesthesiology
February 2011
Department of Anesthesiology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
Background: The management of elderly patients can be challenging for anesthesiologists for many reasons, including altered pharmacokinetics and dynamics. This study compared the efficacy, safety, and pharmacokinetics of sugammadex for moderate rocuronium-induced neuromuscular blockade reversal in adult (aged 18-64 yr) versus elderly adult (aged 65 yr or older) patients.
Methods: This phase 3a, multicenter, parallel-group, comparative, open-label study enrolled 162 patients aged 18 yr and older, American Society of Anesthesiologists class 1-3, scheduled for surgery with general anesthesia and requiring neuromuscular blockade.
J Pathol
April 2010
Chordoma Foundation, Greensboro, NC, USA, and Division of Medical Oncology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Currently there is no effective chemotherapy for chordoma. Recent studies report co-expression of insulin-like growth factor-1 receptor (IGF1R) and its cognate ligand in chordoma, but it is unknown whether this receptor tyrosine kinase is activated in these tumours. Additionally, genetic studies have confirmed frequent deletions of chromosome 9p in chordomas, which encompasses the cyclin-dependent kinase inhibitor 2A (CDKN2A) locus.
View Article and Find Full Text PDFBiologics
September 2008
Department of Medicine and Research Service, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
Glomerulonephritis is a common cause of chronic kidney disease and end stage renal failure. Current therapy relies on variably effective, nonspecific and toxic immunosuppression. Recent insights into underlying biology and disease pathogenesis in human glomerulonephritis combined with advances in the fields of inflammation and autoimmunity promise a cadre of novel targeted interventions.
View Article and Find Full Text PDFExpert Opin Pharmacother
July 2009
Duke University Medical Center and Durham Veterans Affairs Medical Center, Department of Psychiatry, Durham, NC 27705, USA.
Background: Doxepin is a tricyclic compound that has been used extensively for the treatment of depressive and anxiety disorders for approximately thirty years. It was noted early to have sedative effects and assist with the improvement of disrupted sleep patterns, but in higher antidepressant doses it was also noted to have significant anticholinergic and antinoradrenergic properties. These properties led to significant dose-limiting side effects, which at times precluded its effective use.
View Article and Find Full Text PDFNeurosci Lett
April 2009
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, United States.
Previous studies have shown that acute stress stimulates colonic motor function via a central corticotropin releasing factor (CRF) in rodents. However, little is known whether colonic motility is altered following chronic stress. We studied the changes of colonic motor function in response to chronic stress or daily administration of CRF in rats.
View Article and Find Full Text PDFAnn Intern Med
March 2009
Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
Background: The Centers for Medicare & Medicaid Services limit coverage of cancer drugs for off-label indications to indications listed in specified compendia.
Purpose: To assess whether compendia provide comprehensive, research-based, and timely information for off-label prescribing in oncology.
Data Sources: 6 drug compendia, English-language literature searches of MEDLINE and the Cochrane Central Register of Controlled Trials from 2006 and 2008, and American Society of Clinical Oncology annual meeting abstracts from 2004 to 2007.
Semin Oncol
December 2008
Division of Medical Oncology and Cell Therapy, Division of Geriatrics, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.
Cancer-related fatigue (CRF) is one of the most common and debilitating symptoms experienced by elderly cancer patients and by cancer survivors. However, this has not translated into an increase in clinical trials for assessment and therapy of CRF in this population. The early recognition and formal assessment of this symptom is important in order to be able to treat it, before it negatively impacts the patient's quality of life.
View Article and Find Full Text PDFClin Exp Pharmacol Physiol
August 2008
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina, USA.
1. Corticotropin-releasing factor (CRF) alters colonic motor function in response to restraint stress. It remains unclear whether peripheral CRF released by restraint stress correlates with stress-mediated colonic motility.
View Article and Find Full Text PDFAm J Physiol Renal Physiol
August 2008
Division of Nephrology, Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Activation of the renin-angiotensin system contributes to the progression of chronic kidney disease. Based on the known cellular effects of ANG II to promote inflammation, we posited that stimulation of lymphocyte responses by ANG II might contribute to the pathogenesis of hypertensive kidney injury. We therefore examined the effects of the immunosuppressive agent mycophenolate mofetil (MMF) on the course of hypertension and kidney disease induced by chronic infusion of ANG II in 129/SvEv mice.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
June 2008
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
During the early stages of diabetes, gastric emptying is often accelerated, rather than delayed. The mechanism of accelerated gastric emptying in diabetes has not been fully studied. A recent study showed that plasma ghrelin levels were elevated in diabetes.
View Article and Find Full Text PDFDig Dis Sci
May 2008
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Background: Stress and central corticotropin releasing factor (CRF) are contributing factors to the pathogenesis of irritable bowel syndrome (IBS). It has been shown that restraint stress and central CRF stimulate colonic motility in rats. Short-chain fatty acids (SCFAs) are produced by bacterial fermentation from dietary fibers.
View Article and Find Full Text PDFAnesth Analg
September 2007
Department of Anesthesiology, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA.
The effects of IV-administered dyes on pulse oximetry have been well described. However, the effects on near-infrared cerebral oximetry have not been well documented. We report a series of four patients undergoing radical prostatectomy who were monitored with cerebral oximetry during surgery.
View Article and Find Full Text PDFJ Gastroenterol
April 2007
Department of Surgery, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Background: Fecal pellet output has been assessed as a colonic motor activity because of its simplicity. However, it remains unclear whether an acceleration of colonic transit correlates well with an increase in fecal pellet output. We examined the causal relationship between colonic transit and fecal pellet output stimulated by the central application of corticotropin-releasing factor (CRF) and restraint stress.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
November 2006
Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.
Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key causative feature, but this has been difficult to test experimentally, and recent studies have challenged this hypothesis. Based on the critical role of the renin-angiotensin system (RAS) and the type I (AT1) angiotensin receptor in essential hypertension, we developed an experimental model to separate AT1 receptor pools in the kidney from those in all other tissues.
View Article and Find Full Text PDFClin Med Res
August 2005
Division of Medical Oncology and Division of Geriatrics, Duke University Medical Center and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA.
Non-Hodgkin's lymphoma (NHL) is the most common hematological malignancy in the United States with a rapidly increasing incidence. Most follicular NHL is indolent but incurable, whereas the more aggressive varieties do respond to therapy. Most patients with follicular NHL who transform to an aggressive NHL are very difficult to treat successfully.
View Article and Find Full Text PDF© LitMetric 2025. All rights reserved.