Rapid regression of large cardiac rhabdomyomas in neonates after sirolimus therapy.

Cardiac rhabdomyomas are the most common tumours in children and are typically seen in association with the tuberous sclerosis complex. Although benign and often associated with spontaneous regression, in rare circumstances surgical resection is indicated to relieve obstruction or other mass-related effects. Recent clinical trials have demonstrated the benefits of mammalian target of rapamycin inhibitors for the treatment of other tumour sub-types associated with tuberous sclerosis.

The Use of Echocardiography for Pediatric Patients Presenting with Syncope.

Objectives: To assess the frequency, yield, and cost of echocardiograms meeting "rarely appropriate" criteria.

Study Design: Retrospective, single-center study of pediatric patients presenting with syncope. Patients were categorized according to the appropriate use criteria and based upon location of care (emergency department only, primary care setting only, or referred to a pediatric cardiologist).