4 results match your criteria: "Duke Molecular Physiology Institute Duke University School of Medicine Durham NC.[Affiliation]"
Background The interplay between branched-chain amino acid (BCAA) metabolism, an important pathway in adiposity and cardiometabolic disease, and visceral adipose depots such as hepatic steatosis (HS) and epicardial adipose tissue is unknown. We leveraged the PROMISE clinical trial with centrally adjudicated coronary computed tomography angiography imaging to determine relationships between adipose depots, BCAA dysregulation, and coronary artery disease (CAD). Methods and Results The PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial randomized 10 003 outpatients with stable chest pain to computed tomography angiography versus standard-of-care diagnostics.
View Article and Find Full Text PDFLipoprotein Subclasses Associated With High-Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial.
J Am Heart Assoc
January 2023
Division of Cardiology, Department of Medicine Duke University School of Medicine Durham NC.
Article Synopsis
- More than half of major cardiovascular events occur without obstructive coronary artery disease, often linked to high-risk atherosclerotic plaque rupture, with a need for better blood-based biomarkers to predict these events.
- The study analyzed lipoprotein profiles in participants with stable symptoms of potential coronary artery disease, finding associations between certain high-density lipoprotein (HDL) subclasses and indicators of high-risk plaque.
- Results indicated that larger and medium-sized HDL particles inversely correlate with high-risk plaque features and lower rates of major cardiovascular events, pointing towards their potential role in patient risk stratification.
Background Substantial heterogeneity exists in the cardiorespiratory fitness (CRF) change in response to exercise training, and its long-term prognostic implication is not well understood. We evaluated the association between the short-term supervised training-related changes in CRF and CRF levels 10 years later. Methods and Results STRRIDE (Studies of a Targeted Risk Reduction Intervention Through Defined Exercise) trial participants who were originally randomized to exercise training for 8 months and participated in the 10-year follow-up visit were included.
View Article and Find Full Text PDFIntroduction: The role of perinatal diet in postpartum maternal mood disorders, including depression and anxiety, remains unclear. We investigated whether perinatal consumption of a Western-type diet (high in fat and branched-chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A).
Methods: Mouse dams were fed one of four diets (high-fat/high BCAA, low-fat/high BCAA, high-fat, and low-fat) prior to mating and throughout gestation and lactation.