GPT-4: a new era of artificial intelligence in medicine.

GPT-4 is the latest version of ChatGPT which is reported by OpenAI to have greater problem-solving abilities and an even broader knowledge base. We examined GPT-4's ability to inform us about the latest literature in a given area, and to write a discharge summary for a patient following an uncomplicated surgery and its latest image analysis feature which was reported to be able to identify objects in photos. All things considered, GPT-4 has the potential to help drive medical innovation, from aiding with patient discharge notes, summarizing recent clinical trials, providing information on ethical guidelines, and much more.

Assessing the impact of digital patient monitoring on health outcomes and healthcare resource usage in addition to the feasibility of its combination with at-home treatment, in participants receiving systemic anticancer treatment in clinical practice: protocol for an interventional, open-label, multicountry platform study (ORIGAMA).

Introduction: Digital patient monitoring (DPM) tools can enable more effective clinical care and improved patient outcomes in cancer. However, their broad adoption requires ease of use and demonstration of real-world clinical utility/impact. ORIGAMA (MO42720) is an interventional, open-label, multicountry platform study investigating the clinical utility of DPM tools and specific treatments.

Current and potential applications of artificial intelligence in medical imaging practice: A narrative review.

Background And Purpose: Artificial intelligence (AI) is present in many areas of our lives. Much of the digital data generated in health care can be used for building automated systems to bring improvements to existing workflows and create a more personalised healthcare experience for patients. This review outlines select current and potential AI applications in medical imaging practice and provides a view of how diagnostic imaging suites will operate in the future.

Wilson's disease: best practice.

Wilson's disease is an autosomal recessive disorder arising from pathogenic variants in the tp7b gene on chromosome 13. The defective translated ATPase copper (Cu) transport protein produced leads to Cu accumulation, initially affecting the liver but eventually affecting other cells. It is just over 20 years since the last Best Practice on this topic in this journal.

Protocol for a prospective cohort study exploring the gut microbiota of infants with congenital heart disease undergoing cardiopulmonary bypass (the GuMiBear study).

Introduction: The gut microbiota develops from birth and matures significantly during the first 24 months of life, playing a major role in infant health and development. The composition of the gut microbiota is influenced by several factors including mode of delivery, gestational age, feed type and treatment with antibiotics. Alterations in the pattern of gut microbiota development and composition can be associated with illness and compromised health outcomes.

Impact of COVID-19 on Neuro-Ophthalmology in the United States: A National Survey.

Purpose: To evaluate the impacts of the COVID-19 on neuro-ophthalmology practice in the United States.

Design: Cross-sectional study.

Methods: The North American Neuro-ophthalmology Society distributed a survey on the impact of COVID-19 on neuro-ophthalmic practice to its members.

Non-pharmacological interventions in the treatment of rheumatoid arthritis: A systematic review and meta-analysis.

Purpose: To investigate the role of non-pharmaceutical therapies on disease activity in rheumatoid arthritis through systematic review and meta-analysis.

Methods: A review of Pubmed, EMBASE, Web of Science, and the Cochrane Library was performed from inception until March 26, 2019. Only randomized controlled trials which assessed oral, non-pharmacological interventions (e.

Position paper: Models of post-transplant care for individuals with cystic fibrosis.

There is no consensus on the best model of care for individuals with CF to manage the non-pulmonary complications that persist after lung transplant. The CF Foundation virtually convened a group of international experts in CF and lung-transplant care. The committee reviewed literature and shared the post-lung transplant model of care practiced by their programs.

Centile reference chart for resting metabolic rate through the life course.

Objective: Reference centile charts are widely used for the assessment of growth and have progressed from describing height and weight to include body composition variables such as fat and lean mass. Here, we present centile charts for an index of resting energy expenditure (REE) or metabolic rate, adjusted for lean mass versus age, including both children and adults across the life course.

Design, Participants And Intervention: Measurements of REE by indirect calorimetry and body composition using dual-energy X-ray absorptiometry were made in 411 healthy children and adults (age range 6-64 years) and serially in a patient with resistance to thyroid hormone α (RTHα) between age 15 and 21 years during thyroxine therapy.

Respiratory Immune Responses during Infection and Pollution Inhalation.

The COVID-19 pandemic highlighted the importance of lung immune responses to pathogens and environmental factors [...

Glucagon-like peptide-1 agonists combined with sodium-glucose cotransporter-2 inhibitors reduce weight in type 1 diabetes.

Objective: This study evaluated whether adding sodium-glucose cotransporter-2 inhibitors (SGLT2i) and/or glucagon-like peptide-1 receptor agonists (GLP1-RA) to insulin reduced weight and glycemia in people with type 1 diabetes.

Methods: This retrospective analysis of electronic health records evaluated 296 people with type 1 diabetes over 12 months after medications were first prescribed. Four groups were defined: control n = 80, SGLT2i n = 94, GLP1-RA n = 82, and combination of drugs (Combo) n = 40.

The impact of COVID-19 on managing ophthalmic diseases: an international, descriptive study.

Background: Anecdotally, the COVID-19 pandemic has resulted in more severe cases of eye disease, decreased medication compliance/availability, and decreased treatment volume due to the lockdown.

Aims: We aim to quantify and bring together a variety of international perspectives from ophthalmologists of different subspecialties to characterize the global impact of COVID-19 on managing various ophthalmic disease.

Methods: An online survey of 10 questions was conducted among ophthalmologists using a specialized survey program.

Management of Hemorrhage During Cesarean Delivery in a Patient With Vascular Ehlers-Danlos Syndrome: A Case Report.

Parturients with vascular Ehlers-Danlos syndrome are at particular risk of hemorrhage, and there is little evidence to guide prevention or management of hemorrhage in these patients. We present the case of a patient with vascular Ehlers-Danlos syndrome who had a cesarean delivery complicated by an intraoperative hemorrhage. Administration of desmopressin and tranexamic acid appeared to be of marked benefit in achieving hemostasis.

Transfer learning as an AI-based solution to address limited datasets in space medicine.

The advent of artificial intelligence (AI) has a promising role in the future long-duration spaceflight missions. Traditional AI algorithms rely on training and testing data from the same domain. However, astronaut medical data is naturally limited to a small sample size and often difficult to collect, leading to extremely limited datasets.

An Analysis of Burnout among Female Nurse Educators in Saudi Arabia Using K-Means Clustering.

Nurse educators are often burnt out and suffer from depression due to their demanding job settings. Biochemical markers of burnout can provide insights into the physiological changes that lead to burnout and may help us prevent burnout symptoms. Research was conducted using a descriptive cross-sectional survey design and a multi-stage sampling method.