19 results match your criteria: "Drug-Induced Pseudolymphoma Syndrome"
Ethosuximide-induced drug reaction with eosinophilia and systemic symptoms with mediastinal lymphadenopathy.
Pediatr Dermatol
July 2019
Department of Dermatology, Naval Medical Center San Diego, San Diego, California.
Article Synopsis
- * A case study of a 7-year-old boy highlights these symptoms after starting ethosuximide for absence seizures, showing symptoms like rash, fever, and facial swelling.
- * Concerns about lymphoma led to invasive testing, emphasizing the need for awareness of this atypical symptom in pediatric DRESS syndrome cases.
Drug induced pseudolymphoma.
Semin Diagn Pathol
July 2018
Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.
Article Synopsis
- * These infiltrates may mimic conditions like lymphocytoma cutis and T cell dyscrasias, with connections to various drug classes such as antidepressants and statins impacting lymphoid function.
- * Collaboration between pathologists and clinicians is essential to differentiate between pseudolymphoma and true lymphoma, as pathology alone can't reliably make this distinction.
Lamotrigine-induced Hypersensitivity Syndrome with Histologic Features of CD30+ Lymphoma.
Indian J Dermatol
April 2016
Department of Oncology, Bellevue Medical Center, Beirut, Lebanon.
Article Synopsis
- DRESS syndrome, also known as DIHS, is a serious allergic reaction to drugs that can appear similar to skin or systemic lymphomas.
- The case presented involves a patient who developed DRESS syndrome from the medication lamotrigine, showing histological features resembling a type of lymphoma (CD30+).
- The patient's condition improved with a gradual decrease in steroid medication, emphasizing the need for medical professionals to recognize these unusual lymphoma-like drug reactions.
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms with histologic features mimicking cutaneous pseudolymphoma.
J Dermatol
September 2014
Department of Dermatology, Showa University School of Medicine, Tokyo, Japan; Division of Dermatology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Severe drug-induced dermatoses.
Semin Cutan Med Surg
March 2014
Department of Dermatology, University of California San Francisco, CA USA. Email:
Article Synopsis
- Common skin conditions can have types that are triggered by medications.
- The article covers how these conditions show up, their causes, the medications responsible, and how to manage them.
- Specific conditions discussed include drug-induced lupus, vasculitis, pemphigus, and more, detailing their symptoms and treatment options.
Cutaneous targets in drug-induced reactions.
G Ital Dermatol Venereol
April 2014
Unit of Dermatology "A. Perrino" Hospital, Brindisi, Italy.
Article Synopsis
- Skin experiences the majority of adverse drug reactions (ADRs), accounting for 30% of all cases, but these reactions are often overlooked due to challenges in identifying the responsible medication.
- A detailed patient history is essential for connecting ADRs to specific drugs, although histological exams may be necessary for further diagnosis, complicating the process due to overlap with other skin conditions.
- The study reviews common histological presentations of drug-induced ADRs and categorizes them based on the skin area affected, including the epidermis, dermal-epidermal junction, dermis, subcutaneous fat, and adnexal structures.
Cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma after dapsone-induced hypersensitivity syndrome.
Korean J Pathol
December 2012
Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea.
Article Synopsis
- - A 36-year-old woman developed widespread skin rashes, fever, chills, and jaundice after 8 months on dapsone, along with lymph node swelling and spleen enlargement.
- - A biopsy initially suggested angioimmunoblastic T-cell lymphoma due to lymph node changes, but her symptoms were considered to be a hypersensitivity reaction to dapsone instead.
- - After a liver biopsy confirmed drug-induced hepatitis, she was treated with intravenous glucocorticoids, leading to a significant improvement in her symptoms.
Lymphomatoid drug reaction secondary to methylphenidate hydrochloride.
Cutis
January 2008
Department of Dermatology, Drexel University College of Medicine, 219 N Broad Street, 4th Fl, Philadelphia, PA 19107, USA.
Article Synopsis
- Lymphomatoid drug reactions are uncommon and can affect anyone, regardless of gender, race, or age.
- They can be divided into two main types: drug-induced pseudolymphoma and anticonvulsant-induced pseudolymphoma syndrome, which presents with skin lesions, fever, and swollen lymph nodes.
- This case is the first documented instance of methylphenidate hydrochloride, commonly used for ADHD, causing a pseudolymphoma reaction.
[Mycosis fungoides-type eruptions induced by carbamazepine].
Actas Dermosifiliogr
June 2006
Servicio de Dermatología, Hospital Universitario La Princesa, Madrid, Spain.
Article Synopsis
- - Cutaneous pseudolymphomas are skin diseases that mimic malignant lymphomas in appearance and structure, and drug-induced cases are rare and vary in their presentation.
- - These conditions are broadly divided into two types: one mimicking cutaneous lymphomas and the other categorized as hypersensitivity syndromes, with no clear way to distinguish between them and actual lymphomas.
- - Diagnosis typically relies on the improvement of symptoms after stopping the medication, and the text discusses three cases of carbamazepine-induced pseudolymphomas that resemble mycosis fungoides but present differently.
Impact of phenytoin therapy on the skin and skin disease.
Expert Opin Drug Saf
November 2004
St. Lukes Roosevelt Hospital Center, Department of Dermatology, 1090 Amsterdam Avenue, Suite 11D, New York, NY 10025, USA.
Article Synopsis
- * Some serious skin reactions linked to phenytoin include Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as a hypersensitivity syndrome that presents with fever and rash.
- * Long-term use of phenytoin may lead to issues such as gingival hyperplasia, alterations in vitamin and mineral levels, and potential structural and developmental problems in newborns if used during pregnancy.
Phenytoin in cutaneous medicine: its uses, mechanisms and side effects.
Dermatol Online J
August 2003
Department of Dermatology, St.-Lukes Roosevelt Hospital Center, New York, USA.
Article Synopsis
- - Phenytoin, also known as Dilantin, is mainly used to treat grand mal and psychomotor epilepsy, and has applications in dermatology for conditions like ulcers and inflammatory issues, potentially promoting wound healing by inhibiting collagenase.
- - Common side effects include gingival hyperplasia and changes in appearance, while rare but serious reactions may involve severe skin conditions and hypersensitivity syndrome.
- - Despite its long history of use, phenytoin's effects on vitamin levels, clotting function, and potential risks during pregnancy emphasize the need for ongoing research to better understand its mechanisms and safety.
[Misleading or rare cutaneous drug reactions].
Rev Prat
June 2000
Service de dermatologie CHU-Hôtel-Dieu, Clermont-Ferrand.
Article Synopsis
- Drug hypersensitivity syndrome and drug-induced cutaneous pseudolymphoma were once thought to be the same but are now recognized as distinct conditions; the former has a 10% mortality rate, while the latter has an excellent prognosis.
- Acute generalized exanthematous pustulosis, identified in 1980, is a rare drug-related skin reaction.
- An increasing number of medications are linked to issues with the buccal mucous membrane, with some, like nicorandil, causing severe oral ulcers and gingival hypertrophy being a less common reaction.
Carbamazepine-induced pseudolymphoma with CD-30 positive cells.
J Am Acad Dermatol
May 1998
Division of Dermatology, University of Kansas Medical Center, Kansas City 66160, USA.
Article Synopsis
- A 44-year-old woman with a history of phenytoin allergy was treated with carbamazepine for one month, leading to symptoms like fever, lymphadenopathy, and skin eruptions.
- A skin biopsy revealed atypical lymphocytes showing specific markers, indicating the presence of T-cell issues.
- The patient was diagnosed with anticonvulsant hypersensitivity syndrome, characterized by features of pseudolymphoma, and her condition improved rapidly after stopping carbamazepine, highlighting the potential for cross-reactivity among anticonvulsants.
[Febrile toxiderma in children].
Rev Prat
September 1997
Service de dermatologie Centre hospitalier universitaire, Poitiers.
Article Synopsis
- Febrile skin reactions due to drugs account for 6% of pediatric skin-related hospitalizations, making diagnosis challenging because infections and allergies can present similar symptoms.! -
- A single child can experience multiple skin reactions from different causes and drugs, complicating the diagnosis further.! -
- Diagnosis largely relies on clinical methods rather than lab tests, with immediate symptomatic treatment provided upon admission, and the responsible drug should be stopped and reported to health authorities once identified.!
Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS).
Semin Cutan Med Surg
December 1996
Department of Dermatology, Hopital Henri Mondor, Université Paris XII, Créteil, France.
Article Synopsis
- The term "drug-induced pseudolymphoma" refers to skin reactions that resemble malignant lymphoma, first described in 1959.
- It encompasses two patterns: hypersensitivity syndrome, which has acute symptoms like fever and severe skin reactions within the first two months of drug use, and drug-induced pseudolymphoma, which develops more gradually without systemic symptoms.
- The article suggests rebranding hypersensitivity syndrome as DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) to reduce confusion around the terminology.
Drug-induced pseudolymphoma and hypersensitivity syndrome. Two different clinical entities.
Arch Dermatol
November 1996
Department of Dermatology, Hôpital Henri Mondor, Creteil, France.
Article Synopsis
- The study aimed to determine if drug-induced pseudolymphoma and hypersensitivity syndrome are distinct conditions through a retrospective analysis across five medical centers from 1980 to 1993.
- Researchers analyzed 24 patients suspected of having lymphoma due to drug exposure, separating them into two groups based on symptoms and onset: one group showed signs of pseudolymphoma with localized skin issues, while the other had widespread symptoms indicative of hypersensitivity syndrome.
- Findings suggest these conditions have different clinical and biological characteristics despite some overlapping pathological features; thus, further prospective studies are necessary to validate these differences and evaluate treatment options.
Drug-induced pseudolymphoma syndrome.
Indian J Dermatol Venereol Leprol
October 2012
Department of Dermatology and Venereology, Government Medical College, Patiala-147 001, India, .
Article Synopsis
- - Five children aged 6-12 developed pseudolymphoma syndrome (PS) after taking anticonvulsant medications, primarily carbamazepine and phenobarbitone.
- - Symptoms included morbilliform rash or erythroderma, fever, general lymph node swelling, and liver or spleen enlargement in four out of the five cases.
- - Treatment involved stopping the medication and administering prednisolone, resulting in recovery for four children, while one child sadly died from heart failure.
Article Synopsis
- * Rare complications noted include cases of autoimmune hemolytic anemia, pernicious anemia, hypoplastic anemia, and thrombocytopenic purpura, with some cases linked to drug reactions.
- * The disease’s progression can involve symptoms like lymphadenopathy and splenomegaly, with some patients eventually developing malignancies or chronic lympho-proliferative diseases, indicating the complexity of Sjögren's syndrome.