459 results match your criteria: "Drug-Induced Pigmentation"
Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation.
Dermatol Reports
September 2024
Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola (FC).
Article Synopsis
Imatinib-induced hyperpigmentation.
JAAD Case Rep
October 2024
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
Effects of tauroursodeoxycholate on arsenic-induced hepatic injury in mice: A comparative transcriptomic analysis.
J Trace Elem Med Biol
December 2024
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, PR China; National Health Commission & Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Harbin 150081, PR China; Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health, Harbin Medical University, Harbin 150081, PR China; Institute of Cell Biotechnology, China and Russia Medical Research Center, Harbin Medical University, Harbin 150081, PR China. Electronic address:
Article Synopsis
- Prolonged arsenic exposure can harm various body systems, particularly the liver, causing symptoms like skin changes, gastrointestinal issues, and anemia, with TUDCA showing potential protective effects against liver injury.
- A study was conducted on mice to investigate TUDCA's role in alleviating arsenic-induced liver damage, spanning over 24 weeks with two distinct phases of experiments.
- Through RNA sequencing, researchers identified differentially expressed genes that may explain how TUDCA mitigates liver injury from arsenic, aiming to uncover useful insights for treatment.
Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia.
Mov Disord
October 2024
Department of Human Genetics, McGill University, Montréal, Canada.
Background: Levodopa-induced dyskinesia (LID) is a common adverse effect of levodopa, one of the main therapeutics used to treat the motor symptoms of Parkinson's disease (PD). Previous evidence suggests a connection between LID and a disruption of the dopaminergic system as well as genes implicated in PD, including GBA1 and LRRK2.
Objectives: Our goal was to investigate the effects of genetic variants on risk and time to LID.
A Series of Eight Cases of Pigment Nephropathy: An Obscured Aspect of Acute Kidney Injury.
Cureus
July 2024
Department of Nephrology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Article Synopsis
- Pigment-induced acute kidney injury (AKI) occurs when harmful pigments from myoglobin or hemoglobin cause damage to the kidneys, often linked to conditions like rhabdomyolysis or hemolysis.
- The study reports eight cases of pigment-induced AKI, primarily from myoglobin and hemoglobin casts, triggered by factors such as intense exercise, infections, or certain medications.
- While most patients required dialysis initially, their short-term kidney recovery was positive, highlighting the need for ongoing monitoring to check for potential long-term effects.
Drug-Induced Pigmentation: A Review.
Drugs
September 2024
Department of Dermatology, Henry Ford Health, 3031 W Grand Blvd, Detroit, MI, 48202, USA.
Article Synopsis
- * A comprehensive physical examination and medication history are crucial for identifying the specific offending drug, as DIP typically results from melanin accumulation or drug and iron deposition in the skin.
- * Preventive measures like using broad-spectrum sunscreen and photoprotective clothing are important, and various laser treatments have shown effectiveness in clearing DIP.
Citalopram-Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature.
Cureus
May 2024
Oral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Article Synopsis
- Certain systemic medications, like antimalarials and hormones, can cause oral pigmentation by increasing melanin production or accumulating in the body, with citalopram being a notable example.
- A case study of an 89-year-old woman revealed multiple melanotic macules in her mouth linked to her use of citalopram, highlighting its unusual effect of causing oral instead of skin hyperpigmentation.
The matricellular protein CCN5 prevents anti-VEGF drug-induced epithelial-mesenchymal transition of retinal pigment epithelium.
Sci Rep
June 2024
College of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, 61005, Korea.
Article Synopsis
- * The study discovered that anti-VEGF drugs like bevacizumab, ranibizumab, and aflibercept promote epithelial-mesenchymal transition (EMT) in retinal cells, increasing the levels of CCN2, a pro-fibrotic factor.
- * Co-treatment with CCN5, which inhibits CCN2, mitigated the negative effects of anti-VEGF drugs, indicating that targeting these pathways could improve treatment outcomes for nAMD.
Antitubercular drug-induced lichen planus: A case study with a mini literature review.
J Family Med Prim Care
February 2024
Department of Pharmacy, KLE College of Pharmacy, Bengaluru, Karnataka, India.
Article Synopsis
- Drug-induced lichen planus is a rare skin reaction associated with antitubercular therapy, presenting as flat-topped, reddish-purple bumps on the skin.
- A case study involved a 63-year-old male with tuberculosis who developed skin lesions after two months on treatment; he was diagnosed with drug-induced lichen planus and managed through the cessation of antitubercular drugs and various medications.
- The patient showed improvement after rechallenging with certain medications, highlighting the importance of monitoring drug reactions while balancing the risk of worsening tuberculosis.
Article Synopsis
- - Isobavachalcone (IBC), a flavonoid from Psoraleae Fructus, is known to increase skin pigmentation and possibly treat vitiligo, but it also has hepatotoxic effects.
- - This study used depigmented zebrafish models to compare the liver damage caused by IBC in normal versus depigmented zebrafish, revealing significant differences in liver volume and lipid metabolism.
- - Findings highlighted that the hepatotoxic effects of IBC in depigmented zebrafish are closely linked to calcium signaling, lipid metabolism, and oxidative stress, suggesting a deeper understanding of IBC's toxicity mechanisms.
Dasatinib-Induced Transverse Melanonychia.
Skin Appendage Disord
December 2023
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Transverse melanonychia, characterized by grey to black pigmented bands traversing the nail plate, can occur as a side-effect of certain medications. While no documented reports specifically associate dasatinib, a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia, with nail changes, we present a case of transverse melanonychia possibly related to dasatinib therapy.
Case Report: A 54-year-old male with CML, receiving dasatinib for 1.
Participates in Anti-VEGF-Induced Epithelial Mesenchymal Transformation in RPE Cells.
Clin Ophthalmol
October 2023
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, People's Republic of China.
Article Synopsis
- The study investigates how an unspecified factor contributes to epithelial-mesenchymal transformation (EMT) induced by the anti-VEGF drug bevacizumab in ARPE-19 retinal cells, seeking better treatment strategies to enhance vision.
- Researchers exposed ARPE-19 cells to clinical levels of bevacizumab, measuring gene expression through RT-PCR and assessing protein levels via immunofluorescence and Western blotting after transfecting with specific mimics and inhibitors.
- Findings showed that bevacizumab not only caused EMT but also increased the expression of a particular factor; inhibiting this factor reduced EMT effects, while overexpression intensified them, suggesting it could be a viable miRNA-target for decreasing drug-induced subret
A Rare Finding of Gastric Pseudomelanosis in Chronic Kidney Disease: A Case Report.
Cureus
May 2023
Gastroenterology, Borland Groover, Jacksonville, USA.
Article Synopsis
- * It’s rarely reported, often noticed in older females with dark stools due to excessive iron use, yet a unique case involved a 75-year-old male with the same issue.
- * In this case, his blackish stools were attributed to iron tablets for anemia, and an upper endoscopy confirmed the diagnosis of gastric pseudomelanosis.
ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration.
Biol Pharm Bull
July 2023
Department of Pharmaceutical Sciences, Suzuka University of Medical Science.
Article Synopsis
- Anticancer drugs, including 5-fluorouracil (5-FU), often cause skin pigmentation as a side effect, negatively impacting patients' quality of life (QOL).
- This study aimed to uncover the mechanism behind 5-FU-induced skin pigmentation using specific mice models that were treated with the drug for 8 weeks.
- The findings revealed that the pigmentation process involves an oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway, which can be inhibited to reduce pigmentation in 5-FU-treated mice.
Facial Demodicosis-Induced Skin Hyperpigmentation in an Immunocompromised Man Treated Successfully with Ivermectin 1% Cream: A Case Report.
Clin Cosmet Investig Dermatol
May 2023
Department of Dermatology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, Saudi Arabia.
Article Synopsis
- Demodex folliculorum is a common skin parasite that lives in hair follicles and sebaceous glands, and its connection to skin diseases is known, but there's little information on its role in skin pigmentation issues.
- A case study is presented about a 35-year-old Saudi male with facial hyperpigmentation caused by Demodex, who was being treated with immunosuppressive drugs.
- The patient was effectively treated with ivermectin 1% cream, showing significant improvement after three months, highlighting the need to consider Demodex as a cause of facial hyperpigmentation that can be diagnosed and managed easily.
Acute Liver Failure Secondary to Anthocyanidin Use-A Case Report.
Transplant Proc
November 2023
Liver Transplant Unit, University of Campinas, Campinas, São Paulo, Brazil.
Article Synopsis
- Drug-induced liver injury is the leading cause of acute liver failure (ALF), which can happen in two ways: through high doses or unexpectedly in some individuals.
- A case study is presented about a 37-year-old woman who experienced severe liver damage after taking Morosil, a supplement made from Moro oranges, leading to symptoms like jaundice and encephalopathy.
- The patient was prioritized for a liver transplant due to her severe condition, and the surgery was successfully conducted using a specific technique, highlighting the rarity of ALF cases linked to Morosil.
A RARE CAUSE OF RECURRENT HAEMOLYTIC ANAEMIA: CARBOPLATIN AND PACLITAXEL-INDUCED AUTOIMMUNE HAEMOLYTIC ANAEMIA.
Eur J Case Rep Intern Med
January 2023
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Article Synopsis
- Drug-induced immune haemolytic anaemia (DIIHA) is a rare but serious condition that may occur in about 1 in 1,000,000 patients, often misdiagnosed, highlighting the importance of thorough evaluation of medical and drug histories.
- The case presented involves DIIHA triggered by chemotherapy (carboplatin and paclitaxel) that led to complications like acute kidney injury from haemolysis.
- Effective management of DIIHA primarily involves stopping the suspected drug and offering supportive care, with uncertain benefits from corticosteroids, while monitoring for related kidney injury through urinalysis.
Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina.
Int J Mol Sci
February 2023
School of Veterinary Medicine, Rakuno Gakuen University, 582, Bunkyodai-Midorimachi, Ebetsu 069-8501, Hokkaido, Japan.
Article Synopsis
- Metabolic activation is key to chemical toxicity, particularly in the liver, where the enzyme Cytochrome P450 2E (CYP2E) is crucial for substances like acetaminophen (APAP).
- Researchers developed transgenic zebrafish expressing rat CYP2E1 and EGFP to investigate toxicity, confirming CYP2E1 activity was linked to specific fluorescent changes.
- Findings showed that APAP reduces retina and liver sizes in zebrafish expressing CYP2E1 but not in those without it, while liver damage from APAP could be prevented with -acetylcysteine, indicating CYP2E1's role in certain toxic effects.
Amoxicillin/Clavulanic Acid-Induced Symmetric Drug-Related Intertrigious and Flexural Exanthema.
Cureus
January 2023
Department of Immunology and Allergic Diseases, Kirikkale University Faculty of Medicine, Kirikkale, TUR.
Article Synopsis
- β-Lactams like penicillins can trigger allergic reactions, with a rare condition called symmetric drug-related intertriginous and flexural exanthema (SDRIFE) highlighted in a case involving a 65-year-old male patient.
- The patient developed blue-purple pigmentation in specific body areas after taking amoxicillin/clavulanic acid and reported similar reactions following previous antibiotic use, leading to a diagnosis of SDRIFE.
- Treatment included topical corticosteroids and antihistamines, and it's crucial for the patient to discontinue use of the antibiotic to avoid future reactions.
Seven-year outcome after 1-year fixed regimen of intravitreal aflibercept injections followed by pro re nata treatment for neovascular age-related macular degeneration.
Graefes Arch Clin Exp Ophthalmol
July 2023
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto City, Kyoto Prefecture, 606-8507, Japan.
Article Synopsis
- - The study examines the long-term visual outcomes, specifically best-corrected visual acuity (BCVA), in patients with neovascular age-related macular degeneration (nAMD) after a 1-year treatment with intravitreal aflibercept injections (IVA).
- - Over a 7-year period, BCVA showed initial improvement in the first two years followed by a gradual decline, while central retinal thickness and choroidal thickness decreased significantly.
- - The findings suggest that maintaining BCVA for an extended period is possible with early diagnosis and treatment, highlighting the importance of ongoing monitoring and intervention for nAMD management.
Xanthene-Based Nitric Oxide-Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window.
Angew Chem Int Ed Engl
March 2023
Department of Chemistry, Mississippi State University, 310 President Circle, Mississippi State, MS 39762, USA.
Article Synopsis
- Shortwave infrared (SWIR) dyes can absorb light in the 900-1400 nm range, which is effective for deep tissue imaging due to reduced light scattering.*
- A new series of SWIR xanthene dyes was developed using a simple three-step process, featuring conjugates like thiophene and bithiophene.*
- The study successfully used one of these dyes in a nanoparticle to visualize high nitric oxide levels in a liver injury model through SWIR photoacoustic imaging, showcasing its potential for imaging applications.*
A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo.
Cureus
August 2021
Department of Dermatology, University of California San Diego, La Jolla, CA, USA.
Article Synopsis
- - Two patients with long-term vitiligo experienced unexpected skin repigmentation in areas exposed to sunlight after starting loop diuretic medication, which has not been reported before.
- - Loop diuretics are known to block certain transporters in cells and have been linked to skin issues like bullous pemphigoid and increased sensitivity to sunlight, but not previously to repigmentation in vitiligo patients.
- - The report investigates how loop diuretics might influence skin pigmentation changes, looking at both direct and indirect effects of these medications.
[Pigmented lesions of the mucosa].
Dermatologie (Heidelb)
September 2022
Hautklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, Erlangen, Deutschland.
Article Synopsis
- - Pigmented lesions in the mouth are common and can be confusing for both patients and doctors due to their varied causes and potential risks, including malignancy.
- - These lesions can be categorized as either focal (like melanotic macules or nevi) or multifocal/diffuse (often linked to drugs or medical conditions), with some being benign and others necessitating further investigation.
- - Understanding the characteristics and causes of these lesions is crucial for accurately assessing their nature and determining whether additional testing is required for diagnosis.