955 results match your criteria: "Drug-Induced Bullous Disorders"
Anti-Cancer Drug-Induced Lyell's Syndrome: A Series of Two Patients.
Curr Oncol
November 2024
Institut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, France.
Article Synopsis
- Lyell's syndrome, also known as Toxic Epidermal Necrolysis (TEN), is a severe skin condition primarily caused by an allergic reaction to medications.* -
- Recent developments in cancer treatments, such as targeted therapy and immunotherapy, are increasingly linked to cases of Lyell's syndrome, although traditional anti-cancer drugs were less frequently associated.* -
- Two case studies illustrate TEN occurring in patients undergoing treatment for metastatic cancers with new therapies; unfortunately, both patients succumbed to the condition despite prompt medical intervention.*
TNF-α inhibitors as therapy for drug-induced severe cutaneous adverse reactions: a case series.
J Dermatolog Treat
December 2024
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- - Severe cutaneous adverse reactions (SCARs) like AGEP, DRESS, SJS, and TEN are serious conditions associated with high mortality rates, and while corticosteroids are commonly used for treatment, their effectiveness is uncertain due to infection risks.
- - Recent studies have introduced TNF-α inhibitors, which have shown promise in treating SCARs, with a report indicating that four patients (21-54 years old) treated with these inhibitors had successful recoveries without complications.
- - The TNF-α inhibitors work by targeting the harmful immune response linked to SCARs, but more large-scale trials are needed to confirm their efficacy and ensure a safe approach to their use.
S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) - Part 2: Supportive therapy of EN in the acute and post-acute stages.
J Dtsch Dermatol Ges
November 2024
Department of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Article Synopsis
- Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe, drug-induced skin conditions that can be life-threatening and are now viewed as different levels of the same disease known as epidermal necrolysis (EN).
- A new guideline has been created based on scientific literature and expert consensus to help medical professionals in diagnosing and treating EN.
- This guideline targets various specialists like dermatologists and intensive care doctors, as well as informing patients, families, insurers, and policymakers about EN and includes recommendations for acute care and follow-up treatment.
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a severe and potentially deadly skin reaction caused by common medications, featuring rapid skin detachment due to cell death, with no effective treatments currently available.
- Researchers used deep visual proteomics to analyze skin biopsies from TEN patients, identifying significant changes in proteins related to type I and II interferon signaling and activated phosphorylated STAT1, which are believed to drive the condition.
- The study found that using JAK inhibitors, like tofacitinib and baricitinib, effectively reduced skin damage in both mouse models and human patients with TEN, indicating these pathways could be targeted for potential new treatments.
S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) - Part 1: Diagnosis, initial management, and immunomodulating systemic therapy.
J Dtsch Dermatol Ges
October 2024
Department of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, mostly drug-related conditions that affect the skin and mucous membranes, categorized under the umbrella term epidermal necrolysis (EN), which varies in severity.* -
- A new guideline for diagnosing and treating SJS/TEN was created based on extensive scientific research and consensus among experts, involving various medical specialties to provide a comprehensive approach to patient care.* -
- The guideline is designed for healthcare professionals across multiple fields, as well as patients, their families, insurers, and policymakers, with the first part specifically addressing diagnosis, initial treatment, and systemic immunotherapy.*
Toxic epidermal necrolysis following heart transplantation may caused by cefoperazone sodium and sulbactam sodium.
J Cardiothorac Surg
September 2024
Department of Cardiac Surgery Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Article Synopsis
- * A 56-year-old male with dilated cardiomyopathy faced a serious skin condition (toxic epidermal necrolysis) after receiving certain antibiotics during his heart transplant surgery but was successfully treated with various immunomodulatory therapies and physical rehabilitation.
- * The case emphasizes that striking a balance between immunosuppression and infection prevention is crucial for achieving the best results in heart transplantation, reinforcing the importance of tailored immunosuppressive plans.
Update on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management.
Am J Clin Dermatol
November 2024
Department of Dermatology, Emek Medical Center, Afula, Israel.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, drug-induced skin conditions with high rates of illness and death, creating challenges for healthcare providers.
- Despite numerous documented cases, there is a lack of agreed-upon diagnostic criteria and treatment options for SJS/TEN.
- Recent advancements in understanding the genetic factors and causes of SJS/TEN are discussed in this review, along with updated strategies for diagnosis and management over the past five years.
[Drug-induced lichen ruber pemphigoides].
Dermatologie (Heidelb)
October 2024
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, LMU München, Frauenlobstr. 9-11, 80337, München, Deutschland.
Non-IgE-mediated drug-induced hypersensitivity reactions in pediatrics.
Curr Opin Pediatr
December 2024
Division of Clinical Pharmacology, Departments of Medicine and Pharmacology.
Purpose Of Review: Despite their prevalence and potential severity, non-IgE-mediated drug-induced hypersensitivity reactions (DHRs) are under-researched and poorly defined, particularly in children. Presentations range from mild cutaneous reactions to severe systemic diseases, with pathophysiological mechanisms and reliable diagnostic markers not well established. The lack of validated tests often leads to permanent drug restrictions, reliance on second-line drugs, and increased costs.
View Article and Find Full Text PDFA case report of Stevens-Johnson syndrome caused by omeprazole.
Medicine (Baltimore)
September 2024
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Article Synopsis
- Stevens-Johnson syndrome (SJS) is a serious condition marked by painful skin and mucosal blistering, often leading to significant complications like pneumonia and organ failure.
- A 51-year-old woman developed SJS after taking omeprazole, which resulted in worsening liver function and chronic acute liver failure.
- After stopping the suspected medication and administering supportive treatments, the patient's rash resolved and her liver and kidney functions improved significantly, highlighting the need for understanding drug-induced SJS in patients with liver conditions.
Stevens-Johnson syndrome-toxic epidermal necrolysis overlap in a patient taking quetiapine and famotidine: a case report.
J Med Case Rep
July 2024
Department of Pharmacy, Cathay General Hospital Medical Center, No 280, Sec 4, Renai Road, Taipei, 10630, Taiwan, Republic of China.
Article Synopsis
- Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) is a severe skin disorder that can be drug-induced, has a high mortality rate, and is characterized by widespread rashes, blisters, and mucosal involvement.
- An 82-year-old female patient experienced a rare delayed onset of SJS-TEN after starting famotidine and quetiapine, leading to extensive skin damage and eventual death 12 days after hospital admission.
- The case highlights the need for greater clinical awareness of potential drug side effects, the importance of timely supportive care, and the necessity for further research to establish effective management guidelines for SJS-TEN.
Characterizing drug-induced epidermal necrolysis in a pediatric cohort.
Pediatr Dermatol
November 2024
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- * Sixteen pediatric patients were analyzed, with 75% experiencing the condition due to antiepileptic drugs and 25% from antibiotics.
- * The study highlights that anti-epileptic drugs often had a delayed onset and that patients receiving these medications should be closely monitored for longer periods, especially during dose increases.
Coma Blister After Trazodone Misuse: A Case Report.
Am J Dermatopathol
October 2024
Department of Dermatology, Tulane University School of Medicine, New Orleans, LA.
Article Synopsis
- Coma blisters are fluid-filled bumps that can occur on the skin when someone is in a prolonged state of unconsciousness, and they can form due to various drug intoxications, primarily barbiturates in adults.
- New evidence suggests that other substances, including trazodone, may also trigger these blister-like lesions even in noncomatose individuals.
- This case highlights the importance of understanding how certain drugs can lead to these skin issues, which can help doctors recognize and stop medications that might cause them.
Immune checkpoint inhibitor associated epidermal necrosis, beyond SJS and TEN: a review of 98 cases.
Arch Dermatol Res
May 2024
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue, RMSB, Room 2023-A Miami, Miami, FL, 33136, USA.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can cause serious side effects, including a severe skin condition called epidermal necrosis, which can resemble Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
- In a study of 98 cases of ICI-associated epidermal necrosis, it was noted that symptoms can develop anywhere from 1 day to 3 years after starting treatment, with more severe cases often showing a preceding rash and mucosal involvement linked to fatal outcomes.
- Most patients recover, but young age was associated with worse outcomes in extensive disease, highlighting that ICI-associated epidermal necrosis may be different from other drug-induced skin conditions.
Uncommon toxic epidermal necrolysis -like presentation of cutaneous lupus erythematosus: A series of 6 cases.
Lupus
August 2024
Department of Pathology and Lab Medicine, AIIMS Jodhpur, Jodhpur, India.
Article Synopsis
- TEN like Lupus erythematosus (LE) is a rare and severe form of lupus that can lead to skin failures and is often confused with drug-induced TEN, making accurate diagnosis vital for proper treatment.
- In a study of Indian patients, researchers reviewed six cases of female patients who met the criteria for systemic lupus erythematosus (SLE) and were clinically diagnosed with TEN like LE.
- The majority of these patients had previous connective tissue disease symptoms, with half experiencing palmoplantar involvement and most presenting systemic issues such as nephritis, arthritis, autoimmune hepatitis, and hemolytic anemia.
Drug-Induced Pseudoporphyria: A Case Report.
Cureus
April 2024
Dermatology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- - Pseudoporphyria is a rare skin condition that resembles porphyria cutanea tarda (PCT), and distinguishing between the two is crucial for accurate diagnosis.
- - It’s linked to chronic kidney failure, certain medications, and tanning bed use, and can cause skin issues like fragility, blisters, and scarring, especially in sun-exposed areas.
- - A case report highlights a 20-year-old male diagnosed with pseudoporphyria after ruling out true porphyria, who was treated with hydroxychloroquine sulfate and advised to take strict sun protection measures.
Severe cutaneous adverse reactions.
Nat Rev Dis Primers
April 2024
Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei/Linkou branches, and Chang Gung University, Taoyuan, Taiwan.
Article Synopsis
- Severe cutaneous adverse reactions (SCARs) are life-threatening conditions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, caused by immune reactions to drugs.
- The development of SCARs is influenced by genetic factors, drug metabolism, and immune responses, leading to potential genetic screening before prescribing certain medications.
- Treatment is evolving from traditional corticosteroids to precision therapies involving biologics and targeted small molecules, tailoring approaches based on individual patient profiles.
Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.
Pharmacogenet Genomics
July 2024
Department of Pain Medicine, Singapore General Hospital, Singapore.
Article Synopsis
- This umbrella review investigates the link between the HLA-B*1502 gene and the development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients taking certain antiepileptic medications.
- A thorough search of Pubmed, Scopus, and EMBASE was conducted to gather relevant studies, which included systematic reviews, meta-analyses, and case-control studies assessing the HLA-B*1502 allele’s impact on various antiepileptics.
- The review concludes that while the HLA-B*1502 allele poses a stronger risk for SJS/TEN with carbamazepine and oxcarbazepine, there is still a notable risk with lamot
A Bayesian Network Meta-Analysis of the Effect of Targeted Therapies on the Total Length of Hospital Stay in Children with Drug-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Syndrome.
Pediatr Allergy Immunol Pulmonol
March 2024
Department of Pediatric Allergy and Immunology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin conditions, but there's no standard treatment to lessen complications, especially in kids.
- This study uses a Bayesian network meta-analysis to evaluate different treatments for pediatric SJS/TEN based on how long patients stay in the hospital; six studies with 103 patients were analyzed.
- Results indicate that systemic corticosteroids (CS) might lead to shorter hospital stays compared to other treatments, but no significant advantages were observed overall, highlighting the need for more extensive research to establish effective treatment guidelines.
Drug-induced Stevens-Johnson syndrome in Post traumatic facial injury.
Indian J Pharmacol
January 2024
Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India.
Article Synopsis
- * A patient experienced severe symptoms—including ulcerations and rashes—after being treated with several drugs, particularly ceftriaxone and aceclofenac + paracetamol, four days post-treatment.
- * The patient received corticosteroids and other medications after stopping the suspected drugs, highlighting the need for healthcare providers to be vigilant about potential adverse reactions from commonly used medications.
Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review.
Dermatol Clin
April 2024
Department of Dermatology, University Hospital of Basel, Burgfelderstrasse 101, Basel 4055, Switzerland; Department of Biomedical Research, University of Basel, Allschwil 4123, Switzerland; Department of Biomedical Engineering, University of Basel, Allschwil 4123, Switzerland; Department of Clinical Research, University of Basel, Allschwil 4123, Switzerland. Electronic address:
Article Synopsis
- Generalized pustular rashes can be tough to diagnose and treat, with various underlying causes.
- The article discusses specific conditions like generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, detailing their causes, symptoms, diagnosis difficulties, and treatment options.
- It also emphasizes recent genetic research and new biologic therapies for GPP, pointing towards future advancements in personalized medicine and prevention methods.
Putative pemphigus-like reaction to oral fluralaner in a dog.
Vet Dermatol
August 2024
Hospital Clínic Veterinari UAB, Barcelona, Spain.
Article Synopsis
- - A 9-month-old mixed-breed dog developed widespread pustular skin lesions and showed signs of lethargy and increased body temperature a week after receiving oral fluralaner treatment.
- - Skin evaluations confirmed the condition as pustular acantholytic dermatitis, indicating an immune response likely triggered by the medication.
- - After a 4-month course of immunosuppressive therapy, the dog's skin lesions healed completely and did not return once the medication was stopped.
Terbinafine induced bullous pemphigoid.
Therapie
August 2024
Department of Dermatology, Fattouma Bourguiba Hospital, University of Monastir, 5000 Monastir, Tunisia.
Adult-onset linear IgA bullous dermatosis: a retrospective single-center cohort study of 81 patients and literature review.
Int J Dermatol
July 2024
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune disorder that can be caused by medications or associated with malignancies; this study aimed to identify differentiating characteristics in patients with idiopathic, drug-induced, or malignancy-related LABD.
- A total of 81 patients were studied, revealing that those with drug-induced or malignancy-associated LABD had a significantly shorter disease duration and quicker diagnosis and improvement compared to idiopathic cases.
- The findings suggest the importance of screening for underlying health issues like malignancy or inflammatory bowel disease in newly diagnosed LABD patients, although the study had limitations such as retrospective data collection and lack of diverse participants.
Article Synopsis
- * A case study reveals that a lung cancer patient initially diagnosed with herpes simplex was actually suffering from DIP, as confirmed by detailed laboratory tests including histology and immunofluorescence.
- * The findings suggest that positive herpesvirus IgG antibodies are not definitive indicators of herpesvirus infection, highlighting the need for thorough histological evaluations in patients presenting with unexplained skin blisters.