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Drug-induced QT Interval Prolongation in the Intensive Care Unit.
Curr Clin Pharmacol
April 2019
University of Buenos Aires, Faculty of Medicine, Drug Safety and Surveillance Center, Laboratory of Cardiovascular Safety of Drugs, Buenos Aires, Argentina.
Background: The most common acquired cause of Long QT syndrome (LQTS) is drug induced QT interval prolongation. It is an electrophysiological entity, which is characterized by an extended duration of the ventricular repolarization. Reflected as a prolonged QT interval in a surface ECG, this syndrome increases the risk for polymorphic ventricular tachycardia (Torsade de Pointes) and sudden death.
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