28,835 results match your criteria: "Drug Eruptions"

: Dermatological complaints are commonly seen in the emergency department (ED) setting and may be attributed to infectious, inflammatory, allergic, hypersensitivity, or traumatic processes, yet few studies have been carried out in Saudi Arabia addressing this topic. This study, therefore, aimed to explore this issue by investigating the most common dermatology-related ED encounters in a large tertiary care center in Riyadh, Saudi Arabia, and estimating the incidence of these encounters. : This was a retrospective cohort study conducted in the ED of King Abdulaziz Medical City, a tertiary care center in Riyadh, Saudi Arabia.

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Life-threatening dermatoses.

Clin Dermatol

December 2024

Department of Dermatology, Yale University School of Medicine, New Haven, CT. Electronic address:

While rare, life-threatening dermatoses encompass various inflammatory, infectious, vasculitic/vasculopathy, paraneoplastic, and neoplastic skin diseases. Complications include skin barrier dysfunction, secondary infection, and internal organ involvement. Skin signs may serve as a critical window into systemic disease.

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Toxic epidermal necrolysis (TEN) is a severe skin reaction caused by extensive epidermal and mucosal necrosis. This clinical phenomenon is known as an acute syndrome of apoptotic pan-epidermolysis (ASAP). The ASAP phenomenon is observed in conditions that mimic TEN, highlighting the challenge in distinguishing these conditions.

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Purpose: To investigate the rare side effects of Osimertinib in a case of toxic epidermal necrosis.

Case Presentation: We report on a case of a 44-year old woman with lung adenocarcinoma harboring an EGFR-sensitizing mutation who was treated with Osimertinib as the second-line treatment. Ten days after Osimertinib initiation, a diffuse erythematous rash rapidly spread over the patient's trunk along with vesicles and purpuric macules; furthermore, she developed erythema and exfoliation on the face and trunk and severe mucositis.

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Background: Erythroderma is a dermatologic condition characterized by widespread red and scaly skin. The causes include, but are not limited to, psoriasis, eczema, drug eruptions, pityriasis rubra pilaris (PRP), and cutaneous T-cell lymphoma. Most of these are typified by Type 2 (e.

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Type 2 responses determine skin rash during recombinant interleukin-2 therapy.

J Immunotoxicol

October 2024

Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Department for Preclinical Pharmacology and Toxicology, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Member of the Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Hanover, Germany.

The skin is the organ most often affected by adverse drug reactions. Although these cutaneous adverse drug reactions (CADRs) often are mild, they represent a major burden for patients. One of the drugs inducing CADRs is aldesleukin, a recombinant interleukin-2 (recIL-2) originally approved to treat malignant melanoma and metastatic renal cell carcinoma which frequently led to skin rashes when applied in high doses for anti-cancer therapy.

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Symmetric drug-related intertriginous and flexural exanthem (SDRIFE) is a rare delayed-type hypersensitivity reaction that is considered a variant of systemic allergic contact dermatitis. It is typically triggered by drugs such as beta-lactam antibiotics or antihypertensives. The reaction presents as erythema with flexural prominence.

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A rare long-term side effect of COVID-19 vaccines: Symmetrical drug-related intertriginous and flexural exanthema-like reaction SDRIFE and potential immunogens for delayed type hypersensitivity reactions.

Int Immunopharmacol

January 2025

Ege University, Faculty of Medicine, Department of Pulmonary Medicine, Immunology and Allergy, Laboratory of Occupational/Environmental Respiratory Diseases and Asthma, 35100 Izmir, Türkiye; EgeSAM (Ege University Translational Pulmonary Research Center), 35100 Izmir, Türkiye. Electronic address:

Background: Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is an important clinical entity that is rare and may develop with a Type IV delayed type hypersensitivity immune response to drug antigens. The incidence and characteristics of SDRIFE attributed to COronaVIrus Disease of 2019 (COVID-19) vaccines remain unclear, this issue requires further elucidation.

Objective: We aim to investigate the vaccine-related-SDRIFE and potential immunogens of COVID-19 vaccines through a literature review accompanied by a real case.

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Article Synopsis
  • - Pigmentary disorders like Lichen planus pigmentosus (LPP) and vitiligo can lead to significant cosmetic concerns and psychosocial stress for patients.
  • - A 61-year-old man with LPP developed vitiligo and was successfully treated with low-dose isotretinoin and topical tacrolimus ointment.
  • - The coexistence of LPP and vitiligo might be explained by an autoimmune process affecting skin pigmentation called melanocytorrhagy.
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  • - Bubbles are vital in various fields, such as ultrasound imaging and studying natural phenomena like volcanic eruptions, due to their unique acoustic properties as resonant scatterers.
  • - Researchers have developed a method to confine a cubic bubble using 3D printing, allowing them to study its interactions with the surrounding environment at a single-bubble level.
  • - This new technique enables near-field acoustic imaging with much higher resolution than traditional methods, potentially leading to the creation of affordable acoustic microscopes using these caged bubbles.
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  • * The article explores the synthesis of bis-thiazole derivatives as potential antiviral candidates against Coxsackievirus B, focusing on one particularly effective derivative, 7a, which inhibits both viral adsorption and replication.
  • * Molecular docking studies revealed that several compounds effectively bind to significant Cox B virus proteins, suggesting their ability to inhibit viral enzyme activity, while an ADMET study indicates these compounds meet favorable physicochemical criteria for drug development.
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Anti-Cancer Drug-Induced Lyell's Syndrome: A Series of Two Patients.

Curr Oncol

November 2024

Institut du Cancer Avignon Provence, 250 Chemin de Baigne-Pieds, 84000 Avignon, France.

Article Synopsis
  • Lyell's syndrome, also known as Toxic Epidermal Necrolysis (TEN), is a severe skin condition primarily caused by an allergic reaction to medications.* -
  • Recent developments in cancer treatments, such as targeted therapy and immunotherapy, are increasingly linked to cases of Lyell's syndrome, although traditional anti-cancer drugs were less frequently associated.* -
  • Two case studies illustrate TEN occurring in patients undergoing treatment for metastatic cancers with new therapies; unfortunately, both patients succumbed to the condition despite prompt medical intervention.*
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  • The study investigates the prevalence of the HLA-B*58:01 allele, which is linked to severe skin reactions from allopurinol, among gout patients in Malaysia's multiethnic population.
  • A total of 547 patients from Malay, Chinese, and Indian backgrounds were tested, revealing an overall allele prevalence of 16.8%, with the highest at 21.8% in Chinese patients.
  • Notably, despite having the HLA-B*58:01 allele, none of the patients who used allopurinol developed severe cutaneous reactions, indicating the need for a better predictive model for these reactions.
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Article Synopsis
  • - Severe cutaneous adverse reactions (SCARs) like AGEP, DRESS, SJS, and TEN are serious conditions associated with high mortality rates, and while corticosteroids are commonly used for treatment, their effectiveness is uncertain due to infection risks.
  • - Recent studies have introduced TNF-α inhibitors, which have shown promise in treating SCARs, with a report indicating that four patients (21-54 years old) treated with these inhibitors had successful recoveries without complications.
  • - The TNF-α inhibitors work by targeting the harmful immune response linked to SCARs, but more large-scale trials are needed to confirm their efficacy and ensure a safe approach to their use.
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Article Synopsis
  • An 11-year-old girl developed severe Grade IV skin graft-versus-host disease resembling toxic epidermal necrolysis after receiving hematopoietic progenitor cell transplantation from a fully compatible unrelated donor.
  • On the 35th day post-transplant, she exhibited rash-like lesions, and a skin biopsy confirmed a diagnosis of TEN-like acute cutaneous GVHD, highlighting serious skin damage and inflammation.
  • After adjusting her immunosuppressant medications, the patient achieved an 80% reduction in symptoms, indicating a positive response to treatment.
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Lyell syndrome, also known as toxic epidermal necrolysis (TEN), is a rare but life-threatening skin condition, often triggered by certain medications. Antiepileptics, allopurinol, and some nonsteroidal anti-inflammatory drugs are the most common causes. Some antibiotics are also common culprits, although tetracyclines are rarely linked to this condition.

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Efficacy of ChatGPT in Educating Patients and Clinicians About Skin Toxicities Associated With Cancer Treatment.

JMIR Dermatol

November 2024

Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98th St, 5th Floor, New York, NY, 10029, United States, 1 212-241-9728.

This study investigates the application of ChatGPT, an artificial intelligence tool, in providing information on skin toxicities associated with cancer treatments, highlighting that while ChatGPT can serve as a valuable resource for clinicians, its use for patient education requires careful consideration due to the complex nature of the information provided.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare severe cutaneous adverse drug reaction associated with multi-organ involvement and long-term sequelae. Human herpesviridae species reactivation has been observed, however, risk factors for reactivation and its impact on the clinical course and outcomes is unclear. We aimed to explore the impact of viral reactivation on DRESS on clinical outcomes and to identify potential risk factors for reactivation.

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[A rare side effect of antithyroid drug therapy].

Praxis (Bern 1994)

October 2024

Klinik für Endokrinologie, Diabetologie, Osteologie und Stoffwechselerkrankungen, Kantonsspital St. Gallen.

We report a case of Graves' disease in a patient who initially received carbimazole therapy, which was switched to propylthiouracil due to adverse effects. After 14 months of propylthiouracil therapy, the patient developed cutaneous ANCA-associated vasculitis. Prompt cessation of propylthiouracil and topical treatment led to complete resolution of the skin lesions.

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