7,423 results match your criteria: "Drexel University College of Medicine[Affiliation]"

Residency websites can often be crucial for influencing neurosurgery applicants' first impressions of programs. This study explores the representation of diversity on neurological surgery residency program websites and evaluates the impact of Diversity, Equity, and Inclusion (DEI) statements. The websites of 117 neurological surgery residency programs were evaluated for the presence of 12 diversity and inclusion elements.

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Background: Both chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) confer a high risk of cardiovascular disease and mortality. These entities frequently coincide. The separate and joint impact of CKD and T2DM on the risk of major cardiovascular events (MACE) and survival is unclear.

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A 70-year-old female underwent open reduction and internal fixation (ORIF) of her right ankle following a mechanical trip and fell two weeks before hospital admission. Two weeks following surgery, the patient experienced sudden-onset bilateral anterior thigh paresthesias and burning mid-back pain. Over the ensuing two days, the patient developed bilateral lower extremity weakness, bilateral lower extremity numbness, and urinary retention with constipation, which led to hospital presentation.

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Chimeric antigen receptor (CAR) T-cell therapy has transformed treatment of refractory B-cell malignancies; however, treatment puts patients at risk for side effects secondary to the amplified immune response it induces. Fulminant cerebral edema (FCE) is one of the rarest, yet most devastating side effects following CAR T-cell therapy. Due to this rarity, FCE has not been well characterized and the risk factors associated with its development are not fully understood.

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Fidgetin binds spastin to attenuate the microtubule-severing activity.

Biochim Biophys Acta Mol Cell Res

December 2024

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address:

Microtubule-severing enzymes such as spastin, katanin, and fidgetin, characterized by their AAA ATPase domains, are pivotal in modulating microtubule dynamics and behavior across various cellular processes. While spastin and katanin are recognized for their predominant and robust severing of stable microtubules, thereby enhancing microtubule turnover, fidgetin exhibits comparatively weaker severing activity and selectively targets labile microtubules. The interplay among these enzymes and their mutual regulatory mechanisms remains inadequately understood.

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Imaging of gallstones and complications.

Curr Probl Diagn Radiol

December 2024

Department of Radiology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA. Electronic address:

Gallbladder pathologies caused by gallstones are commonly encountered in clinical practice, making accurate diagnosis critical for effective patient management. Radiologists play a key role in differentiating these conditions through imaging interpretation, ensuring that appropriate treatment is initiated. The imaging features of gallstone associated diseases are classified into various categories, such as inflammatory conditions, benign lesions, malignant tumors, and associated complications.

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Background: Non-small cell lung cancer (NSCLC) patients often develop brain metastases (BMs), complicating management. We have shown that increasing frailty is associated with decreased overall survival (OS) and central nervous system progression free survival (PFS) for patients undergoing stereotactic radiosurgery (SRS) to BMs. Leveraging the International Radiosurgery Research Foundation, we sought to expand upon these findings, in NSCLC specifically.

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Topic: Autoimmune retinopathy (AIR) is a group of rare inflammatory diseases treated with immunosuppression; however, there is no treatment consensus. This meta-analysis and review aims to investigate treatment effectiveness in slowing AIR progression.

Clinical Relevance: Autoimmune retinopathy is a group of diseases characterized by progressive vision loss that is both difficult to diagnose and treat.

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Endoscopic and microscopic video modules are effective for teaching middle ear anatomy.

Laryngoscope Investig Otolaryngol

December 2024

Department of Otolaryngology-Head and Neck Surgery Mass Eye and Ear Boston Massachusetts USA.

Objectives: To evaluate the efficacy of video modules in improving trainees' objective knowledge of middle ear anatomy and to compare the efficacy of using the endoscope to the microscope in video modules.

Methods: Medical students and residents were recruited. Two videos reviewing middle ear anatomy were developed.

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Cervical radicular pain following anterior cervical discectomy and fusion (ACDF) is a challenging condition, particularly in the presence of hardware complications. This case report discusses the successful use of a cervical interlaminar steroid injection to alleviate radicular pain in a patient who presented with a fractured screw following C6/7 ACDF. The patient's symptoms, treatment plan, and outcome are reviewed, highlighting the success of an interlaminar steroid injection in managing radicular pain until the patient could receive corrective surgery.

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Article Synopsis
  • A retrospective cohort study aimed to compare three socioeconomic status (SES) indexes and their association with outcomes after anterior cervical discectomy and fusion (ACDF) or lumbar fusion.
  • The study involved identifying adult patients who underwent these surgeries at a medical center from 2014 to 2020, analyzing their preoperative conditions and outcomes based on SES classifications derived from community-level indexes.
  • Results indicated that while patients from lower SES communities had worse preoperative outcomes, the community-wide SES indexes were ineffective in predicting surgical outcomes post-surgery.
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Central Pathology in Spasmodic Dysphonia.

J Voice

December 2024

Drexel University College of Medicine, Philadelphia, Pennsylvania, USA; Department of Otolaryngology Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. Electronic address:

Introduction: Spasmodic dysphonia a voice disorder characterized by loss of voluntary control of vocal fold movements during speech production. The pathophysiology is not well understood, but there have been proposed connections to areas within the brain such as the reticular formation surrounding the tractus solitarius, spinal trigeminal and ambiguus nuclei, inferior olive, and pyramids.

Objective: To determine whether there are differences on brain Magnetic resonance imaging (MRI) with and without gadolinium in patients affected by spasmodic dysphonia compared with those without to determine whether there is a central process involved in spasmodic dysphonia (SD) pathophysiology.

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Objectives: This study explores how ambulatory medical practices adapted their policies in response to the global COVID-19 crisis. Practice and provider characteristics were used to build an artificial intelligence model that predicts future medical practice closures during critical events.

Methods: We surveyed 261 outpatient medical practices and collected information on clinician age, gender, the protective measures implemented, closure status, and utilization of telemedicine services.

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Ecological Psychology: A Framework for Mentoring and Career Development in Academic Medicine.

Acad Med

December 2024

J.A. Cleland is vice dean for education and director, Medical Education Research & Scholarship Unit, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Effective mentoring can help individuals navigate the complex, dynamic environment of academic medicine as they work to develop meaningful and fulfilling careers. Despite robust research into the characteristics of effective mentoring relationships and successful mentoring programs, resources that support mentors and mentees in engaging in career development in academic medicine are limited. Ecological psychology, a theory focusing on how the dynamic interplay between individuals and their environment influences cognition and behavior, offers a promising framework for exploring how mentors and mentees can support positive career development outcomes.

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Minimally Invasive Sternocleidomastoid Muscle Thinning for Cervical Feminization.

Facial Plast Surg Aesthet Med

December 2024

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, USA.

At present, there is no gender-affirming facial surgery that offers feminization of the lateral neck. To demonstrate reliable relationship between the great auricular nerve point (GAP) and spinal accessory nerve along the sternocleidomastoid muscle (SCM) in human anatomical specimens and demonstrate feasibility of muscle transection in one transgender female patient. A total of 14 human anatomical specimen dissections were performed to determine if a transection of the SCM perpendicular to the GAP could be performed without potential compromise of the spinal accessory nerve.

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Remnant cholesterol and long-term incidence of death in coronary artery disease patients.

Atherosclerosis

November 2024

VIVIT-Institute, Academic Teaching Hospital Feldkirch, Feldkirch, Austria; Private University in the Principality of Liechtenstein, Triesen, Liechtenstein; Drexel University College of Medicine, Philadelphia, PA, USA.

Article Synopsis
  • Remnant cholesterol (RC) has gained attention as a potential lipid factor for assessing cardiovascular risk, though previous data were often imprecise due to factors like non-fasting samples.
  • In a study involving 1,474 CAD patients, researchers measured RC using strictly fasting samples and tracked all-cause and cardiovascular mortality, along with major adverse cardiovascular events (MACE), over an average follow-up of 11.6 years.
  • The results indicated that higher RC levels were significantly associated with increased risks of all-cause mortality, cardiovascular mortality, and MACE, regardless of patient demographics or statin use, establishing RC as a reliable indicator of residual risk in CAD patients.
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  • * In a study using EcoHIV mouse models, researchers found that HIV infection enhances cocaine locomotor sensitization and induces changes in astrocytes, specifically an increase in Sox9 expression in the NAc.
  • * Chemogenetic activation of NAc astrocytes showed potential in reversing the effects of EcoHIV on cocaine sensitization, suggesting that targeting these astrocytes could offer strategies for managing cocaine-related behaviors in PLWH.
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  • - Parkinson's disease involves the loss of dopamine-producing neurons, leading to disrupted brain circuitry that negatively impacts both cognitive function and decision-making behavior due to elevated glutamate levels.
  • - The study investigates GTS467, a drug that activates an important transporter responsible for clearing excess glutamate, hypothesizing it could mitigate cognitive deficits without increasing impulsivity in PD patients.
  • - Chronic treatment with GTS467 in rat models showed improved task performance and reduced impulsive actions, alongside beneficial changes in glutamate levels and gene expression related to brain health, supporting its potential as a therapeutic option for PD.
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  • The study analyzes data from the Kids-DOTT trial to investigate the treatment and outcomes of children with cerebral sinovenous thrombosis (CSVT) compared to those with other types of venous thromboembolism (VTE).
  • CSVT was found to be more common in neonates and young children, often linked to infections, while treatment involved varying durations of anticoagulation, with no significant difference in outcomes between 6 weeks and longer treatments.
  • The findings suggest that 6 weeks of anticoagulant therapy is safe and effective for treating acute pediatric CSVT, but caution is advised in generalizing results due to the nature of subgroup analysis.
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  • - Psoriatic arthritis (PsA) is a long-term inflammatory disease that requires ongoing treatment, with options like guselkumab and IL-17A inhibitors (ixekizumab, secukinumab) approved for use in adults by the FDA.
  • - A retrospective analysis studied adults with PsA who started treatment with either guselkumab or IL-17A inhibitors, assessing how long they continued their therapy based on insurance claims data from July 2020 to June 2022.
  • - Results showed that patients on guselkumab were significantly more likely to stick with their treatment for at least a year compared to those on IL-17A inhibitors, with longer median persistence and lower discontinuation rates for the gus
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Objective: Innovations in robotics continue to reshape the landscape of neurosurgery. Here, the authors evaluated the safety and efficacy of the ExcelsiusGPS robot in the treatment of neuro-oncological, intracranial lesions.

Methods: The authors conducted a retrospective analysis of 19 consecutive adult patients with a neuro-oncological diagnosis who underwent intracranial biopsy and/or laser interstitial thermal therapy (LITT) with the assistance of the ExcelsiusGPS robot and intraoperative CT.

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Article Synopsis
  • Mepolizumab is effective for eosinophil-associated disorders like eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), but traditional treatments often fall short and have side effects.
  • The study aimed to analyze adverse reactions related to mepolizumab in CRSwNP patients by using data from the FDA Adverse Event Reporting System between Q1 2021 and Q1 2023.
  • Results indicated that CRSwNP patients experienced significantly fewer adverse reactions compared to asthma patients, with common issues being pulmonary, generalized, neurologic, and hematologic, and concurrent asthma treatment raised the risk for serious reactions in CRSwNP cases.
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