Enhancing the mechanical properties' performances coconut fiber and CDW composite in paver block: multiple AI techniques with a Performance analysis.

The present research incorporates five AI methods to enhance and forecast the characteristics of building envelopes. In this study, Response Surface Methodology (RSM), Support Vector Machine (SVM), Gradient Boosting (GB), Artificial Neural Networks (ANN), and Random Forest (RF) machine learning method for optimization and predicting the mechanical properties of natural fiber addition incorporated with construction and demolition waste (CDW) as replacement of Fine Aggregate in Paver blocks. In this study, factors considered were cement content, natural fine aggregate, CDW, and coconut fibre, while the resulting measure was the machinal properties of the paver blocks.

Tumor microenvironment-responsive nanoformulations for breast cancer.

Nanomedicine, the most promising approach for regulated and targeted drug delivery, is frequently applied in cancer treatment. Essentially, accumulating evidence indicates that nanomedicine has positive results in the treatment of breast cancer (BC), with many BC patients benefiting from nanomedicine-related treatments. Currently, nanodrug delivery systems based on stimulus responses are gaining popularity because of their additional ability to manage drug release depending on the interior environment of the cancer.

Proton -conducting lanthanide metal-organic frameworks: a multifunctional platform.

Lanthanide metal-organic frameworks (LMOFs) have established themselves as promising proton-conducting materials among all types of porous coordination polymers and covalent organic frameworks. The structural diversity of LMOFs and high oxophilicity with a high coordination number of lanthanide ions make LMOFs a standout material for proton conduction. In the last few years, ample research efforts have been devoted to designing and developing proton-conducting lanthanide metal-organic frameworks (PCLMOFs).

Sources of bias in studies reporting birth prevalence of congenital anomalies: a scoping review and reporting checklist.

Background: Data on the birth prevalence of congenital anomalies in low- and middle-income countries report wide variations in prevalence estimates. We conducted a scoping review to identify the sources of bias in studies reporting birth prevalence of congenital anomalies in World Health Organization South-East Asia region (SEAR) countries.

Methods: PubMed and Google Scholar databases were screened for relevant literature.

Group Antenatal Care Start-Up in the Indian Private Sector: An Implementation Journey to Improve Quality of Care.

Introduction: The introduction of the innovative group antenatal and postnatal care model into the private health sector in India has the potential to pivot the experiences of families during pregnancy and beyond. Growing evidence worldwide shows this model moves fragmented healthcare systems toward a more integrated model to improve quality in care and outcomes for mothers and children. The aim of this study was to better understand the challenges and benefits of implementation of the group model of antenatal care in the Indian private health sector for the purpose of improving quality of care.

A review on recent progress in polymer composites for effective electromagnetic interference shielding properties - structures, process, and sustainability approaches.

The rapid proliferation and extensive use of electronic devices have resulted in a meteoric increase in electromagnetic interference (EMI), which causes electronic devices to malfunction. The quest for the best shielding material to overcome EMI is boundless. This pursuit has taken different directions, right from materials to structures to process, up to the concept of sustainable materials.

Investigating wall shear stress and the static pressure in bone scaffolds: a study of porosity and fluid flow dynamics.

In bone tissue engineering, scaffolds are crucial as they provide a suitable structure for cell proliferation. Transporting Dulbecco's Modified Eagle Medium (DMEM) to the cells and regulating the scaffold's biocompatibility are both controlled by the dynamics of the fluid passing through the scaffold pores. Scaffold design selection and modeling are thus important in tissue engineering to achieve successful bone regeneration.

Bio-mechanical analysis of porous Ti-6Al-4V scaffold: a comprehensive review on unit cell structures in orthopaedic application.

A scaffold is a three-dimensional porous structure that is used as a template to provide structural support for cell adhesion and the formation of new cells. Metallic cellular scaffolds are a good choice as a replacement for human bones in orthopaedic implants, which enhances the quality and longevity of human life. In contrast to conventional methods that produce irregular pore distributions, 3D printing, or additive manufacturing, is characterized by high precision and controlled manufacturing processes.

Anxiolytic and Antianhedonic-like Effects of Leaf in Alcohol-Withdrawn Mice.

Objectives: Alcohol withdrawal syndrome manifests through a range of symptoms, including anxiety and anhedonia, significantly affecting the quality of life of those affected. This study investigates the potential therapeutic effects of the methanolic extract of leaves (MPG) on anxiety and anhedonia in Swiss albino female mice undergoing alcohol withdrawal.

Methods: Four groups of mice underwent alcohol withdrawal, with one group undergoing saline withdrawal as a control.

A multicomponent nanosystem for capturing circulating tumor cells from cancer patients with PD-L1 as an immunotherapy oncotarget.

Capturing circulating tumor cells (CTCs) from the peripheral blood of cancer patients, where they are disseminated among billions of other blood cells, is one of the most daunting challenge. We report OncoDiscover®, a multicomponent nano-system consisting of iron oxide (FeO) nanoparticles (NPs), polyamidoamine generation 4 dendrimers (PAMAM-G4-NH), graphene oxide (GO) sheets and an anti-epithelial cell adhesion molecule (anti-EpCAM) antibody (Fe-GSH-PAMAM-GO-EpCAM) for the selective and precise capture of CTCs. We further evaluated this system for therapeutically important oncotargets, exemplifying overexpression of the programmed death ligand 1 (PD-L1) as a functional assay on CTCs in cancer patients.

Deep Learning for Automatic Knee Osteoarthritis Severity Grading and Classification.

Introduction: Knee osteoarthritis (OA) is a prevalent condition that significantly impacts the quality of life, often leading to the need for knee replacement surgery. Accurate and timely identification of knee degeneration is crucial for effective treatment and management. Traditional methods of diagnosing OA rely heavily on radiological assessments, which can be time-consuming and subjective.

H, N and C resonance assignments of the S2A and H64A double mutant of human carbonic anhydrase II.

Protein-water interactions profoundly influence protein structure and dynamics. Consequently, the function of many biomacromolecules is directly related to the presence and exchange of water molecules. While structural water molecules can be readily identified through X-ray crystallography, the dynamics within functional protein-water networks remain largely elusive.

Real-time sign language detection: Empowering the disabled community.

Interaction and communication for normal human beings are easier than for a person with disabilities like speaking and hearing who may face communication problems with other people. Sign Language helps reduce this communication gap between a normal and disabled person. The prior solutions proposed using several deep learning techniques, such as Convolutional Neural Networks, Support Vector Machines, and K-Nearest Neighbors, have either demonstrated low accuracy or have not been implemented as real-time working systems.

Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies.

Background: Phytochemicals and their derivatives are promising target drugs for various ailments and have served as therapeutic agents for several decades. Using in vivo and in vitro models and molecular docking, this study investigated the pharmacological potential of a flavonoid-rich fraction of the ethanolic extract of Sesbania grandiflora (SG).

Objectives: This research aimed to determine whether flavonoid-rich whole-plant extracts of SGs have any cytoprotective or in vivo hepatoprotective effects.

A solution-processable benzothiazole-substituted formazanate zinc(II) complex designed for a robust resistive memory device.

A novel mononuclear bis(formazanate)zinc complex (1) based on a redox-active 1-(benzothiazol-2-yl)-5-(2-benzoyl-4-chlorophenyl)-3-phenyl formazan ligand has been synthesized and characterized. Complex 1 was prepared by reacting one equivalent of Zn(OCOCH)·2HO with two equivalents of the corresponding formazan derivative. X-ray crystallography was employed to ascertain the solid-state structure of compound 1, and the analysis revealed a distorted octahedral geometry for the complex where the symmetrical ligands exhibit a preference for coordinating with the zinc center in the 'open' form, generating five-membered chelate rings.

Co(II)-Cu(II) mixed-oxide catalysts for single-step synthesis of 2,4,5-triaryl-1-imidazole derivatives under microwave irradiation.

In this study, a catalyst composite of Co-Cu was prepared from chloride-containing precursor of Co(II) and Cu(II) metals using the milky latex of the plant following green principles of synthesis. The catalyst composite was characterized using XRD, EDAX, SEM, HR-TEM, FTIR, XPS and TOF-MS. The crystallinity of the mixed-oxide composite with a distorted octahedral nature was confirmed from analysis.

Sensing the future: A review on emerging technologies for assessing and monitoring bone health.

Bone health is crucial at all stages of life. Several medical conditions and changes in lifestyle affect the growth, structure, and functions of bones. This may lead to the development of bone degenerative disorders, such as osteoporosis, osteoarthritis, rheumatoid arthritis, etc.

Evaluating the Feasibility of Short Dental Implants as Alternatives to Long Dental Implants in Mandibular Bone: A Finite Element Study.

This study uses finite element analysis to investigate the potential application of shorter dental implants as a substitute for longer implants in the lower jaw (mandible). FEA allows the evaluation of the stress patterns around the implant-bone interface, a critical factor for successful osseointegration. Ten models were generated, encompassing five long (L1-L5) and five short implant models (S1-S5) with variations in diameter and length.

Elucidating the Intricate Roles of Gut and Breast Microbiomes in Breast Cancer Metastasis to the Bone.

Background: Breast cancer is the most predominant and heterogeneous cancer in women. Moreover, breast cancer has a high prevalence to metastasize to distant organs, such as the brain, lungs, and bones. Patients with breast cancer metastasis to the bones have poor overall and relapse-free survival.

Acute and subacute oral toxicity evaluation of Ayurvedic formulation in rats.

Ayurveda is one of the oldest systems of traditional medicine that provides treatments for a wide range of acute and chronic health problems. It is a common myth amongst people that Ayurvedic drugs have no side effects, whereas the fact is that these drugs can cause adverse effects. Despite their wide use, the safety data of many Ayurvedic formulations are still unavailable.

Corrigendum to "Different pre-treatments and kinetic models for bioethanol production from lignocellulosic biomass: A review" [Heliyon 9(6) June 2023 e16604].

[This corrects the article DOI: 10.1016/j.heliyon.

Evaluating the influence of ambient conditions in the cooking space of railway pantry car using selected thermal indices and physiological parameter.

Background: Hot and humid indoor environment of the kitchen affects worker performance. The Indian Railway's pantry car culinary is one of them that cooks food for the on-board passengers, which could be bothered by the hot indoor climate.

Objective: The current study aimed to identify the indoor working environment of the railway "pantry car" using heat stress indices such as "Universal Thermal Climate Index-UTCI," "Wet-Bulb Globe Temperature-WBGT," "Discomfort Index-DI," "Tropical Summer Index-TSI," "Heat Index-HI," and Heart Rate-HR with clothing insulation.

An overview of Skp2: a promising new therapeutic target of psoriasis.

Introduction: Psoriasis is a chronic immune-mediated disorder affecting over 2-3% of the population worldwide, significantly impacting quality of life. Despite the availability of various therapeutic interventions, concerns persist regarding lesion recurrence and potential alterations in immune surveillance promoting cancer progression. Recent advancements in understanding cellular and molecular pathways have unveiled key factors in psoriasis etiology, including IL-17, 22, 23, TNF-α, PDE-4, JAK-STAT inhibitors, and AhR agonists.

Role of Biosynthesis and Catabolism of Neurotransmitters in Drug Discovery for Anxiety and Depression.

The purpose of this review is to correlate the probable causes of anxiety disorders with the imbalance of neurotransmitters in the brain and also highlight the drugs for these mental disorders that have been discovered based on the biosynthesis and catabolism of these brain chemicals. Peer-reviewed journal's articles, news and books published in English between 1997 and 2023 describing the role of neurotransmitters in anxiety disorders were searched in Google Scholar, Research Gate and PubMed databases. The contents were carefully analyzed by the authors and understood and compiled to build a concise perspective on the role of biosynthesis and catabolism of neurotransmitters in anxiety and depression.