Engineered photonic near-infrared light activated photothermal theranostic nanovaccine induced targeted remodeling of tumor microenvironment.

Tumor recurrence, which happens as a result of persisting tumor cells and minor lesions after treatments like surgery and chemotherapy, is a major problem in oncology. Herein, a strategy to combat this issue by utilize a theranostic nanovaccine composed of photonic HCuS. This nanovaccine aims to eradicate cancer cells and their traces while also preventing tumor recurrence via optimizing the photothermal immune impact.

Development of Promising Flower-like Ag/SrFeO Nanosheet Electrode Materials: An Efficient and Selective Electrocatalytic Detection of Caffeic Acid in Coffee and Green Tea.

The development of highly efficient electrocatalytic sensors is necessary for detection in various paramedical and industrial applications. Motivated by this concept, we demonstrate flower-like Ag/SrFeO nanostructures prepared by a facile route to modify electrocatalyst material for the detection of caffeic acid (CA). The surface morphology, phase structure, particle size, and pore volume were investigated through different physicochemical analytical techniques.

The dynamic therapeutic effect of a targeted photothermal nanovaccine incorporating toll-like receptor 7 agonist enhanced cancer immunotherapy.

Photothermal therapy (PTT) is a noninvasive and effective thermal therapeutic approach. Near-infrared (NIR) light responsive organic nanoparticles (NPs) have been shown to enhance the efficacy of cancer PTT. However, photothermal ablation induced NPs are currently more effective in treating primary and metastatic cancer.

One-Pot Synthesis of Silver Nanoparticles Derived from Aqueous Leaf Extract of and Their Biological Efficacy.

The main objective of the present research work is to assess the biological properties of the aqueous plant extract (ACAE) synthesised silver nanoparticles from the herbal plant , and their biological applications. The silver nanoparticle syntheses from Ageratum conyzoides (Ac-AgNPs) were optimised with different parameters, such as pH (2, 4, 6, 8 and 10) and varied silver nitrate concentration (1 mM and 5 mM). Based on the UV-vis spectroscopy analysis of the synthesised silver nanoparticles, the concentration of 5 mM with the pH at 8 was recorded as the peak reduction at 400 nm; and these conditions were optimized were used for further studies.

Computational Analysis of Darcy-Forchheimer Flow of Cu/Al-AlO Hybrid Nanofluid in Water over a Heated Stretchable Plate with Nonlinear Radiation.

The aim of this study is to examine the Darcy-Forchheimer flow = of H2O-based Al-Al2O3/Cu-Al2O3 hybrid nanofluid past a heated stretchable plate including heat consumption/ generation and non-linear radiation impacts. The governing flow equations are formulated using the Naiver-Stokes equation. These flow equations are re-framed by using the befitted transformations.

Thermal Behavior of the Time-Dependent Radiative Flow of Water-Based CNTs/Au Nanoparticles Past a Riga Plate with Entropy Optimization and Multiple Slip Conditions.

This communication deliberates the time-reliant and Darcy-Forchheimer flow of water-based CNTs/gold nanoparticles past a Riga plate. In addition, nonlinear radiation, heat consumption and multiple slip conditions are considered. Entropy generation is computed through various flow parameters.

Stigmasterol- an Acetylcholinesterase Inhibitor from with relevance to Alzheimer's disease Therapy.

This study observed screening, purification and identification of cholinesterase inhibitors from the microalgae . Mixed microalgal culture was screened from freshwater samples for sp. Single colony was purified and authenticated as .

RGO nanosheet wrapped β-phase NiCuS nanorods for advanced supercapacitor applications.

A new integration strategy of transition metal sulfide with carbon-based materials is used to boost its catalytic property and electrochemical performances in supercapacitor application. Herein, crystalline reduced graphene oxide (rGO) wrapped ternary metal sulfide nanorod composites with different rGO ratios are synthesized using hydrothermal technique and are compared for their physical, chemical, and electrochemical performances. It is found that their properties are tuned by the weight ratios of rGO.

Investigation on Thermally Radiative Mixed Convective Flow of Carbon Nanotubes/ Nanofluid in Water Past a Stretching Plate with Joule Heating and Viscous Dissipation.

The nature of this prevailing inquisition is to scrutinize the repercussion of MHD mixed convective flow of CNTs/Al2O3 nanofluid in water past a heated stretchy plate with injection/suction, heat consumption and radiation. The Joule heating and viscous dissipation are included in our investigation. The Navier-Stokes equations are implemented to frame the governing flow expressions.

Bio-Inspired Graphitic Carbon-Based Large-Area (10 × 10 cm) Perovskite Solar Cells: Stability Assessments under Indoor, Outdoor, and Water-Soaked Conditions.

In the emerging photovoltaic (PV) technologies, the golden triangle rule includes higher efficiency, longevity (or stability), and low cost, which are the foremost criteria for the root of commercial feasibility. Accordingly, a unique low-cost, ecofriendly, all-solution-processed, "bio-inspired" graphitic carbon (extracted from the most invasive plant species of : listed as one of the 100 most dangerous species by the International Union for Conservation of Nature) and a mixed halide perovskite interface-engineered, unique single-cell large-scale (10 × 10 sq.cm with an active area of 88 cm) carbon-based perovskite solar cell (C-PSC) are demonstrated for the first time, delivering a maximum PCE of 6.

Comparison of three different structures of zeolites prepared by template-free hydrothermal method and its CO adsorption properties.

In this study, zeolite sodalite SOD (50NaO:AlO:5SiO), zeolite LTA (2NaO:AlO:1.926SiO) and zeolite FAU (16NaO:AlO:4SiO) of different structures were synthesized successfully through simple conventional hydrothermal crystallization technique without using any template agent. Morphological analysis of three different types of zeolites revealed that the samples exhibit three different shapes such as the "Raspberry-like", "Dice" cube like and "Octahedral" shaped morphology respectively.

Green synthesis of gold nanoparticles using Gracilaria crassa leaf extract and their ecotoxicological potential: Issues to be considered.

The use of vegetal species for gold nanoparticles (AuNPs) biosynthesis can constitute an alternative to replacing the extensive use of several hazardous chemicals commonly used during NPs synthesis and, therefore, can reduce biological impacts induced by the release of these products into the natural environment. However, the "green nanoparticles" and/or "eco-friendly nanoparticles" label does not ensure that biosynthesized NPs are harmless to non-target organisms. Thus, we aimed to synthesize AuNPs from seaweed Gracilaria crassa aqueous extract through an eco-friendly, fast, one-pot synthetic route.

TiO/AgO composites by one step photo reduction technique as electron transport layers (ETL) for dye-sensitized solar cells.

Dye-sensitized solar cell's electron transport layer is responsible for transporting photo-generated electrons to the outer circuit. Utilizing localized surface plasmon resonance (SPR), light absorption could be enhanced to a greater degree, which can drive dye molecules to excited state more effectively than far-field light. In this work, TiO nanoparticles were prepared by solvothermal method, and Ag nanoparticles were decorated over TiO surface through photodeposition method.

Biomimetic development of chitosan and sodium alginate-based nanocomposites contains zirconia for tissue engineering applications.

Nanostructured materials possess unique structural and functional properties that play a crucial position in tissue engineering applications. Present investigation is aimed to synthesize chitosan-sodium alginate (CS) nanocomposite using hydrothermally prepared zirconia nanoparticles. In this, three different weight percentages of (0.

Biodegradation of Endosulfan-a Chlorinated Cyclodiene Pesticide by Indigenous Pseudomonas sp. MSCAS BT01.

Endosulfan remains as a lipophilic insecticide that causes serious medical problems because of biological stability and toxicity also found in air, water, soil sediments, and foodstuffs. Henceforward, the present study reveals a novel bacterial species isolated from pesticide-contaminated soil for enhanced endosulfan degradation. Next, isolated bacterial species was characterized with biochemical assays and 16S rRNA sequencing technique.

Mycofabrication of AgONPs derived from Aspergillus terreus FC36AY1 and its potent antimicrobial, antioxidant, and anti-angiogenesis activities.

Background: There is an emergency need for the natural therapeutic agents to treat arious life threatening diseases such as cardio- vascular disease, Rheumatoid arthritis and cancer. Among these diseases, cancer is found to be the second life threatening disease; in this view the present study focused to synthesize the silver oxide nanoparticles (AgONPs) from endophytic fungus.

Methods: The endophytic fungus was isolated from a medicinal tree Aegle marmelos (Vilva tree) and the potential strain was screened through antagonistic activity.

Preparation and Characterization of Mg Doped ZnAI₂O₄Spinel Nanoparticles.

In the present study, combustion technique is adopted to study the impact of Mg ion doping on ZnAI₂O₄ nanoparticles (NPs). L-arginine is used as a fuel component. The Mg ions play a pivotal role in persuading various characteristics of ZnAI₂O₄ NPs.

ZnO nanoparticles as efficient sunlight driven photocatalyst prepared by solution combustion method involved lime juice as biofuel.

We have prepared high purity Zinc oxide (ZnO) nanoparticles (NPs) by solution combustion synthesis (SCS) method with the aid of lime juice extract. From powder X-ray diffraction (XRD) spectra, it is observed that the ZnO NPs possess single phase, hexagonal wurzite structure with sharp intense peak at (101) plane, agrees with the planes of SAED pattern. Further, the crystallite size is found to be around 18 nm.

Development of CuAlO-Encapsulated Reduced Graphene Oxide Nanocomposites: An Efficient and Selective Electrocatalyst for Detection of Neurodegenerative Disorders.

Carbon-based nanomaterials continue to simulate wide interest in diverse disciplines including electrochemical biosensors, which have great ability to function as next-generation clinical diagnostics. Motivated by this point, we for the first time developed a CuAlO-encapsulated reduced graphene oxide (rGO) nanocomposite by a facile wet-chemical process to modify a glassy carbon electrode for dopamine detection with high selectivity and good sensitivity. The size, shape, phase purity, chemical composition, and surface area were investigated for the samples through transmission electron microscopy, scanning electron microscopy, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and Brunauer-Emmett-Teller analysis.

Extremely-randomized-tree-based Prediction of N-Methyladenosine Sites in .

Introduction: N-methyladenosine (m6A) is one of the most common post-transcriptional modifications in RNA, which has been related to several biological processes. The accurate prediction of m6A sites from RNA sequences is one of the challenging tasks in computational biology. Several computational methods utilizing machine-learning algorithms have been proposed that accelerate screening of m6A sites, thereby drastically reducing the experimental time and labor costs involved.

Efficient and tunable shape selective synthesis of Ag/CeO nanostructures modified highly stable SERS substrate for ultrasensitive detection of pesticides on the surface of an apple.

Detection of pesticide residues from fruits and vegetables is of significant importance to ensuring human health and environmental safety. An efficient and tunable shape-selective synthesis of Ag/CeO nanostructures as an active flexible SERS substrate for the detection of thiram on an apple surface a paste, peel off, and paste again process was performed. The well-controlled formation of silver assembled CeO microspheres constituting nanospheres and nanospindles with an average size of approximately 56 and 32 nm with anisotropic structures has been confirmed through morphological and crystallographic analysis.

Genetic risk factors for lumbar disc disease.

Aim And Background: Lumbar disc degeneration (LDD) is thought to be multifactorial in origin. Very recently the focus has shifted to the involvement of a family of candidate genes in the pathogenesis of LDD. There is particular emphasis on the vitamin D receptor gene (VDR gene).

Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors.

Background: Insulinoma-associated protein 1 (INSM1), a transcriptional regulator with a zinc-finger DNA-binding domain, has been validated as a cytoplasmic marker for neuroendocrine differentiation of tumor cells. Next to its abundant expression in the fetal pancreas, it is expressed in brain tumors, pheochromocytomas, medullary thyroid carcinomas, insulinomas and pituitary and small-cell lung carcinomas. INSM1 is not expressed in normal adult tissues and/or most non-neuroendocrine tumors.

Biomimetic TiO-chitosan/sodium alginate blended nanocomposite scaffolds for tissue engineering applications.

The study is aimed to synthesize potent metal oxide based biomimetic nanocomposites to overcome the risk associated with artificial bone tissue engineering. High purity TiO nanoparticles are synthesized via hydrothermal route. A biomimetic nanocomposite scaffolds containing chitosan-sodium alginate (4: 4) blended with three different (0.