A cross-sectional study on assessing depression among hemodialysis patients.

Depression is the most common disorder of psychiatric illness experienced by hemodialysis patients. Failure to measure depression may diminish their well-being. The main objective of this study is to assess depression in hemodialysis patients.

An Unnecessary Russell's Viper Bite on the Tongue Due to Live Snake Worship and Dangerous First Aid Emphasise the Urgent Need for Stringent Policies.

India suffers the highest incidence of snakebite envenomation (SBE) in the world. Rural communities within India and other countries have long-held cultural beliefs surrounding snakes and SBE treatments, with snake statues present in numerous Hindu temples. While most cultural beliefs are well respected and do not affect anyone, some people worship live venomous snakes without any safety precautions.

Molecular docking analysis of flavonoids with aldose reductase.

Diabetes mellitus is a group of metabolic disorders that has risen to become the third most common cause in humans in recent years. The development of new bioactive substances from natural sources is a relatively new area. Flavonoids are believed to have a variety of beneficial properties in nature, including anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, and anti-HIV properties.

Molecular docking analysis of metformin analogues with GSK-3β.

We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis (methyl-biguanide hydrochloride] with GSK3.

COVID-19 outbreak data analysis and prediction.

Covid-19 is a novel pandemic disease with no potential vaccine treatment or medicine, the world is facing currently as of now. The death toll has increased to several lakhs and recovery rate is comparatively very less, was initially spotted in Wuhan (China). This spreads through close contact with people and socializing.

Natural Products as the Modulators of Oxidative Stress: An Herbal Approach in the Management of Prostate Cancer.

Prostate cancer is the most commonly diagnosed and frequently occurred cancer in the males globally. The current treatment strategies available to treat prostate cancer are not much effective and express various adverse effects. Hence, there is an urgent need to identify novel treatment that can improve patient outcome.

Peptide-based direct electrochemical detection of receptor binding domains of SARS-CoV-2 spike protein in pristine samples.

RNA isolation and amplification-free user-friendly detection of SARS-CoV-2 is the need of hour especially at resource limited settings. Herein, we devised the peptides of human angiotensin converting enzyme-2 (ACE-2) as bioreceptor at electrode interface for selective targeting of receptor binding domains (RBD) of SARS-CoV-2 spike protein (SP). Disposable carbon-screen printed electrode modified with methylene blue (MB) electroadsorbed graphene oxide (GO) has been constructed as cost-efficient and scalable platform for ACE-2 peptide-based SARS-CoV-2 detection.

Does bimanual task training benefit manual ability and hand function of children with bilateral spastic cerebral palsy?

Purpose: Sixty percent of children with bilateral cerebral palsy have impaired hand function. The study's purpose was to examine the benefits of bimanual task practice on the manual ability and hand function of children with bilateral spastic cerebral palsy.

Methods: In this pre-post study design, 18 children with bilateral spastic cerebral palsy with an average age of 11.

Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.

Background And Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).

Microneedle mediated transdermal delivery of β-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia.

Plant-derived 5 α-reductase inhibitors, such as β-sitosterol and phytosterol glycosides, have been used to treat androgenic alopecia, but their oral absolute bioavailability is poor. This study aimed to develop a transdermal drug delivery system of β-sitosterol (BS) using a nanostructured lipid carrier (NLC) incorporated into polymeric microneedles (MN). Using a high-speed homogenization method, NLC was formulated variables were optimized by Box-Behnken statistical design.

Unmet Need for Further LDL-C Lowering in India despite Statin Therapy: Lipid Association of India Recommendations for the Use of Bempedoic Acid.

Lipid-lowering therapy plays a crucial role in reducing adverse cardiovascular (CV) events in patients with established atherosclerotic cardiovascular disease (ASCVD) and familial hypercholesterolemia. Lifestyle interventions along with high-intensity statin therapy are the first-line management strategy followed by ezetimibe. Only about 20-30% of patients who are on maximally tolerated statins reach recommended low-density lipoprotein cholesterol (LDL-C) goals.

A Study on -Fortified Bread: Predicted Glycemic Index and Bioactive Component.

Bread is one of the highest-selling food products throughout the world. Lots of demand arose from the bread producers by the consumers to convert the traditional bread into functional food. In this study, normal bread was converted to functional herbal bread by infusing it with extracts of .

Skin Diseases Classification Using Hybrid AI Based Localization Approach.

One of the most prevalent diseases that can be initially identified by visual inspection and further identified with the use of dermoscopic examination and other testing is skin cancer. Since eye observation provides the earliest opportunity for artificial intelligence to intercept various skin images, some skin lesion classification algorithms based on deep learning and annotated skin photos display improved outcomes. The researcher used a variety of strategies and methods to identify and stop diseases earlier.

Prospect and retrospect of 3D bio-printing.

3D bioprinting has become a popular medical technique in recent years. The most compelling rationale for the development of 3D bioprinting is the paucity of biological structures required for the rehabilitation of missing organs and tissues. They're useful in a multitude of domains, including disease modelling, regenerative medicine, tissue engineering, drug discovery with testing, personalised medicine, organ development, toxicity studies, and implants.

Efficacy of capacity building educational interventions in the management of obstetric complications: A systematic review.

Background: Delay in the diagnosis and management of obstetric complications lead to raised mortality rate. This can be curtailed by appropriate implementation of the educational intervention among the health-care providers. Hence, this review aimed to identify the literature evidence of the efficacy of various educational interventions training in the management of obstetric complications.

Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies.

Gene expression changes are one of the hallmarks of malignant cells and such changes in specific genes have been identified for a variety of human cancers. Such an association in gene expression changes becomes very significant for breast cancers due to the genetic heterogeneity seen in such cancers. It is due to such genetic implication that breast cancers are classified into several subtypes; based on the expression and the magnitude of expression of estrogen and progesterone receptor genes.

The time taken for retrieval of separated instrument and the change in root canal volume after two different techniques using CBCT: An study.

Introduction: Retrieval of separated instrument from a root canal may lead to increased dentin loss and prolonged treatment time.

Aim: The aim of this study was to evaluate the retrieval time and increase in root canal volume after instrument retrieval with two retrieval techniques under dental operating microscope.

Materials And Methods: Forty extracted human mandibular molars with 30°-40° mesiobuccal root canal curvature were selected based on cone-beam computed tomography (CBCT) and divided into two groups (n = 20 each).

Depleting levels of endogenous anti-oxidant superoxide dismutase in oral sub-mucous fibrosis: A systematic review and meta-analysis.

Objective: The systematic review is aimed to assess the antioxidant status by superoxide dismutase level in oral sub-mucous fibrosis using available literature.

Materials And Methods: A literature search was accomplished electronically in Pubmed (MeSH), Science Direct, Scopus, Web of Science core collection, Cochrane, and Cross-reference, using the keywords such as 'oral submucous fibrosis,' 'antioxidant status' and 'superoxide dismutase.'

Results: Of the 352 articles identified, only 16 satisfied the selection criteria and were included in the systematic review.

Development of patient derived organoids for cancer drug screening applications.

Cancer is a disease characterised by abnormal cell growth that can invade or spread to other regions of the body. Organoids are three-dimensional ex vivo tissue cultures made from embryonic stem cells, induced pluripotent stem cells, progenitor cells or tissue that serve as a physiological model for cancer research. These are designed to recapitulate the in vivo properties of tumours.

Ethnic-Guided Soft Tissue Cephalometric Analysis on Lambani Indian Inhabitants for Forensic Facial Reconstruction.

Background: Forensic craniofacial reconstruction is a combination of both scientific technique and artistic skill that assist facial soft tissue approximation on the skull to obtain an image of an individual that varies in the different ethnic groups depending on genetic and environmental factors such as soft tissue norms.

Objectives: The present study was aimed to evaluate the soft tissue norms for Lambani Indian tribes spread across the state of Karnataka in India and compare them with the local inherent ethnolinguistic Kannadiga population.

Material And Methods: Forty healthy individuals encompassing 20 Lambanis and 20 Kannadigas were selected using demographic information.

Design and Implementation of Advanced Machine Learning Management and Its Impact on Better Healthcare Services: A Multiple Regression Analysis Approach (MRAA).

In the current information and technology era, business enterprises are focusing in performing the process effectively by reducing the waiting time in completing the work, reduce latency and deploy the resources effectively so as to service the patient, medical practitioners, societies, and other stakeholders in an efficient manner. Hence, several organisations are using the emerging technologies so as to obtain high performance and enhance competitive edge. The advancement in machine learning, deep learning, business analytics, etc.

Efficacy of herbal alternatives in maintaining oral health in cancer patients: A systematic review.

Herbal rinses possess different medicinal properties. Numerous studies have reported the usefulness of various herbal oral rinses. Few studies claimed that herbal rinses are superior to synthetic mouth rinses for certain purposes, but there appears to be a lack of sound scientific evidence to prove the efficacy of herbal rinses in controlling oral plaque in cancer patients.

Dentists in India feel hopeless as a fulltime academician: A national survey.

Aims: Assess the relationship between job satisfaction and feeling of hopelessness among dental academicians.

Settings And Design: Cross sectional study was conducted among dental academicians across India through email and social media using a pretested questionnaire.

Methods And Materials: An Internet-based cross-sectional survey was conducted among dental academicians via social media and electronic mail (e-mail) throughout India.

Relationship between perceived chewing ability, oral health related quality of life and depressive symptoms among completely edentulous individuals.

Background: Edentulism affects the chewing ability of a person and can engender nutritional deficiencies which can affect the overall quality of life and depression.

Aim: Our aim was to evaluate the association between perceived chewing ability, oral health-related quality of life (OHRQoL) and depressive symptoms among completely edentulous patients with and without dentures.

Settings And Design: Institutional study and cross-sectional design.