Pathological Sequelae of Chronic Vestibular Migraine and Cerebrovascular Insufficiency Leading to Cognitive Decline and Dementia.

Chronic vestibular migraine (CVM) and cerebrovascular insufficiency are recognized contributors to cognitive impairment. Vestibular dysfunction affects spatial orientation and balance, while compromised cerebral perfusion impacts neuronal health. This study explores the combined pathological effects of these conditions and their role in cognitive decline and dementia.

A Rare Case of Nasopharyngeal Adenocarcinoma Presenting with Vernet's Syndrome.

A rare case of Nasopharyngeal Adeno Carcinoma [NAC] causing Vernet's Syndrome in a 59 years old male is reported. Brief recap of NAC pathology, classification, literature review, the clinical history, misleading signs, missed diagnosis and the value of careful history taking and detailed examination are presented.

Epidemiology of Iodine Deficiency Disorders in North-Eastern Part of Karnataka, India.

The north-eastern part of Karnataka lies on the Deccan Plateau of the South Indian Peninsula, characterized by black soil. This region is known for its mineral resources, including a gold ore mine in Hatti (Raichur District), an iron ore mine in Toranagallu (Bellary District), and uranium deposits in Gogi (Yadgir District). However, the soil in this area is deficient in iodine, leading to iodine deficiency disorders such as goiter and hypothyroidism.

Administration of Antibiotics for Root Canal Treatment - A Questionnaire Based Survey Amongst Dentists.

Aim: This study aims to assess the use of antibiotics among dentists in performing endodontic procedures.

Methodology: A cross-sectional survey was conducted using a pretested, structured, and validated questionnaire approved by the institutional ethics committee. It included questions on demographics, choice, frequency, and duration of antibiotics use in endodontic practice.

Impact of Educational Interventions on Obesity Awareness and Weight Management Among Urban Women in Salem Municipal Corporation, Tamil Nadu: A Quasi-Experimental Study.

Introduction: A study assessed women's knowledge of obesity and weight loss management in Southern India.

Materials And Methods: The study used a quasi-experimental design, with two urban areas selected for control and study groups. Biographic data were collected through SIS, and pre and post-tests were conducted using a SSAKQ and an Interventional Module.

Assessment of Knowledge, Attitude, and Practice about "SADE" Among Dentists - A Cross-Sectional Study.

Background: Intellectual and developmental disabilities (IDDs), including autism spectrum disorder (ASD), often lead to sensory challenges and dental anxiety, complicating oral healthcare. Sensory adapted dental environment (SADE) can alleviate anxiety and enhance cooperation during dental procedures, but awareness and implementation among dentists remain limited.

Objective: To assess general dentists' knowledge, attitudes, and practices regarding SADE and identify gaps for targeted educational programs.

In Silico Molecular Docking of Phytochemicals: Targeting Key Biomarkers in Oral Cancer.

Background: Oral cancer is the sixth most common cancer occurring anywhere in the globe. Cancers of the mouth are caused by tobacco and alcohol overuse, and also between pre-malignancy and full-fledged malignancy. In order to avoid the onset of illness, proper cleanliness of the mouth is important.

Unlocking the Therapeutic Benefits of Artemisia Annua: A Comprehensive Overview of its Medicinal Properties.

Artemisia annua L., also referred to as sweet wormwood, sweet annie, sweet sagewort, and annual wormwood (Chinese: qngho), is a species of wormwood native to temperate Asia but naturalised worldwide. It is a member of the Asteraceae family.

Anti-Candidal Action of Epigallocatechin Gallate as Intracanal Medicament-A Microbiological and Dentin Model Study.

Aim: To evaluate the antifungal activity of Triple Antibiotic Paste (TAP) with Epigallocatechin Gallate (EGCG) against .

Materials And Methods: Disk diffusion test: Thirty Kirby-Bauer disks were soaked in: Group 1-TAP (ciprofloxacin, minocycline, and metronidazole in saline); Group 2-TAP + EGCG + saline; Group 3-EGCG + saline; Group 4-Fluconazole. Disks were dried, placed in a suspension, and incubated at 37°C for 24 hours.

Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic-Induced Toxicity in the HCT-116 Cell Model: A Luminesce-Based Study.

Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS that interacts with vital organs. Chelation therapy is currently recommended for arsenic toxicity.

Effectiveness of Oral Health Education Among Visually Challenged Children using Oral and Braille - A comparative study.

Background: The present investigation is motivated by the fact that the incidence of visual impairment is increasing all over the world. Visually challenged people may encounter specific problems in maintaining their oral hygiene, leading to a higher risk of periodontal diseases.

Materials And Methods: This comparative study was conducted among visually challenged 5-20 year old school children.

Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner.

Introduction: The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with being a primary culprit. Tissue conditioners, used to reline ill-fitting dentures, can temporarily alleviate discomfort but are prone to microbial colonization. To address this, researchers have explored incorporating antifungal agents directly into tissue conditioners.

Exploring the potential of stem cell therapy: Applications, types, and future directions.

One of the most significant treatment approaches now accessible is stem cell therapy. Over the last few decades, a lot of study has been done in this field, and this fascinating feature of plasticity could have therapeutic uses. The potential of stem cells to restore function lost as a result of disease, trauma, congenital defects, and age has made stem cell research a key priority for scientific and medical organizations across the world.

Marine-Derived Chemotherapeutic Agent for Acute Leukemia: In Silico and In Vitro Evaluation.

Acute leukemia, a severe hematological malignancy marked by abnormal white blood cell proliferation, often resists conventional therapies. The growing interest in natural therapeutics has spotlighted marine-derived compounds for their unique bioactivities. This study explores the therapeutic potential of Ascophyllum nodosum extract, focusing on Laminine, in modulating key leukemia-associated proteins, lactate dehydrogenase (LDH), and phosphoinositide 3-kinase (PIK3), using in silico and in vitro approaches.

Exploring the therapeutic potential of leriodenine and nuciferine from for renal fibrosis: an analysis.

A major problem in chronic kidney illnesses is renal fibrosis. This research investigates the therapeutic potential of compounds derived from (Lotus). Comprehensive screening identified these compounds, which exhibit promising binding affinities with key targets associated with renal fibrosis.

Mental health characteristics of re-entering dropout Indian students.

Education plays a pivotal role in shaping individual development and societal progress, yet dropout rates remain a significant challenge, particularly in developing countries like India. Dropout decisions often stem from complex social, economic and psychological factors, impacting students' mental health. This comparative descriptive study assessed and compared the mental health characteristics of 30 re-entering dropout students and 30 regular students from Integral Coach Factory (ICF) Hr.

Evaluation of antibacterial and antifungal activities of a commercially available herbal mouthwash in accordance with the PN-EN 1040 and EN 1650 standards.

Periodontitis is complex microbial plaque induced condition. In this study, HiOra herbal mouthwash widely marketed in India, achieved a 5-log reduction in standard fungi and bacterial strains within 60 min. Thereby demonstrating antibacterial and antifungal activity similar to chlorhexidine and accordance with the PN EN 1040 and EN 1650 standards.

Signature of collagen alpha-1(x) gene expression in human cancers and their therapeutic implications.

Cancers are a class of disorders that entail uncontrollably unwanted cell development with dissemination. One in six fatalities globally is attributed to cancer, a global health issue. The analysis of the entire DNA sequence and how it expresses itself in tumor cells is known as cancer genomics.

An overview of artificial intelligence based automated diagnosis in paediatric dentistry.

Artificial intelligence (AI) is a subfield of computer science with the goal of creating intelligent machines (1) Machine learning is a branch of artificial intelligence. In machine learning a datasets are used for training diagnostic algorithms. This review comprehensively explains the applications of AI in the diagnosis in paediatric dentistry.

Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway.

The central nervous system is affected by multiple sclerosis (MS), a chronic autoimmune illness characterized by axonal destruction, demyelination, and inflammation. This article summarizes the state of the field, highlighting its complexity and significant influence on people's quality of life. The research employs a network pharmacological approach, integrating systems biology, bioinformatics, and pharmacology to identify biomarkers associated with MS.

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study.

Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both.

Exploration of the Reasons for Poor Adherence Among Metabolic Syndrome Patients Attending a Tertiary Care Hospital in Tamil Nadu, India: A Mixed Method Study.

Background A major challenge in the treatment of MetS is the prevalence of low rates of adherence to the treatment regimen for individual components by the affected persons. This study aimed to estimate the medication adherence level among those with metabolic syndrome, determine the factors significantly associated with low adherence to medication, and explore the reasons for poor adherence to medication Materials and methods This sequential explanatory type of mixed method study was conducted among the metabolic syndrome patients attending the lifestyle clinic of a tertiary care hospital in the Salem district of Tamil Nadu, India. For the quantitative component, 210 was the sample size and for the qualitative component, the sample size was six.

Biogenic synthesized CuO nanoparticles and 5-fluorouracil loaded anticancer gel for HeLa cervical cancer cells.

Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic effect against cervical cancer, working synergistically with CuO NPs to maximize the therapeutic impact while potentially reducing the 5-Fu's systemic side effects.

Hydroxyl chalcone derivative DK02 as a multi-target-directed ligand for Alzheimer's disease: A preclinical study in zebrafish.

Background And Purpose: Alzheimer's disease (AD) is a widespread neurodegenerative condition characterized by amyloid-beta (Aβ) plaques and tau protein aggregates, leading to significant cognitive decline. Existing treatments primarily offer symptomatic relief, underscoring the urgent need for novel therapies that address multiple AD pathways. This study evaluates the efficacy of DK02, a hydroxyl chalcone derivative, in a scopolamine-induced dementia model in zebrafish, hypothesizing that it targets several neurodegenerative mechanisms simultaneously.