Efficacy of herbal alternatives in maintaining oral health in cancer patients: A systematic review.

Herbal rinses possess different medicinal properties. Numerous studies have reported the usefulness of various herbal oral rinses. Few studies claimed that herbal rinses are superior to synthetic mouth rinses for certain purposes, but there appears to be a lack of sound scientific evidence to prove the efficacy of herbal rinses in controlling oral plaque in cancer patients.

Evaluation of Surface Roughness, Hardness, and Gloss of Composites After Three Different Finishing and Polishing Techniques: An In Vitro Study.

Introduction The purpose of this in vitro study was to evaluate the effect of three different polishing systems on the microhardness, surface roughness, and gloss of resin composites. Materials and Methods The materials evaluated were 3M™ ESPE™ Filtek™ Z-350 XT (3M™, St. Paul, MN, USA), Grandio (Voco, Cuxhaven, Germany), 3M™ ESPE™ Filtek™ Z250 (3M™, St.

School Interventions-based Prevention of Early-Childhood Caries among 3-5-year-old children from very low socioeconomic status: Two-year randomized trial.

Objectives: To assess the effectiveness of school-based interventions to prevent early childhood caries (ECC) among preschool children from very low socioeconomic background over a period of 2 years.

Materials And Methods: Four hundred and twenty preschool children between the ages of 3-5 years participated in this double blind, three parallel arm clinical trial. School only interventions such as prohibition of sugary snack consumption in school, teacher supervised daily brushing using fluoridated toothpaste, and oral health education were implemented with regular follow-up at 6 months, 1, and 2 years.

Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer.

Hypoxia inducible factor 1 alpha (HIF-1α) is a key regulator of the genes involved in the cellular response to hypoxia. This study aims to determine the HIF-1α gene polymorphism and its association with protein expression in diabetic subjects with and without diabetic foot ulcers (DFU). A total of 529 patients with T2DM (N = 185), DFU (N = 199) and Control (N = 145) were accounted for the study.

Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism.

Many studies reported the neuroprotective effects of angiotensin II type 1 receptor (AT1R) antagonists in Parkinson's disease (PD). However, the role of AT1R blockade on astroglial, in turn, dopaminergic functions in chronic PD is still to be studied. In the present study, telmisartan (TEL; 3 and 10 mg/kg/day; p.

Effectiveness of Pomegranate Mouthrinse in Reducing Bacterial Plaque, Gingival Inflammation and Total Salivary Proteins over a Period of 90 Days: A Double-Blind Randomized Trial.

Objective: Pomegranate is proven to possess effective antibacterial and anti-infl ammatory properties. Hence, we evaluated the effi cacy of pomegranate mouthrinse on plaque accumulation, gingivitis and total salivary proteins among adolescents aged 15 to 19 years over a period of three months.

Materials And Methods: A double-blind, single-center, controlled clinical trial was conducted among 40 adolescents.

Impact of various foot arches on dynamic balance and speed performance in collegiate short distance runners: A cross-sectional comparative study.

Objective: To compare the impact of foot arches on dynamic balance and speed performance.

Materials And Methods: 30 collegiate male short distance runners were divided into three groups based on foot arches, high, neutral and low. Balance and speed performance were estimated based on scores of star excursion balance test (SEBT), 40 yard dash test and vertical jump test (VJT).

Cytotoxicity and Apoptotic Assay in HT-29 Cell Line Using Linn: Leaves Extract.

Background: Linn. (Family ), well-known beneficial medicinal shrub, has been traditionally used for the treatment of various diseases such as leukoderma.

Objective: The aim of the present study is to investigate the efficacy of ethanolic leaves extract for antiproliferative, apoptotic, cell cycle blockade, and wound healing.

Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.

The present study was designed to ascertain the role of naringenin (NGN), a citrus fruit flavanone, against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced α-synuclein (SYN) pathology and neuroinflammation in a mouse model. NGN was administered to C57BL/6J mice once a day for 5 consecutive days prior to the MPTP intoxication. On day 5, 40-50 min after the NGN or vehicle administration, MPTP was injected in two divided doses (2× 40 mg/kg, i.

Crystal structures of the Schiff base derivatives ()-'-[(1-indol-3-yl)methyl-idene]isonicotino-hydrazide ethanol monosolvate and ()--methyl-2-[1-(2-oxo-2-chromen-3-yl)ethyl-idene]hydrazinecarbo-thio-amide.

The crystal structures of two title Schiff base derivatives, CHNO·CHO () and CHNOS (), were determined at 110 and 100 K, respectively. In the crystal of compound , the ()-'-[(1-indol-3-yl)methyl-idene]isonicotinohydrazide and ethanol mol-ecules are linked by O-H⋯O, N-H⋯O and N-H⋯N hydrogen bonds, forming a tape structure running along the axis direction. The tapes are weakly linked a C-H⋯N inter-action.

Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions.

Interlink between excitotoxicity and cellular bioenergetics depletion is implicated as one of the central deteriorative pathways in many neurodegenerative diseases including Huntington's disease (HD). Chronic administration of 3-nitropropionic acid (3-NP) depletes ATP and NAD and increases TNFα, IL-6 and glutamate content resulting in "immunoexcitotoxicity". Present study was designed to determine whether the combination of memantine (MN) and 3-aminobenzamide (3-AB), PARP inhibitor, can ameliorate immunoexcitotoxicity and improve bioenergetics in a better manner than individual administration against 3-NP intoxication in mice.

An in vivo assessment of the influence of needle gauges on endodontic irrigation flow rate.

Aim: The aim of this clinical study was to assess the influence of irrigation needle gauge on endodontic irrigation flow rates.

Settings And Design: In vivo assessment.

Materials And Methods: Five specialist endodontists performed intracanal irrigation procedures on 50 mesiobuccal canal of mandibular first molars using three different irrigation needle gauges.

Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma.

Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug-drug interactions.

Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)-3-(3-nitro-phen-yl)propanamide.

In the title compound, C15H11N3O4, the acetamide group is inclined to the furan ring by 66.5 (1)°. The dihedral angle between the furan ring and the benzene ring is 66.

Erratum: Crystal structure of 2-cyano-N-(furan-2-ylmeth-yl)acetamide. Corrigendum.

The address of one of the authors in the paper by Subhadramma et al. [Acta Cryst. (2015), E71, o455-o456] is corrected.

L-NAME combats excitotoxicity and recuperates neurological deficits in MCAO/R rats.

Purpose Of Research: Since, transient focal cerebral ischaemia exhibits detrimental effect not only during the course of ischaemia but also after the onset of reperfusion, the current study is focussed on identifying the appropriate therapeutic time point at which NG-nitro-l-arginine methyl ester (l-NAME) exerts better neuroprotection.

Principal Results: Pre-ischaemic administration of l-NAME ameliorated neurological deficits much better than the during ischaemic and post-ischaemic groups. Pre-ischaemic l-NAME has also mitigated glutamate excitotoxicity, increased glutamine synthetase activity, ATP and NAD levels, decreased nitrate/nitrite content, down regulated TNF-α and upregulated IL-10 expressions and reduced the cerebral infarction significantly than the during ischaemic and post-ischaemic groups.

Deciphering the impact of somatic mutations in exon 20 and exon 9 of PIK3CA gene in breast tumors among Indian women through molecular dynamics approach.

We examined 25 breast tumor samples for somatic mutations in exon 20 and exon 9 of PIK3CA gene in South Indian population. Genomic DNA was isolated and amplified for PIK3CA gene, followed by direct sequencing of purified polymerase chain reaction products. We identified PI3K3CA mutations in 5 of 25 (20%), including four of the mutations in p.

Rehabilitation of partially eviscerated eye with custom made ocular prosthesis-a case report.

Human eyes are the most precious gift from nature; presence of a pair of eye not only gives expression to life but also adds dignity to the face. The loss of an eye causes disfigurement of the face and causes anxiety, stress and depression in their life. The rehabilitation of patients with congenital or acquired defects of the eye is a challenging job.

2,15-Dioxa-7,18,19,20,23-penta-aza-hepta-cyclo-[21.6.1.1(17,20).0(1,8).0(3,7).0(9,14).0(24,29)]hentriaconta-9,11,13,17(31),18,24,26,28-octaen-30-one.

In the title compound, C24H23N5O3, the oxindole ring system is nearly planar, with a dihedral angle between the two fused rings of 3.3 (1)°. In the fused pyrrolo-oxazole ring system, the oxazole and pyrrolidine rings adopt envelope conformations with the spiro C atom and one of the methyl-ene C atoms, respectively, as the flap atoms.