and exploration of newly synthesized triazolyl- isonicotinohydrazides as potent antitubercular agents.

In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives (), the click chemistry approach. The synthesized isoniazid-triazole derivatives have potent antitubercular activity against the (MTB) H37Rv strain. Among these compounds, , , , , , , , , and were found to be the most active ones with a MIC value of 0.

Antimicrobial Activity of Novel Ni(II) and Zn(II) Complexes with (E)-2-((5-Bromothiazol-2-yl)imino)methyl)phenol Ligand: Synthesis, Characterization and Molecular Docking Studies.

In order to address the challenges associated with antibiotic resistance by bacteria, two new complexes, Ni(II) and Zn(II), have been synthesized using the conventional method based on Schiff base ligand (E)-2-((5-bromothiazol-2-yl) imino) methyl) phenol. The Schiff base ligand (HL) was synthesized using salicylaldehyde and 5-(4-bromophenyl)thiazol-2-amine in both traditional and efficient, ecologically friendly, microwave-assisted procedures. The ligand and its complexes were evaluated by elemental analyses, FTIR spectroscopy, UV-Vis spectroscopy, nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA) and magnetic susceptibility.

Design, synthesis and antitubercular assessment of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives.

A library of 1, 2, 3-triazole incorporated thiazolylcarboxylate derivatives (7a-q) and (8a-j) were synthesized and evaluated for their in-vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The two compounds 7h and 8h have displayed excellent antitubercular activity with MIC values of 3.12 and 1.

Incorporation of exemestane into ternary nanosponge system for enhanced anti-tumor potential in breast cancer.

The present investigation reports the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. Fourier transform infrared, and nuclear magnetic resonance (NMR) spectroscopic analysis confirmed the encapsulation of ring B, C, and D of exemestane in the nanosponge cavity. studies demonstrated a 6.

Exploring DSSC Efficiency Enhancement: SQI-F and SQI-Cl Dyes with Iodolyte Electrolytes and CDCA Optimization.

This investigation delves into the potential use of halogen bonding to enhance both the short-circuit current () and overall efficiency of dye-sensitized solar cells (DSSCs). Specifically, we synthesized two distinct dyes, SQI-F and SQI-Cl, and characterized them using FT-IR, HNMR, C NMR, and mass spectroscopy. These dyes are based on the concept of incorporating halogen atoms within unsymmetrical squaraine structures with a donor-acceptor-donor (D-A-D) configuration.

Molecular Docking, Pharmacokinetic and Molecular Simulation Analysis of Novel Mono-Carbonyl Curcumin Analogs as L858R/T790M/C797S Mutant EGFR Inhibitors.

Introduction: Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety. Curcumin's stability challenges can be overcome by removing the diketone moiety and shortening the 7-carbon chain, resulting in mono-carbonyl analogs. Cancer proliferation is caused by the activation of Epidermal Growth Factor (EGFR) pathways.

Targeting Breast Cancer Signaling via Phytomedicine and Nanomedicine.

Background: The development of breast cancer (BC) and how it responds to treatment have both been linked to the involvement of inflammation. Chronic inflammation is critical in carcinogenesis, leading to elevated DNA damage, impaired DNA repair machinery, cell growth, apoptosis, angiogenesis, and invasion. Studies have found several targets that selectively modulate inflammation in cancer, limit BC's growth, and boost treatment effectiveness.

Spherical Ni/NiO nanoparticles decorated on nanoporous carbon (NNC) as an active electrode material for urea and water oxidation reactions.

Herein, we report a chemical method for scalable synthesis of spherical Ni/NiO nanoparticle-decorated nanoporous carbon (NNC) based electrocatalytic system using a simple and easy chemical method with ultra-high activity towards urea electrooxidation. Morphological analysis by scanning electron microscopy (SEM) and high-resolution transmission electron microscopy (HR-TEM) confirms the formation of Ni/NiO NPs on highly nanoporous carbon with an average size of ∼50 nm. X-ray diffraction (XRD) confirms NNC with a face-centred cubic (FCC) crystal structure.

Controlling Intestinal Infections and Digestive Disorders Using Probiotics.

After consumption, probiotics provide health benefits to the host. Probiotics and their metabolites have therapeutic and nutritional properties that help to alleviate gastrointestinal, neurological, and cardiovascular problems. Probiotics strengthen host immunity through various mechanisms, including improved gut barrier function, receptor site blocking, competitive exclusion of pathogens, and the production of bioactive molecules.

Water compatible silica supported iron trifluoroacetate and trichloroacetate: as prominent and recyclable Lewis acid catalysts for solvent-free green synthesis of hexahydroquinoline-3-carboxamides.

Silica supported iron trifluoroacetate and iron trichloroacetate green Lewis acid catalysts were developed by a novel, cheap, environment-friendly approach and utilized in the synthesis of hexahydroquinoline-3-carboxamide derivatives. The structure and morphology of the prepared Lewis acid catalysts were studied by FTIR, PXRD, FE-SEM, HR-TEM, EDX, BET, TGA and NH-TPD techniques. The present catalysts shows maximum conversion efficiency in hexahydroquinoline-3-carboxamide derivatives synthesis at 70 °C in solvent free reaction condition with best product yield in a short reaction time.

Enhancement in the therapeutic potential of lapatinib ditosylate against breast cancer by the use of β-cyclodextrin based ternary nanosponge system.

The present investigation was performed to demonstrate the therapeutic potential of lapatinib ditosylate (LD) loaded nanosponge for the treatment of breast cancer. The study reports the fabrication of nanosponge by reaction of β-cyclodextrin with a cross-linking agent, diphenyl carbonate, at several molar ratios using the ultrasound-assisted synthesis method. The drug was loaded into the rightest nanosponge by lyophilization with and without 0.

Curcumin-based bioactive heterocycles derived via multicomponent reactions.

Curcumin is an important phytochemical, found in the Asian countries, especially in the Indian subcontinent. The use of this "privileged natural product" in the diversity-oriented synthesis of curcumin-based heterocycles via multicomponent reactions (MCRs) is the subject of interest for many medicinal chemists across the globe. This review particularly focuses on the reactions involving curcuminoids as one of the reactants in the MCRs of curcuminoid to synthesize curcumin-based heterocycles.

Intriguing physicochemical properties and impact of co-dopants on N-doped graphene oxide based ZnS nanowires for photocatalytic application.

Superparamagnetic N-doped graphene oxide (GO)- with ZnS nanowires was synthesized by a one-step hydrothermal method by doping dilute amounts of Ga, Cr, In, and Al ions for water treatment and biomedical applications. In these experiments, to enhance their properties, 2% of Ga, In, and or Al were codoped along with 2% Cr ions in these ZnS nanowires. The nanocomposite with the composition, InCrZnS, has better photocatalytic efficiency than other co-doped nanocomposites.

Estimation of neutron and gamma-ray attenuation characteristics of some ferrites: Geant4, FLUKA and WinXCom studies.

Ferrites are ceramic oxide materials consisting of mainly iron oxide and they have become massively important materials commercially and technologically, having a multitude of uses and applications. The protection against neutron-gamma mixed radiation is crucial in several nuclear applications. From this standpoint, mass attenuation coefficient, radiation protection efficiency and transmission factor of some ferrites namely barium, strontium, manganese, copper and cadmium ferrite has been computed using Geant4 and FLUKA simulations.

Therapeutic Delivery of Tumor Suppressor miRNAs for Breast Cancer Treatment.

The death rate from breast cancer (BC) has dropped due to early detection and sophisticated therapeutic options, yet drug resistance and relapse remain barriers to effective, systematic treatment. Multiple mechanisms underlying miRNAs appear crucial in practically every aspect of cancer progression, including carcinogenesis, metastasis, and drug resistance, as evidenced by the elucidation of drug resistance. Non-coding RNAs called microRNAs (miRNAs) attach to complementary messenger RNAs and degrade them to inhibit the expression and translation to proteins.

A Mini-review on Recent Advances in Synthesis of Dihydropyrano [3, 2-c] chromenes Using Magnetic Nanocatalysts.

The development of an active, selective, and long-term selective catalyst for the synthesis of biologically active heterocycles is still challenging. However, magnetic nanocatalysts have divergent applications like high efficiency, selectivity, consumption, and reusability. The current review explores a detailed survey of the latest information on synthetic methods of Pyrano [3, 2-c] chromene derivatives using different magnetic nanocatalysts.

High sensitivity carbon monoxide detector using iron tetraphenyl porphyrin functionalized reduced graphene oxide.

The detection of pollutant and toxic gases has attracted extensive attention due to the growing environmental issues. In the present investigation, free-based tetraphenyl porphyrin (TPP) and iron tetraphenyl porphyrin (FeTPP) are used to functionalize thermally reduced graphene oxide (rGO) and further used for the detection of carbon monoxide (CO). TPP and FeTPP functionalized rGO (FeTPP@rGO) sensors are fabricated on a glass substrate with thermally coated copper electrodes.

Short text topic modelling using local and global word-context semantic correlation.

Nowadays, people use short text to portray their opinions on platforms of social media such as Twitter, Facebook, and YouTube, as well as on e-commerce websites such as Amazon and Flipkart to share their commercial purchasing experiences. Every day, billions of short texts are created worldwide in tweets, tags, keywords, search queries etc. However, this short text possesses inadequate contextual information, which can be ambiguous, sparse, noisy, remains a major challenge.

Silica supported lanthanum trifluoroacetate and trichloroacetate as an efficient and reusable water compatible Lewis acid catalyst for synthesis of 2,4,5-triarylimidazoles a solvent-free green approach.

In the present research article, we have developed solid heterogenous silica supported lanthanum trifluoroacetate and trichloroacetate as green Lewis acid catalysts. These catalysts were synthesized by a novel, simple, cheap, clean, and environment friendly method. The physicochemical properties of the prepared catalysts were well studied and characterized by sophisticated spectroscopic techniques such as FTIR, TGA, XRD, EDX, SEM, TEM and BET analysis.

UPR/Titanium dioxide nanocomposite: Preparation, characterization and application in photon/neutron shielding.

The aim of present investigation is to fabricate TiO reinforced novel composites as an alternate nuclear radiation shields. Unsaturated polyester resin has been reinforced by the incorporation of different weight proportions of titanium dioxide (5, 10, 15 and 20 wt%) nanoparticles. Accordingly, mass and linear attenuation coefficients (μ & μ), half and tenth value layers (HVL & TVL), relaxation length (λ) and effective atomic numbers (Z) have been computed.

A Review: Exploring Synthetic Schemes and Structure-activity Relationship (SAR) Studies of Mono-carbonyl Curcumin Analogues for Cytotoxicity Inhibitory Anticancer Activity.

Introduction: Cancer is the major cause of death globally. Cancer can be treated with naturally occurring Curcumin nuclei. Curcumin has a wide range of biological actions, including anti-inflammatory and anti-cancer properties.

Co-existence of Extended Spectrum β-Lactamase and carbapenemase-producing genes from Diarrheagenic Enteric pathogens isolated in a tertiary care hospital.

Multiple drug resistance (MDR) among bacterial pathogens is a growing concern that clinicians are facing worldwide. Diarrhea among infants is frequent and is caused by various bacterial and viral infectious agents. Two hundred and twelve stool specimens were collected from pediatric patients from a rural quaternary hospital in Barshi, Sholapur, India, between March and December 2017.

Classification of land use/land cover using artificial intelligence (ANN-RF).

Because deep learning has various downsides, such as complexity, expense, and the need to wait longer for results, this creates a significant incentive and impetus to invent and adopt the notion of developing machine learning because it is simple. This study intended to increase the accuracy of machine-learning approaches for land use/land cover classification using Sentinel-2A, and Landsat-8 satellites. This study aimed to implement a proposed method, neural-based with object-based, to produce a model addressed by artificial neural networks (limited parameters) with random forest (hyperparameter) called ANN_RF.

Computational Exploration of Anti-cancer Potential of Flavonoids against Cyclin-Dependent Kinase 8: An Molecular Docking and Dynamic Approach.

Over the centuries, cancer has been considered one of the significant health threats. It holds the position in the list of deadliest diseases over the globe. In women, breast cancer is the most common among many cancers and is the second most common cancer all over the world, while lung cancer is the first.