2,250 results match your criteria: "Dr von Hauner Children's Hospital[Affiliation]"
Qual Life Res
December 2024
Institute of Psychology, Faculty of Psychology and Sport Science, University of Innsbruck, Innsbruck, Austria.
Pediatr Pulmonol
January 2025
Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
This report is a summary of the presentations given at the European Respiratory Society's Research Seminar on Asthma Prevention. The seminar reviewed both epidemiological and mechanistic studies and concluded that; (i) reducing exposure of pregnant women and children to air pollution will reduce incident asthma, (ii) there are promising data that both fish oil and a component of raw cow's milk prevent asthma, and (iii) modulating trained immunity by either mimicking helminth infection or oral and sublingual bacterial products is a promising area of research.
View Article and Find Full Text PDFJ Nanobiotechnology
November 2024
College of Basic Medicine, Army Medical University, Gaotanyan str. 30, Chongqing, 400038, China.
Haematologica
November 2024
Medical Faculty, Masaryk University, Brno, Czech Republic.
Int J Mol Sci
November 2024
Division of Child Neurology and Metabolic Medicine, Department of Pediatrics I, Center for Pediatrics and Adolescent Medicine, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg University, 69120 Heidelberg, Germany.
This study explores the potential of H-NMR spectroscopy-based metabolic profiling in various biofluids as a diagnostic and predictive modality to assess disease severity in individuals with 5q spinal muscular atrophy. A total of 213 biosamples (urine, plasma, and CSF) from 153 treatment-naïve patients with SMA across five German centers were analyzed using H-NMR spectroscopy. Prediction models were developed using machine learning algorithms which enabled the patients with SMA to be grouped according to disease severity.
View Article and Find Full Text PDFPLOS Digit Health
November 2024
Institute for Digital Medicine, University Hospital Augsburg, Augsburg, Germany.
Enrolling in a clinical trial or study requires informed consent. Furthermore, it is crucial to ensure proper consent when storing samples in biobanks for future research, as these samples may be used in studies beyond their initial purpose. For pediatric studies, consent must be obtained from both the child and their legal guardians, requiring the recording of multiple consents at once.
View Article and Find Full Text PDFmedRxiv
November 2024
Department of Genetics, University of Pennsylvania, Philadelphia, PA.
Individuals with monoallelic pathogenic variants in the histone lysine methyltransferase DOT1L display global developmental delay and varying congenital anomalies. However, the impact of monoallelic loss of remains unclear. Here, we present a largely female cohort of 11 individuals with variants with developmental delays and dysmorphic facial features.
View Article and Find Full Text PDFEClinicalMedicine
September 2024
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sjukhusbacken 10, 118 83, Stockholm, Sweden.
J Clin Immunol
November 2024
Department of Pediatrics, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstraße 4 , Munich, European Union (EU), D-80337 , Germany.
Purpose: Netherton syndrome (NS) is a rare inborn error of immunity (IEI) with an incidence of approximately 1:200,000 and the phenotypic triad of trichorrhexis invaginate (bamboo hair), congenital ichthyosiform erythroderma, and multiple atopic manifestations. Treatment options especially in infants are scarce and generally not licensed.
Methods: Case report of a 9-week-old infant with NS treated with dupilumab off-label.
Eur Respir Rev
October 2024
Service de Radiologie, Hopital Bichat, APHP, Université Paris Cité, Paris, France.
The main monogenic causes of pulmonary fibrosis in adults are mutations in telomere-related genes. These mutations may be associated with extrapulmonary signs (hepatic, haematological and dermatological) and typically present radiologically as usual interstitial pneumonia or unclassifiable fibrosis. In children, the monogenic causes of pulmonary fibrosis are dominated by mutations in surfactant-related genes.
View Article and Find Full Text PDFEur J Paediatr Neurol
November 2024
Department of Paediatric Neurology and Developmental Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Germany.
Pediatr Allergy Immunol
November 2024
Department of Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Hamostaseologie
November 2024
Pediatric Thrombosis and Hemostasis Center, Pediatric Hemophilia Center, Dr. von Hauner Children's Hospital, LMU Munich, Germany.
Prophylaxis is the standard of care for patients with severe hemophilia, patients with moderate hemophilia, or those with another congenital bleeding disorder that is associated with a severe bleeding phenotype and/or a high risk of spontaneous life-threatening bleeding. Patients with nonsevere hemophilia (factor VIII [FVIII] ≥ 1%) may also have a bleeding phenotype that requires prophylaxis. To date, however, there are no clear criteria as to when prophylaxis is indicated in these patients.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
November 2024
Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Lindwurmstreet 2a, Munich, 80337, Germany.
Background: Patients with metastatic hepatoblastoma are treated with severely toxic first-line chemotherapies in combination with surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient outcomes making new treatment strategies, tailored to more efficient lung clearance, mandatory.
Methods: We harnessed a comprehensive patient-derived xenograft platform and a variety of in vitro and in vivo assays to establish the preclinical and biological rationale for a new drug for patients with metastatic hepatoblastoma.
BMC Public Health
November 2024
Maastricht University, Care and Public Health Research Institute, Universiteitssingel 40, Maastricht, 6229 ER, Netherlands.
Background: There is a lack of studies evaluating longitudinal changes in adiposity indicators and the association with 24-hour movement behavior guidelines in preschoolers. Therefore, this study aimed to investigate associations between changes in Body Mass Index (BMI) z-scores, waist circumference and waist-to-height ratio, and compliance with the 24-hour movement behavior guidelines in three- to six-year-old children from a European sample.
Methods: In total, data from a European sample of 719 preschoolers (50.
J Exp Med
December 2024
Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Canada.
Allergy
December 2024
German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.
Background: Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental stressors can manifest through DNA methylation (DNAm).
View Article and Find Full Text PDFAnimal Model Exp Med
December 2024
Department of Pediatric Surgery, Johannes-Gutenberg-University Medical Center, Mainz, Germany.
Background: Esophageal strictures following esophageal atresia repair are a source of significant morbidity. To test new therapeutic approaches, we designed a piglet model of esophageal stricture by resecting variable lengths of esophagus with subsequent re-anastomosis. This study describes the model and validates its physiologic impact by blinded analysis of the weight gains of the piglets.
View Article and Find Full Text PDFJ Pediatr Surg
October 2024
Pediatric Surgery, Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany; Pediatric Surgery, Hannover Medical School, Hannover, Germany.
Aim: Enterostomy takedown is common in neonates with Hirschsprung's disease, anorectal malformations, or necrotizing enterocolitis. Stapled bowel anastomosis has become routine in adults, but size of up to 12 mm diameter precludes performing enterostomy takedown in young infants using regular intestinal staplers. After the introduction of miniature (5 mm diameter) staplers, we increasingly used them for enterostomy takedown.
View Article and Find Full Text PDFSemin Nephrol
October 2023
Division of Pediatric Nephrology, Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany.
Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of kidney failure in children and adolescents. CAKUT describes a wide spectrum of structural disorders with a prenatal origin. The etiology of CAKUT is multifactorial, including environmental, nongenetic, and genetic causes that impact kidney development as well as upper and lower urinary tract development.
View Article and Find Full Text PDFJ Pediatr Surg
October 2024
Department of Paediatric Surgery, Dr. von Hauner Children's Hospital, LMU University Hospital, Lindwurmstrasse 4, 80337 Munich, Germany. Electronic address:
Magnetism, recognized in ancient Greece and China, is a fundamental physical force influencing numerous domains, including medicine and surgery. Historically, the medical use of magnets dates back over two millennia. As proof, the ancient Sanskrit medical textbook Sushruta Samhita describes the removal of a metallic arrow lodged in the flesh with a magnet.
View Article and Find Full Text PDFSci Rep
October 2024
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study.
View Article and Find Full Text PDFCell Host Microbe
November 2024
Chair of Nutrition and Immunology, TUM School of Life Sciences, Technische Universität München, 85354 Freising, Germany; TUMCREATE, 1 CREATE way, #10-02 CREATE Tower, Singapore 138602, Singapore; ZIEL Institute for Food & Health, Technische Universität München, 85354 Freising, Germany. Electronic address:
Children (Basel)
September 2024
Department of Child and Adolescent Psychiatry, Saarland University Medical Center, 66421 Homburg, Germany.
BMC Public Health
October 2024
Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.