Medical treatment of squamous hyperplasia and lichen sclerosus of the vulva.

Objective: To evaluate the efficacy of medical treatment in patients with lichen sclerosus (LS), squamous hyperplasia (SH) and lichen sclerosus with associated squamous hyperplasia.

Methods: Forty-eight patients with non-neoplastic epithelial disorders of the vulva, SH in 23 (47.9%), LS in 20 (41.

A study of premature ovarian failure in Turkish women.

The parameters that could be responsible for or could be the end results of the premature ovarian failure were evaluated in 100 patients and compared with the same parameters of a control group consisting of 30 ovulatory healthy women with regular menstrual cycles. The incidence of premature ovarian failure was 6.6%.

The concentration of plasma atrial natriuretic peptide in normotensive and preeclamptic pregnancies.

Unlabelled: Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the cardiovascular, renal and endocrine systems. This study questions previous research findings regarding elevated ANP levels, despite vasoconstriction and hypovolemia, in preeclamptic patients.

Materials And Methods: Seventeen patients with preeclampsia, 5 with superimposed preeclampsia with chronic hypertension and 17 normotensive pregnant women were compared with respect to plasma ANP levels.

Serum CA 125 levels before, during and after treatment for endometriosis.

Objectives: The aim of this study was to assess the treatment of endometriosis with a gonadotropin-releasing hormone (GnRH) agonist in terms of changes to the extent of disease and to CA 125 levels as well as to recurrence during follow-up.

Methods: The levels of serum CA 125 were evaluated in 66 patients with endometriosis diagnosed and staged by laparoscopy according to the revised American Fertility. Society classification, who received a 6-month course of a GnRH agonist.

Polycystic ovaries in association with müllerian anomalies.

The polycystic ovary syndrome, whose etiopathogenesis is not clearly understood, has a wide spectrum of clinical presentations, and may co-exist with other pathologic conditions. In this study, we evaluated the prevalence of ultrasound-defined polycystic ovaries (PCO) in patients with müllerian anomalies (n = 167), and those without müllerian anomalies (n = 3165) from 1990 to 1994, in a population markedly composed of infertility patients. PCO were found in 50 (29.

Cesarean section rates and perinatal outcomes in resident and midwife attended low risk deliveries.

Cesarean section rates and perinatal outcomes of low risk pregnancies were evaluated in two different Turkish state hospitals. In this retrospective study, we compared cesarean section rates of 1668 low risk and non-private pregnancies managed by residents (group 1) and midwives (group 2), 53.3% and 46.

Chronic pelvic pain in adolescent women. Diagnostic laparoscopy and ultrasonography.

Objective: To evaluate the correlation of preoperative pelvic examination and ultrasonography with the laparoscopic findings in 45 adolescent women with chronic pelvic pain.

Study Design: Between January 1, 1989, and December 31, 1992, 45 adolescent women underwent diagnostic laparoscopy following a detailed clinical workup for evaluation of chronic pelvic pain.

Results: Thirty-five of 45 pelvic examination findings correlated with the laparoscopic findings.

Ultrasonographic appearance of fallopian tube carcinoma.

Preoperative diagnosis of tubal carcinoma is difficult and a diagnosis cannot usually be established until the time of operation. However, since prognosis is strictly related to the stage of the neoplasm, it is very important to be familiar with the clinical and imaging characteristics of primary fallopian tube carcinoma in order to make an early and accurate diagnosis. This report presents the ultrasonographic features of three cases of fallopian tube carcinoma and reviews the literature on the subject.

Do the suppression criteria in GnRH-a cycles predict in vitro fertilization outcome?

The addition of gonadotropin releasing hormone analog (GnRH-a) to controlled ovarian hyperstimulation regimes has been reported to have several advantages, such as reduced cancellation rate, fewer premature luteinizations and increased clinical pregnancy rate. The aim of this study was to determine the effect of pituitary/ovarian suppression, in terms of the levels of luteinizing hormone (LH), estradiol and follicle stimulating hormone (FSH), and the duration of GnRH-a administration, on in vitro fertilization (IVF) outcome. Retrospectively, 153 IVF cycles with GnRH-a and human menopausal gonadotropin (hMG) were examined.

Rupture of the uterus.

Objectives: To investigate the frequency of ruptured uterus, possible etiologic factors and fetomaternal outcomes.

Methods: The birth records of 58262 deliveries at Dr Zekai Tahir Burak Women's Hospital from 1 January 1990 to 31 December 1992 were reviewed and the results compared with those of two previous studies reported from this hospital on the same subject.

Results: Forty uterine ruptures occurred between 1990 and 1992, with a frequency of 0.

Endometriosis in association with müllerian anomalies.

There have been many theories proposed regarding etiology and pathogenesis of endometriosis. The theories of retrograde menstruation, celomic metaplasia, and müllerian remnants are among these. In order to find out whether a higher prevalence exists in patients with müllerian anomalies and to test these theories, we reviewed the case records of our reproductive endocrinology clinic set up between 1989 and 1994.

Preoperative assessment of myometrial invasion of endometrial carcinoma by transvaginal ultrasonography.

Preoperative transvaginal ultrasonographic evaluation of myometrial invasion was performed in 33 patients with endometrial cancer and compared with histologic findings. TVU was remarkably precise in predicting deep myometrial invasion (accuracy 91.7%) but superficial myometrial invasion (sensitivity 20%).

Vaginal thrush and its management in pregnancy.

The frequency of vaginal thrush was determined in an unselected group of patients attending the antenatal clinic. Diagnosis was based on phase-contrast microscopy and culture. One hundred and two patients were initially included but only 98 completed this study.

Change in atrial natriuretic peptide concentration after acute plasma volume expansion in normal pregnancy and preeclampsia.

Atrial natriuretic peptide (ANP) is found to be elevated in preeclamptic patients despite the presence of hemodynamic characteristics such as vasoconstriction and hypovolemia. In this study, the effect on ANP secretion of plasma volume expansion with crystalloid solutions was investigated. Seven preeclamptic and seven normotensive pregnant women in their last trimester were compared.

Expectant management of functional ovarian cysts: an alternative to hormonal therapy.

Objective: We studied whether the administration of oral contraceptives facilitates the disappearance of spontaneously formed functional ovarian cysts.

Methods: Eighty patients in whom ultrasonography revealed unilateral, mobile, unilocular, thin-walled ovarian cysts without internal echoes and greater than 30 mm but not exceeding 60 mm in diameter were enrolled into the study. Patients were randomized by stratification to receive a low-dose monophasic pill, a high-dose monophasic pill, a multiphasic pill or no therapy.

Thyroid function: fetal-maternal relationship at term.

The present study was undertaken to examine serum parameters of thyroid function at term in normal pregnant women and their normal fetuses. Paired sera from 56 mothers and their respective newborn infants' umbilical cord were obtained at parturition. Maternal and fetal TSH, FT4, T4, FT3 and T3 levels were measured and the differences between these two groups were analysed.

Malignant mixed müllerian tumor of the fallopian tube.

Primary malignant mixed müllerian tumor of the fallopian tube is uncommon. Only 37 cases of malignant mixed müllerian tumor of the fallopian tube have been reported to date and of these only 16 contained heterologous components (mesodermal mixed tumor). This rarity made us report a case of malignant mixed müllerian tumor of the fallopian tube containing heterologous components which was operated on in our gynecologic oncology department.

How does negative clinical evaluation of ovarian carcinoma after full course of chemotherapy correlate with second-look laparotomy findings?

Surgical reexploration was performed in 46 patients with epithelial nonmucinous ovarian adenocarcinoma requiring adjuvant chemotherapy whose initial therapy consisted of optimum debulking and surgical staging. All patients were placed on CAP (cisplatinum, Adriamycin, cyclophosphamide) chemotherapy for at least six courses until proved to be clinically disease free (mainly CA-125 below 35 U/ml and normal ultrasonography or computerized tomography). All women underwent second-look laparotomy (SLL) after completion of adjuvant therapy.

Lipid profiles in women with hirsutism and polycystic ovaries.

We examined the correlation between hyperandrogenemia and lipid profiles in 25 hirsute patients with polycystic ovary syndrome in our reproductive endocrinology outpatient clinic. Concentrations of triglycerides, low density lipoprotein cholesterol and total cholesterol were increased and concentrations of high density lipoprotein (HDL) cholesterol were decreased in women with severe hirsutism. Total and free testosterone levels were correlated with triglycerides (r = 0.

Accuracy of pipelle endometrial sampling in endometrial carcinoma.

In this prospective study, we compared the histological results of Pipelle endometrial sampling (PES) with that of hysterectomy to examine whether endometrial sampling with the Pipelle device can accurately diagnose endometrial carcinoma. PES was performed in 26 patients with known endometrial carcinoma whose initial therapy consisted of hysterectomy. Discomfort and pain during the biopsy were reported to be mild by 22 patients, moderate by 3 patients and severe by only 1 patient.

Tubal sterilization by laparoscopy and mini-laparotomy.

Laparoscopic tubal sterilization was performed on 179 women using general anesthesia, and tubal sterilization via mini-laparotomy was performed in 52 cases using local anesthesia. The patients ranged in age from 25 to 41 years, with 73.2% between 31 and 40 years.

Pelvic inflammatory disease and intrauterine devices: prophylactic antibiotics to reduce febrile complications.

In the present study, we tried to determine whether IUD insertion related PID and febrile complications could be prevented by prophylactic use of antibiotics. We studied 300 patients who were admitted to our family planning clinic for IUD contraception. Of these, 150 patients received prophylactic Doxycycline (group 1) and the second 150 received no therapy (group 2).

IUD (TCu380A) insertion following induced first trimester abortion.

In this study, 110 women (study group) who received an IUD (TCu380A) immediately after induced legal first trimester abortion were compared with 90 women (group 1) who started another type of contraception following legal abortion. Additionally, 100 women (group 2) who had an interval IUD insertion, were compared with both. In the study group, 3 (2.