Neuropeptide Alterations in Alzheimer's Disease: A Meta‐Analysis of Cerebrospinal Fluid Concentrations.

Background: Neuropeptides are crucial proteins in the central nervous system, which significantly influence neurophysiological processes. This analysis explores cerebrospinal fluid alterations in Alzheimer's disease, offering insights to better understand the condition and explore novel diagnostic and therapeutic avenues.

Method: We systematically searched MEDLINE (PubMed), EMBASE, Cochrane, and Scopus using specific search strategies.

Antivenom ineffectiveness in Echis carinatus sochureki envenoming: a five-year, single-centre experience from India.

Background: Snakebite is a neglected tropical disease that causes significant morbidity and mortality in India. In this study, we describe the clinical characteristics and outcomes of Echis carinatus sochureki envenoming from Western Rajasthan. We document the clinical ineffectiveness of the currently available Indian polyvalent antivenom in managing E.

Cross-Leg Microvascular Free Anterolateral Thigh Flap as a Safe, Viable, and Reserve Option for Reconstruction in a Vessel-Depleted Limb.

We present the case of a 36-year-old male patient with a posttraumatic composite defect of the lower two-thirds of the anterior aspect of the left leg with exposed necrotic tibia in an old, neglected type 3b fracture of the tibia of 9-month duration. The options for definitive soft-tissue cover include microvascular free tissue transfer and cross-leg flaps. In trauma cases, the surrounding tissue is usually damaged, and the recipient vessels are frequently implicated, ruling out the use of a microvascular free flap.

Therapeutic Bronchoscopic Interventions for Non Foreign-Body Removal Indications in Children.

Background: The indications for pediatric airway endoscopy are expanding and a variety of therapeutic interventions are feasible for central airway obstruction (CAO) and other central airway pathologies, apart from foreign body removal.

Methods: In this retrospective chart review from four centers, we describe the indications, procedures, outcomes, and complications of therapeutic bronchoscopic interventions in children for non foreign-body removal indications.

Results: A total of 72 children (mean age:140 [60.

Collet-Sicard Syndrome Secondary to Tuberculosis of the Base of the Skull: A Case Report.

Collet-Sicard syndrome, resulting from the involvement of all four lower cranial nerves, is an extremely rare condition. This case report details a 69-year-old female patient who presented with classic signs and symptoms of lower cranial nerve palsies (IX, X, XI, and XII) and was subsequently diagnosed with Collet-Sicard syndrome secondary to tuberculosis at the base of the skull. A contrast-enhanced MRI of the neck revealed bone marrow edema in the clivus, occipital condyle, and C1 vertebra, along with diffuse surrounding soft tissue swelling and collection, findings consistent with tuberculosis.

Assessment of White Matter Alterations in Patients of Migraine Using Diffusion Tensor Imaging.

Background: Vascular hypotheses was previously considered to play a major role in pathophysiology of migraine. Recently, neurological mechanisms have been proposed with implication of the trigemino-vascular pathway. Deciphering the pathophysiology of this disorder is extremely important for diagnosis, assessment of progression and to explore targeted treatment options.

A Rare Case of Non-ossifying Fibroma Causing Pathological Subtrochanteric Femur Fracture in a Child: A Common Lesion at an Uncommon Location.

Non-ossifying fibroma (NOF) is a benign expansive lytic lesion more frequently found in children and adolescents at the metaphysis of long bones in and around the knee joint, typically resolving spontaneously or by ossification. This report presents a rare case of an 11-year-old child with a pathological subtrochanteric femur fracture attributed to an underlying NOF. We describe the diagnosis and surgical management of curettage and internal fixation using a proximal humerus locking plate, resulting in complete resorption of the lytic zone and an excellent clinical outcome.

Enchondroma Protuberans of the Hand: A Rare Cartilaginous Tumor.

Introduction: Enchondroma protuberans (EP), a rare form of enchondroma with exophytic growth, differs radiographically from classical enchondromas and can mimic osteochondroma, periosteal chondroma, or chondrosarcoma. Proper differentiation is crucial to avoid unnecessary radical resection, as EP requires intralesional curettage rather than the surgical removal typical for osteochondromas.

Case Report: A 14-year-old male presented with a progressively enlarging, painless mass on the lateral aspect of his left hand, initially noticed 4 years ago.

Efficacy And Safety Of Low-Dose Methotrexate In Generalized And Recalcitrant Lichen Planus: A Retrospective Study At A Tertiary Care Center.

Introduction: Methotrexate (MTX) acts by suppressing multiple immune pathways involved in the pathogenesis of lichen planus (LP). Trials assessing the efficacy and relapse rates of methotrexate in LP are lacking.

Objectives: Our objective was to analyze the efficacy and safety of low-dose methotrexate in generalized and recalcitrant LP patients retrospectively and to assess the relapse rates in patients after stopping MTX therapy.

Gold-Induced Cytokine (GOLDIC) for the Management of Knee Osteoarthritis: A Systematic Review.

Gold-induced cytokine (GOLDIC) is a novel orthobiologic approach utilizing gold particles to produce a serum rich in immunoregulating cytokines and growth factors, which is being explored for its potential in tissue regeneration and treating musculoskeletal issues like knee osteoarthritis (OA). This study aims to review its mechanism of action along with the outcomes of , preclinical, and clinical studies, with a secondary focus on documenting clinical trials related to its use in OA of the knee. A systematic search was conducted in four databases (Embase, Scopus, PubMed, Web of Science) for studies on GOLDIC therapy for knee OA, using specific keywords related to knee anatomy and OA.

Predicting unicompartmental arthroplasty success: a three year Indian study.

Purpose: This study evaluated the three year clinical outcomes and predictors of success for unicompartmental knee arthroplasty (UKA) in an Indian population.

Methods: Twenty patients with medial compartment osteoarthritis (≥ Ahlbäck grade 2) underwent UKA. American Knee Society Score (AKSS), Oxford Knee Score (OKS), and Visual Analogue Scale Score (VAS) were assessed at baseline, two weeks, six weeks, three months, and three years.

The Clinical Profile of Heatstroke Patients Admitted to the Intensive Care Unit: A Case Series From a Tertiary Care Center in New Delhi, India.

Heat-related illnesses include a spectrum of disorders ranging from heat syncope, muscle cramps, and heat exhaustion to heat emergencies such as heatstroke. Severe heatwaves can lead to extremely high environmental temperatures and a spurt of cases of heat-related illnesses and heatstroke. The incidence of such heat-related medical emergencies was much higher in 2024 compared to previous years throughout North and Central India.

Combating antimicrobial resistance in osteoarticular infections: Current strategies and future directions.

The emergence of antimicrobial resistance (AMR) has profoundly impacted the management of osteoarticular infections (OAIs), presenting significant challenges for healthcare systems worldwide. This review provides a comprehensive overview of the current landscape of AMR in OAIs, emphasizing the necessity for assertive and innovative strategies to combat this escalating health threat. It discusses the evolution of resistance among key pathogens, including ESKAPEE organisms, and the implications for treatment protocols and healthcare outcomes.

Morphometric Analysis of Petrous Bone With Emphasis on Landmarks Utilized in Lateral Skull Base Approaches.

Background The petrous part of the temporal bone plays a crucial role in various cranial surgical approaches, particularly those involving the middle cranial fossa. Understanding the morphometry of this region is essential for minimizing intraoperative risks and enhancing surgical outcomes. This study aims to provide a detailed morphometric analysis of the petrous bone and its anatomical landmarks in an Indian population, addressing a gap in the literature.

Research in Psychiatry Medical Education through "MUST Enrich Grant": A Scoping Review.

Background: The Indian Teachers of Psychiatry (IToP) forum introduced a unique research grant scheme- IToP-MUST (Minds United Scholarship for Teachers) Enrich Research Grant- for conducting research in psychiatry education. This scoping review's objectives are to (a) assess the research areas and methodologies of MUST Enrich grant-supported research, (b) identify strengths and limitations of these research works, and (c) inform the researchers and funding agency concerning robust methodologies and study areas that can be considered in the future.

Methods: We included all MUST-funded original educational research projects from their inception (2020) to the present, which were either published or, although unpublished, available in the public domain.

Treatment of electrographic seizures versus clinical seizures in neonates: A systematic review and meta-analysis.

Introduction: Electrographic seizures in neonates are commonly associated with poor neurodevelopmental outcomes. However, there is conflict in evidence whether control of electrographic seizures translate into improved neurodevelopmental outcome. We aimed to evaluate whether treating all electrographic seizures compared with treating clinical seizures leads to a better neurodevelopmental outcome at 18-24 months in neonates.