3,374 results match your criteria: "Dover; Helen F. Graham Cancer Center[Affiliation]"

The Doctor of Nursing Practice (DNP) degree prepares nurses for engagement in practice scholarship to improve health outcomes at multiple system levels. Organizational leaders' and employers' perceptions and expectations of DNP-prepared nurses require further study. To explore the perception of organizational leaders regarding expectations and engagement of DNP-prepared nurses in practice scholarship activities.

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Despite the push and pull between pro-diversity advocates and conservative resistance, most organizations have implemented diversity initiatives in an effort to promote equitable and fair organizational practices. Past work has shown that these diversity initiatives may not be as effective as expected and may instead result in unintended negative consequences for the very individuals they are meant to support. In three novel experiments (total N = 3,664), we investigated whether and when the presence of pro-diversity messages in organizational job recruitment materials might facilitate versus hinder the hiring of underrepresented racial minorities.

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Background: Many individuals with advanced dementia die in hospital, despite preferring home death. Existing evidence of factors affecting their place of death is inconsistent. To inform policies/practices for meeting needs/preferences, systematically establishing the evidence is pertinent, particularly given the exponential rise in advanced dementia prevalence.

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Synthetic cannabinoid identification in cases associated with blue lotus and valerian root vaping products.

J Anal Toxicol

October 2024

Division of Forensic Toxicology, Armed Forces Medical Examiner System, Dover AFB, DE 19902, United States.

Synthetic cannabinoids emerged in the early 21st century and have continued to evolve and flourish to present day. Like other novel psychoactive substances (NPS), synthetic cannabinoids have been sold under the guise of legitimate products. Some examples include "potpourri," "incense," and herbal material.

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Salt marsh grass () plays a crucial role in Delaware coastal regions by serving as a physical barrier between land and water along the inland bays and beaches. This vegetation helps to stabilize the shoreline and prevent erosion, protecting the land from the powerful forces of the waves and tides. In addition to providing a physical barrier, salt marsh grass is responsible for filtering nutrients in the water, offering an environment for aquatic species and presenting a focal point of study for high salt tolerance in plants.

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Immune protection associated with consuming colostrum-based peptides is effective against bacterial and viral insults. The goal for this study was to document acute changes to immune surveillance and cytokine levels after consuming a single dose of a nutraceutical blend in the absence of an immune challenge. A double-blind, randomized, placebo-controlled, cross-over pilot study involved healthy participants attending two clinic visits.

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The endophytic fungi, AMFS4 was investigated for its metabolic components and composition of bioactive exopolysaccharides (EPS). Metabolic analysis of the ethyl acetate extract majorly detected sugars derivatives such as, 4-Cholesten-3-one semicarbazone (20.9%), d-Fructose (18.

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Background: Male breast cancer (MaBC) has limited data on genomic alterations. We aimed to comprehensively describe and compare MaBC's genomics with female breast cancer's (FBC) across subtypes.

Methods: Using genomic data from Foundation Medicine, we categorized 253 MaBC into estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative (n = 210), ER-positive/HER2-positive (n = 22) and triple-negative (n = 20).

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To reject, or to accept? A study on radiographers' perspectives on diagnostic radiographs.

J Med Imaging Radiat Sci

December 2024

Department of Radiology, Sengkang General Hospital, 110 Sengkang East Way, Singapore Singapore; Health and Social Science, Singapore Institute of Technology, 10 Dover Drive, Singapore.

Introduction: The overall reject rate (RR) of our newly set up Radiology department was an average of 14%, higher than the recommended 8% target and 10% threshold set by the American Association of Physicists in Medicine (AAPM). An analysis done to identify potential causes of a high RR suggested that radiographers might have been rejecting images of diagnostic value. A lack of consistency in the definition of a diagnostic value image amongst radiographers may be a possible cause in the higher overall RR.

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Reassessing reverse triage in future conflict.

BMJ Mil Health

July 2024

United States Air Force Reserve, Dover, Delaware, USA.

Future warfare will likely involve near-peer or peer-peer conflict in which there is a great risk of mass casualty scenarios. Because of anti-access and area denial, air superiority will not be guaranteed, which will hamper rapid evacuation of casualties as well as resupply. Under such circumstances, military medical personnel may be forced, due to the constraints of the battlefield and tactical necessity to return servicemembers to duty, to implement reverse triage in which servicemembers with less severe injuries are treated first.

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Review of SNP assays for disaster victim identification: Cost, time, and performance information for decision-makers.

J Forensic Sci

September 2024

Armed Forces Medical Examiner System's Armed Forces DNA Identification Laboratory (AFMES-AFDIL), 10 Defense Health Agency, Dover Air Force Base, Dover, Delaware, USA.

In mass disaster events, forensic DNA laboratories may be called upon to quickly pivot their operations toward identifying bodies and reuniting remains with family members. Ideally, laboratories have considered this possibility in advance and have a plan in place. Compared with traditional short tandem repeat (STR) typing, single nucleotide polymorphisms (SNPs) may be better suited to these disaster victim identification (DVI) scenarios due to their small genomic target size, resulting in an improved success rate in degraded DNA samples.

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Multidisciplinary bronchopulmonary dysplasia (BPD) programs provide improved and consistent medical management, care of the developing infant, family support, and smoother transitions in care resulting in improved survival, pulmonary, and extra-pulmonary outcomes. This review summarizes the benefits of interdisciplinary BPD management, as well as strategies for initial programmatic development, program growth, and maintenance at centers across the United States factoring in institutional, provider, and parent reported goals that were derived from a consensus conference on BPD management.

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Catastrophic CPR-Related Injuries in Vascular Ehlers-Danlos Syndrome: A Case Report and Review.

Am J Forensic Med Pathol

December 2024

From Forensic Pathology Investigations, Armed Forces Medical Examiner System, Dover, DE.

This article presents a case of severe CPR-related injuries leading to diagnosis of vascular Ehlers-Danlos syndrome. The subject is a 36-year-old female with a past medical history of a 10-mm aneurysm of the right internal carotid artery discovered on imaging 3 years prior to death. Major autopsy findings included subarachnoid hemorrhage in the base of the brain, bilateral hemothoraces, hemopericardium, laceration of the interatrial septum, laceration of the left pulmonary artery, and changes secondary to chronic alveolar hemorrhage in the lungs.

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Intrinsic PARG inhibitor sensitivity is mimicked by haploinsufficiency and rescued by nucleoside supplementation.

NAR Cancer

September 2024

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre (MAHSC), Manchester Cancer Research Centre, Wilmslow Road, Manchester M20 4GJ, UK.

A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibition of , a replisome accelerator. However, the nature of the vulnerability responsible for intrinsic sensitivity remains undetermined.

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Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome.

J Neurodev Disord

July 2024

Department of Neurology and Semel Institute for Neuroscience, David Geffen School of Medicine, 710 Westwood Plaza, Los Angeles, CA, 90095, USA.

Article Synopsis
  • Sleep disturbances are common in neurodevelopmental disorders like Dup15q syndrome, which is linked to conditions such as autism and intellectual disability, and are associated with significant disruptions in sleep patterns.
  • The study examines sleep physiology in mice genetically mimicking Dup15q syndrome to validate previous EEG findings of increased beta oscillations, particularly during NREM sleep.
  • Researchers collected EEG/EMG data to analyze sleep metrics across different mouse genotypes (Dup15q mutants and wildtype controls), aiming to understand the connection between genetic factors and sleep quality.
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Electrical, Optical and Thermal Properties of Ge-Si-Sn-O Thin Films.

Materials (Basel)

July 2024

Division of Physics, Engineering, Mathematics and Computer Science, and Optical Science Center for Applied Research, Delaware State University, Dover, DE 19901, USA.

This work evaluates the electrical, optical and thermal properties of Sn-doped GeSiO thin films for use as microbolometer sensing materials. The films were prepared using a combination of a radio frequency (RF) magnetron and direct current (DC) sputtering using a Kurt J Leskar Proline PVD-75 series sputtering machine. Thin films were deposited in an O+Ar environment at a chamber pressure of 4 mTorr.

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A trauma expert consensus: Capabilities are required early to improve survivability from traumatic injury.

J Trauma Acute Care Surg

August 2024

From the Joint Trauma System (J.M.G., R.S.K., S.J., B.J.S., J.W., H.M., A.J.R.), Defense Health Agency, Joint Base San Antonio-Fort Sam Houston, Texas; Department of Surgery (J.M.G., S.S., S.J., E.M.), Department of Military and Emergency Medicine (R.S.K., E.M.), and Department of Pathology (A.J.R., E.M.), Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Trauma and Acute Care Surgery (J.B.H.), University of Alabama at Birmingham, Birmingham, Alabama; The Geneva Foundation (A.M.S.), US Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston; Department of Surgery, Trauma and Acute Care Surgery (B.E.), University of Texas Health San Antonio, San Antonio, Texas; Joint Medical Unit (M.S.), Joint Special Operations Command, United States Special Operations Command, Fort Liberty, North Carolina; San Antonio Uniformed Services Health Education Consortium (M.S.), Joint Base San Antonio-Fort Sam Houston, Texas; Defense Health Agency (S.J., S.S.), Colorado Trauma Medical Director, Colorado Springs, Colorado; Department of Trauma and Acute Care Surgery (K.G.), Cooper University Medical Center, Camden, New Jersey; HNL Lab Medicine (E.M.), Allentown, Pennsylvania; and Armed Forces Medical Examiner System (W.W., A.J.R.), Defense Health Agency, Dover Air Force Base, Delaware.

Article Synopsis
  • The study reviews US military fatalities from combat trauma between 2001 and 2021 to identify potential survival-benefitting interventions and improve trauma care systems.
  • Out of 388 fatalities analyzed, 100 were identified as potentially survivable, with the majority occurring prehospital and involving severe injuries such as gunshot wounds.
  • A panel of medical experts recommended 433 interventions, highlighting blood transfusion as the most critical prehospital intervention and thoracotomy as vital in hospital settings for improving survival outcomes.
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Genetic and epigenetic signatures for improved breeding of cultivated blueberry.

Hortic Res

July 2024

Jilin Provincial Laboratory of Crop Germplasm Resources, College of Horticulture, Jilin Agricultural University, No. 2888 Xincheng Street, Economic Development District, Changchun 130118, China.

Article Synopsis
  • Blueberry is an economically important fruit that was domesticated in the early 1900s through hybridization, with the research including 220 accessions from multiple countries.
  • The study focused on identifying genetic traits that differentiate northern highbush blueberries (NHB) from southern highbush blueberries (SHB), revealing specific genes linked to climate adaptability and fruit quality.
  • Whole-genome sequencing and analysis indicated significant genetic variation and epigenetic differences, particularly in the β-alanine metabolic pathway, providing essential resources for future blueberry breeding efforts.
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Background: Pre-frailty is associated with increased healthcare utilization. Over the past decade, public health interventions such as community-based exercises to target pre-frailty have been increasingly studied. However, the effects of community-based exercises on clinical outcome measures amongst community-dwelling older adults with pre-frailty remain unclear.

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Article Synopsis
  • Relapsing polychondritis (RPC) is a rare autoimmune disorder that primarily affects cartilaginous tissues, especially leading to painful swelling of the ear, and often mimics recurrent external ear infections.
  • A 74-year-old male with a history of vascular disease experienced repeated painful swelling of his right ear, misdiagnosed as otitis externa, and showed elevated inflammatory markers and antinuclear antibodies in lab tests.
  • After inadequate results from antibiotics and anti-inflammatory treatments, he was started on prednisone and referred to rheumatology for further management of his recurrent ear issues.
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The coronavirus disease 2019 (COVID-19) pandemic has unveiled numerous clinical challenges, particularly its association with thrombotic events, which significantly contribute to morbidity and mortality. While thrombotic complications such as arterial and venous thromboembolism (VTE) are well-documented, instances of intracardiac thrombus are notably rare. This case report discusses a 60-year-old male with COVID-19 who came to the hospital due to respiratory distress.

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Oral ulcers are one of the most common complaints seen by general practitioners in their offices. Recurrent aphthous stomatitis affects roughly 20% of the general population. When ulcers persist despite conventional treatment, it is crucial to consider systemic diseases such as Behçet's disease to prevent delays in care.

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A new perspective on aortic pressure for transcatheter closure of patent ductus arteriosus in the pediatric population.

Kardiol Pol

December 2024

Department of Coronary Disease and Heart Failure, Jagiellonian University, Medical College, John Paul II Hospital, Kraków, Poland.

Background: Hemodynamic assessment is not routinely performed when closing a patent ductus arteriosus (PDA). Significant PDA flow causes a drop in the aortic pressure distal to the shunt. Closure of PDA should increase distal systemic blood flow and significantly elevate distal aortic pressure, changing the systolic pressure gradient (ΔP) between the proximal and distal aorta.

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