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Dongnam Institute of Radiological & Med... Publications | LitMetric

543 results match your criteria: "Dongnam Institute of Radiological & Medical Sciences (DIRAMS)[Affiliation]"

Development of a web-based high-throughput marker design program: CAPS (cleaved amplified polymorphic sequence) Maker.

Plant Methods

December 2024

Department of Molecular Genetics, Dong-A University, Saha-gu Nakdong-Daero 550 beongil 37, Busan, 49315, Republic of Korea.

Background: Genetic markers are crucial for breeding crops with desired agronomic traits, and their development can be expedited using next-generation sequencing (NGS) and bioinformatics tools. Numerous tools have been developed to design molecular markers, enhancing the convenience, accuracy, and efficiency of molecular breeding. However, these tools primarily focus on genetic variants within short user-input sequences, despite the availability of extensive omics data for genomic variants.

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Background: The study of the human microbiome is crucial for understanding disease mechanisms, identifying biomarkers, and guiding preventive measures. Advances in sequencing platforms, particularly 16S rRNA sequencing, have revolutionized microbiome research. Despite the benefits, large microbiome reference databases (DBs) pose challenges, including computational demands and potential inaccuracies.

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Neuralgic amyotrophy with hourglass-like constrictions: A case report.

World J Clin Cases

December 2024

Department of Physical Medicine and Rehabilitation, Dongnam Institute of Radiological and Medical Sciences, Busan 46033, South Korea.

Article Synopsis
  • - Neuralgic amyotrophy (NA) is a rare condition characterized by sudden shoulder pain followed by weakness in the arm, primarily affecting the upper brachial plexus, and can often mimic cervical radiculopathy due to its similar symptoms.
  • - A 76-year-old male developed NA after hip surgery, experiencing shoulder pain and arm weakness; diagnostic imaging confirmed brachial plexopathy and unique signs of NA including a focal constriction at the suprascapular nerve.
  • - Treatment for NA involved corticosteroids and physical therapy, leading to significant recovery in shoulder muscle strength within a month, highlighting the importance of recognizing NA's distinct features for accurate diagnosis.
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The Korean Breast Cancer Society (KBCS) has collected nationwide registry data on clinicopathologic characteristics and treatment since 1996. This study aimed to analyze the clinical characteristics of breast cancer in Korea and assess changes in breast cancer statistics for 2021 using data from the KBCS registry and the Korean Central Cancer Registry. In 2021, 34,628 women were newly diagnosed with breast cancer.

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Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications.

Cancer Lett

February 2025

Department of Biomedical Sciences, Dong-A University, Busan, 49315, South Korea; Department of Health Sciences, The Graduated of Dong-A University, Busan, 49315, South Korea. Electronic address:

Article Synopsis
  • * The researchers created a 63-gene signature called Chemoresistance-Motility (CrM) to study how NMIBC evolves over time and used it to analyze 1,846 samples, revealing that early resistance stages are linked to increased cell movement and metastasis.
  • * The study suggests that patients with high CrM scores have worse outcomes, ineffective responses to BCG and immune therapies, and identifies five alternative drugs to gemcitabine that may be effective, proposing a need for further validation of these findings.
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Article Synopsis
  • Head and neck squamous cell carcinoma (HNSCC) has poor survival rates and current treatments are highly toxic, creating a demand for new therapies that can effectively target cancer cells.
  • The study explored the combination of radiotherapy, cetuximab, and expanded natural killer (NK) cells to enhance treatment efficacy, showing that radiation increases sensitivity of tumors to NK cells and cetuximab.
  • Results revealed that this combination significantly suppressed cancer progression and improved survival, although adding PD-1 inhibitors did not provide extra benefit, indicating a promising new therapy for HNSCC.
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Introduction: This study aimed to evaluate the influence of early oral feeding (EOF), a key component of enhanced recovery after surgery protocols, on postoperative outcomes in patients undergoing elective colorectal surgery.

Methods: We searched the MEDLINE, Embase, Cochrane Library, and KoreaMed databases to include randomized clinical trials comparing EOF that started on postoperative day 1 and conventional oral feeding that commenced after first flatus. Two authors independently screened the retrieved records and extracted data.

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This study aims to investigate the feasibility of utilizing generative adversarial networks (GANs) to synthesize high-fidelity computed tomography (CT) images from lower-resolution MR images. The goal is to reduce patient exposure to ionizing radiation while maintaining treatment accuracy and accelerating MR image acquisition. The primary focus is to determine the extent to which low-resolution MR images can be utilized to generate high-quality CT images through a systematic study of spatial resolution-dependent magnetic resonance imaging (MRI)-to-CT image conversion.

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Background: Renal function deterioration during systemic therapy in patients with metastatic renal cell carcinoma (mRCC) is a long-term concern in treatment planning. Although hypertension (HTN) and diabetes mellitus (DM) are the most common factors that affect chronic kidney disease (CKD) development and progression, their impact on renal function during targeted therapy is unclear. This study investigated whether DM and HTN were associated with a decline in renal function during first-line targeted therapy for mRCC.

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Purpose: This study aimed to evaluate the impact of facilitating target delineation of continuous positive airway pressure (CPAP) in patients undergoing stereotactic ablative radiation therapy (SABR) for lung tumors by lung expansion and respiratory motion management.

Materials And Methods: We performed a prospective single-institutional trial of patients who were diagnosed with either primary lung cancer or lung metastases and received SABR with a dose of 40 to 60 Gy in 4 fractions. Four-dimensional computed tomography simulations were conducted for each patient: once without CPAP and again with CPAP.

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Downstaging of hepatocellular carcinoma (HCC) is typically defined as the reduction in size or number of viable tumors through locoregional therapy (LRT), aiming to meet the established criteria for liver transplantation (LT). According to the Barcelona Clinic Liver Cancer (BCLC) staging system, a subgroup of patients with BCLC-B may benefit most from downstaging therapies. The United Network Organ Sharing downstaging protocol identifies potential candidates for downstaging by setting out 'inclusion criteria' and defining 'successful downstaging.

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The primary goal during cancer removal surgery is to completely excise the malignant tumor. Because the color of the tumor and surrounding tissues is very similar, it is difficult to observe with the naked eye, posing a risk of damaging surrounding blood vessels during the tumor removal process. Therefore, fluorescence emission is induced using a fluorescent contrast agent, and color classification is monitored through camera imaging.

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Optical Methods for Optimizing Fluorescence Imaging Field of View and Image Quality in Surgical Guidance Procedures.

Diagnostics (Basel)

September 2024

Medical Devices R&D Center, Gachon University Gil Medical Center, 21, 774 Beon-gil, Namdong-daero, Namdong-gu, Incheon 21565, Republic of Korea.

Cancer surgery is aimed at complete tumor resection and accurate lymph node detection. However, numerous blood vessels are distributed within the tumor, and the colors of the tumor, blood vessels, and lymph nodes are similar, making observations with the naked eye difficult. Therefore, tumors, blood vessels, and lymph nodes can be monitored via color classification using an operating microscope to induce fluorescence emission.

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Mitoregulin modulates inflammation in osteoarthritis: Insights from synovial transcriptomics and cellular studies.

Biochem Biophys Res Commun

November 2024

Department of Biochemistry, Department of Convergence Medical Science, and Institute of Medical Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea. Electronic address:

Osteoarthritis is a prevalent musculoskeletal disease that involves cartilage degradation, subchondral bone remodeling, and synovial inflammation and ultimately causes physical disability. Common risk factors for osteoarthritis include age, sex, obesity, and genetic predispositions. Treatment includes nonpharmaceutical and pharmacological approaches; however, disease-modifying osteoarthritis drugs remain undeveloped.

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Article Synopsis
  • A low arousal threshold (LAT) is a specific trait linked to obstructive sleep apnea (OSA), potentially connected to changes in brain connectivity, particularly in the brainstem and cortical areas.
  • The study involved 25 OSA patients (some with and some without LAT) and 15 healthy controls, who underwent functional MRI to assess brain connectivity patterns after sleep monitoring.
  • Findings indicated significant differences in connectivity between brainstem nuclei and cortical regions, with OSA patients showing stronger connections, particularly in areas associated with cholinergic activity, suggesting that this may influence LAT in these patients.
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Article Synopsis
  • - Sentinel node navigation (SNN) is effective for stomach-preserving surgery in early gastric cancer but has technical challenges in practice.
  • - A study analyzed data from the SENORITA trial, evaluating the effectiveness of regional lymphadenectomy without SNN on 237 patients, focusing on lymph node metastasis in relation to tumor location.
  • - Results indicated that while SNN showed higher sensitivity and negative predictive values for detecting metastasis compared to regional lymphadenectomy, completely omitting SNN in surgery was deemed insufficient and not recommended.
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Background: Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation into using the methylation profile of circulating tumor DNA (ctDNA), derived from blood, as a promising indicator for diagnosing and monitoring colon cancer.

Results: We propose a liquid biopsy-based epigenetic method developed by utilizing 49 patients and 260 healthy controls methylation profile data to screen and monitor colon cancer.

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Piperlongumine regulates genes involved in the skin barrier in epidermal keratinocyte HaCaT cells.

Anim Cells Syst (Seoul)

June 2024

Department of Biochemistry, Department of Convergence Medical Science, and Institute of Medical Sciences, School of Medicine, Gyeongsang National University, Jinju, Korea.

Given that the skin is the largest tissue in the human body, performing external barrier functions with innate and adaptive immunity and undergoing substantial changes during aging, it is under investigation as a major target of various bioactive molecules. In the present study, we examined the biological activity of the senolytic piperlongumine by analyzing alterations in mRNA expression of notable skin genes using transformed aneuploid immortal epidermal keratinocytes, HaCaT cells. We observed that piperlongumine increased the mRNA expression of genes playing critical roles in skin barrier function.

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Mutations in the gene are associated with autosomal recessive spastic ataxia of Charlevoix-Saguenay disease (ARSACS) or complex clinical phenotypes of Charcot-Marie-Tooth disease (CMT). This study aimed to identify mutations in a Korean CMT cohort with cerebellar ataxia and spasticity by whole exome sequencing (WES). As a result, eight pathogenic mutations in four families were identified as the underlying causes of these complex phenotypes.

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Echinochrome A (Ech A), a marine biosubstance isolated from sea urchins, is a strong antioxidant, and its clinical form, histochrome, is being used to treat several diseases, such as ophthalmic, cardiovascular, and metabolic diseases. Cancer-associated fibroblasts (CAFs) are a component of the tumor stroma and induce phenotypes related to tumor malignancy, including epithelial-mesenchymal transition (EMT) and cancer stemness, through reciprocal interactions with cancer cells. Here, we investigated whether Ech A modulates the properties of CAFs and alleviates CAF-induced lung cancer cell migration.

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Objectives: Despite numerous published concept analyses of nursing competency, the specific understanding of trauma nursing competency in emergency departments remains limited, with no clear definition. This study aimed to clarify the definitions and attributes of trauma nursing competencies in emergency departments.

Design: Walker and Avant's method was used to clarify the concept of trauma nursing competency in emergency departments.

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Background: Immune checkpoint inhibitor (ICI)-based therapy such as atezolizumab plus bevacizumab or durvalumab plus tremelimumab became mainstream first-line systemic treatment in advanced hepatocellular carcinoma (HCC) patients since remarkably superior efficacy of ICI-based therapy compared to tyrosine kinase inhibitors (TKIs) was reported in two recent randomized controlled trials (RCTs) (IMbrave150, HIMALAYA). However, the optimal second-line therapy after treatment failure of first-line ICI-based therapy remains unknown as no RCT has examined this issue.

Summary: Therefore, at present, most clinicians are empirically treating patients with TKIs or retrial of ICI or locoregional treatment (LRT) modality such as transarterial therapy, radiofrequency ablation, and radiation therapy in this clinical setting without solid evidence.

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Cirrhotic cardiomyopathy (CCM) is defined as cardiac dysfunction associated with cirrhosis in the absence of pre-existing heart disease. CCM manifests as the enlargement of cardiac chambers, attenuated systolic and diastolic contractile responses to stress stimuli, and repolarization changes. CCM significantly contributes to mortality and morbidity in patients who undergo liver transplantation and contributes to the pathogenesis of hepatorenal syndrome/acute kidney injury.

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Protective effects of tauroursodeoxycholate against radiation-induced intestinal injury in a mouse model.

Biochem Biophys Res Commun

September 2024

College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, 61186, Republic of Korea. Electronic address:

In patients with high-level radiation exposure, gastrointestinal injury is the main cause of death. Despite the severity of damage to the gastrointestinal tract, no specific therapeutic option is available. Tauroursodeoxycholic acid (TUDCA) is a conjugated form of ursodeoxycholic acid that suppresses endoplasmic reticulum (ER) stress and regulates various cell-signaling pathways.

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Background: Programmed cell death 6 (PDCD6) is known to be involved in apoptosis and tumorigenesis. Given the reported association with urinary cancer susceptibility through SNP analysis, we further analyzed the entire genomic structure of PDCD6.

Methods: Three VNTR regions (MS1-MS3) were identified through the analysis of the genomic structure of PDCD6.

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