An exploratory study on the perception of the over-the-top (OTT) industry among film and media production major university students: Utilizing the Q methodology.

This study investigates the perceptions of university students majoring in film and media production (FMP) regarding the over-the-top (OTT) industry. We used the Q methodology to achieve this study's purpose, with 33 Q sets and 22 university students majoring in FMP. The study revealed three perception structures of FMP major university students regarding the OTT industry.

Nickel Nanocluster-Stabilized Unsaturated Ni-N3 Atomic Sites for Efficient CO2-to-CO Electrolysis at Industrial-Level Current.

Unsaturated Ni single atom catalysts (SACs), Ni-Nx (x=1,2,3), have been investigated to break the conventional Ni-N4 structural limitation and provide more unoccupied 3d orbitals for CO2RR intermediates adsorption, but their intrinsically low structural stability has seriously hindered their applications. Here, we developed a strategy by integrating Ni nanoclusters to stabilize unsaturated Ni-N3 atomic sites for efficient CO2 electroreduction to CO at industrial-level current. DFT calculations revealed that the incorporation of Ni nanocluster effectively stabilizes the unsaturated Ni-N3 atomic sites and modulates their electronic structure to enhance the adsorption of the key intermediate *COOH during CO2RR.

Damage Localization and Severity Assessment in Composite Structures Using Deep Learning Based on Lamb Waves.

In composite structures, the precise identification and localization of damage is necessary to preserve structural integrity in applications across such fields as aeronautical, civil, and mechanical engineering. This study presents a deep learning (DL)-assisted framework for simultaneous damage localization and severity assessment in composite structures using Lamb waves (LWs). Previous studies have often focused on either damage detection or localization in composite structures.

Sustained-Release Solid Dispersions of Fenofibrate for Simultaneous Enhancement of the Extent and Duration of Drug Exposure.

Background/objectives: A sustained-release formulation of fenofibrate while enhancing drug dissolution with minimal food effect is critical for maximizing the therapeutic benefits of fenofibrate. Therefore, this study aimed to develop an effective solid dispersion formulation of fenofibrate for simultaneous enhancement in the extent and duration of drug exposure.

Methods: Fenofibrate-loaded solid dispersions (FNSDs) were prepared using poloxamer 407 and Eudragit RSPO at varied ratios via solvent evaporation.

Small Molecules in Parkinson's Disease Therapy: From Dopamine Pathways to New Emerging Targets.

Parkinson's disease (PD) is a chronic, progressive neurological disorder affecting approximately 10 million people worldwide, with prevalence expected to rise as the global population ages. It is characterized by the degeneration of dopamine-producing neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremor, rigidity, bradykinesia, postural instability, and gait disturbances, as well as non-motor symptoms including olfactory disturbances, sleep disorders, and depression. Currently, no cure exists for PD, and most available therapies focus on symptom alleviation.

Recent Advancements in CoO-Based Composites for Enhanced Electrocatalytic Water Splitting.

The pursuit of efficient and economical catalysts for water splitting, a critical step in hydrogen production, has gained momentum with the increasing demand for sustainable energy. Among the various electrocatalysts developed to date, cobalt oxide (CoO) has emerged as a promising candidate owing to its availability, stability, and catalytic activity. However, intrinsic limitations, including low catalytic activity and poor electrical conductivity, often hinder its effectiveness in electrocatalytic water splitting.

High Correlation Between Li Solvation Energy and Li Ionic Conductivity in Lithium Metal Battery Electrolytes.

In lithium metal batteries, accurately estimating the Li solvation ability of solvents is essential for effectively modulating the Li solvation sheath to form a stable interphase and achieve high ionic conductivity. However, previous studies have shown that the theoretically calculated Li binding energy, commonly used to evaluate solvation ability, exhibits only a moderate correlation with experimentally measured ionic conductivity (R = 0.68).

Subjective Perception Types of Older Adults Living Alone as Farmers in Korea: A Q Methodology Study.

This study explores the psychological characteristics of older adults living alone as farmers in South Korea, categorising their subjective experiences. Using Q methodology, interviews were conducted with participants from Seosan, Chungcheong Province, South Korea, on 19 and 22 June 2023. A total of 25 participants conducted Q sorting with 33 finalized Q sample items in three locations: Chungju, Chungcheong Province, on 14 July 2023; Ildong, Gyeonggi Province, on 28 July 2023; and Seosan, Chungcheong Province, on 14 August 2023.

Emerging Love: A Subjective Exploration of Romantic Bonds in Early Adulthood Within the South Korean Context.

This study examines and categorises subjective perceptions of love among individuals in their twenties and thirties, offering insights into their viewpoints during early adulthood. The study employed the Q methodology, suitable for analysing subjective perceptions such as perspectives, thoughts, beliefs, and attitudes. It included 23 participants selected through purposive sampling from the 2030 generation residing in South Korea, with 40 statements constructed for the research.

Comparison of Rheological and Tribological Properties of Cold Thickened Beverages for Dysphagia Management.

This study investigated the rheological and tribological properties of cold beverages [bottled water (BW), sports drink (SD), orange juice (OJ), and whole milk (WM)] thickened with various concentrations (1%, 2%, and 3%, w/w) of xanthan gum-based food thickeners. All thickened beverages exhibited high pseudoplastic behavior, with increasing thickener concentration leading to higher viscosity and viscoelastic moduli and a lower flow behavior index. Thickened BW, SD, and WM exhibited typical Stribeck curves covering the boundary, mixed, and hydrodynamic lubrication regimes.

Development of analysis method for -xylenediamine as aldehyde scavenger using HPLC-PDA.

The objective of this study was to develop an analytical method for -xylenediamine (-XDA), an aldehyde scavenger, in various food simulants and food matrices. The analysis was performed using HPLC-UV (270 nm) with a Capcell pak MGII C18 column (4.6 × 250 mm, 5 μm).

Knee osteoarthritis severity detection using deep inception transfer learning.

Osteoarthritis (OA) is a prevalent condition resulting in physical limitations. Early detection of OA is critical to effectively manage this condition. However, the diagnosis of early-stage arthritis remains challenging.

Assessing the environmental determinants of micropollutant contamination in streams using explainable machine learning and network analysis.

Even at trace concentrations, micropollutants, including pesticides and pharmaceuticals, pose considerable ecological risks, and the increasing presence of synthetic chemical substances in aquatic systems has emerged as a growing concern. Moreover, limited machine-learning (ML) approaches exist for analyzing environmental data, and the increasing complexity of ML models has made it challenging to understand predictor-outcome relationships. In particular, understanding complex interactions among multiple variables remains challenging.

Arvimicrobium flavum gen. nov., sp. nov., A Novel Genus in the Family Phyllobacteriaceae Isolated From Forest Soil.

During the study of microbial diversity of forest soil in the Republic of Korea, a yellow pigment-producing, Gram-stain-negative, rod-shaped, motile bacterium was isolated and designated as strain 1W2. This strain grew at temperature of 10-37 °C, at pH of 5.0-9.

Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes.

This study aimed to investigate the effects of fluconazole, a moderate inhibitor of CYP2C9 and CYP3A4, on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes. A total of thirty-nine healthy Korean male volunteers were divided into three different CYP2C9 genotype groups (CYP2C9*1/*1, *1/*3 and *3/*3 genotypes) and were enrolled in the celecoxib alone trial, celecoxib with fluconazole trial, or both. In the celecoxib alone trial, participants received a single oral dose of 200 mg celecoxib.

Indole-3-carbinol alleviates allergic skin inflammation via periostin/thymic stromal lymphopoietin suppression in atopic dermatitis.

Background: Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disorder with a complex etiology. Despite its increasing prevalence, treatment of AD is still limited. Indole-3-carbinol (I3C) is found in cruciferous vegetables and is formed when these vegetables are cut, chewed, or cooked; it exerts diverse pharmacological activities.

Nutritional Composition, Phytochemical Profiles, and Pharmacological Effects of Ethiopian Eggplant ( L.).

Natural product therapy has been used to treat illness for thousands of years, and modern-day medicines, such as various anticancer, antihypertensive, and antimigraine drugs, have been developed from natural products. Natural medicines are advantageous as they tend to have fewer side effects and are considered a relatively safe option. L.

Laser Desorption/Ionization on Au@TiO Core@Shell Nanostars for Mass Spectrometric Analysis of Small Molecules.

The core@shell nanostars composed of star-like Au nanocores with TiO shells (Au@TiO NSs) are synthesized in a one-pot reaction without any reducing or surface-controlling agents. The Au@TiO NSs exhibit strong absorption in the UV region based on the interaction between the Au nanocore and the TiO shell, and this optochemical property leads to the efficient laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) analysis of small molecules with low background interference and high reproducible mass signals compared with spherical Au nanoparticles (NPs). The limit of detection and dynamic range values of various analytes also improved with Au@TiO NSs compared with those obtained with spherical Au NPs.

Determination of Flavonoid Glycoside Isomers Using Vision Transformer and Tandem Mass Spectrometry.

A vision transformer (ViT)-based deep neural network was applied to classify the flavonoid glycoside isomers by analyzing electrospray ionization tandem mass spectrometry (ESI-MS/MS) spectra. Our model successfully classified the flavonoid isomers with various substitution patterns (3-O, 6-C, 7-O, 8-C, 4'-O) and multiple glycosides, achieving over 80% accuracy during training. In addition, the experimental spectra from flavonoid glycoside standards were acquired with different adducts, and our model showed robust performance regardless of the experimental conditions.

Anti-Aging Effect of Traditional Plant-Based Food: An Overview.

Aging is a complex process that involves many physiological mechanisms that gradually impair normal cellular and tissue function and make us more susceptible to diseases and death. It is influenced by intrinsic factors like cellular function and extrinsic factors like pollution and UV radiation. Recent scientific studies show that traditional plant-based foods and supplements can help mitigate the effects of aging.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Structural analysis of ExaC, an NAD-dependent aldehyde dehydrogenase, from Pseudomonas aeruginosa.

The opportunistic pathogen Pseudomonas aeruginosa (Pa) utilizes ethanol as an energy source, however, ethanol metabolism generates acetaldehyde, a toxic byproduct. To mitigate this toxicity, P. aeruginosa employs aldehyde dehydrogenases (ALDHs) to oxidize acetaldehyde into less harmful compounds.