[Analysis of the cause of pregnancy failure with combined MLPA assay for subtelomeric regions and ultrasonography].

Objective: To explore the value of multiplex ligation-dependent probe amplification (MLPA) for the detection of chromosome abnormalities in miscarriage tissues, and to correlate the result with ultrasound findings.

Methods: A total of 421 cases of spontaneous abortions and fetal deaths were detected with the MLPA method.

Results: Among the 421 samples, 232 (55.